Abstract：
:Recently, it has been appreciated that cultured mast cells are significant sources of cytokines. However, the role of interkeukin-1 (IL-1) on mast cells and/or basophil degranulation is still unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) and histamine (from 22.50 to 43.49%), compared to untreated cells (control). When IL-1RA-treated and untreated RBLC were stimulated with a secretagogue (anti-IgE), no difference was found in the percent of 5HT and histamine release. Moreover, in another set of experiments using rat peritoneal mast cells (RPMC) treated and untreated with IL-1RA, we found that IL-1RA did not affect the release of 5HT or histamine, even when the secretagogue anti-IgE or compound 48/80 (C48/80) were used. The present studies describe an additional biological activity of IL-1RA, inhibiting histamine and 5HT release from RBLC cultures.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Conti P,Bouchet W,Feliciani C,Mammarella S,Kudchadker L,Barbacane RC,Reale M,Haggag I,Bruneau G,Thibault J,Theoharides TCdoi
10.1007/BF00714334subject
Has Abstractpub_date
1996-02-09 00:00:00pages
61-8issue
1eissn
0300-8177issn
1573-4919journal_volume
155pub_type
杂志文章abstract：:6, 4'-Dihydroxy-7-methoxyflavanone (DMF) has been shown to possess anti-inflammatory, anti-oxidative, and neuroprotective activities. However, its effect on oxidative stress-induced aging remains undemonstrated. This study aimed at investigating the anti-senescence effect of DMF on hydrogen peroxide (H2O2)-induced pre...
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journal_title：Molecular and cellular biochemistry
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journal_title：Molecular and cellular biochemistry
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更新日期：2009-10-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Molecular and cellular biochemistry
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journal_title：Molecular and cellular biochemistry
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pub_type： 杂志文章,评审
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journal_title：Molecular and cellular biochemistry
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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journal_title：Molecular and cellular biochemistry
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journal_title：Molecular and cellular biochemistry
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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abstract：:The link between chronic alcohol consumption and cardiovascular injury including hypertension is well known. However, molecular mediators implicated with alcohol-induced elevation in blood pressure (BP) remain elusive. The aim of this study was to investigate the relationship of chronic ethanol-induced endothelial inj...
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pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
