Enzyme stabilization: state of the art.

abstract：:Dysregulated expression of lysosomal cysteine cathepsins is associated with adverse cardiac remodeling, a characteristic of several cardiovascular diseases. However, the information regarding the role of cysteine cathepsin L (CTSL) and cathepsin B (CTSB) in dilated cardiomyopathy (DCM) is limited. The present study wa...

journal_title：Molecular and cellular biochemistry

authors： Mehra S,Kumar M,Manchanda M,Singh R,Thakur B,Rani N,Arava S,Narang R,Arya DS,Chauhan SS

更新日期：2017-04-01 00:00:00

abstract：:It has been reported that apelin functions as an adipokine, which has been associated to obesity and insulin resistance. The objective of this study was to analyze the apelin mRNA expression in white adipose tissue (WAT) from high-fat (Cafeteria) fed rats, in order to examine potential relationships with obesity marke...

journal_title：Molecular and cellular biochemistry

authors： García-Díaz D,Campión J,Milagro FI,Martínez JA

更新日期：2007-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a rapidly progressing, incurable cancer that frequently spreads to portal vein and lung. New insights are needed to identify therapeutic targets to prevent or retard HCC metastatic progression. Because microRNAs (miRNA) often act as tumor regulators, we investigated their role in prec...

journal_title：Molecular and cellular biochemistry

authors： Shi X,Teng F

更新日期：2015-10-01 00:00:00

abstract：:Henna leaf (Lawsonia inermis), commonly known as Mehndi is cultivated throughout India and is a very popular natural dye to color hand and hair. It is an integral part of indigenous culture, and is also known for its medicinal value. The effect of 200 and 400 mg/kg body weight of 80% ethanolic extract of the fresh lea...

journal_title：Molecular and cellular biochemistry

authors： Dasgupta T,Rao AR,Yadava PK

更新日期：2003-03-01 00:00:00

abstract：:Carbohydrate has been removed from a number of glycoproteins without major effect on the structure or enzyme activity of the protein. Thus carbohydrate has been suggested to underly a non-primary function for proteins, such as in relatively non-specific interactions with other carbohydrates or macromolecules, stabiliz...

journal_title：Molecular and cellular biochemistry

authors： West CM

更新日期：1986-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have recently been shown to be involved in a multiplicity of physiological responses through modulation of signaling pathways. Some of the specific signaling components altered by reactive oxygen and nitrogen species (RONS) have begun to be identified. ...

journal_title：Molecular and cellular biochemistry

authors： Forman HJ,Torres M,Fukuto J

更新日期：2002-05-01 00:00:00

abstract：:It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which...

journal_title：Molecular and cellular biochemistry

authors： Cester N,Staffolani R,Rabini RA,Magnanelli R,Salvolini E,Galassi R,Mazzanti L,Romanini C

更新日期：1994-02-23 00:00:00

abstract：:Antecedent studies have suggested that lipid composition and fluidity of cellular membranes of various organs are altered in response to thyroid hormone status. To date, the effects of thyroid hormone status on these parameters have not been examined in rat renal apical membrane in regard to sodium-dependent phosphate...

journal_title：Molecular and cellular biochemistry

authors： Prasad R,Kumar V

更新日期：2005-01-01 00:00:00

abstract：:Somatostatin has been shown to inhibit the release of various polypeptide hormones including insulin, glucagon, gastrin, thyroid stimulating hormone, and growth hormone. The mechanism by which somatostatin inhibits the release of these various polypeptide hormones has not been fully elucidated. It has been reported th...

journal_title：Molecular and cellular biochemistry

authors： Vesely DL

更新日期：1980-11-20 00:00:00

abstract：:Tryptophan as a circulating precursor of serotonin (5-HT) may suppress food intake and body weight. Tryptophan administration can enhance the generation of reactive oxygen species (ROS) by inducing oxidative pathway in vivo and in vitro. We have examined the effect of repeated tryptophan administration on food consump...

journal_title：Molecular and cellular biochemistry

authors： Coşkun S,Ozer C,Gönül B,Take G,Erdoğan D

更新日期：2006-06-01 00:00:00

abstract：:Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats. To further explore the mechanism of action of arjunolic acid, antiplatelet activity, anticoagulant assays, electroca...

