Remote renal preconditioning-induced cardioprotection: a key role of hypoxia inducible factor-prolyl 4-hydroxylases.

abstract：:A method for non-invasive, quantitative 31P NMR spectroscopic investigation of mitochondrial function in human skeletal muscle in situ is described. High time resolution 31P NMR measurements of phosphocreatine, inorganic phosphate and ATP resonances were conducted on human forearm flexor muscle during involuntary twit...

journal_title：Molecular and cellular biochemistry

authors： Jeneson JA,Wiseman RW,Kushmerick MJ

更新日期：1997-09-01 00:00:00

abstract：:Skp2 is frequent amplified and overexpressed in breast cancer, making it a potential molecular target for cancer therapy. The objective of this study was to examine the effect of PPARγ overexpression on Skp2 expression in breast cancer cell lines. First, we investigated the role of PPARγ and Skp2 in human breast cance...

journal_title：Molecular and cellular biochemistry

authors： Meng J,Ding Y,Shen A,Yan M,He F,Ji H,Zou L,Liu Y,Wang Y,Lu X,Wang H

更新日期：2010-12-01 00:00:00

abstract：:Osteosarcoma (OS) is a type of malignant tumor arising from soft-tissues of bone and displays poor prognosis in most cases. However, the molecular mechanism by which OS initiates and progresses is still not completely elucidated. miR-155 has been shown to be overexpressed in OS specimen and cell lines. Our study is in...

journal_title：Molecular and cellular biochemistry

authors： Sun X,Geng X,Zhang J,Zhao H,Liu Y

更新日期：2015-05-01 00:00:00

abstract：:Beta-arrestin-2 is an adaptor protein that terminates G protein activation and seems to be involved in the modulation of the inflammatory response. Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear f...

journal_title：Molecular and cellular biochemistry

authors： Campo GM,Avenoso A,D'Ascola A,Scuruchi M,Calatroni A,Campo S

更新日期：2015-01-01 00:00:00

abstract：:Physiological responses to high altitude hypoxia are complex and involve a range of mechanisms some of which occur within minutes of oxygen deprivation while others reset a cascade of biosynthetic and physiological programs within the cellular milieu. The O2 sensitive events occur at various organisational levels in t...

journal_title：Molecular and cellular biochemistry

authors： Sarkar S,Banerjee PK,Selvamurthy W

更新日期：2003-11-01 00:00:00

abstract：:Myocardial infarction is the most common cause of congestive cardiac failure. Free radicals, cytokines, nitric oxide (NO) and antioxidants play a major role both in atherosclerosis and myocardial damage and preservation. In the early stages of atherosclerosis, neutrophils and monocytes infiltrate the intima and genera...

journal_title：Molecular and cellular biochemistry

authors： Das UN

更新日期：2000-12-01 00:00:00

abstract：:Fenofibrate, a selective (1)PPAR-alpha activator, is prescribed to treat human dyslipidemia. The aim of this study was to delineate the mechanism of fenofibrate-mediated reductions in adiposity, improvements in insulin sensitivity, and lowering of triglycerides (TG) and free fatty acids (FFA) and to investigate if the...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RA,Jahagirdar R,Azhar S,Sharma S,Bisgaier CL

更新日期：2006-04-01 00:00:00

abstract：:The purpose of this study was to determine if selected biochemical parameters representing the contractile and calcium regulating systems of cardiac muscle scaled among mammals having inherently different resting heart rates (RHR). Eight mammalian species with RHR ranging from 51 to 475 beats per minute (bpm) were stu...

journal_title：Molecular and cellular biochemistry

authors： Hamilton N,Ianuzzo CD

更新日期：1991-08-14 00:00:00

abstract：:HMGb1 is a DNA-binding protein whose role as an extracellular cytokine in inflammation and tissue regeneration has also been reported. Given the importance of keratinocytes in wound healing, we have studied the mechanism of action of HMGb1 on HaCaT keratinocytes during in vitro scratch wound repair. Western blot and c...

