Essential arginine residues in beef kidney D-aspartate oxidase (a preliminary report).

abstract：:The PKC family of serine/threonine kinases have been implicated in a diverse array of cellular responses. Adult cardiac myocytes express multiple PKC isozymes, which participate in the response of muscle cells to extracellular stimuli, modulate contractile properties, and promote cell growth and survival. Recently, th...

journal_title：Molecular and cellular biochemistry

authors： Malhotra A,Kang BP,Opawumi D,Belizaire W,Meggs LG

更新日期：2001-09-01 00:00:00

abstract：:Human glomerular mesangial cells (HMCs) have a finite lifespan and eventually enter irreversible growth arrest known as cellular senescence which is thought to contribute to kidney aging and age-related kidney disorders, such as chronic kidney disease. The signal transducer and activator of transcription 1 (STAT1) is ...

journal_title：Molecular and cellular biochemistry

authors： Jiao S,Meng F,Zhang J,Yang X,Zheng X,Wang L

更新日期：2012-06-01 00:00:00

abstract：:Oxidation of semiquinone by O2 in the Q cycle is known to be one of the sources of superoxide anion (O2.-) in aerobic cells. In this paper, such a phenomenon was analyzed using the chemical kinetics model of electron transfer from succinate to cytochrome c, including coenzyme Q, the complex III non-heme iron protein F...

journal_title：Molecular and cellular biochemistry

authors： Demin OV,Kholodenko BN,Skulachev VP

更新日期：1998-07-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine, which is caused by PRRS virus (PRRSV). CD151, one of PRRSV entry mediators, determines the cell susceptibility for PRRSV. Emerging evidence indicates that the host microRNAs (miRNAs) play key roles in modu...

journal_title：Molecular and cellular biochemistry

authors： Wu J,Peng X,Zhou A,Qiao M,Wu H,Xiao H,Liu G,Zheng X,Zhang S,Mei S

更新日期：2014-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of death worldwide. Novel non-invasive, high diagnostic value screening test is urgently needed to improve survival rate, treatment and prognosis. Stable, small, circulating microRNA (miRNA) offers unique opportunities for the early diagnosis of several diseases. It acts as tum...

journal_title：Molecular and cellular biochemistry

authors： Sabry D,El-Deek SEM,Maher M,El-Baz MAH,El-Bader HM,Amer E,Hassan EA,Fathy W,El-Deek HEM

更新日期：2019-04-01 00:00:00

abstract：:Exploring the function of interleukin (IL) 17 and related cytokine interactions have been proven useful toward understanding the role of inflammation in autoimmune diseases. Production of the inflammatory cytokine IL-23 by dendritic cells (DC's) has been shown to promote IL-17 expression by Th17 cells. It is well esta...

journal_title：Molecular and cellular biochemistry

authors： Salimi Elizei S,Poormasjedi-Meibod MS,Wang X,Kheirandish M,Ghahary A

更新日期：2017-07-01 00:00:00

abstract：:This comparative study investigates the relationship between sarcoplasmic reticulum (SR) calcium(Ca2+)-ATPase transport activity and phospholamban (PLB) phosphorylation in whole cardiac homogenates of spontaneously hypertensive rats (SHR) and their parent, normotensive Wistar Kyoto (WKY) strain during early postnatal ...

journal_title：Molecular and cellular biochemistry

authors： Freestone N,Singh J,Krause EG,Vetter R

更新日期：1996-10-01 00:00:00

abstract：:Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats. To further explore the mechanism of action of arjunolic acid, antiplatelet activity, anticoagulant assays, electroca...

journal_title：Molecular and cellular biochemistry

authors： Sumitra M,Manikandan P,Kumar DA,Arutselvan N,Balakrishna K,Manohar BM,Puvanakrishnan R

更新日期：2001-08-01 00:00:00

abstract：:Hepatic stellate cells (HSCs), also referred to as Ito cells, perisinusiodal cells and fat-storing cells, have numerous vital functions. They are the main extracellular matrix-producing cells within the liver and are involved in the storage of retinol. HSCs are also known to secrete a number of liver mitogens. Current...

journal_title：Molecular and cellular biochemistry

authors： Riccalton-Banks L,Bhandari R,Fry J,Shakesheff KM

更新日期：2003-06-01 00:00:00

abstract：:Liver glycogen synthase b phosphatase, chromatographically separable from phosphorylase a phosphatase, is decreased in 48-hour alloxan diabetic rats. The phosphatase activities are measured in an in vitro system using exogenous isolated phospho-enzyme as substrates with added phosphatases. Synthase and phosphorylase p...