journal_title：Molecular and cellular biochemistry

authors： Sumitra M,Manikandan P,Kumar DA,Arutselvan N,Balakrishna K,Manohar BM,Puvanakrishnan R

更新日期：2001-08-01 00:00:00

abstract：:Progression of prostate cancer is facilitated by growth factors that activate critical signaling cascades thereby promote prostate cancer cell growth, survival, and migration. To investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (PC-...

journal_title：Molecular and cellular biochemistry

authors： Senthilkumar K,Elumalai P,Arunkumar R,Banudevi S,Gunadharini ND,Sharmila G,Selvakumar K,Arunakaran J

更新日期：2010-11-01 00:00:00

abstract：:The aim of this study was to investigate the effects of oxidative stress on PLD activity, [Ca2+]i and pHi levels and the possible relationship among them. Moreover, since atrial natriuretic peptide (ANP) protects against oxidant-induced injury, we investigated the potential protective role of the hormone in rat aortic...

journal_title：Molecular and cellular biochemistry

authors： De Vito P,Di Nardo P,Palmery M,Peluso I,Luly P,Baldini PM

更新日期：2003-10-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbid events in hypertension. TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. Six hundred and eighty essential hype...

journal_title：Molecular and cellular biochemistry

authors： Xu HY,Hou XW,Wang LF,Wang NF,Xu J

更新日期：2010-02-01 00:00:00

abstract：:Glioblastoma is the most common and deadly type of brain cancer. The poor prognosis may be largely attributed to inadequate disease response to current chemotherapeutic agents. Activation of p38 is associated with deleterious outcomes in glioblastoma patients, as its signaling mediates chemoresistance mechanisms. Anti...

journal_title：Molecular and cellular biochemistry

authors： Su BC,Chen JY

更新日期：2020-01-01 00:00:00

abstract：:Pig coronary artery cultured smooth muscle cells were skinned using saponin. In the presence of an ATP-regenerating system and oxalate, the skinned cells showed an ATP-dependent azide insensitive Ca(2+)-uptake which increased linearly with time for > 1 h. The Ca(2+)-uptake occurred with Km values of 0.20 +/- 0.03 micr...

journal_title：Molecular and cellular biochemistry

authors： Elmoselhi AB,Blennerhassett M,Samson SE,Grover AK

更新日期：1995-10-18 00:00:00

abstract：:Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest resear...

journal_title：Molecular and cellular biochemistry

authors： Bower JJ,Leonard SS,Shi X

更新日期：2005-11-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are widely used to treat hyperacid secretion and stomach ulcers. The study investigated the anti-secretory and anti-ulcer effects of esomeprazole, the S-isomer of omeprazole on dimaprit, histamine and dibutyryl adenosine 3, 5 cyclic monophosphate (dbcAMP)-evoked gastric acid secretion, ac...

journal_title：Molecular and cellular biochemistry

authors： Bastaki SM,Chandranath IS,Singh J

更新日期：2008-02-01 00:00:00

abstract：:A membrane-bound L-asparaginase (EC 3.5.1.1) of Tetrahymena pyriformis was purified to homogeneity. The purified enzyme is a lipoprotein, since it is inactivated by phospholipase C and its activity is restored by the addition of naturally occurring lipids, such as phosphatidylcholine, triolein and oleyl acetate. The r...

journal_title：Molecular and cellular biochemistry

authors： Tsirka SA,Kyriakidis DA

更新日期：1988-10-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein, whose metabolism is poorly understood. Efficient and secure drugs that can lower elevated plasma Lp(a) concentrations are currently lacking. Fibroblast growth factor-21 (FGF-21), a member of the FGFS super family, regulates glucose and lipid metabolism in hep...

journal_title：Molecular and cellular biochemistry

authors： Lin X,Li G,He X,Ma X,Zhang K,Zhang H,Zeng G,Wang Z

更新日期：2014-08-01 00:00:00

abstract：:Acanthamoeba rRNA transcription involves the binding of a transcription initiation factor (TIF) to the core promoter of rDNA to form the preinitiation complex. This complex is formed in the absence of RNA polymerase I, and persists for multiple rounds of initiation. Polymerase I next binds to form the initiation compl...

journal_title：Molecular and cellular biochemistry

authors： Paule MR,Bateman E,Hoffman L,Iida C,Imboden M,Kubaska W,Kownin P,Li H,Lofquist A,Risi P

