The chronic effects of neonatal alloxan-induced diabetes mellitus on ventricular myocyte shortening and cytosolic Ca2+.

abstract：:Sildenafil citrate (Viagra) is a potent and specific inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which exhibits cardioprotective action against ischemia/reperfusion injury in intact and isolated heart. The mechanism of its cardioprotective action is not completely under...

journal_title：Molecular and cellular biochemistry

authors： Fernandes MA,Marques RJ,Vicente JA,Santos MS,Monteiro P,Moreno AJ,Custódio JB

更新日期：2008-02-01 00:00:00

abstract：:Histone acetylation and deacetylaion play important roles in chromatin remodeling and gene expression. An imbalance of these reactions leads to aberrant behavior of the cells in the cell cycle, which in turn contributes to carcinogenesis. Histone deacetylase (HDAC) inhibitors have been shown to have anti-tumor effects...

journal_title：Molecular and cellular biochemistry

authors： Lee KH,Choi EY,Kim MK,Kim KO,Jang BI,Kim SW,Kim SW,Song SK,Kim JR

更新日期：2010-10-01 00:00:00

abstract：:Glomerular mesangial cells play an important role in the development of glomerulosclerosis. Mesangial cell apoptosis has been shown to be involved in different stages of development of glomerulonephritis. The aim of the present study was to evaluate the effect of inhibition of serine/threonine phosphatases by okadaic ...

journal_title：Molecular and cellular biochemistry

authors： Parameswaran N,Spielman WS,Brooks DP,Nambi P

更新日期：2004-05-01 00:00:00

abstract：:The aim of the current study was to comparatively investigate the effect of inhibition of nitric oxide (NO) production by N-nitro-L-arginine methyl ester (L-NAME), an isoform non-specific inhibitor of nitric oxide synthase (NOS), after oral mucosal incision on wound tissue NO levels. A standard incision was applied to...

journal_title：Molecular and cellular biochemistry

authors： Coşkun S,Karataş F,Acartürk F,Olmuş H,Selvi M,Erbaş D

更新日期：2005-10-01 00:00:00

abstract：:Subsequent to the first alpha 2-adrenergic receptor (alpha 2-AR) gene cloning of alpha 2-C10 from human platelet, cloning of the first rodent alpha 2-AR cDNA, cA2-47, was reported. Based on the structural and limited pharmacological comparison, it was concluded that the rodent receptor is a molecular and pharmacologic...

journal_title：Molecular and cellular biochemistry

authors： Wypijewski K,Duda T,Sharma RK

更新日期：1995-03-23 00:00:00

abstract：:The fibrinolytic system is known to play an important role in the protection of lung architecture and function. This study investigated the effects on lungs of inhibiting the fibrinolytic system using tranexamic acid (TXA). Thirty cats were used, 15 experimental and 15 control. TXA was administered intravenously to th...

journal_title：Molecular and cellular biochemistry

authors： Hoşgör I,Yarat A,Tüzüner N,Alkan F,Emekli N,Ahmad S

更新日期：2002-12-01 00:00:00

abstract：:The accessibility of pyridoxal 5'-phosphates of the phosphorylase ab hybrid to resolution by imidazole citrate and cysteine was studied and compared with that of the b and a forms. Promotion of resolution of phosphorylated forms by raising the temperature or in the presence of glycogen indicates that the resistance of...

journal_title：Molecular and cellular biochemistry

authors： Vereb G,Pallagi E,Gergely P

更新日期：1992-03-25 00:00:00

abstract：:Mucus hypersecretion is a major manifestation in patients with chronic inflammatory airway diseases, and MUC5AC protein is a major component of airway mucus. Earlier studies have demonstrated that neutrophil elastase (NE), a serine protease, mainly produced by neutrophils, stimulates the production of MUC5AC from airw...

journal_title：Molecular and cellular biochemistry

authors： Zhong T,Perelman JM,Kolosov VP,Zhou XD

更新日期：2011-12-01 00:00:00

abstract：:Peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) induced by hypoxia regulates mitochondrial biogenesis and oxidative stress. However, the potential role of PGC-1α in hypoxia-promoted proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is completely unknown. In this study, ...

journal_title：Molecular and cellular biochemistry

authors： Rao J,Li J,Liu Y,Lu P,Sun X,Sugumaran PK,Zhu D

更新日期：2012-08-01 00:00:00

abstract：:The aim of the work was to study the influence of vaspin on oxidative stress-induced apoptosis of mouse mesenchymal stem cells (MSCs). MSCs originated from bone marrow of C57BL/6 mouse were treated with vaspin and/or H2O2 in a dose-dependent manner. Cellular viability detected by CCK-8 and cell apoptosis studied by fl...

