PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.

abstract：:Activation of either the A(1) adenosine receptor (A(1)R) or the A(3) adenosine receptor (A(3)R), by their specific agonists CCPA and Cl-IB-MECA, respectively, protects cardiac cells in culture against ischemic injury. Yet the full protective mechanism remains unclear. In this study, we therefore examined the involveme...

journal_title：Molecular and cellular biochemistry

authors： Leshem-Lev D,Hochhauser E,Chanyshev B,Isak A,Shainberg A

更新日期：2010-12-01 00:00:00

abstract：:The Arrhenius plots for the active and low activity soluble forms of the ATPase purified from the membranes of Micrococcus lysodeikticus grown at 30 degrees C presented discontinuities at 30 and 33 degrees C, respectively. Their activation parameters differed, being highest for the low activity form of the enzyme. Bot...

journal_title：Molecular and cellular biochemistry

authors： Ayala J,Carreira J,Nieto M,Muñoz E

更新日期：1977-08-19 00:00:00

abstract：:The expression of calcium-binding protein regucalcin mRNA in the kidney cortex of rats ingested with saline was investigated. The alteration in regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb of open reading frame). Rats were freely given saline as drinking wat...

journal_title：Molecular and cellular biochemistry

authors： Shinya N,Yamaguchi M

更新日期：1998-01-01 00:00:00

abstract：:Studies presented here show that cellular NAD, which we hypothesize to be the relevant biomarker of niacin status, is significantly lower in humans than in the commonly studied animal models of carcinogenesis. We show that nicotinamide and the resulting cellular NAD concentration modulate expression of the tumor suppr...

journal_title：Molecular and cellular biochemistry

authors： Jacobson EL,Shieh WM,Huang AC

更新日期：1999-03-01 00:00:00

abstract：:This study aims to investigate the unclear molecular relationship involved in the activation of intrinsic pathway of apoptosis and NSAID-activated gene-1 (NAG-1) induction as a putative target in NSAIDs-mediated chemoprevention of colorectal cancer. Male Sprague-Dawley rats were administered with a colon-specific pro-...

journal_title：Molecular and cellular biochemistry

authors： Vaish V,Piplani H,Rana C,Vaiphei K,Sanyal SN

更新日期：2013-06-01 00:00:00

abstract：:Overexpressed cysteine-rich protein 61 (Cyr61) is believed to enhance osteosarcoma (OS) cell metastasis, but the mechanism of Cyr61 overexpression in OS is not clear so far. In this study 33 OS samples were analyzed by immunostaining and focused on two parts: the correlation between overexpression of Cyr61 and OS meta...

journal_title：Molecular and cellular biochemistry

authors： Chen J,Song Y,Yang J,Gong L,Zhao P,Zhang Y,Su H

更新日期：2013-12-01 00:00:00

abstract：:Satb2 is a special AT-rich binding transcription factor essential for osteoblast differentiation and bone formation. Specific microRNAs (miRNAs) have been identified to regulate the complex process of osteogenic differentiation. It remains unclear how miRNA expressions is changed in the Satb2-induced osteogenic differ...

journal_title：Molecular and cellular biochemistry

authors： Gong Y,Lu J,Yu X,Yu Y

更新日期：2016-06-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) family of transcription factors play a key role in lipid metabolism and have been implicated in a number of disease states, most notably of which is obesity. Controlled regulation of lipid metabolism is a key ingredient for successful hibernation. Partial cDNA sequ...

journal_title：Molecular and cellular biochemistry

authors： Eddy SF,Morin P Jr,Storey KB

更新日期：2005-01-01 00:00:00

abstract：:Ileal bile acid-binding protein (I-BABP) is a soluble bile acids (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. In the gut, its expression is strictly restricted to the ileum, where it is thought to be involved in the active BA reabsorption. Therefore, I-BABP gene expression levels...

journal_title：Molecular and cellular biochemistry

authors： Landrier JF,Grober J,Zaghini I,Besnard P

更新日期：2002-10-01 00:00:00

abstract：:In rat cardiac sarcolemmal membranes a phosphoinositide-specific phospholipase C (PLC) was found to be present. The enzyme hydrolysed exogenous [3H-]phosphatidylinositol 4,5-biphosphate ([3H-]PtdIns(4,5)P2) in an optimized assay mixture containing 15 micrograms SL protein, 100 mM NaCl, 1 mM free Ca2+, 14 mM Na-cholate...

