Role of antioxidant enzymes in cell immortalization and transformation.

abstract：:This study aims to investigate the unclear molecular relationship involved in the activation of intrinsic pathway of apoptosis and NSAID-activated gene-1 (NAG-1) induction as a putative target in NSAIDs-mediated chemoprevention of colorectal cancer. Male Sprague-Dawley rats were administered with a colon-specific pro-...

journal_title：Molecular and cellular biochemistry

authors： Vaish V,Piplani H,Rana C,Vaiphei K,Sanyal SN

更新日期：2013-06-01 00:00:00

abstract：:To extend the available information on the significance of the interactions between glycolytic enzymes and the actin component of the cellular ultrastructure, investigations into the compositional characteristics of the actin binding site on one of the major glycolytic enzymes, aldolase, have been undertaken. As the e...

journal_title：Molecular and cellular biochemistry

authors： Don M,Masters C

更新日期：1988-06-01 00:00:00

abstract：:To investigate insulin action in muscle and adipose tissue in hepatic cirrhosis, a recently described animal model was used. Dimethylnitrosamine administration induced histologically proven cirrhosis. Contrary to expectation, muscle strips from cirrhotic rats displayed increased insulin sensitivity both with respect t...

journal_title：Molecular and cellular biochemistry

authors： Chowdhury SA,Taylor R

更新日期：1989-08-15 00:00:00

abstract：:MicroRNA-125b (miR-125b) reduces myocardial infarct area and restrains myocardial ischemia reperfusion injury (I/R). In this study, we aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosomes carrying miR-125b on I/R rats. The myocardial I/R model in rats was constructed by ligation...

journal_title：Molecular and cellular biochemistry

authors： Chen Q,Liu Y,Ding X,Li Q,Qiu F,Wang M,Shen Z,Zheng H,Fu G

更新日期：2020-02-01 00:00:00

abstract：:Increased matrix metalloproteinase (MMP) levels are involved in vascular remodeling of hypertension. In this study, we hypothesized that doxycycline (a MMP inhibitor) could exert antioxidant effects, reverse establish vascular remodeling, and lower blood pressure in spontaneously hypertensive rats (SHR). SHR and Wista...

journal_title：Molecular and cellular biochemistry

authors： Antonio RC,Ceron CS,Rizzi E,Coelho EB,Tanus-Santos JE,Gerlach RF

更新日期：2014-01-01 00:00:00

abstract：:Workers who are exposed to extreme heat or work in hot environments may be at risk of heat stress. Exposure to extreme heat can result in occupational illnesses and injuries. On the other hand, local and regional heat therapy has been used for the treatment of some cancers, such as liver cancer, lung cancer, and kidne...

journal_title：Molecular and cellular biochemistry

authors： Han J,Xu X,Qin H,Liu A,Fan Z,Kang L,Fu J,Liu J,Ye Q

更新日期：2013-06-01 00:00:00

abstract：:The IL-6-related cytokines, LIF and cardiotrophin-1, are important growth promoting and cardioprotective agents for cardiomyocytes. However, factors that regulate their actions in the heart are poorly understood. In this study, we tested the hypothesis that endothelin-1, a peptide hormone that produces a pattern of ca...

journal_title：Molecular and cellular biochemistry

authors： Booz GW,Day JN,Speth R,Baker KM

更新日期：2002-11-01 00:00:00

abstract：:Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein. It is both a receptor and a guanylate cyclase. This critical conclusion...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1991-01-16 00:00:00

abstract：:Renilla luciferase reporter is a widely used internal control in dual luciferase reporter assay system, where its transcription is driven by a constitutively active promoter. However, the authenticity of the Renilla luciferase response in some experimental settings has recently been questioned. Testicular receptor 4 (...

journal_title：Molecular and cellular biochemistry

authors： Zhang D,Atlasi SS,Patel KK,Zhuang Z,Heaney AP

更新日期：2017-06-01 00:00:00

abstract：:Ischemic heart disease is the leading cause of death for both men and women worldwide, accruing 7.4 million deaths in 2012. There has been a continued search for better cardioprotective modalities that would reduce myocardial ischemia-reperfusion injury. Among these attempts, a more convenient model of ischemic precon...

