Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates.

abstract：:Differentiation of 3T3-L1 preadipocytes, induced by methyl-isobutylxanthine (MIX), dexamethasone (DEX), and insulin, results in cells with the morphological and biochemical characteristics of adipocytes. Following incubation of 3T3-L1 cells with MIX, DEX, and insulin, poly(ADP-ribose) synthetase activity decreased abr...

journal_title：Molecular and cellular biochemistry

authors： Pekala PH,Moss J

更新日期：1983-01-01 00:00:00

abstract：:Brain membrane lipid fatty acid composition and consequently membrane fluidity change with increasing age. Intracellular fatty acid binding proteins (FABPs) such as heart H-FABP and the brain specific B-FABP, detected by immunoblotting of brain tissue, are thought to be involved in fatty acid uptake, metabolism, and d...

journal_title：Molecular and cellular biochemistry

authors： Pu L,Igbavboa U,Wood WG,Roths JB,Kier AB,Spener F,Schroeder F

更新日期：1999-08-01 00:00:00

abstract：:We studied the effects of SEB on [14C]-choline transport and metabolism of choline containing phospholipids in cultured human kidney proximal tubular (PT) cells. SEB increased the uptake of [14C]-choline in PT cells as a function of toxin concentration, incubation time, and pH. The maximum increase in uptake (3.5-5-fo...

journal_title：Molecular and cellular biochemistry

authors： Khullar M,Chatterjee S

更新日期：1995-05-24 00:00:00

abstract：:Proteins which are major substrates of epidermal transglutaminases can be identified in cultured keratinocytes of human, cow, and new-born rat. Cow and human keratinocytes both contain substrate proteins which are 30 000 to 50 000 daltons in size but dissociable in SDS to 12 000 daltons or less. In both species these ...

journal_title：Molecular and cellular biochemistry

authors： Kubilus J,Baden HP

更新日期：1984-01-01 00:00:00

abstract：:Incubation of Clone 9 cells, a nontransformed rat liver cell line, in the presence of 5 mM azide results in an induction of GLUT1 mRNA which becomes detectable after approximately 3 h of continuous exposure to the agent. In examining the role of on-going protein synthesis in this response, we found that: (i) the induc...

journal_title：Molecular and cellular biochemistry

authors： Behrooz A,Ismail-Beigi F

更新日期：1998-10-01 00:00:00

abstract：:There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels i...

journal_title：Molecular and cellular biochemistry

authors： Soundararajan A,Prabu P,Mohan V,Gibert Y,Balasubramanyam M

更新日期：2019-08-01 00:00:00

abstract：:Two alternatively spliced forms of human PPAR alpha mRNA, PPAR alpha1 and PPAR alpha2, have been identified. PPAR alpha1 mRNA gives rise to an active PPAR alpha protein while PPAR alpha2 mRNA gives rise to a form of PPAR which lacks the ligand-binding domain. PPAR alpha2 is unable to activate a peroxisome proliferator...

journal_title：Molecular and cellular biochemistry

authors： Hanselman JC,Vartanian MA,Koester BP,Gray SA,Essenburg AD,Rea TJ,Bisgaier CL,Pape ME

更新日期：2001-01-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse...

journal_title：Molecular and cellular biochemistry

authors： Hong Z,Hong Z,Wu D,Nie H

更新日期：2016-08-01 00:00:00

abstract：:Biochemical and ultrastructural studies indicate that the atrophy of adrenal cortex in hypoyhysectomized rats involves the following changes: (1) One to two days after hypophysectomy, there is loss of "template activity" resulting from cumulative DNA-damage and heterochromatinization. In vivo ACTH-administration led t...

journal_title：Molecular and cellular biochemistry

authors： Tchen TT,Chan SW,Kuo TH,Mostafapour KM,Drzewiecki VH

更新日期：1977-04-12 00:00:00

abstract：:Insulin stimulated phosphorylation of tyrosine residues by the insulin receptor kinase may be part of a signalling mechanism associated with insulin's action. We report that indomethacin inhibited the phosphorylation of the beta-subunit of the solubilized adipocyte insulin receptor. Indomethacin also inhibited several...

journal_title：Molecular and cellular biochemistry

authors： Malchoff CD,Messina JL,Gordon V,Tamura S,Larner J

更新日期：1985-11-01 00:00:00

abstract：:The present study was undertaken to characterize the contractile effects of vanadate on thoracic aorta rings from virgin and term-pregnant rats. Vanadate caused concentration-dependent contraction in rat aortic rings with an EC50 (concentration producing 50% maximum response) of 0.10 mM. Contractions in response to va...

