Guanylyl cyclases in unicellular organisms.

abstract：:Transmission of extra cellular signals across biological membranes results in the generation of lipid metabolites which in turn influence specific cellular events such as cell growth or differentiation. Many of these lipid messengers can activate protein kinase C (PKC) isozymes of which one function is to perpetuate t...

journal_title：Molecular and cellular biochemistry

authors： Sista P,Edmiston S,Darges JW,Robinson S,Burns DJ

更新日期：1994-12-21 00:00:00

abstract：:In liver fibrosis, the quiescent hepatic stellate cells (HSC) are activated to proliferate and express the activated myofibroblast phenotype, losing fat droplets and the stored vitamin A, and depositing more extracellular matrix. Therapeutic strategies for liver fibrosis are focused on HSC. Pentoxifylline (PTF), an an...

journal_title：Molecular and cellular biochemistry

authors： Cardoso CC,Paviani ER,Cruz LA,Guma FC,Borojevic R,Guaragna RM

更新日期：2003-12-01 00:00:00

abstract：:Lithostathine may play a physiological role in preventing the precipitation of excess calcium in the pancreatic juice. The hypothesis has been advanced that in chronic calcifying pancreatitis the abnormal biosynthesis of lithostathine might be the original defect to which genetic proneness to the disease may be ascrib...

journal_title：Molecular and cellular biochemistry

authors： Cavallini G,Bovo P,Bianchini E,Carsana A,Costanzo C,Merola M,Sgarbi D,Frulloni L,Di Francesco V,Libonati M,Palmieri M

更新日期：1998-08-01 00:00:00

abstract：:Techniques routinely utilized in this laboratory for recording currents through single ionic channels of isolated atrial and ventricular rat cardiomyocytes are described. Emphasis is placed in two main areas: first, on methods for obtaining a sufficient yield of Ca++-tolerant myocytes suitable for patch clamp experime...

journal_title：Molecular and cellular biochemistry

authors： Vogel SM

更新日期：1988-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the potential for self-renewal and multipotential differentiation to regenerate damaged tissues or recover functional absence in diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents in magnetic resonance imaging (MRI) for labeling cells in vitro a...

journal_title：Molecular and cellular biochemistry

authors： Zeng G,Wang G,Guan F,Chang K,Jiao H,Gao W,Xi S,Yang B

更新日期：2011-11-01 00:00:00

abstract：:Pig intestinal brush borders (BB) were radiolabeled by iodination using the lactoperoxidase-hydrogen peroxide procedure. The BB were then detergent solubilized, centrifuged to remove particulate material, and chromatographed on Sepharose CL-4B. The fractions were incubated with K88+ E. coli using an in vitro binding a...

journal_title：Molecular and cellular biochemistry

authors： Staley TE,Wilson IB

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:It has been reported that long intergenic non-protein-coding RNA 324 (LINC00324) promotes liver cancer by upregulating Fas ligand (FasL), which is a major player in intervertebral disk degeneration (IDD), indicating the involvement of LINC00324 in IDD. This study was carried out to investigate the interactio...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Wu Y,Chen R,Xu C,Chen Q

更新日期：2021-01-28 00:00:00

abstract：:Despite its wide range of known substrates, the signaling function of protein kinase CK2 is still enigmatic. Mounting evidence suggests that CK2alpha, the catalytic subunit of holoenzymic CK2, may exist free of its usual regulatory partner CK2beta, raising the possibility that 'free' CK2alpha has regulation and functi...

journal_title：Molecular and cellular biochemistry

authors： Lebrin F,Bianchini L,Rabilloud T,Chambaz EM,Goldberg Y

更新日期：1999-01-01 00:00:00

abstract：:To identify PBMC-expressed genes significant for RA, and to ascertain their upstream regulatory factors, as well as downstream functional effects relevant to RA pathogenesis. We performed peripheral blood mononuclear cells (PBMCs) transcriptome-wide mRNA expression profiling in a case-control discovery sample. Differe...

journal_title：Molecular and cellular biochemistry

authors： He P,Wu LF,Bing PF,Xia W,Wang L,Xie FF,Lu X,Lei SF,Deng FY

更新日期：2019-06-01 00:00:00

abstract：:In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity...

