Generation of monoclonal antibodies to the zinc finger domain of the eukaryotic transcription factor Sp1.

abstract：:Naturally chromatin remodeling is highly organized, consisting of histone acetylation (opening/relaxation of the compact chromatin structure), DNA methylation (inhibition of the gene expression activity) and sequence rearrangement by shifting. All this is essentially required for proper "in-printing and off-printing" ...

journal_title：Molecular and cellular biochemistry

authors： Tyagi SC,Stanisic D,Singh M

更新日期：2020-10-08 00:00:00

abstract：:Magnesium ions variably influenced activity of highly purified thymidylate synthetase preparations from different mouse tumors, activating the enzyme from Ehrlich ascites carcinoma (EAC) cells and inhibiting the enzyme from L1210 and L5178Y cells and from 5-fluorodeoxyuridine (FdUrd)-resistant EAC cells. In the presen...

journal_title：Molecular and cellular biochemistry

authors： Rode W,Jastreboff MM

更新日期：1984-01-01 00:00:00

abstract：:The fibrinolytic system is known to play an important role in the protection of lung architecture and function. This study investigated the effects on lungs of inhibiting the fibrinolytic system using tranexamic acid (TXA). Thirty cats were used, 15 experimental and 15 control. TXA was administered intravenously to th...

journal_title：Molecular and cellular biochemistry

authors： Hoşgör I,Yarat A,Tüzüner N,Alkan F,Emekli N,Ahmad S

更新日期：2002-12-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse...

journal_title：Molecular and cellular biochemistry

authors： Hong Z,Hong Z,Wu D,Nie H

更新日期：2016-08-01 00:00:00

abstract：:Susceptibility of four major rat tissues to oxidative damage in terms of lipid peroxidation induced by in vitro by ascorbate-Fe2+ in homogenates and mitochondria has been examined. Lipid peroxidation, as assessed by thiobarbituric acid reactive substances (TBARS) and conjugated dienes was maximum in brain followed by ...

journal_title：Molecular and cellular biochemistry

authors： Pushpendran CK,Subramanian M,Devasagayam TP,Singh BB

更新日期：1998-01-01 00:00:00

abstract：:Cardiac failure is one of the leading causes of mortality in developed countries. As life expectancies of the populations of these countries grow, the number of patients suffering from cardiac insufficiency also increases. Effective treatments are being sought and recently a new class of drugs, the calcium sensitisers...

journal_title：Molecular and cellular biochemistry

authors： Sorsa T,Pollesello P,Solaro RJ

更新日期：2004-11-01 00:00:00

abstract：:The existence and expression of gene encoding the Ca(2+)-binding protein regucalcin in various species and tissues were investigated with Southern and Northern hybridization analyses using regucalcin cDNA (0.9 kb of open reading frame). Genomic Southern hybridization analysis demonstrated that regucalcin gene was wide...

journal_title：Molecular and cellular biochemistry

authors： Shimokawa N,Isogai M,Yamaguchi M

更新日期：1995-02-09 00:00:00

abstract：:Recently it has been demonstrated that hydroxylamine is an activator of triglyceride catabolism. We have studied the effect of hydroxylamine on isocitrate lyase activity and lipid catabolism and have noted a stimulation of isocitrate lyase biosynthesis by 5 mM hydroxylamine. The specificity of this effect was tested w...

journal_title：Molecular and cellular biochemistry

authors： Vanni P,Vincenzini MT,Vincieri F,Baccari V

更新日期：1977-04-12 00:00:00

abstract：:The aim of the present investigation was to study the regulation of apolipoprotein E by two dietary nutrients, saturated fat and cholesterol, known to raise plasma cholesterol levels. ApoE is a protein component of several classes of lipoproteins including VLDL and HDL, and dietary lipids may regulate VLDL and apoE-co...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RA

