FGF21 inhibits apolipoprotein(a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway.

abstract：:The optical properties, copper content, catalytic activity and quaternary structure of many preparations of ascorbate oxidase purified with two different methods were examined. Fresh samples appeared identical and were characterized by optical ratios A280/A610 = 25 +/- 1 and A330/A610 = 0.8 +/- 0.05, by specific activ...

journal_title：Molecular and cellular biochemistry

authors： Avigliano L,Vecchini P,Sirianni P,Marcozzi G,Marchesini A,Mondovi B

更新日期：1983-01-01 00:00:00

abstract：:During fetal life, myocardial ATP is derived predominantly from glycolysis and lactate oxidation. Following birth, a rapid maturational increase in fatty acid oxidation occurs along with a decline in glycolytic and lactate oxidative rates, thus changing the major source of myocardial ATP production. This shift in ener...

journal_title：Molecular and cellular biochemistry

authors： Makinde AO,Kantor PF,Lopaschuk GD

更新日期：1998-11-01 00:00:00

abstract：:Metabolic syndrome (MetS) is associated with alterations in coronary vascular smooth muscle and endothelial function. The current study examined the contractile response of the isolated coronary arterioles to serotonin in pigs with and without MetS and investigated the signaling pathways responsible for serotonin-indu...

journal_title：Molecular and cellular biochemistry

authors： Lawandy I,Liu Y,Shi G,Zhang Z,Scrimgeour LA,Pavlov V,Jaworski R,Sellke FW,Feng J

更新日期：2019-11-01 00:00:00

abstract：:Antecedent studies have suggested that lipid composition and fluidity of cellular membranes of various organs are altered in response to thyroid hormone status. To date, the effects of thyroid hormone status on these parameters have not been examined in rat renal apical membrane in regard to sodium-dependent phosphate...

journal_title：Molecular and cellular biochemistry

authors： Prasad R,Kumar V

更新日期：2005-01-01 00:00:00

abstract：:In order to understand the molecular basis of cold adaptation, we have used directed evolution to transform a thermophilic lipase LipR1 into its psychrophilic counterpart. A single round of random mutagenesis followed by screening for improved variants yielded a mutant with single-point mutation LipR1M1 (S130T), with ...

journal_title：Molecular and cellular biochemistry

authors： Sharma M,Kumar R,Singh R,Kaur J

更新日期：2017-06-01 00:00:00

abstract：:Lens epithelial cells are the metabolic unit of the lens and antioxidant enzymes are mainly concentrated here. The purpose of this study was to maintain human lens epithelial cells (HLEC) in culture and examine the status of antioxidant enzymes (glutathione peroxidase (GSHPx), catalase (CAT), glutathione-S-transferase...

journal_title：Molecular and cellular biochemistry

authors： Mohanty I,Joshi S,Trivedi D,Srivastava S,Tandon R,Gupta SK

更新日期：2002-09-01 00:00:00

abstract：:Oxidative metabolism of blood-borne fuels provides myocardium the energy required to sustain its contractile performance. Recent research has revealed that, in addition to supplying energy, certain fuels are able to detoxify harmful oxidants and bolster the myocardium's endogenous antioxidant defenses. These antioxida...

journal_title：Molecular and cellular biochemistry

authors： Mallet RT,Sun J

更新日期：2003-11-01 00:00:00

abstract：:The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascor...

journal_title：Molecular and cellular biochemistry

authors： Rajakumar DV,Rao MN

更新日期：1994-11-09 00:00:00

abstract：:Glucocorticoid hormones (GCH) are anti-inflammatory and immunosuppressive agents that inhibit T-cell growth and activation. Since the T-cell receptor (TCR)/CD3 complex mediates T-lymphocyte activation, we studied the effect of in vitro dexamethasone (DEX), a synthetic GCH, on TCR/CD3 expression. DEX-treatment of a hyb...

journal_title：Molecular and cellular biochemistry

authors： Migliorati G,Bartoli A,Nocentini G,Ronchetti S,Moraca R,Riccardi C

更新日期：1997-02-01 00:00:00

abstract：:N-cadherin is a transmembrane glycoprotein expressed by mesenchymal origin cells and is located at the adherens junctions. It regulates also cell motility and contributes to cell signaling. In previous studies, we identified that its anomalous expression in bladder carcinoma was a tumor progression marker. A pharmacol...

