Omega-3 fatty acids from fish oils and cardiovascular disease.

abstract：:Recent studies have shown that adult osteoporosis could be induced by ageing and estrogen deficiency and homocysteine (Hcy) is an independent risk factor of fracture in osteoporosis patients. In this study, we found hypermethylation of the promoter A region in the estrogen receptor alpha (ERα) gene, and methylation in...

journal_title：Molecular and cellular biochemistry

authors： Lv H,Ma X,Che T,Chen Y

更新日期：2011-09-01 00:00:00

abstract：:We have examined a possibility whether or not severity and extent of coronary atherosclerosis may associate with degree of local inflammation in relation to endothelial dysfunction as is indicated by reduced NO formation. Blood samples were obtained from aortic root (Ao) and coronary sinus (CS) of 39 patients who unde...

journal_title：Molecular and cellular biochemistry

authors： Matsubara T,Ishibashi T,Hori T,Ozaki K,Mezaki T,Tsuchida K,Nasuno A,Kubota K,Tanaka T,Miida T,Aizawa Y,Nishio M

更新日期：2003-07-01 00:00:00

abstract：:Induction and activation of the p53 tumour suppressor protein occurs in response to a number of cellular stresses, including disruption of RNA polymerase II-mediated transcription. Both p53 itself and its principle negative regulator, the E3 ubiquitin ligase Mdm2, are substrates for phosphorylation by the protein kina...

journal_title：Molecular and cellular biochemistry

authors： Allende-Vega N,McKenzie L,Meek D

更新日期：2008-09-01 00:00:00

abstract：:Activating mutations within the tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR) gene are observed in 10 ~ 30% of the patients diagnosed with non-small cell lung cancer (NSCLC), and are causally related to NSCLC initiation and progression. Treatments with tyrosine kinase inhibitors (TKIs) targeti...

journal_title：Molecular and cellular biochemistry

authors： Chen C,Peng S,Li P,Ma L,Gan X

更新日期：2020-12-01 00:00:00

abstract：:It has been reported that mitochondria-independent or mitochondria-dependent (type I/II) Fas signaling pathways in leukemia cells depend on the amount of active caspase-8. However, Bid molecules, which could not be cleaved in type I cells, could be effectively cleaved by recombinant active caspase-8 in vitro. The clea...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Qi L,Iwao A,Kihira K,Dida F,Song Z,Azuma E,Komada Y

更新日期：2009-11-01 00:00:00

abstract：:Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in th...

journal_title：Molecular and cellular biochemistry

authors： Cohen BD

更新日期：2007-04-01 00:00:00

abstract：:Nucleocytoplasmic transport of transcription factors is essential in eukaryotes. We previously reported the presence of two functional NLSs in the homeodomain protein, aristaless-related homeobox (Arx) protein, which is a key transcriptional repressor of LMO1, SHOX2, and PAX4 during development. NLS2, that overlaps th...

journal_title：Molecular and cellular biochemistry

authors： Ye W,Lin W,Tartakoff AM,Ma Q,Tao T

更新日期：2013-09-01 00:00:00

abstract：:The Arrhenius plots for the active and low activity soluble forms of the ATPase purified from the membranes of Micrococcus lysodeikticus grown at 30 degrees C presented discontinuities at 30 and 33 degrees C, respectively. Their activation parameters differed, being highest for the low activity form of the enzyme. Bot...

journal_title：Molecular and cellular biochemistry

authors： Ayala J,Carreira J,Nieto M,Muñoz E

更新日期：1977-08-19 00:00:00

abstract：:The JNK-interacting protein 3 (JIP3) is a molecular scaffold, expressed predominantly in neurons, that serves to coordinate the activation of the c-Jun N-terminal kinase (JNK) by binding to JNK and the upstream kinases involved in its activation. The JNK pathway is involved in the regulation of many cellular processes...

journal_title：Molecular and cellular biochemistry

authors： Caswell PT,Dickens M

更新日期：2018-07-01 00:00:00

abstract：:To identify PBMC-expressed genes significant for RA, and to ascertain their upstream regulatory factors, as well as downstream functional effects relevant to RA pathogenesis. We performed peripheral blood mononuclear cells (PBMCs) transcriptome-wide mRNA expression profiling in a case-control discovery sample. Differe...