journal_title：Molecular and cellular biochemistry

authors： Ranzato E,Patrone M,Pedrazzi M,Burlando B

更新日期：2009-12-01 00:00:00

abstract：:We evaluated the effects of Rubus tereticaulis in healing process by determining the total carbonyl content, collagen synthesis, and total protein level on rat wounded tissues. Wounds were performed in the back of 54 Wistar rats, using a biopsy punch instrument with 0.6 mm in diameter. Rats were randomly divided into ...

journal_title：Molecular and cellular biochemistry

authors： Aksoy H,Demirbağ Ç,Şen A,Şekerler T,Özakpınar Ö,Şener A,Ahmad S,Tetik S

更新日期：2020-09-01 00:00:00

abstract：:Comparison of Ca2+ uptake by isolated mouse liver mitochondria, and mitochondria prepared from mastocytoma cells grown with and without N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) and theophylline showed several differences in their capacity to take up and retain calcium. In particular mitocho...

journal_title：Molecular and cellular biochemistry

authors： McHardy JE,Ralph RK

更新日期：1980-03-20 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates the expression of integrins alpha 5 beta 1 and v beta 3 as well as focal adhesion kinase (FAK) and phosphorylated FAK (pY3...

journal_title：Molecular and cellular biochemistry

authors： Cai WJ,Li MB,Wu X,Wu S,Zhu W,Chen D,Luo M,Eitenmüller I,Kampmann A,Schaper J,Schaper W

更新日期：2009-02-01 00:00:00

abstract：:Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED and the conn...

journal_title：Molecular and cellular biochemistry

authors： Liu B,Qiao J,Hu J,Fan M,Zhao Y,Su H,Wang Z,Yu Q,Ma Q,Li Y,Lv Z,Wang R

更新日期：2020-10-01 00:00:00

abstract：:Purpurogallin (PPG) is a phenolic compound extracted from nutgalls formed on oak trees. It has been used as an additive to edible or nonedible oils or fats, and to hydrocarbon fuels or lubricants to retard their oxidation. We investigated by luminol-dependent chemiluminescence (PMNL-CL), the ability of PPG to scavenge...

journal_title：Molecular and cellular biochemistry

authors： Prasad K,Kapoor R,Lee P

更新日期：1994-10-12 00:00:00

abstract：:Both reactive oxygen- and nitrogen-derived reactive species play important roles in physiological and pathophysiological conditions. Flavones, luteolin and luteolin-7-O-glucoside along with a rich plant source of both flavones, namely dandelion (Taraxacum officinale) flower extract were studied for antioxidant activit...

journal_title：Molecular and cellular biochemistry

authors： Hu C,Kitts DD

更新日期：2004-10-01 00:00:00

abstract：:Guanylyl cyclases in eukaryotic unicells were biochemically investigated in the ciliates Paramecium and Tetrahymena, in the malaria parasite Plasmodium and in the ameboid Dictyostelium. In ciliates guanylyl cyclase activity is calcium-regulated suggesting a structural kinship to similarly regulated membrane-bound guan...

journal_title：Molecular and cellular biochemistry

authors： Linder JU,Schultz JE

更新日期：2002-01-01 00:00:00

abstract：:Under normal and ischemic conditions backdiffusion of radiolabeled non-esterified fatty acids (NEFA) has been demonstrated. In the fasted normal canine heart the extraction fraction (EF) during interventions with glucose or lactate loading, vasodilation, and metabolic level augmentation was determined, and compared wi...

journal_title：Molecular and cellular biochemistry

authors： Duwel CM,Visser FC,van Eenige MJ,Roos JP

更新日期：1989-06-27 00:00:00

abstract：:A relation between fatty acid oxidation capacity and cytosolic FABP content was found in heart and various muscles of the rat. Other tissues do not show such a relation, since they are involved in more or other pathways of fatty acid metabolism. At postnatal development FABP content and fatty acid oxidation capacity r...

journal_title：Molecular and cellular biochemistry

authors： Veerkamp JH,van Moerkerk HT

更新日期：1993-06-09 00:00:00

abstract：:Fish and fish oils contain the omega-3 fatty acids known as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA). Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiat...