journal_title：Molecular and cellular biochemistry

authors： Elie-Caille C,Lascombe I,Péchery A,Bittard H,Fauconnet S

更新日期：2020-08-01 00:00:00

abstract：:Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17beta-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular motility in human colon cancer cells. Upregulation of cyclooxygenase-2 (...

journal_title：Molecular and cellular biochemistry

authors： Lai TY,Chen LM,Lin JY,Tzang BS,Lin JA,Tsai CH,Lin YM,Huang CY,Liu CJ,Hsu HH

更新日期：2010-09-01 00:00:00

abstract：:Glycogen content as well as glycolytic, gluconeogenic and fatty acid synthesis enzyme activities were monitored in young and adult male rats fed diets differing in fat content: 11% (low), 22% (medium) and 42% (high) of total energy from fat. The results showed significant differences in the responses of young and adul...

journal_title：Molecular and cellular biochemistry

authors： Brooks SP,Lampi BJ

更新日期：1996-06-07 00:00:00

abstract：:NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. Although methods for expression and purification of...

journal_title：Molecular and cellular biochemistry

authors： Ohashi K,Kawai S,Koshimizu M,Murata K

更新日期：2011-09-01 00:00:00

abstract：:The amylase-protein amylase inhibitor system offers a unique model of specific and reversilbe protein-protein interaction. The monomeric and dimeric inhibitors, exhibiting closely related properties and interacting with the same amylase, also provide a convenient test to compare effects of monomer-monomer and monomer-...

journal_title：Molecular and cellular biochemistry

authors： Silano V,Poerio E,Buonocore V

更新日期：1977-12-29 00:00:00

abstract：:The study was carried out to examine whether chronic exposure to smoke during daily household cooking with biomass fuel (BMF) elicits changes in airway cytology and expressions of Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2]), Keap1 (Kelch-like erythroid-cell-derived protein with CNC homology [ECH]...

journal_title：Molecular and cellular biochemistry

authors： Mondal NK,Saha H,Mukherjee B,Tyagi N,Ray MR

更新日期：2018-10-01 00:00:00

abstract：:Frequent abnormalities in 7p12 locus in different tumors like lung cancer candidate this region for novel regulatory elements. MiRNAs as novel regulatory elements encoded within the human genome are potentially oncomiRs or miR suppressors. Here, we have used bioinformatics tools to search for the novel miRNAs embedded...

journal_title：Molecular and cellular biochemistry

authors： Hoballa MH,Soltani BM,Mowla SJ,Sheikhpour M,Kay M

更新日期：2018-07-01 00:00:00

abstract：:Shin et al. (Biochim Biophys Acta 444: 794-801, 1976) described the subcellular location of [3H]folic acid after injection into rats. The microsomal fraction of the liver contained relatively large amounts of tracer initially but lower amounts at later times. Because of the heterogeneous nature of the microsomal fract...

journal_title：Molecular and cellular biochemistry

authors： Brody T,Stokstad EL

更新日期：1990-09-03 00:00:00

abstract：:We firstly characterized zinc uptake phenomenon across basolateral membrane vesicles (BLMVs) isolated from normal rat kidney. The process was found to be time, temperature, and substrate concentration dependent, and displayed saturability. Zn(2+) uptake was competitively inhibited in the presence of 2 mM Cd with Ki of...

journal_title：Molecular and cellular biochemistry

authors： Kaur J,Sharma N,Attri S,Gogia L,Prasad R

更新日期：2006-02-01 00:00:00

abstract：:Muscle injury is a common result of muscle exertion caused by overload and over-activity. In this presentation, an attempt was made to discuss models of muscle injury which involve exertion but not excessive strain, although most functional activities of the extremities require some eccentric muscle actions. Muscle in...

journal_title：Molecular and cellular biochemistry

authors： Stauber WT,Smith CA

更新日期：1998-02-01 00:00:00

abstract：:A proliferation-inducing ligand (APRIL) is overexpressed in most tumor cells and tissues, especially in tumors of the alimentary system, such as colorectal cancer (CRC), gastric cancer, and liver cancer. RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown and holds great promise for the tr...