journal_title：Molecular and cellular biochemistry

authors： Zhu X,Zhang L,Chen Y,Chen B,Huang H,Lv J,Hu S,Shen J

更新日期：2019-12-01 00:00:00

abstract：:Dual-specificity phosphatases (DSPs), which dephosphorylate proteins at Ser/Thr as well as Tyr residues, are thought to be involved in critical signaling events such as control of MAP kinases (MAPKs). We have isolated the cDNA for a novel DSP and termed it low molecular mass DSP-4 (LDP-4). LDP-4 is composed of 211 ami...

journal_title：Molecular and cellular biochemistry

authors： Takagaki K,Shima H,Tanuma N,Nomura M,Satoh T,Watanabe M,Kikuchi K

更新日期：2007-02-01 00:00:00

abstract：:Carbohydrate has been removed from a number of glycoproteins without major effect on the structure or enzyme activity of the protein. Thus carbohydrate has been suggested to underly a non-primary function for proteins, such as in relatively non-specific interactions with other carbohydrates or macromolecules, stabiliz...

journal_title：Molecular and cellular biochemistry

authors： West CM

更新日期：1986-11-01 00:00:00

abstract：:The present study was aimed at addressing the effect of hyperglycemia on antioxidant enzymes. The expression of catalase, superoxide dismutase and glutathione peroxidase, the three primary scavenger enzymes involved in detoxifying reactive oxygen species has been evaluated in the renal cortex of rats after 6 weeks of ...

journal_title：Molecular and cellular biochemistry

authors： Limaye PV,Raghuram N,Sivakami S

更新日期：2003-01-01 00:00:00

abstract：:The action of 7.2 microM cardiotoxin on 0.25% human erythrocytes in a plasma extender solution was studied by the interaction of toxin with intact red blood cells and subsequent hemolysis of the cells. The binding of toxin to cells was completed within 10 min, whereas the membrane rigidity was weakened in a non-lytic ...

journal_title：Molecular and cellular biochemistry

authors： Chen YH,Liou RF,Hu CT,Juan CC,Yang JT

更新日期：1987-01-01 00:00:00

abstract：:The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosome...

journal_title：Molecular and cellular biochemistry

authors： Mangos S,Krawetz R,Kelly GM

更新日期：2000-12-01 00:00:00

abstract：:There is a wealth of information regarding the import and export of nuclear proteins in general. Nevertheless, the available data that deals with the nucleocytoplasmic movement of steroid hormone receptors remains highly limited. Some research findings reported during the past five years have succeeded in identifying ...

journal_title：Molecular and cellular biochemistry

authors： Sebastian T,Sreeja S,Thampan RV

更新日期：2004-05-01 00:00:00

abstract：:Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain dam...

journal_title：Molecular and cellular biochemistry

authors： Streck EL,De Prá SDT,Ferro PR,Carvalho-Silva M,Gomes LM,Agostini JF,Damiani A,Andrade VM,Schuck PF,Ferreira GC,Scaini G

更新日期：2017-11-01 00:00:00

abstract：:Prolonged ischemia-reperfusion results in various damages in skeletal muscle. Following reperfusion, although the damaged muscles undergo regeneration, the precise process and mechanism of regeneration have not yet been fully understood. Here, we show the altered levels of plasma biochemical markers of muscle damage, ...

journal_title：Molecular and cellular biochemistry

authors： Itoh M,Shimokawa N,Tajika Y,Murakami T,Aotsuka N,Lesmana R,Farenia R,Iwasaki T,Okda J,Yorifuji H,Koibuchi N

更新日期：2013-01-01 00:00:00

abstract：:Our interest in the role of sulfhydryl groups (SH) in regulating or altering transport across biological membranes has focused on the significance of a critical SH group associated with the Ca2+-release protein from skeletal muscle sarcoplasmic reticulum (SR). We have shown that binding of heavy metals to this group o...

journal_title：Molecular and cellular biochemistry

authors： Abramson JJ,Salama G

更新日期：1988-07-01 00:00:00

abstract：:Tripeptide aminopeptidase (EC 3.4.11.4) was purified from bovine dental follicles by a series of chromatographies. Purified enzyme had a specific activity of 59.5 units per mg protein with L-prolyl-glycylglycine as substrate. The pH optimum was 8.0. The purified native enzyme had a Mr of 230,000 and was shown to be a ...

