Abstract:
:This review examines the mechanism of translocation of cytoplasmically synthesized proteins into mitochondria. Approximately 10% of the mitochondrial proteins are synthesized within the organelles while most mitochondrial proteins are coded for by nuclear genes and synthesized on cytoplasmic ribosomes. Those mitochondrial proteins synthesized on cytoplasmic ribosomes have to be transferred at some point into one of the mitochondrial compartments, a process which would require their insertion through one or both mitochondrial membranes. Data accumulated during the past five years indicate that the cytoplasmically synthesized mitochondrial proteins are synthesized on free polysomes then released into the cytoplasm. Most of the proteins examined so far are synthesized in the cytoplasm as larger precursors whose conformations may differ from the conformations of their respective mature forms. These precursor proteins become translocated into mitochondrial post-translationally and processed to their mature forms either during or immediately following translocation into the organelles. The translocation step appears to require mitochondrial ATP. Some processing activities have been localized in the matrix fractions of mitochondria from liver and yeast and they appear to be associated with soluble endopeptidases which act selectively on precursors of mitochondrial proteins. Although it is not clear how the precursor proteins interact with or recognize mitochondrial membranes, studies in yeast indicate that the interactions occur at specific regions on the other mitochondrial membranes.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Ades IZdoi
10.1007/BF00423100subject
Has Abstractpub_date
1982-03-19 00:00:00pages
113-27issue
2eissn
0300-8177issn
1573-4919journal_volume
43pub_type
杂志文章abstract::Oxidized LDL is highly atherogenic as it stimulates macrophage cholesterol accumulation and foam cell formation, it is cytotoxic to cells of the arterial wall and it stimulates inflammatory and thrombotic processes. LDL oxidation can lead to its subsequent aggregation, which further increases cellular cholesterol accu...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章,评审
doi:
更新日期:1998-11-01 00:00:00
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journal_title:Molecular and cellular biochemistry
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/BF00248464
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-010-0440-7
更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/a:1020814709118
更新日期:2002-12-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-016-2731-0
更新日期:2016-07-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-021-04048-x
更新日期:2021-01-27 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-015-2571-3
更新日期:2016-01-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/a:1025575521060
更新日期:2003-10-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-020-03873-w
更新日期:2020-12-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/BF00228450
更新日期:1990-07-17 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/a:1006835808554
更新日期:1999-04-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章,评审
doi:10.1007/BF00421049
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-006-9370-9
更新日期:2007-06-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-007-9692-2
更新日期:2008-04-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-007-9598-z
更新日期:2008-01-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 已发布勘误
doi:10.1007/s11010-018-3354-4
更新日期:2018-07-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/BF00944078
更新日期:1994-08-31 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/b:mcbi.0000012836.11573.41
更新日期:2004-03-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/a:1006986629206
更新日期:1999-09-01 00:00:00
abstract::A rapid growth of the coronary vasculature occurs during prenatal and early postnatal periods as precursor cells from the epi- and sub-epicardium differentiate, migrate and form vascular structures (vasculogenesis) which then fuse, branch and in some cases recruit cells to form three tunics (angiogenesis). These proce...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章,评审
doi:10.1023/b:mcbi.0000044369.88528.a3
更新日期:2004-09-01 00:00:00
abstract::Ovarian cancer is one of the greatest causes of cancer death in women. The association of TMEM49 and ovarian cancer is poorly defined. Here, we reported that TMEM49 was significantly increased in ovarian tumor tissues compared to ovarian normal tissues. Furthermore, down-regulation of TMEM49 through RNA interference i...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-016-2684-3
更新日期:2016-05-01 00:00:00