journal_title：Molecular and cellular biochemistry

authors： Meij JT,Panagia V

更新日期：1992-10-21 00:00:00

abstract：:This review examines the mechanism of translocation of cytoplasmically synthesized proteins into mitochondria. Approximately 10% of the mitochondrial proteins are synthesized within the organelles while most mitochondrial proteins are coded for by nuclear genes and synthesized on cytoplasmic ribosomes. Those mitochond...

journal_title：Molecular and cellular biochemistry

authors： Ades IZ

更新日期：1982-03-19 00:00:00

abstract：:Succinic acid monoethyl ester (EMS) is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. Oxidative stress has been suggested to be a contributory factor in the development and complications of diabetes. In the present study the effect of EMS and Metformin on pla...

journal_title：Molecular and cellular biochemistry

authors： Saravanan R,Pari L

更新日期：2007-02-01 00:00:00

abstract：:In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity...

journal_title：Molecular and cellular biochemistry

authors： Yu YS,Zheng H

更新日期：2012-06-01 00:00:00

abstract：:Those genes which are transcribed by RNA polymerase III continue to give surprising results with respect to their cis-acting elements and transacting factors. As a result, a broader view of class III promoters has emerged and the internal promoters are not universal in classical polymerase III genes. The involvement o...

journal_title：Molecular and cellular biochemistry

authors： Shastry BS

更新日期：1993-07-07 00:00:00

abstract：:The capacity of noradrenaline (NA) and its end metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) to modulate the chemotaxis of lymphocytes from a primary immunocompetent organ (thymus) and a secondary one (spleen) was investigated over a range of concentrations from 10(-12) M to 10(-5) M. Lymphocyte chemotaxis was eva...

journal_title：Molecular and cellular biochemistry

authors： García JJ,del Carmen Sáez M,De la Fuente M,Ortega E

更新日期：2003-12-01 00:00:00

abstract：:Hyperlipidemia is a well-known risk factor for atherosclerosis and statins are widely used to treat patients with elevated levels of lipids in their plasma. Notwithstanding the proven benefits of statin drugs on both primary and secondary prevention of heart disease, the high cost of statin treatment, in addition to p...

journal_title：Molecular and cellular biochemistry

authors： Man RY,Lynn EG,Cheung F,Tsang PS,O K

更新日期：2002-04-01 00:00:00

abstract：:Three antisera were prepared against non-histone protein classes named NHCP1, NHCP2 and dehistonized chromatin (with different affinity to DNA) from hamster liver. Two main antigenic bands of MW 17,000 and 36,000 were specific in the NHCP1 fraction and one antigen of MW 56,000 was specific for the NHCP2 fraction from ...

journal_title：Molecular and cellular biochemistry

authors： Wojtkowiak Z,Kiliańska Z,Kłyszejko-Stefanowicz L

更新日期：1990-01-18 00:00:00

abstract：:Genetic adaptation is one of the key features of Escherichia coli (E. coli) that ensure its survival in different hostile environments. E. coli seems to initiate biofilm development in response to specific environmental cues. A number of properties inherent within bacterial biofilms indicate that their gene expression...

journal_title：Molecular and cellular biochemistry

authors： Adnan M,Morton G,Hadi S

更新日期：2011-11-01 00:00:00

abstract：:Oxidative metabolism of blood-borne fuels provides myocardium the energy required to sustain its contractile performance. Recent research has revealed that, in addition to supplying energy, certain fuels are able to detoxify harmful oxidants and bolster the myocardium's endogenous antioxidant defenses. These antioxida...

journal_title：Molecular and cellular biochemistry

authors： Mallet RT,Sun J

更新日期：2003-11-01 00:00:00

abstract：:Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor signaling. This has been implicated in the development of insulin resistance. Insulin signaling in the target tissues is mediated by stress kinases such as p38 mitogen-activated protein kinase, c-Jun NH2-terminal kinase, inhibitor of NF-k...

journal_title：Molecular and cellular biochemistry

authors： Nandipati KC,Subramanian S,Agrawal DK

更新日期：2017-02-01 00:00:00

abstract：:Techniques routinely utilized in this laboratory for recording currents through single ionic channels of isolated atrial and ventricular rat cardiomyocytes are described. Emphasis is placed in two main areas: first, on methods for obtaining a sufficient yield of Ca++-tolerant myocytes suitable for patch clamp experime...