journal_title：Molecular and cellular biochemistry

authors： Wang J,Ding W,Sun B,Jing R,Huang H,Shi G,Wang H

更新日期：2012-04-01 00:00:00

abstract：:Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest resear...

journal_title：Molecular and cellular biochemistry

authors： Bower JJ,Leonard SS,Shi X

更新日期：2005-11-01 00:00:00

abstract：:The action of 7.2 microM cardiotoxin on 0.25% human erythrocytes in a plasma extender solution was studied by the interaction of toxin with intact red blood cells and subsequent hemolysis of the cells. The binding of toxin to cells was completed within 10 min, whereas the membrane rigidity was weakened in a non-lytic ...

journal_title：Molecular and cellular biochemistry

authors： Chen YH,Liou RF,Hu CT,Juan CC,Yang JT

更新日期：1987-01-01 00:00:00

abstract：:The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes i...

journal_title：Molecular and cellular biochemistry

authors： Wilkie D

更新日期：1977-02-04 00:00:00

abstract：:SIAH-1, an E3 ubiquitin ligase, plays an important role in regulating cell cycle, tumorigenesis and several neurodegenerative diseases. In this study, we found a novel SIAH-1-interacting protein, EEF1D (Eukaryotic translation elongation factor 1 delta). The interaction was confirmed in vitro and in vivo, and both prot...

journal_title：Molecular and cellular biochemistry

authors： Wu H,Shi Y,Lin Y,Qian W,Yu Y,Huo K

更新日期：2011-11-01 00:00:00

abstract：:Cardiac hypertrophy in rats was produced by aortic banding for 6 weeks and regression of hypertrophy in these experimental animals was induced by administration of angiotensin converting enzyme inhibitor, enalapril (10 mg/kg/day) for 6 weeks. The left ventricular muscle mass and systolic pressure were decrease upon tr...

journal_title：Molecular and cellular biochemistry

authors： Makino N,Matsui H,Masutomo K,Hata T,Yanaga T

更新日期：1993-02-17 00:00:00

abstract：:L-Asparaginase activity reaches maximal values at the stationary phase of growth of Tetrahymena pyriformis and fluctuates upon the growth conditions and the composition of the medium. Most of the L-asparaginase activity (80%) is associated with the endoplasmic reticulum, and the remaining with the pellicles. Detergent...

journal_title：Molecular and cellular biochemistry

authors： Triantafillou DJ,Georgatsos JG,Kyriakidis DA

更新日期：1988-05-01 00:00:00

abstract：:Long-term survival of oxygen deprivation by animals with well-developed anoxia tolerance depends on multiple biochemical adaptations including strong metabolic rate depression. We investigated whether the AMP-activated protein kinase (AMPK) could play a regulatory role in the suppression of protein synthesis that occu...

journal_title：Molecular and cellular biochemistry

authors： Rider MH,Hussain N,Dilworth SM,Storey KB

更新日期：2009-12-01 00:00:00

abstract：:Retinal pigment epithelium (RPE) exerts critical roles in the maintenance of the normal functions of the retina, whereas RPE dysfunction can induce retina neovascularization. p75 neurotrophin receptor (p75(NTR)) has been shown to play essential roles in angiogenesis. However, the function of p75(NTR) in the RPE remain...

journal_title：Molecular and cellular biochemistry

authors： Zhang J,Zhao J,Bai Y,Huang L,Yu W,Li X

更新日期：2015-01-01 00:00:00

abstract：:Since the glucose-lowering effects of vanadium could be related to increased muscle glycogen synthesis, we examined the in vivo effects of vanadium and insulin treatment on glycogen synthase (GS) activation in Zucker fatty rats. The GS fractional activity (GSFA), protein phosphatase-1 (PP1), and glycogen synthase kina...

journal_title：Molecular and cellular biochemistry

authors： Semiz S,McNeill JH

更新日期：2002-07-01 00:00:00

abstract：:Hibernating mammals endure conditions of low body temperature and oxidative stress that would be highly injurious to humans and most other mammals. Stress conditions frequently trigger the production of molecular chaperones; in the endoplasmic reticulum the glucose-regulated protein-78 (GRP78) helps to minimize protei...

journal_title：Molecular and cellular biochemistry

authors： Mamady H,Storey KB

更新日期：2006-11-01 00:00:00