journal_title：Molecular and cellular biochemistry

authors： Yu YS,Zheng H

更新日期：2012-06-01 00:00:00

abstract：:Parkinson disease (PD) is a neurodegenerative disease characterized by progressive dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) area. The present study was undertaken to evaluate the neuroprotective effect of β-caryophyllene (BCP) against rotenone-induced oxidative stress and neuroinflamm...

journal_title：Molecular and cellular biochemistry

authors： Ojha S,Javed H,Azimullah S,Haque ME

更新日期：2016-07-01 00:00:00

abstract：:Activation of either the A(1) adenosine receptor (A(1)R) or the A(3) adenosine receptor (A(3)R), by their specific agonists CCPA and Cl-IB-MECA, respectively, protects cardiac cells in culture against ischemic injury. Yet the full protective mechanism remains unclear. In this study, we therefore examined the involveme...

journal_title：Molecular and cellular biochemistry

authors： Leshem-Lev D,Hochhauser E,Chanyshev B,Isak A,Shainberg A

更新日期：2010-12-01 00:00:00

abstract：:A major component of the soluble fraction of rat heart is a homopolymer (Mr about 400-650 k) of a small protein (Mr about 20 k). This cardiac protein, which is highly homologous to alpha-B-crystallin, was isolated in its native state and visualized by electron microscopy. A homogeneous population of globular particles...

journal_title：Molecular and cellular biochemistry

authors： Longoni S,Lattonen S,Bullock G,Chiesi M

更新日期：1990-09-21 00:00:00

abstract：:Effect of several vanadium salts, sodium orthovanadate, vanadyl sulfate and sodium metavanadate on protein tyrosine phosphorylation and serine/threonine kinases in chinese hamster ovary (CHO) cells overexpressing a normal human insulin receptor was examined. All the compounds stimulated protein tyrosine phosphorylatio...

journal_title：Molecular and cellular biochemistry

authors： Pandey SK,Chiasson JL,Srivastava AK

更新日期：1995-12-06 00:00:00

abstract：:The NGF secretion from cultured mouse astrocytes was enhanced by sublethal concentrations of phosphatidic acid (PA), ceramide, or sphingosine (Sph), and concentration dependently by lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC), or sphingosine-1-phosphate (S1P), but was unaffected by any concentration...

journal_title：Molecular and cellular biochemistry

authors： Furukawa A,Kita K,Toyomoto M,Fujii S,Inoue S,Hayashi K,Ikeda K

更新日期：2007-11-01 00:00:00

abstract：:Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we attempt to define the role of Notch2 signaling in cell growth, ...

journal_title：Molecular and cellular biochemistry

authors： Qu J,Song M,Xie J,Huang XY,Hu XM,Gan RH,Zhao Y,Lin LS,Chen J,Lin X,Zheng DL,Lu YG

更新日期：2016-01-01 00:00:00

abstract：:A sialic acid binding lectin, AchatininH, was purified in single step from the hemolymph of the land snail, Achatina fulica, by the affinity chromatography on sheep submaxillary mucin coupled to Sepharose 4B. The yield of the lectin was found to be 3 mg from 100 ml of hemolymph. The homogeneity of the lectin was estab...

journal_title：Molecular and cellular biochemistry

authors： Basu S,Sarkar M,Mandal C

更新日期：1986-08-01 00:00:00

abstract：:The heptahelical lutropin receptor (LHR) signals primarily via the Gs-adenylyl cyclase pathway and undergoes ligand-mediated receptor desensitization and internalization. A loss-of-function rat LHR mutant was recently described in which a single amino acid residue replacement in exoloop 3, K583E, had no effect on huma...

journal_title：Molecular and cellular biochemistry

authors： Bhowmick N,Narayan P,Puett D

更新日期：1998-10-01 00:00:00

abstract：:Cytokines from the interleukin-6 (IL-6) family have been reported to play an important synergistic role with angiotensin II in the development of pathological cardiac hypertrophy. Whether their expression pattern changes in vivo, in an angiotensin I-dependent hypertrophied myocardium has not been reported. In this stu...

journal_title：Molecular and cellular biochemistry

authors： Kurdi M,Randon J,Cerutti C,Bricca G

更新日期：2005-01-01 00:00:00

abstract：:We have demonstrated that in normal and b/b rat red blood cells (RBCs) hsp70-like protein (heat shock protein 70-like) is localized in the cytosol and it is exported via exosomes during in vivo reticulocytes maturation. As we have presumed, in the mutant (b/b) rat, hsp70-like protein transfers from cytosol to the RBC ...

