Abstract:
:Human Fibroblast growth factor 1 (FGF1) has been recognized as a valuable protein drug for the treatment of many diseases because of its multiple functions in regulating a variety of biological processes involved in embryonic development, cell growth and differentiation, morphogenesis, tissue repair, and others. The aim of this study was to develop an FGF1 mammary gland-specific expression vector to produce FGF1 on a large scale from transgenic cows to meet the demand for FGF1 in medical use. In this study, we generated an FGF1 mammary gland-specific expression vector and validated its function in human MCF-7 cells. This vector was shown to successfully express functional FGF1, thus potentially enabling the generation of transgenic cows to be used as mammary gland bioreactors.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Zhou Y,Ren L,Zhu J,Yan S,Wang H,Song N,Li L,Ouyang H,Pang Ddoi
10.1007/s11010-011-0803-8subject
Has Abstractpub_date
2011-08-01 00:00:00pages
39-46issue
1-2eissn
0300-8177issn
1573-4919journal_volume
354pub_type
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