更新日期：1991-05-29 00:00:00

abstract：:The aim of the present study was to determine whether heat shock protein 72 (HSP72) is induced in a heated rat model at rectal temperatures below 42 degrees C. Rats were divided into a control group and six groups (n = 6) heated to different rectal temperatures: 39 degrees C for 1 h (39), 40.0 degrees C for either 15 ...

journal_title：Molecular and cellular biochemistry

authors： Ruell PA,Hoffman KM,Chow CM,Thompson MW

更新日期：2004-12-01 00:00:00

abstract：:Cultured cardiac myocytes were depleted of ATP by incubation with oligomycin (1 mg/ml). Then the ability of the cells to oxidize various substrates and to restore ATP levels was studied. Following ATP depletion, the cells were found to be able to oxidize glucose given alone, but not palmitate. However, with both subst...

journal_title：Molecular and cellular biochemistry

authors： Tirosh R,Mishor T,Pinson A

更新日期：1996-09-20 00:00:00

abstract：:Endothelial cells are known to produce reactive oxygen species by several mechanisms. Functional consequences of increased production of reactive oxygen species were investigated in vitro after stimulation with several proinflammatory cytokines. Time dependent increases in DCF-fluorescence as a measure of reactive oxy...

journal_title：Molecular and cellular biochemistry

authors： Volk T,Hensel M,Schuster H,Kox WJ

更新日期：2000-03-01 00:00:00

abstract：:Failure in obtaining expression of functional adrenocorticotropic hormone receptor (ACTHR, or melanocortin 2 receptor, MC2R) in non-adrenal cells has hindered molecular analysis of ACTH signaling pathways. Here, we ectopically expressed the mouse ACTHR in Balb/c mouse 3T3 fibroblasts to analyze ACTH signaling pathways...

journal_title：Molecular and cellular biochemistry

authors： Forti FL,Dias MH,Armelin HA

更新日期：2006-12-01 00:00:00

abstract：:The activity of yeasts citrate synthase in cells grown under different hypoxic conditions has been investigated. A linear relationship between the citrate synthase activity and the respiratory capacity of the cells has been found. When Saccharomyces cerevisiae was grown on fermentable substrates the activity decreased...

journal_title：Molecular and cellular biochemistry

authors： Nuñez de castro I,Arias de Saavedra JM,Machado A,Mayor F

更新日期：1976-09-30 00:00:00

abstract：:The present study is to investigate the effect and mechanism of action of interleukin (IL)-17A and its receptor IL-17RA on non-small cell lung cancer (NSCLC). A total of 139 NSCLC patients were included in the study. NSCLC tissues and tumor-adjacent tissues were collected from the patients. Human NSCLC cell lines H157...

journal_title：Molecular and cellular biochemistry

authors： Wu Z,He D,Zhao S,Wang H

更新日期：2019-05-01 00:00:00

abstract：:Loss of cardiomyocytes due to myocardial infarction results in ventricular remodeling which includes non-contractile scar formation, which can lead to heart failure. Stem cell therapy aims to replace the scar tissue with the functional myocardium. Mesenchymal stem cells (MSCs) are undifferentiated cells capable of sel...

journal_title：Molecular and cellular biochemistry

authors： Qazi RE,Naeem N,Khan I,Qadeer Q,Shaheen F,Salim A

更新日期：2020-12-01 00:00:00

abstract：:Previous studies in isolated perfused heart and in atrial preparations have demonstrated significant reductions in beating rate in STZ-induced diabetic rats, which suggests that sinus arrhythmias in diabetes mellitus may be partly caused by intrinsic alteration of sino-atrial node (SAN) function. The effects of diabet...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Nowotny N,Zilahi E,El Haj MA,Lei M

更新日期：2007-11-01 00:00:00

abstract：:We have demonstrated that in normal and b/b rat red blood cells (RBCs) hsp70-like protein (heat shock protein 70-like) is localized in the cytosol and it is exported via exosomes during in vivo reticulocytes maturation. As we have presumed, in the mutant (b/b) rat, hsp70-like protein transfers from cytosol to the RBC ...

journal_title：Molecular and cellular biochemistry

authors： Zarić J,Glisin V,Popović Z

更新日期：1998-01-01 00:00:00