journal_title：Molecular and cellular biochemistry

authors： St-Louis J,Sicotte B,Breton E,Srivastava AK

更新日期：1995-12-06 00:00:00

abstract：:Long-chain fatty acids (e.g. arachidonic acid) have been implicated in physiological control of insulin secretion. We previously reported histidine phosphorylation of at least two islet proteins (e.g., NDP kinase and the beta subunit of trimeric G-proteins), and suggested that such a signalling step may have regulator...

journal_title：Molecular and cellular biochemistry

authors： Kowluru A

更新日期：2004-11-01 00:00:00

abstract：:Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED and the conn...

journal_title：Molecular and cellular biochemistry

authors： Liu B,Qiao J,Hu J,Fan M,Zhao Y,Su H,Wang Z,Yu Q,Ma Q,Li Y,Lv Z,Wang R

更新日期：2020-10-01 00:00:00

abstract：:Ovarian cancer has the highest mortality in gynecologic malignancies. LncRNA BLACAT1 serves crucial functions in various cancers, but its role in ovarian cancer has not been investigated. In this article, our team explored the role and the potential regulatory mechanism of BLACAT1 in ovarian cancer. Quantitative RT-PC...

journal_title：Molecular and cellular biochemistry

authors： Yang H,Qi Y,Wang XL,Gu JJ,Shi TM

更新日期：2020-04-01 00:00:00

abstract：:This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy) and modulation in...

journal_title：Molecular and cellular biochemistry

authors： Mishra S,Reddy DS,Jamwal VS,Bansal DD,Patel DD,Malhotra P,Gupta AK,Singh PK,Jawed S,Kumar R

更新日期：2013-07-01 00:00:00

abstract：:Airways inflammation, a pathological hallmark of asthma, is associated with the recruitment of pro-inflammatory and inflammatory cells like eosinophils, polymorphonuclear leucocytes cells, mononuclear cells, macrophages, epithelial desquamation, and airways remodeling with sub-epithelial fibrosis. Activated inflammato...

journal_title：Molecular and cellular biochemistry

authors： Khanduja KL,Kaushik G,Khanduja S,Pathak CM,Laldinpuii J,Behera D

更新日期：2011-01-01 00:00:00

abstract：:Cultured endothelial cells have been used in the past as a source of endothelium-derived relaxing factor (EDRF) and of prostacyclin (PGI2). Although cell cultures are essential for observation of prolonged exposure to media or when there is delayed response, they are time consuming and sterile conditions are essential...

journal_title：Molecular and cellular biochemistry

authors： Kibira S,Dudek R,Narayan KS,Bing RJ

更新日期：1991-11-13 00:00:00

abstract：:Twenty-six days of fat deficiency brought about a decrease of linoleic and an increase of oleic acid in rough endoplasmic reticulum (RER) of guinea pig liver. Arachidonic acid was only slightly decreased in some phospholipids whereas eicose-5,8,11-trienoic acid was not enhanced except in phosphatidyl-inositol. All the...

journal_title：Molecular and cellular biochemistry

authors： Soulages JL,Brenner RR

更新日期：1987-12-01 00:00:00

abstract：:Cardiac failure is one of the leading causes of mortality in developed countries. As life expectancies of the populations of these countries grow, the number of patients suffering from cardiac insufficiency also increases. Effective treatments are being sought and recently a new class of drugs, the calcium sensitisers...

journal_title：Molecular and cellular biochemistry

authors： Sorsa T,Pollesello P,Solaro RJ

更新日期：2004-11-01 00:00:00

abstract：:Glutathione acts as a protein disulphide reductant, which detoxifies herbicides by conjugation, either spontaneously or by the activity of one of a number of glutathione-S-transferases (GSTs), and regulates gene expression in response to environmental stress and pathogen attack. GSTs play roles in both normal cellular...

journal_title：Molecular and cellular biochemistry

authors： Banerjee S,Goswami R

更新日期：2010-03-01 00:00:00

abstract：:Chemotherapy remains the core of anticancer treatment. However, despite the tremendous strides made in the development of targeted anticancer therapies, emergence of resistance to chemotherapeutic drugs is still a major obstacle in the successful management of resistant tumors. Therefore, profound investigation into t...