journal_title：Molecular and cellular biochemistry

authors： Hiraoka BY,Harada M

更新日期：1993-12-08 00:00:00

abstract：:Resveratrol (trans-3,5,4'-trihydroxystilbene), a compound found largely in the skins of red grapes and wines, possesses anti-cancer and anti-angiogenic properties and protects the cardiovascular system. However, the molecular mechanisms by which resveratrol inhibits angiogenesis are currently subjects of intense inves...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RK,Unterman TG,Shankar S

更新日期：2010-04-01 00:00:00

abstract：:Ionizing radiation induces apoptosis in human Molt-4 leukemia cells in a p53-dependent manner. The tumor suppressor p53 stimulates various downstream targets that presumably trigger, individually or in concert, de novo ceramide synthesis and intrinsic apoptosis via mitochondrial outer membrane permeabilization (MOMP)....

journal_title：Molecular and cellular biochemistry

authors： Kobeissy H,Hage-Sleiman R,Dakdouk Z,Kozhaya L,Dbaibo G

更新日期：2020-12-01 00:00:00

abstract：:'Enzyme stabilization' is one of the most important fields in basic and applied enzymology. In basic enzymology, it is of particular relevance to understand enzyme stabilization principles first elucidating how and why the enzymes lose their biological activity and then deriving structure-stability relationships exist...

journal_title：Molecular and cellular biochemistry

authors： Gianfreda L,Scarfi MR

更新日期：1991-02-02 00:00:00

abstract：:Targeting angiogenesis is considered an effective strategy for treating the expansion and metastasis of tumors. The aim of this study is to assess the effects of perifosine, an inhibitor of Akt, on cell proliferation, apoptosis, angiogenesis, and VEGF-induced cell migration in cultured human umbilical vein endothelial...

journal_title：Molecular and cellular biochemistry

authors： Wang FZ,Fei HR,Li XQ,Shi R,Wang de C

更新日期：2012-09-01 00:00:00

abstract：:Autophagy of mitochondria, i.e., mitophagy, plays a crucial role in coping with stressors in the aging process, metabolic disturbances, and neurological disorders. Impairments of the process might consequently lead to enhanced accumulation of aged and aggregated proteins and reduced cellular integrity in response to s...

journal_title：Molecular and cellular biochemistry

authors： Civelek M,Mehrkens JF,Carstens NM,Fitzenberger E,Wenzel U

更新日期：2019-02-01 00:00:00

abstract：:Saccharomyces cerevisiae contains vacuoles corresponding to lysosomes in higher eukaryotes. Lysosomes are dynamic (not silent) organelles in which enzymes can be easily integrated or released when exposed to stressful conditions. Changes in lysosomal enzymes have been observed due to oxidative stress, resulting in an ...

journal_title：Molecular and cellular biochemistry

authors： Yoon J,Sekhon SS,Kim YH,Min J

更新日期：2016-06-01 00:00:00

abstract：:A rapid growth of the coronary vasculature occurs during prenatal and early postnatal periods as precursor cells from the epi- and sub-epicardium differentiate, migrate and form vascular structures (vasculogenesis) which then fuse, branch and in some cases recruit cells to form three tunics (angiogenesis). These proce...

journal_title：Molecular and cellular biochemistry

authors： Tomanek RJ,Zheng W,Yue X

更新日期：2004-09-01 00:00:00

abstract：:Hyperhomocysteinemia is associated with various pathologies including cardiovascular disease, stroke, and cognitive dysfunctions. Systemic administration of homocysteine can trigger seizures in animals, and patients with homocystinuria suffer from epileptic seizures. Available data suggest that homocysteine can be har...

journal_title：Molecular and cellular biochemistry

authors： Rasić-Marković A,Stanojlović O,Hrncić D,Krstić D,Colović M,Susić V,Radosavljević T,Djuric D

更新日期：2009-07-01 00:00:00

abstract：:Chronic ethanol abuse can lead to harmful consequences for the heart, resulting in systolic dysfunction, variability in the heart rate, arrhythmia, and cardiac remodelling. However, the precise molecular mechanism responsible for ethanol-induced cardiomyopathy is poorly understood. In this regard, the present study ai...

journal_title：Molecular and cellular biochemistry

authors： Liu X,Zhang D,Dong X,Zhu R,Ye Y,Li L,Jiang Y

更新日期：2020-11-01 00:00:00

abstract：:Although considerable evidence lends credence to the association between insulin resistance, hyperinsulinemia and essential hypertension, the precise nature of this relationship remains unexplained. In the present investigation, we examined the proposition that these metabolic defects contribute causally to the develo...

journal_title：Molecular and cellular biochemistry

authors： Bhanot S,Michoulas A,McNeill JH

更新日期：1995-12-06 00:00:00