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Nitric oxide mediates cell aggregation and mesenchymal to epithelial transition in anoikis-resistant lung cancer cells.

Abstract：

:Cancer cell aggregation has been long known to facilitate metastatic potential of cancer cells. In addition, the presence of nitric oxide (NO) in cancer area may have a significant impact on aggregation behavior of the cells. We show herein that lung cancer H460 cells possessing high ability of anoikis resistance formed loose aggregates in detached condition. Importantly, NO treatment tightened the aggregates by enhancing cell-cell interaction via E-cadherin-dependent mechanism, and such E-cadherin contact increased anoikis resistance potential by up-regulating pro-survival signals of the cells including active ATP-dependent tyrosine kinase and extracellular-regulated protein kinases (ERK1/2). Since an increase of E-cadherin was frequently found in mesenchymal to epithelial transition (MET) process, we further tested the cells for MET markers and found that NO treatment of these cells significantly enhanced MET. As aggregation and MET of cancer cells may facilitate cancer metastasis by many means, the insights gained from the present study could benefit the deep understanding in the biology of cancer cell metastasis.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Powan P,Chanvorachote P

doi

10.1007/s11010-014-2066-7

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

237-45

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

393

pub_type

杂志文章

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