journal_title：Molecular and cellular biochemistry

authors： Peng L,Zhu H,Wang J,Sui H,Zhang H,Jin C,Li L,Xu T,Miao R

更新日期：2015-07-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are two hormones produced and secreted by the heart to control blood pressure, body fluid homeostasis and electrolyte balance. Each peptide binds to a common family of 3 receptors (GC-A, GC-B and C-receptor) with varying degrees of affinity. The pro...

journal_title：Molecular and cellular biochemistry

authors： Tse MY,Watson JD,Sarda IR,Flynn TG,Pang SC

更新日期：2001-03-01 00:00:00

abstract：:Brain-type creatine kinases B-CK (cytosolic) and UbCKmit (mitochondrial) are considered important for the maintenance and distribution of cellular energy in the central nervous system. Previously, we have demonstrated an abnormal behavioral phenotype in mice lacking the B-CK creatine kinase isoform, regarding explorat...

journal_title：Molecular and cellular biochemistry

authors： Streijger F,Jost CR,Oerlemans F,Ellenbroek BA,Cools AR,Wieringa B,Van der Zee CE

更新日期：2004-01-01 00:00:00

abstract：:When Leishmania donovani promastigote forms, were cultured in TC-199 medium at 28 degrees C and subsequently incubated at 38 degrees C, they turned into aflagellate (amastigote-like) forms. A return of the incubation-culture temperature to 28 degrees C these amastigote-like forms to revert to promastigotes. The amasti...

journal_title：Molecular and cellular biochemistry

authors： Castilla JJ,Sanchez-Moreno M,Mesa C,Osuna A

更新日期：1995-01-26 00:00:00

abstract：:It has been recently shown that long-term thyroxine administration increases the tolerance of the heart to ischaemia. The present study investigated whether thyroxine induced cardioprotection involves alterations in the pattern of p38 mitogen activated protein kinase (p38MAPK) and c-Jun NH2-terminal kinases (JNKs) act...

journal_title：Molecular and cellular biochemistry

authors： Pantos C,Malliopoulou V,Paizis I,Moraitis P,Mourouzis I,Tzeis S,Karamanoli E,Cokkinos DD,Carageorgiou H,Varonos D,Cokkinos DV

更新日期：2003-01-01 00:00:00

abstract：:Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models. Their receptor is the Na+,K+ ATPase, but other plasma membrane proteins might bind CGs as well. Herein, we evaluated the short- and long-lasting cytotoxic effects o...

journal_title：Molecular and cellular biochemistry

authors： Schneider NFZ,Menegaz D,Dagostin ALA,Persich L,Rocha SC,Ramos ACP,Cortes VF,Fontes CFL,de Pádua RM,Munkert J,Kreis W,Braga FC,Barbosa LA,Silva FRMB,Simões CMO

更新日期：2021-01-18 00:00:00

abstract：:Vasculogenesis was long considered to be a mechanism of blood vessel formation limited to the embryo, and not used in adult vascular repair. Similarly, myocardial proliferation was generally thought to cease in the adult. Yet there is an extensive older literature suggesting that blood might be a source of adult angio...

journal_title：Molecular and cellular biochemistry

authors： Schatteman GC

更新日期：2004-09-01 00:00:00

abstract：:Fatty acid-binding proteins (FABP) are abundant cytosolic proteins whose levels is responsive to nutritional, endocrine, and a variety of pathological states. Although FABPs have been investigated in vitro for several decades, little is known of their physiological function. Liver L-FABP binds both fatty acids and cho...

journal_title：Molecular and cellular biochemistry

authors： Schroeder F,Jefferson JR,Powell D,Incerpi S,Woodford JK,Colles SM,Myers-Payne S,Emge T,Hubbell T,Moncecchi D

更新日期：1993-06-09 00:00:00

abstract：:The (Ca2+ + Mg2+) ATPase which serves as a Ca2+ pump in the kidney basolateral membranes is essential to the maintenance of an intracellular Ca2+ concentration optimal for kidney function. Since atrial natriuretic peptide (ANP) is known to participate in the Ca2+ homeostasis mechanism, altered levels of ANP in diabete...

journal_title：Molecular and cellular biochemistry

authors： Sahai A,Ganguly PK

更新日期：1991-06-26 00:00:00

abstract：:The present study was designed to evaluate the in vitro and in vivo ameliorative antioxidant potential of secoisolariciresinol diglucoside (SDG). In vitro antioxidant activity of synthetic SDG was carried out using DPPH, reducing power potency, and DNA protection assays. Wistar albino rats weighing 180-220 g were used...

journal_title：Molecular and cellular biochemistry

authors： Moree SS,Rajesha J

更新日期：2013-01-01 00:00:00