Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators.

abstract：:GD3, a minor ganglioside in most normal tissues, is involved in important biological events and its expression could increase in pathological conditions. Organism integrity requires a tight balance between the anabolic and catabolic processes, thus it is important to control the intracellular expression of those "key"...

journal_title：Molecular and cellular biochemistry

authors： Rimoldi S,Papis E,Bernardini G,Prati M,Gornati R

更新日期：2007-07-01 00:00:00

abstract：:Cyclic AMP (300 micron) activates phosphofructokinase from dialyzed haemolysates of mature rat erythrocytes. The main conclusions are: a) Cyclic AMP, at pH 7.1 and low concentrations of fructose-6-phosphate, is able to reverse the inhibition produced by different amounts of ATP (up to 1.5 mM). b) The cyclic nucleotide...

journal_title：Molecular and cellular biochemistry

authors： Pinilla M,Luque J

更新日期：1977-05-03 00:00:00

abstract：:In the present study we investigated if administration of vitamin A could protect rat liver microsomes and mitochondria from in vitro peroxidation. Appreciable decrease of chemiluminescence and lipid peroxidation was measured in microsomal membranes from rats receiving vitamin A, with respect to control animals. In me...

journal_title：Molecular and cellular biochemistry

authors： Palacios A,Piergiacomi VA,Catalá A

更新日期：1996-01-12 00:00:00

abstract：:The mitochondrial pathologies are a heterogeneous group of metabolic disorders that are characterized by anomalies of oxidative phosphorylation, especially in the respiratory chain. The diagnosis of these pathologies involves many investigations among which biochemical study is at present the main tool. However, the a...

journal_title：Molecular and cellular biochemistry

authors： Durrieu G,Letellier T,Antoch J,Deshouillers JM,Malgat M,Mazat JP

更新日期：1997-09-01 00:00:00

abstract：:Spray-dried milk enriched with n-3 fatty acids from linseed oil (LSO) or fish oil (FO) were fed to rats to study its influence on liver lipid peroxides, hepatic antioxidant enzyme activities, serum prostaglandins and platelet aggregation. Significant level of alpha linolenic acid, eicosapentaenoic acid and docosahexae...

journal_title：Molecular and cellular biochemistry

authors： Ramaprasad TR,Baskaran V,Krishnakantha TP,Lokesh BR

更新日期：2005-09-01 00:00:00

abstract：:The effect of ginsenoside Rg1 (Rg1) on hepatic damage caused by concanavalin A (Con A) has not been fully elucidated. This study was designed to evaluate the protective effect of Rg1 on Con A-induced hepatitis in mice and explore the potential mechanisms of this effect. C57BL/6 mice were divided randomly into the foll...

journal_title：Molecular and cellular biochemistry

authors： Cao L,Zou Y,Zhu J,Fan X,Li J

更新日期：2013-08-01 00:00:00

abstract：:Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was ex...

journal_title：Molecular and cellular biochemistry

authors： Wang Z,Ren W,Zhao F,Han Y,Liu C,Jia K

更新日期：2020-02-01 00:00:00

abstract：:The prooxidant and antioxidant actions of Trolox were examined in an in vitro system measuring ferric ion-induced oxidation of erythrocyte membrane lipids. Trolox was found to produce a concentration-dependent biphasic effect on the ferric ion-stimulated lipid peroxidation, with the mode of action being similar to tho...

journal_title：Molecular and cellular biochemistry

authors： Ko KM,Yick PK,Poon MK,Ip SP

更新日期：1994-12-07 00:00:00

abstract：:This paper investigated the effects of ox-LDL on PCSK9, and the molecular mechanisms of PCSK9 siRNA-inhibited apoptosis induced by ox-LDL in human umbilical vein endothelial cells (HUVECs), to clarify the role of PCSK9 in atherosclerogenesis. HUVECs were incubated with ox-LDL for 24 h. The apoptosis was observed by Ho...

journal_title：Molecular and cellular biochemistry

authors： Wu CY,Tang ZH,Jiang L,Li XF,Jiang ZS,Liu LS

更新日期：2012-01-01 00:00:00

abstract：:Parasitic nematodes have recently been found to produce proteins which represent two new classes of fatty acid and retinoid binding protein. The first is the nematode polyprotein allergens/antigens (NPAs) which, as their name suggests, are synthesised as large polyproteins which are subsequently cleaved at regularly s...

journal_title：Molecular and cellular biochemistry

authors： McDermott L,Cooper A,Kennedy MW

更新日期：1999-02-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a devastating disease that results in irreversible central vision loss. TLRs signaling pathway has been found to play an important role in AMD pathogenesis as evidenced by several studies. The objective of the study was to determine the single nucleotide polymorphism (SNP) cha...