更新日期：1996-02-23 00:00:00

abstract：:Zonation of ethanol oxidation and metabolic effects along the hepatic acini were investigated in the bivascularly perfused liver of fed rats. Ethanol was infused into the hepatic artery in antegrade and retrograde perfusion. Inhibition of glycolysis by ethanol, expressed as micromol min(-1) (ml accessible cell space)(...

journal_title：Molecular and cellular biochemistry

authors： Lopez CH,Constantin J,Gimenes D,Suzuki-Kemmelmeier F,Bracht A

更新日期：2004-03-01 00:00:00

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:The contribution of anti-inflammatory property of celecoxib in the improvement of metabolic disorders in cancer is unknown. The purpose of this study was to compare the effects of celecoxib and ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDs), on several metabolic changes observed in Walker-256 tumor-bearing ...

journal_title：Molecular and cellular biochemistry

authors： de Souza CO,Kurauti MA,de Fatima Silva F,de Morais H,Borba-Murad GR,de Andrade FG,de Souza HM

更新日期：2015-01-01 00:00:00

abstract：:Diabetes mellitus is a serious global health problem, and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The chronic effects of neonatal alloxan- (ALX) induced diabetes mellitus on ventricular myocyte contraction and intracellular Ca(2+) transport have been investigat...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Hassan Z,Qureshi MA

更新日期：2011-01-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein, whose metabolism is poorly understood. Efficient and secure drugs that can lower elevated plasma Lp(a) concentrations are currently lacking. Fibroblast growth factor-21 (FGF-21), a member of the FGFS super family, regulates glucose and lipid metabolism in hep...

journal_title：Molecular and cellular biochemistry

authors： Lin X,Li G,He X,Ma X,Zhang K,Zhang H,Zeng G,Wang Z

更新日期：2014-08-01 00:00:00

abstract：:To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intim...

journal_title：Molecular and cellular biochemistry

authors： Tertov VV,Kaplun VV,Mikhailova IA,Suprun IV,Orekhov AN

更新日期：2001-09-01 00:00:00

abstract：:Tyrosine levels are abnormally elevated in tissues and physiological fluids of patients with inborn errors of tyrosine catabolism, especially in tyrosinemia type II, which is caused by deficiency of tyrosine aminotransferase and provokes eyes, skin, and central nervous system disturbances. Considering that the mechani...

journal_title：Molecular and cellular biochemistry

authors： de Andrade RB,Gemelli T,Rojas DB,Funchal C,Dutra-Filho CS,Wannmacher CM

更新日期：2012-05-01 00:00:00

abstract：:In order to initiate the study of the functional differences between myosin alkali light chain isoforms and to investigate the mechanisms of their differential expression, we have isolated cDNA clones for two human alkali light chain isoforms. Here we report DNA sequence and RNA blotting analyses that demonstrate that...

journal_title：Molecular and cellular biochemistry

authors： Wade R,Feldman D,Gunning P,Kedes L

更新日期：1989-06-01 00:00:00

abstract：:Utrophin is a widely expressed cytoskeleton protein and is associated with lipid droplets (LDs) in adipocytes. The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. Here we show that SNTB2 forms a complex with utrophin...

journal_title：Molecular and cellular biochemistry

authors： Krautbauer S,Neumeier M,Haberl EM,Pohl R,Feder S,Eisinger K,Rein-Fischboeck L,Buechler C

更新日期：2019-02-01 00:00:00

abstract：:NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. Although methods for expression and purification of...

journal_title：Molecular and cellular biochemistry

authors： Ohashi K,Kawai S,Koshimizu M,Murata K

更新日期：2011-09-01 00:00:00

abstract：:Myocardial infarction is the most common cause of congestive cardiac failure. Free radicals, cytokines, nitric oxide (NO) and antioxidants play a major role both in atherosclerosis and myocardial damage and preservation. In the early stages of atherosclerosis, neutrophils and monocytes infiltrate the intima and genera...