journal_title：Molecular and cellular biochemistry

authors： Gill R,Kuriakose R,Gertz ZM,Salloum FN,Xi L,Kukreja RC

更新日期：2015-04-01 00:00:00

abstract：:Angiotensin receptor blockers provide cardiovascular protection in heart failure patients. We have studied the effect of 8 weeks treatment with telmisartan (5 mg kg(-1) day(-1)) on cardiovascular complications associated with streptozotocin (STZ) diabetic rats. Wistar rats were made diabetic with STZ (45 mg kg(-1), iv...

journal_title：Molecular and cellular biochemistry

authors： Goyal BR,Mesariya P,Goyal RK,Mehta AA

更新日期：2008-07-01 00:00:00

abstract：:GPR12, a member of the orphan G-protein-coupled receptor family, constitutively activates the Gs protein and increases intracellular cyclic AMP concentrations. GPR12 can be activated by its known ligand-sphingosylphosphorylcholine, which regulates cellular physiological activities, including proliferation, neurite ext...

journal_title：Molecular and cellular biochemistry

authors： Lu X,Zhang N,Meng B,Dong S,Hu Y

更新日期：2012-07-01 00:00:00

abstract：:The effects of different dietary fats on peritoneal macrophage plasma membrane fluidity, intracellular cyclic AMP (cAMP) production, GTP hydrolysis and TNF binding and TNF-induced IL1 and IL6 production was investigated. After a four week period, fluidity, as determined by both fluorescence recovery after photobleachi...

journal_title：Molecular and cellular biochemistry

authors： Tappia PS,Ladha S,Clark DC,Grimble RF

更新日期：1997-01-01 00:00:00

abstract：:Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. These processes are mediated by the binding of ADP to an externally oriented protein of the platelet plasma membrane. An affinity analog of ATP, a competitive inhibitor of the action of ADP,...

journal_title：Molecular and cellular biochemistry

authors： Colman RW,Figures WR

更新日期：1984-01-01 00:00:00

abstract：:Ileal bile acid-binding protein (I-BABP) is a soluble bile acids (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. In the gut, its expression is strictly restricted to the ileum, where it is thought to be involved in the active BA reabsorption. Therefore, I-BABP gene expression levels...

journal_title：Molecular and cellular biochemistry

authors： Landrier JF,Grober J,Zaghini I,Besnard P

更新日期：2002-10-01 00:00:00

abstract：:Tyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Increased or decreased neuronal activity, stress, lesions, drug effects, endocrinological manipulations and experimental models of hypertension are associated with alt...

journal_title：Molecular and cellular biochemistry

authors： Masserano JM,Weiner N

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVES:To assess the oxidative effects of raloxifene use in postmenopausal women by investigating protein carbonyl levels in the plasma. METHODS:Nineteen osteoporotic postmenopausal women treated with raloxifene for 12 months were included in the study. Another seventeen postmenopausal women matched for age and po...

journal_title：Molecular and cellular biochemistry

authors： Korucuoğlu U,Ciftçi B,Gülbahar O,Biri A,Nas T,Gürsoy R,Aricioğlu A

更新日期：2006-10-01 00:00:00

abstract：:Proteoglycans carrying chondroitin sulfate side chains have been shown to fulfill important biological functions in development, disease, and signaling. One area of considerable interest is the functional importance of chondroitin sulfates as inhibitors of the regeneration of axonal projections in the mammalian centra...

journal_title：Molecular and cellular biochemistry

authors： Klüppel M

更新日期：2011-05-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are known as crucial regulators in the development of OC. In the current study, we aim to explore the function and molecular mechanism of lncRNA DLEU1 in OC. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine the expression of DLEU1, miR-429, and TFAP2A i...

journal_title：Molecular and cellular biochemistry

authors： Xu H,Wang L,Jiang X

更新日期：2020-11-10 00:00:00

abstract：:Chemical and enzymatic properties of four collagenases newly isolated from anaerobic Clostridium histolyticum, aerobic Achromobacter iophagus, and from two lower eucaryotes, the fungus Entomophthora coronata and the insect Hypoderma lineatum are reviewed. The problems of their biosynthesis and precursors, namely the e...

journal_title：Molecular and cellular biochemistry

authors： Keil B

更新日期：1979-01-26 00:00:00

abstract：:A high molecular weight protein has been isolated as a major polypeptide comprising 85% of the total extractable proteins in the fruit pericarp of the plant Impatiens balsamina. The protein has been purified to homogeneity following fractionation of the crude cell supernatant with ammonium sulphate, chromatography on ...

