Abstract：
:A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which allow exploration of the complex biological relationships and signaling pathways involved in response to metal exposure at the molecular level. The 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held at NIOSH in Morgantown, West Virginia, Sept. 8-11, 2002. One hundred thirty scientist from sixteen countries presented their novel findings and investigations of metal-induced carcinogenesis. The conference focused on state-of-the-art research and developments in metal toxicity and carcinogenesis. Emphasis was placed on delineating molecular mechanisms involved in free radical effects, cellular uptake, signaling pathways/interaction, dose response, biomarkers, and resistance mechanisms. This article reviews some of the novel information presented at the conference and discusses future avenues of research in this field.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Leonard SS,Bower JJ,Shi Xdoi
10.1023/b:mcbi.0000007255.72746.a6keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
3-10issue
1-2eissn
0300-8177issn
1573-4919journal_volume
255pub_type
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