journal_title：Molecular and cellular biochemistry

authors： Gold AH,Dickemper D,Haverstick DM

更新日期：1979-05-06 00:00:00

abstract：:Doxorubicin (DOX) is a DNA topoisomerase II inhibitor widely used in anticancer treatment, however, it can lead to irreversible cardiac damage with severe debilitation. TBP-binding associated factor 1 (TAF1) is increased in DOX damaged hearts in vivo and in cardiomyocytes in vitro. To identify the functional role for ...

journal_title：Molecular and cellular biochemistry

authors： Servant N,Marcantonio D,Th'ng JP,Chalifour LE

更新日期：2004-04-01 00:00:00

abstract：:In this review we analyze the concepts and the experimental data on the mechanisms of the regulation of energy metabolism in muscle cells. Muscular energetics is based on the force-length relationship, which in the whole heart is expressed as a Frank-Starling law, by which the alterations of left ventricle diastolic v...

journal_title：Molecular and cellular biochemistry

authors： Saks VA,Kuznetsov AV,Vendelin M,Guerrero K,Kay L,Seppet EK

更新日期：2004-01-01 00:00:00

abstract：:Targeting angiogenesis is considered an effective strategy for treating the expansion and metastasis of tumors. The aim of this study is to assess the effects of perifosine, an inhibitor of Akt, on cell proliferation, apoptosis, angiogenesis, and VEGF-induced cell migration in cultured human umbilical vein endothelial...

journal_title：Molecular and cellular biochemistry

authors： Wang FZ,Fei HR,Li XQ,Shi R,Wang de C

更新日期：2012-09-01 00:00:00

abstract：:Cultured cardiac myocytes were depleted of ATP by incubation with oligomycin (1 mg/ml). Then the ability of the cells to oxidize various substrates and to restore ATP levels was studied. Following ATP depletion, the cells were found to be able to oxidize glucose given alone, but not palmitate. However, with both subst...

journal_title：Molecular and cellular biochemistry

authors： Tirosh R,Mishor T,Pinson A

更新日期：1996-09-20 00:00:00

abstract：:This study investigated the anticancer effects of embelin in human gastric cancer cells and the underlying molecular mechanisms. Gastric cancer cells were treated with embelin and 5-FU for methyl-thiazolyl-tetrazolium bromide cell viability assay and flow cytometric detection of cell viability and apoptosis. Protein p...

journal_title：Molecular and cellular biochemistry

authors： Wang DG,Sun YB,Ye F,Li W,Kharbuja P,Gao L,Zhang DY,Suo J

更新日期：2014-01-01 00:00:00

abstract：:This study examined the effect of melatonin (MLT) on in vitro phagocytosis of testicular macrophages taken from control and streptozotocin (STZ)-induced diabetic rats and the possible mechanism of its action. The phagocytic activity was measured as a number of latex beads ingested by 100 macrophages (PI, phagocytic in...

journal_title：Molecular and cellular biochemistry

authors： Pawlak J,Singh J,Lea RW,Skwarlo-Sonta K

更新日期：2005-07-01 00:00:00

abstract：:A crude preparation of heavy sarcoplasmic reticulum (HSR) was isolated using 1 gram of muscle obtained from swine susceptible to malignant hyperthermia (MH) and from control swine. The caffeine and ATP concentration-dependency of Ca-release was determined using suction filtration with radioisotopic 45Ca as a tracer. R...

journal_title：Molecular and cellular biochemistry

authors： O'Brien PJ

更新日期：1990-03-05 00:00:00

abstract：:This work investigated the role of Ca2+ mobilization and heterotrimeric G protein activation in mediating angiotensin II-dependent tyrosine phosphorylation signaling patterns. We demonstrate that the predominant, angiotensin II-dependent, tyrosine phosphorylation signaling patterns seen in vascular smooth muscle cells...

journal_title：Molecular and cellular biochemistry

authors： Sayeski PP,Ali MS,Bernstein KE

更新日期：2000-09-01 00:00:00

abstract：:The incorporation of radiolabeled arachidonic acid (3[H]-AA) in normoxic cardiomyocytes (MC), cardiac endothelial cells (EC) and fibroblast-like cells (FL) isolated from adult rat heart was studied. Deposition of 3[H]-AA in the cellular lipid pool was assessed with biochemical and autoradiographic techniques. Extracti...

journal_title：Molecular and cellular biochemistry

authors： Linssen MC,Willemsen PH,Heijnen VV,van der Vusse GJ

更新日期：1992-10-21 00:00:00

abstract：:In this study we tested the hypothesis that reduced myofibrillar ATPase activities in end-stage heart failure are associated with a redistribution of myosin isozymes. Cardiac myofibrils were isolated from left ventricular free wall from normal human hearts and hearts at end-stage heart failure caused by coronary arter...