journal_title：Molecular and cellular biochemistry

authors： Pal M,Biswas S

更新日期：1994-01-26 00:00:00

abstract：:RGPR-p117 was originally discovered as a novel protein that binds to a nuclear factor I (NFI) consensus motif TTGGC(N)(6)CC, which is present in the 5'-flanking region of the regucalcin gene (rgn). RGPR-p117 has been identified in human, rat, mouse, bovine, rabbit, and chicken livers. Phylogenetic analysis of six vert...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M

更新日期：2009-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the potential for self-renewal and multipotential differentiation to regenerate damaged tissues or recover functional absence in diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents in magnetic resonance imaging (MRI) for labeling cells in vitro a...

journal_title：Molecular and cellular biochemistry

authors： Zeng G,Wang G,Guan F,Chang K,Jiao H,Gao W,Xi S,Yang B

更新日期：2011-11-01 00:00:00

abstract：:Chromium(VI) [Cr(VI)] induces chronic inflammation in hepatocytes. Inflammation has been shown to play an important role in tumorigenesis, tumor progression, and metastasis. To examine the effects of the Styrax Japonica Siebold et al. Zuccarini (SJSZ) glycoprotein on inflammation in BNL CL.2 cells, we evaluated the ac...

journal_title：Molecular and cellular biochemistry

authors： Lee J,Lim KT

更新日期：2012-08-01 00:00:00

abstract：:XPO5 (Exp5, Exportin-5) is a transporter protein mainly mediating pre-microRNAs' nuclear export. Recent studies have demonstrated that XPO5 may play crucial roles in a few of cancers. However, little is known about XPO5 in hepatocellular carcinoma (HCC). In the present study, we elucidated the expression of XPO5 by qu...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Wang X,He B,Cai H,Gao Y

更新日期：2016-04-01 00:00:00

abstract：:Colchicine has been demonstrated to suppress the release of fibroblast growth factors, retard collagen formation and augment collagenase activity. Trials with colchicine in patients with hepatic fibrosis have suggested clinical benefit. The development of impaired myocardial function in the spontaneously hypertensive ...

journal_title：Molecular and cellular biochemistry

authors： Cicogna AC,Brooks WW,Hayes JA,Robinson KG,Sen S,Conrad CH,Bing OH

更新日期：1997-01-01 00:00:00

abstract：:CK2 is a highly conserved protein kinase involved in different cellular processes, which shows a higher activity in actively proliferating mammalian cells and in various types of cancer and cancer cell lines. We recently demonstrated that CK2 activity is strongly influenced by growth rate in yeast cells as well. Here,...

journal_title：Molecular and cellular biochemistry

authors： Tripodi F,Cirulli C,Reghellin V,Brambilla L,Marin O,Coccetti P

更新日期：2011-10-01 00:00:00

abstract：:Cardiac hypertrophy in rats was produced by aortic banding for 6 weeks and regression of hypertrophy in these experimental animals was induced by administration of angiotensin converting enzyme inhibitor, enalapril (10 mg/kg/day) for 6 weeks. The left ventricular muscle mass and systolic pressure were decrease upon tr...

journal_title：Molecular and cellular biochemistry

authors： Makino N,Matsui H,Masutomo K,Hata T,Yanaga T

更新日期：1993-02-17 00:00:00

abstract：:It is well known that mitochondria are only partly an autonomous system since they are subjected to nuclear control. For this reason, in studying mitochondrial genes one has to consider constantly the integration of mitochondrial and nuclear genetic systems. This fact makes experimental approaches still more sophistic...

journal_title：Molecular and cellular biochemistry

authors： Neifakh SA

更新日期：1977-02-04 00:00:00

abstract：:In vivo administration of pyridine has been shown to increase the activity and content of several forms of cytochrome P450 by transcriptional and posttranscriptional mechanisms. The effect of pyridine on CYP1A and CYP2E1 isozymes was studied in a rat hepatocyte culture model. Hepatocytes were isolated from non-induced...

journal_title：Molecular and cellular biochemistry

authors： Wu D,Ramin SA,Cederbaum AI

更新日期：1997-08-01 00:00:00