journal_title：Molecular and cellular biochemistry

authors： Holub DJ,Holub BJ

更新日期：2004-08-01 00:00:00

abstract：:Highly sensitive and specific synthetic substrates were used to quantitate cathepsin B and D activity in peritoneal macrophages in response to stimulation in vivo with mineral oil and thioglycollate. After intraperitoneal instillation of mineral oil the activity of cathepsin B increased significantly (to 15 300 units/...

journal_title：Molecular and cellular biochemistry

authors： Lesser M,Chang JC,Orlowski M

更新日期：1985-11-01 00:00:00

abstract：:Production of human papillomavirus type 16 major capsid protein L1 in undifferentiated cells is negatively regulated by several yet unidentified cis-acting inhibitory RNA elements, among which a major element is located within the first 514 nucleotides of the L1-mRNA. By Northern blotting we examined effect of the maj...

journal_title：Molecular and cellular biochemistry

authors： Mori S,Ozaki S,Yasugi T,Yoshikawa H,Taketani Y,Kanda T

更新日期：2006-08-01 00:00:00

abstract：:Bipolar disorder (BD) is a psychiatric disorder characterized by alternating episodes of mania and depression. The intracerebroventricular (i.c.v) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been used as an animal model of mania, because present face, construct and predictive validities. Seve...

journal_title：Molecular and cellular biochemistry

authors： Freitas TP,Rezin GT,Gonçalves CL,Jeremias GC,Gomes LM,Scaini G,Teodorak BP,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-08-01 00:00:00

abstract：:Inhibition of synthesis of estradiol 17beta by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17beta, or addition of tamoxifen - an estrogen receptor antagonist, to human placental minces resulted in an increase in the level of LDL-receptor mRNA. This increase could be blocked b...

journal_title：Molecular and cellular biochemistry

authors： Shanker YG,Shetty UP,Rao AJ

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:It has been reported that long intergenic non-protein-coding RNA 324 (LINC00324) promotes liver cancer by upregulating Fas ligand (FasL), which is a major player in intervertebral disk degeneration (IDD), indicating the involvement of LINC00324 in IDD. This study was carried out to investigate the interactio...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Wu Y,Chen R,Xu C,Chen Q

更新日期：2021-01-28 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine, which is caused by PRRS virus (PRRSV). CD151, one of PRRSV entry mediators, determines the cell susceptibility for PRRSV. Emerging evidence indicates that the host microRNAs (miRNAs) play key roles in modu...

journal_title：Molecular and cellular biochemistry

authors： Wu J,Peng X,Zhou A,Qiao M,Wu H,Xiao H,Liu G,Zheng X,Zhang S,Mei S

更新日期：2014-09-01 00:00:00

abstract：:Glycodelin A (GdA) is a dimeric glycoprotein synthesized by the human endometrium under progesterone regulation. Based on the high sequence similarity with β-lactoglobulin, it is placed under the lipocalin superfamily. The protein is one of the local immunomodulators present at the feto-maternal interface which affect...

journal_title：Molecular and cellular biochemistry

authors： Ponnalagu D,Karande AA

更新日期：2013-05-01 00:00:00

abstract：:Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production. The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enh...

journal_title：Molecular and cellular biochemistry

authors： Kirtikara K,Laulederkind SJ,Raghow R,Kanekura T,Ballou LR

更新日期：1998-04-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:The effects of Mg2+ concentration (Mg2+o, 0, 1.2, 2.4, and 4.8 mM) on the incidence of reperfusion arrhythmias and on the cellular electrical activity were studied in spontaneously beating rat hearts. The surface electrogram and the membrane potential were recorded in control conditions, during 10 min of regional isch...

journal_title：Molecular and cellular biochemistry

authors： Ponce Zumino A,Risler NR,Schanne OF,Ruiz Petrich E,Carrión A

更新日期：1997-06-01 00:00:00

abstract：:The naturally occurring flavonoid, quercetin, in the presence of Cu(II) and molecular oxygen caused breakage of calf thymus DNA, supercoiled pBR322 plasmid DNA and single stranded M13 phage DNA. In the case of the plasmid, the product(s) were relaxed circles or a mixture of these and linear molecules depending upon th...

journal_title：Molecular and cellular biochemistry

authors： Rahman A,Fazal F,Greensill J,Ainley K,Parish JH,Hadi SM

更新日期：1992-04-01 00:00:00