journal_title：Molecular and cellular biochemistry

authors： Das UN

更新日期：2000-12-01 00:00:00

abstract：:The effect of peritoneal dialysis (PD) with high-glucose dialysis fluid on the VEGF family, tristetraprolin (TTP), angiogenesis and lymphangiogenesis was investigated. Forty male SD rats were randomised into five groups: normal group, sham operation group, uraemia group, PD 2-week group and PD4-week group. After 4 wee...

journal_title：Molecular and cellular biochemistry

authors： Xiao J,Gao H,Jin Y,Zhao Z,Guo J,Liu Z,Zhao Z

更新日期：2014-07-01 00:00:00

abstract：:Ehrlich ascites tumor cells incorporate [methyl-3H]thymidine into DNA independently of exogenous growth factors or fetal calf serum. Using an acid/ethanol extraction procedure we have obtained from these tumor cells a fraction that induces both the proliferation and the formation of cell foci by Swiss 3T3 mouse fibrob...

journal_title：Molecular and cellular biochemistry

authors： Elexpuru A,Martín-Nieto J,Jimenez A,Gómez C,Villalobo A

更新日期：1997-05-01 00:00:00

abstract：:Resveratrol (trans-3,5,4'-trihydroxystilbene), a compound found largely in the skins of red grapes and wines, possesses anti-cancer and anti-angiogenic properties and protects the cardiovascular system. However, the molecular mechanisms by which resveratrol inhibits angiogenesis are currently subjects of intense inves...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RK,Unterman TG,Shankar S

更新日期：2010-04-01 00:00:00

abstract：:Mucus hypersecretion is an important manifestation in patients with chronic inflammatory airway diseases. Mucin 5AC (MUC5AC) is a major component of airway mucus. MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species (ROS). Hyaluronan (HA), a linear...

journal_title：Molecular and cellular biochemistry

authors： Yu H,Li Q,Zhou X,Kolosov VP,Perelman JM

更新日期：2011-06-01 00:00:00

abstract：:During fetal life, myocardial ATP is derived predominantly from glycolysis and lactate oxidation. Following birth, a rapid maturational increase in fatty acid oxidation occurs along with a decline in glycolytic and lactate oxidative rates, thus changing the major source of myocardial ATP production. This shift in ener...

journal_title：Molecular and cellular biochemistry

authors： Makinde AO,Kantor PF,Lopaschuk GD

更新日期：1998-11-01 00:00:00

abstract：:Physiological responses to high altitude hypoxia are complex and involve a range of mechanisms some of which occur within minutes of oxygen deprivation while others reset a cascade of biosynthetic and physiological programs within the cellular milieu. The O2 sensitive events occur at various organisational levels in t...

journal_title：Molecular and cellular biochemistry

authors： Sarkar S,Banerjee PK,Selvamurthy W

更新日期：2003-11-01 00:00:00

abstract：:The interaction of glyceraldehyde 3-phosphate dehydrogenase with microtubules has been studied by measurement of the amount of enzyme which co-assembles with in vitro reconstituted microtubules. The binding of glyceraldehyde 3-phosphate dehydrogenase to microtubules is a saturable process; the maximum binding capacity...

journal_title：Molecular and cellular biochemistry

authors： Durrieu C,Bernier-Valentin F,Rousset B

更新日期：1987-03-01 00:00:00

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are known as crucial regulators in the development of OC. In the current study, we aim to explore the function and molecular mechanism of lncRNA DLEU1 in OC. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine the expression of DLEU1, miR-429, and TFAP2A i...

journal_title：Molecular and cellular biochemistry

authors： Xu H,Wang L,Jiang X

更新日期：2020-11-10 00:00:00

abstract：:When severe ischemia, such as that resulting from a sudden and complete coronary artery occlusion, is prolonged for more than 20-40 min, myocardial infarction develops, and there is irreversible loss of contractile function. When myocardial ischemia is less severe but nevertheless prolonged, the myocardium is dysfunct...

journal_title：Molecular and cellular biochemistry

authors： Heusch G,Schulz R

更新日期：1998-09-01 00:00:00