journal_title：Molecular and cellular biochemistry

authors： Sharma NK,Sharma K,Gupta A,Prabhakar S,Singh R,Gupta PK,Anand A

更新日期：2014-08-01 00:00:00

abstract：:The antioxidant activity of epigallocatechin gallate (EGCG) was studied in different in vitro model systems, which enabled evaluation of both chemical and physical factors involved in assessing the role of EGCG in oxidative reactions. EGCG suppressed the initiation rate and prolonged the lag phase duration of peroxyl ...

journal_title：Molecular and cellular biochemistry

authors： Hu C,Kitts DD

更新日期：2001-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-D is a crucial mediator of angiogenesis. Following myocardial infarction (MI), cardiac VEGF-D and VEGF receptor (VEGFR)-3 are significantly upregulated. In addition to endothelial cells, myofibroblasts at the site of MI highly express VEGFR-3, implicating the involvement of VE...

journal_title：Molecular and cellular biochemistry

authors： Zhao T,Zhao W,Meng W,Liu C,Chen Y,Bhattacharya SK,Sun Y

更新日期：2016-02-01 00:00:00

abstract：:Biochemical and ultrastructural studies indicate that the atrophy of adrenal cortex in hypoyhysectomized rats involves the following changes: (1) One to two days after hypophysectomy, there is loss of "template activity" resulting from cumulative DNA-damage and heterochromatinization. In vivo ACTH-administration led t...

journal_title：Molecular and cellular biochemistry

authors： Tchen TT,Chan SW,Kuo TH,Mostafapour KM,Drzewiecki VH

更新日期：1977-04-12 00:00:00

abstract：:Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acetylcholine, and calcium. NO availability is reduced in end-stage renal...

journal_title：Molecular and cellular biochemistry

authors： Di Pietro N,Giardinelli A,Sirolli V,Riganti C,Di Tomo P,Gazzano E,Di Silvestre S,Panknin C,Cortese-Krott MM,Csonka C,Kelm M,Ferdinandy P,Bonomini M,Pandolfi A

更新日期：2016-06-01 00:00:00

abstract：:Autophagy of mitochondria, i.e., mitophagy, plays a crucial role in coping with stressors in the aging process, metabolic disturbances, and neurological disorders. Impairments of the process might consequently lead to enhanced accumulation of aged and aggregated proteins and reduced cellular integrity in response to s...

journal_title：Molecular and cellular biochemistry

authors： Civelek M,Mehrkens JF,Carstens NM,Fitzenberger E,Wenzel U

更新日期：2019-02-01 00:00:00

abstract：:Hyperlipidemia is a well-known risk factor for atherosclerosis and statins are widely used to treat patients with elevated levels of lipids in their plasma. Notwithstanding the proven benefits of statin drugs on both primary and secondary prevention of heart disease, the high cost of statin treatment, in addition to p...

journal_title：Molecular and cellular biochemistry

authors： Man RY,Lynn EG,Cheung F,Tsang PS,O K

更新日期：2002-04-01 00:00:00

abstract：:Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia. High-serum uric acid can trigger renal inflammation. The inflammasome family has several members and shows a significant effect on inflammatory responses. NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of ex...

journal_title：Molecular and cellular biochemistry

authors： Wen L,Yang H,Ma L,Fu P

更新日期：2021-01-03 00:00:00

abstract：:Cervical cancer is the most common cancer in Indian females and is associated with infection with high risk Human papillomaviruses (HPVs). Curcumin (Diferuloyl methane), a chemopreventive agent, is a natural compound extracted from Curcuma longa that allows suppression of carcinogenesis. The objective of this study wa...

journal_title：Molecular and cellular biochemistry

authors： Singh M,Singh N

更新日期：2009-05-01 00:00:00

abstract：:The ubiquitin specific peptidase 22 (USP22) is a positive regulator of the growth of tumors. However, little is known about the impact of USP22 knockdown on the growth of human bladder cells. In the present study, we designed a series of asymmetric interfering RNAs (aiRNAs) and compared the efficacy of aiRNA and conve...

journal_title：Molecular and cellular biochemistry

authors： Lv L,Xiao XY,Gu ZH,Zeng FQ,Huang LQ,Jiang GS

更新日期：2011-01-01 00:00:00

abstract：:Induction and activation of the p53 tumour suppressor protein occurs in response to a number of cellular stresses, including disruption of RNA polymerase II-mediated transcription. Both p53 itself and its principle negative regulator, the E3 ubiquitin ligase Mdm2, are substrates for phosphorylation by the protein kina...