journal_title：Molecular and cellular biochemistry

authors： Alousi AA,Grant AM,Etzler JR,Cofer BR,Van der Bel-Kahn J,Melvin D

更新日期：1990-07-17 00:00:00

abstract：:Fatty acid-binding proteins (FABP) are abundant cytosolic proteins whose levels is responsive to nutritional, endocrine, and a variety of pathological states. Although FABPs have been investigated in vitro for several decades, little is known of their physiological function. Liver L-FABP binds both fatty acids and cho...

journal_title：Molecular and cellular biochemistry

authors： Schroeder F,Jefferson JR,Powell D,Incerpi S,Woodford JK,Colles SM,Myers-Payne S,Emge T,Hubbell T,Moncecchi D

更新日期：1993-06-09 00:00:00

abstract：:Many glomerular diseases are associated with changes in the expression and distribution in the components of extracellular matrix. A remarkable feature in acute renal failure induced by mercuric chloride in rats was large fibronectin (Fn) deposits in kidneys 1 h post-HgCl2 injection (5 mg/kg body wt., s.c.). Our study...

journal_title：Molecular and cellular biochemistry

authors： Saball E,Salvarrey M,Serra E,Picó G,Elías MM

更新日期：2001-10-01 00:00:00

abstract：:Cardiac hypertrophy is an independent risk factor in the development of heart failure. However, the cellular mechanisms underlying the transition from compensated hypertrophy to heart failure are incompletely understood. The aim of this study was to investigate changes in myocardial substrate utilisation and function ...

journal_title：Molecular and cellular biochemistry

authors： Akki A,Smith K,Seymour AM

更新日期：2008-04-01 00:00:00

abstract：:Streptococcus pneumoniae is an important pathogen of pneumonia in human. Human alveolar epithelium acts as an effective barrier and is an active participant in host defense against invasion of bacterial by production of various mediators. Sirtuin 1 (SIRT1), the prototypic class III histone deacetylase, is involved in ...

journal_title：Molecular and cellular biochemistry

authors： Lin L,Wen SH,Guo SZ,Su XY,Wu HJ,Chong L,Zhang HL,Zhang WX,Li CC

更新日期：2014-09-01 00:00:00

abstract：:Glycyrrhizin, a major constituent of licorice (Glycyrrhiza glabra) root, has been reported to ameliorate insulin resistance, hyperglycemia, dyslipidemia, and obesity in rats with metabolic syndrome. Liver dysfunction is associated with this syndrome. The objective of this study is to investigate the effect of glycyrrh...

journal_title：Molecular and cellular biochemistry

authors： Sil R,Ray D,Chakraborti AS

更新日期：2015-11-01 00:00:00

abstract：:The endocannabinoids (eCBs) are endogenous arachidonoyl-containing lipid mediators with important roles in host defense. Macrophages are first-line defenders of the innate immune system and biosynthesize large amounts of eCBs when activated. The cellular levels of eCBs are controlled by the activities of their biosynt...

journal_title：Molecular and cellular biochemistry

authors： Lee JH,Hou X,Kummari E,Borazjani A,Edelmann MJ,Ross MK

更新日期：2018-07-01 00:00:00

abstract：:The molecular mechanisms potentially responsible for cadmium carcinogenesis were investigated by differential gene expression analysis of Balb/c-3T3 cells morphologically transformed with cadmium chloride. Differential display analysis of gene expression revealed overexpression of mouse Translation Initiation Factor 3...

journal_title：Molecular and cellular biochemistry

authors： Joseph P,Lei YX,Ong TM

更新日期：2004-01-01 00:00:00

abstract：:Somatostatin has been shown to inhibit the release of various polypeptide hormones including insulin, glucagon, gastrin, thyroid stimulating hormone, and growth hormone. The mechanism by which somatostatin inhibits the release of these various polypeptide hormones has not been fully elucidated. It has been reported th...

journal_title：Molecular and cellular biochemistry

authors： Vesely DL

更新日期：1980-11-20 00:00:00

abstract：:Huge data accumulated in last few years have shown that differential expression of candidate miRNAs in normal versus transformed cell provides important insights into the pathogenesis of cancer including leukemias. In our previous report, we have revealed that miR-196b was significantly down-regulated in both EB-3 cel...

journal_title：Molecular and cellular biochemistry

authors： Bhatia S,Kaul D,Varma N

更新日期：2011-01-01 00:00:00

abstract：:The influence of hypotonic solution on cell volume and electrophysiology properties of the failing heart of cardiomyopathic hamsters (TO-2) was investigated. The results showed an increase in cell volume of quiescent isolated ventricular myocytes by 66% within 30 min. Angiotensin (1-7) [Ang (1-7)] (10(-8) M) administe...

journal_title：Molecular and cellular biochemistry

authors： De Mello WC

更新日期：2009-10-01 00:00:00