journal_title：Molecular and cellular biochemistry

authors： He P,Wu LF,Bing PF,Xia W,Wang L,Xie FF,Lu X,Lei SF,Deng FY

更新日期：2019-06-01 00:00:00

abstract：:Using rat liver mitochondria, as model systems, we have examined the ability of the natural compound and the food-flavoring agent, vanillin to protect membranes against oxidative damage induced by photosensitization at concentrations normally used in food preparations. Vanillin, at a concentration of 2.5 mmol/L, has a...

journal_title：Molecular and cellular biochemistry

authors： Kamat JP,Ghosh A,Devasagayam TP

更新日期：2000-06-01 00:00:00

abstract：:Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17beta-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular motility in human colon cancer cells. Upregulation of cyclooxygenase-2 (...

journal_title：Molecular and cellular biochemistry

authors： Lai TY,Chen LM,Lin JY,Tzang BS,Lin JA,Tsai CH,Lin YM,Huang CY,Liu CJ,Hsu HH

更新日期：2010-09-01 00:00:00

abstract：:Purified mitochondria from rat liver were found to contain protein synthesis inhibitors, that could be extracted by disruption of mitochondrial membranes and fractionated by gel filtration into two fractions of low and high molecular weight. Small size inhibitors were also released from the latter peak by high ionic s...

journal_title：Molecular and cellular biochemistry

authors： Pérez JL,Dorta B,González-Cadavid N

更新日期：1984-06-01 00:00:00

abstract：:Hypermethylation of promoter CpG islands represents an alternative mechanism to inactivate tumor suppressor genes. This study was to detect promoter methylation status and mRNA expression levels of ARRDC3, ELP3, GATA5, and PAX6, and to explore the association between methylation and expression in invasive ductal carci...

journal_title：Molecular and cellular biochemistry

authors： Wang D,Yang PN,Chen J,Zhou XY,Liu QJ,Li HJ,Li CL

更新日期：2014-11-01 00:00:00

abstract：:Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative stress in periphera...

journal_title：Molecular and cellular biochemistry

authors： Quintanilha JCF,Visacri MB,Sousa VM,Bastos LB,Vaz CO,Guarnieri JPO,Amaral LS,Malaguti C,Lima CSP,Vercesi AE,Moriel P

更新日期：2018-03-01 00:00:00

abstract：:Bone-morphogenetic proteins (BMPs) play an important role in development and many cellular processes. However, their functional role in the development and progression of breast cancer is not clearly understood. In the present study, we performed a systematic expression analysis of the 14 types of BMPs in 10 human bre...

journal_title：Molecular and cellular biochemistry

authors： Guo D,Huang J,Gong J

更新日期：2012-04-01 00:00:00

abstract：:We studied the effects of SEB on [14C]-choline transport and metabolism of choline containing phospholipids in cultured human kidney proximal tubular (PT) cells. SEB increased the uptake of [14C]-choline in PT cells as a function of toxin concentration, incubation time, and pH. The maximum increase in uptake (3.5-5-fo...

journal_title：Molecular and cellular biochemistry

authors： Khullar M,Chatterjee S

更新日期：1995-05-24 00:00:00

abstract：:A method for non-invasive, quantitative 31P NMR spectroscopic investigation of mitochondrial function in human skeletal muscle in situ is described. High time resolution 31P NMR measurements of phosphocreatine, inorganic phosphate and ATP resonances were conducted on human forearm flexor muscle during involuntary twit...

journal_title：Molecular and cellular biochemistry

authors： Jeneson JA,Wiseman RW,Kushmerick MJ

更新日期：1997-09-01 00:00:00

abstract：:Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed t...

journal_title：Molecular and cellular biochemistry

authors： Parray HA,Yun JW

更新日期：2016-05-01 00:00:00

abstract：:Recent reports considered that it was the disturbance of calcium homeostasis and the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that activated hepatic stellate cells (HSCs) apoptosis and promoted fibrosis resolution. However, the signal-transducing events that are activated by ER stress after...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Li X,Wang Y,Wang H,Huang C,Li J

更新日期：2014-09-01 00:00:00

abstract：:Hybridization characteristics of purified chloroplast DNA, immobilized in 'dot blots' on nitrocellulose filters using radiolabeled chloroplast DNA restriction fragments or recombinant DNA probes were investigated. Conditions are described which proved a near linear relationship between amounts of hybridization and amo...