journal_title：Molecular and cellular biochemistry

authors： Allende-Vega N,McKenzie L,Meek D

更新日期：2008-09-01 00:00:00

abstract：:The present study was aimed to investigate the protective effects of 17β-estradiol (E2) and estrogen receptor α (ERα) on isoproterenol (ISO)-treated H9c2 cardiomyoblast cells. In the present study, we treated H9c2 cells with ISO, a β-adrenergic receptor agonist, to induce myocardiac hypertrophy. Pre-administration of ...

journal_title：Molecular and cellular biochemistry

authors： Pai P,Velmurugan BK,Kuo CH,Yen CY,Ho TJ,Lin YM,Chen YF,Lai CH,Day CH,Huang CY

更新日期：2017-10-01 00:00:00

abstract：:Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two gro...

journal_title：Molecular and cellular biochemistry

authors： Meyyazhagan A,Balasubramanian B,Easwaran M,Alagamuthu KK,Shanmugam S,Kuchi Bhotla H,Pappusamy M,Arumugam VA,Thangaraj A,Kaul T,Keshavarao S,Cacabelos R

更新日期：2020-11-01 00:00:00

abstract：:Cross-talk between coding RNAs and regulatory non-coding microRNAs, within human genome, has provided compelling evidence for the existence of flexible checkpoint control of T-Cell activation. The present study attempts to demonstrate that the interplay between miR-2909 and its effector KLF4 gene has the inherent capa...

journal_title：Molecular and cellular biochemistry

authors： Kaul D,Malik D,Wani S

更新日期：2019-01-01 00:00:00

abstract：:Ovarian cancer has the highest mortality in gynecologic malignancies. LncRNA BLACAT1 serves crucial functions in various cancers, but its role in ovarian cancer has not been investigated. In this article, our team explored the role and the potential regulatory mechanism of BLACAT1 in ovarian cancer. Quantitative RT-PC...

journal_title：Molecular and cellular biochemistry

authors： Yang H,Qi Y,Wang XL,Gu JJ,Shi TM

更新日期：2020-04-01 00:00:00

abstract：:This study was designed to investigate the alterations in the levels of various proteases such as angiotensin converting enzyme (ACE), kallikrein, aminopeptidases, urokinase and plasmin in serum-heart and kidney and to find out whether the changes in the levels of these enzymes could explain the pathogeneses of hypert...

journal_title：Molecular and cellular biochemistry

authors： Rajashree S,Puvanakrishnan R

更新日期：1999-07-01 00:00:00

abstract：:Activation of extracellular signal-related kinase (ERK) is involved in decreased melanogenesis by sphingosylphosphorylcholine (SPC). In the present study, we confirmed that SPC activated ERK and that a specific inhibitor of the ERK pathway (PD98059) recovered SPC-induced hypopigmentation. Moreover, we found that SPC s...

journal_title：Molecular and cellular biochemistry

authors： Jeong HS,Park KC,Kim DS

更新日期：2012-08-01 00:00:00

abstract：:Secretory phospholipase A2 (sPLA2) is a key enzyme participating in the inflammatory cascade followed by the action of cyclooxygenase-2 and lipoxygenases. Therefore, inhibitors of sPLA2 could be used as potent anti-inflammatory agents to treat the early phase of inflammation. In this study, we have prepared the fenopr...

journal_title：Molecular and cellular biochemistry

authors： Kameshwar VH,R KJ,Priya BS,Swamy SN

更新日期：2017-02-01 00:00:00

abstract：:The antioxidant efficacy of vitamin E on Perchloroethylene (PER) induced cytotoxicity has been studied in rats. Feeding PER to rats for 42 days using sesame oil as vehicle alters total protein and protein bound carbohydrate components in liver and kidney of experimental animals. Supplementation of vitamin E prevented ...

journal_title：Molecular and cellular biochemistry

authors： Ebrahim AS,Gopalakrishnan R,Murugesan A,Sakthisekaran D

更新日期：1995-03-09 00:00:00

abstract：:Human Fibroblast growth factor 1 (FGF1) has been recognized as a valuable protein drug for the treatment of many diseases because of its multiple functions in regulating a variety of biological processes involved in embryonic development, cell growth and differentiation, morphogenesis, tissue repair, and others. The a...

journal_title：Molecular and cellular biochemistry

authors： Zhou Y,Ren L,Zhu J,Yan S,Wang H,Song N,Li L,Ouyang H,Pang D

更新日期：2011-08-01 00:00:00