journal_title：Molecular and cellular biochemistry

authors： Vogel SM

更新日期：1988-03-01 00:00:00

abstract：:Clinically significant occlusive vascular lesions contain more extracellular matrix (ECM) proteins and lipid deposition than healthy vascular tissue. The events leading to this condition remain unresolved. One possibility is that ECM deposition may exceed ECM degradation which would contribute to the expansion of the ...

journal_title：Molecular and cellular biochemistry

authors： Wilson D,Massaeli H,Russell JC,Pierce GN,Zahradka P

更新日期：2003-07-01 00:00:00

abstract：:Endothelial dysfunction is one of the most important pathological events during the development of several diabetic complications including stroke. The aim of this work was to investigate the role of actin depolymerizing factor (ADF) in advanced glycation endproducts (AGEs)-induced impairment in mouse brain microvascu...

journal_title：Molecular and cellular biochemistry

authors： Liu X,Zhang R,Di H,Zhao D,Wang J

更新日期：2017-09-01 00:00:00

abstract：:To differentiate whether the primary volume signal in dog red cells arises from a change in cell configuration or the concentration and dilution of cell contents, we prepared resealed ghosts that had the same surface area and hemoglobin concentration as intact cells but less than 1/3 their volume. Shrinkage of both in...

journal_title：Molecular and cellular biochemistry

authors： Parker JC,Colclasure GC

更新日期：1992-09-08 00:00:00

abstract：:The aim of this study was to investigate the effects of oxidative stress on PLD activity, [Ca2+]i and pHi levels and the possible relationship among them. Moreover, since atrial natriuretic peptide (ANP) protects against oxidant-induced injury, we investigated the potential protective role of the hormone in rat aortic...

journal_title：Molecular and cellular biochemistry

authors： De Vito P,Di Nardo P,Palmery M,Peluso I,Luly P,Baldini PM

更新日期：2003-10-01 00:00:00

abstract：:Cell culture in collagen lattice is known to be a more physiological model than monolayer for studying the regulation of extracellular matrix protein deposition. The synthesis of sulfated glycosaminoglycans (GAG) and dermatan sulfate (DS) proteoglycans by 3 cell strains were studied in confluent monolayers grown on pl...

journal_title：Molecular and cellular biochemistry

authors： Wegrowski Y,Gillery P,Kotlarz G,Perreau C,Georges N,Maquart FX

更新日期：2000-02-01 00:00:00

abstract：:The results of our previous studies demonstrated that acute streptozotocin-induced diabetes in rats evoked a decrease in skin collagen content with little effect on glycosaminoglycans (GAG) content. In our present study we employed the model of chronic diabetes in order to check its effect on skin GAG content. It was ...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Pałka J,Bańkowski E

更新日期：1996-01-12 00:00:00

abstract：:This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy) and modulation in...

journal_title：Molecular and cellular biochemistry

authors： Mishra S,Reddy DS,Jamwal VS,Bansal DD,Patel DD,Malhotra P,Gupta AK,Singh PK,Jawed S,Kumar R

更新日期：2013-07-01 00:00:00

abstract：:This study aimed to explore the potential contribution of myofibrils to contractile dysfunction in Ca2+-paradox hearts. Isolated rat hearts were perfused with Krebs-Henseleit solution (Control), followed by Ca2+-depletion, and then Ca2+-repletion after Ca2+-depletion (Ca2+-paradox) by Langendorff method. During heart ...

journal_title：Molecular and cellular biochemistry

authors： Kovács Á,Kalász J,Pásztor ET,Tóth A,Papp Z,Dhalla NS,Barta J

更新日期：2017-06-01 00:00:00

abstract：:The role of C-X-C chemokine receptor type 4 (CXCR4) in umbilical mesenchymal stem cells (UMSCs) as therapy for liver disease is ill understood. The aim of the study was to evaluate rat UMSCs (rUMSCs) on CXCR4 expression and homing to injured liver tissue. rUMSCs were isolated from umbilical cords of pregnant rats. Acu...

journal_title：Molecular and cellular biochemistry

authors： Deng C,Qin A,Zhao W,Feng T,Shi C,Liu T

更新日期：2014-11-01 00:00:00