journal_title：Molecular and cellular biochemistry

authors： Zarić J,Glisin V,Popović Z

更新日期：1998-01-01 00:00:00

abstract：:Oxygen is a diradical and because of its unique electronic configuration, it has the potential to form strong oxidants (e.g. superoxide radical, hydrogen peroxide and hydroxyl radical) called oxygen free radicals or partially reduced forms of oxygen (PRFO). These highly reactive oxygen species can cause cellular injur...

journal_title：Molecular and cellular biochemistry

authors： Singal PK,Dhalla AK,Hill M,Thomas TP

更新日期：1993-12-22 00:00:00

abstract：:Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have recently been shown to be involved in a multiplicity of physiological responses through modulation of signaling pathways. Some of the specific signaling components altered by reactive oxygen and nitrogen species (RONS) have begun to be identified. ...

journal_title：Molecular and cellular biochemistry

authors： Forman HJ,Torres M,Fukuto J

更新日期：2002-05-01 00:00:00

abstract：:The function of the uterine smooth muscle in gestation and parturition is affected by a variety of hormones and biomolecules, some of which alter the intracellular levels of cAMP and Ca2+. Since the activity of smooth muscle MLCK has been shown to be modulated by phosphorylation, the effect of this modification of pre...

journal_title：Molecular and cellular biochemistry

authors： Pato MD,Kerc E,Lye SJ

更新日期：1995-08-01 00:00:00

abstract：:The sarcoplasmic reticulum (SR) plays a critical role in mediating cardiac contractility and its function is abnormal in the diabetic heart. However, the mechanisms underlying SR dysfunction in the diabetic heart are not clear. Because protein phosphorylation regulates SR function, this study examined the phosphorylat...

journal_title：Molecular and cellular biochemistry

authors： Vasanji Z,Dhalla NS,Netticadan T

更新日期：2004-06-01 00:00:00

abstract：:Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightl...

journal_title：Molecular and cellular biochemistry

authors： Mahajan PB,Thompson EA

更新日期：1991-05-29 00:00:00

abstract：:A multi-component solution, containing α-ketoglutaric acid (α-KG), 5-hydroxymethylfurfural (5-HMF), N-acetyl-seleno-L-methionine (NASeLM), and N-acetyl-L-methionine (NALM) as active ingredients, has been tested considering its supposed antioxidative effect with respect to heart transplantations. Oxidative stress was i...

journal_title：Molecular and cellular biochemistry

authors： Russ M,Jauk S,Wintersteiger R,Andrä M,Brcic I,Ortner A

更新日期：2019-11-01 00:00:00

abstract：:Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production. The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enh...

journal_title：Molecular and cellular biochemistry

authors： Kirtikara K,Laulederkind SJ,Raghow R,Kanekura T,Ballou LR

更新日期：1998-04-01 00:00:00

abstract：:We firstly characterized zinc uptake phenomenon across basolateral membrane vesicles (BLMVs) isolated from normal rat kidney. The process was found to be time, temperature, and substrate concentration dependent, and displayed saturability. Zn(2+) uptake was competitively inhibited in the presence of 2 mM Cd with Ki of...

journal_title：Molecular and cellular biochemistry

authors： Kaur J,Sharma N,Attri S,Gogia L,Prasad R

更新日期：2006-02-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 a...

journal_title：Molecular and cellular biochemistry

authors： Sun X,Zhang XD,Cheng G,Hu YH,Wang HY

更新日期：2009-10-01 00:00:00

abstract：:Both idiopathic restrictive cardiomyopathy (IRCM) and hypertrophic cardiomyopathy (HCM) are part of the same disease spectrum and are due to sarcomeric gene mutations. A patient with restrictive physiology without left ventricular hypertrophy (LVH) would be diagnosed as IRCM, while one with LVH would be diagnosed as H...

journal_title：Molecular and cellular biochemistry

authors： Rai TS,Ahmad S,Ahluwalia TS,Ahuja M,Bahl A,Saikia UN,Singh B,Talwar KK,Khullar M

更新日期：2009-11-01 00:00:00