journal_title：Molecular and cellular biochemistry

authors： Smith MA

更新日期：1984-09-01 00:00:00

abstract：:Ischemia/reperfusion injury causes cardiomyocyte apoptosis, ventricular remodeling, leading to a dilated heart. Hypoxia is one of the causes involved in ischemia damage, and BNIP3 is a hypoxia-inducible marker and also a sensor to induce mitochondria-dependent apoptosis. Recent reports discussed ablating BNIP3 can res...

journal_title：Molecular and cellular biochemistry

authors： Weng YJ,Kuo WW,Kuo CH,Tung KC,Tsai CH,Lin JA,Tsai FJ,Hsieh DJ,Huang CY,Hwang JM

更新日期：2010-12-01 00:00:00

abstract：:Bladder smooth muscle contraction is mediated by both direct calcium entry through the cell membrane, and by calcium induced calcium release (CICR) from the sarcoplasmic reticulum (SR) storage sites. Ryanodine is a neutral plant alkaloid which binds to an ion channel located on the SR membrane. Its effects in cardiac ...

journal_title：Molecular and cellular biochemistry

authors： Gong C,Zderic SA,Levin RM

更新日期：1994-08-31 00:00:00

abstract：:The treatment of obstructive sleep apnea-hypopnea syndrome targets the narrow anatomic structure of the upper airway (UA) and lacks an effective therapy for UA dilator muscle dysfunction. Long-term hypoxia can cause damage to UA dilator muscles and trigger a vicious cycle. We previously confirmed that hypoxia-inducibl...

journal_title：Molecular and cellular biochemistry

authors： Lu Y,Mao J,Han X,Zhang W,Li Y,Liu Y,Li Q

更新日期：2021-01-03 00:00:00

abstract：:Cardiac myocytes proliferate most rapidly during the hyperplastic phase of heart development; however, the level of cell cycle activity is drastically down regulated after birth. Further growth of the heart is achieved by hypertrophic growth of cardiac myocytes. The mechanism that controls the switch from hyperplastic...

journal_title：Molecular and cellular biochemistry

authors： Evans HJ,Goodwin RL

更新日期：2007-09-01 00:00:00

abstract：:Physiological, pharmacological, histochemical and biochemical studies indicate that dopamine receptors are heterogenous in the central nervous system with each individual functions. This review describes pharmacological and biochemical characteristics of dopamine receptors, particularly in canine caudate nucleus, whic...

journal_title：Molecular and cellular biochemistry

authors： Maeno H

更新日期：1982-03-19 00:00:00

abstract：:The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review tra...

journal_title：Molecular and cellular biochemistry

authors： Haus-Seuffert P,Meisterernst M

更新日期：2000-09-01 00:00:00

abstract：:Concentrations of 1-4 mumol l-1 isoproterenol cause both in right ventricular papillary muscles and in enzymatically isolated myocytes of the guinea-pig a Ca2+ overload-induced state which is functionally characterized by biphasic (multiphasic) twitches and biphasic (multiphasic) intracellular calcium transients, resp...

journal_title：Molecular and cellular biochemistry

authors： Löhn M,Szymanski G,Markwardt F

更新日期：1996-07-01 00:00:00

abstract：:Interactions of cytochrome P450 2B1 were probed using 8-anilino-1-naphthalenesulfonic acid (ANS), a well known and frequently used reporter group for hydrophobic interactions. Titration of cytochrome P450 2B1 with ANS revealed 6.6 +/- 0.2 ANS binding sites per molecule of P450 2B1 with a Kd value of 42 +/- 2 microM. I...

journal_title：Molecular and cellular biochemistry

authors： Yu XC,Strobel HW

更新日期：1996-09-20 00:00:00

abstract：:Treatment of bovine pulmonary artery smooth muscle plasma membrane suspension with the oxidant tert-butylhydroperoxide (t-buOOH) increases Ca2+ATPase activity. The smooth muscle plasma membrane possesses a Ca2+ dependent protease activity in the gelatin containing zymogram having an apparent molecular mass of 72 kDa. ...

journal_title：Molecular and cellular biochemistry

authors： Das S,Chakraborti T,Mandal M,Mandal A,Chakraborti S

更新日期：2002-08-01 00:00:00