Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.

abstract：:Plasma membrane fractions from normal, regenerating liver and the AS-30D ascites hepatocarcinoma exhibited a high degree of enrichment when a set of plasma membrane enzyme markers were studied in comparison to the ones associated to the mitochondrial and cytosolic compartments. While the (Ca2+, Mg2+)-ATPase observed f...

journal_title：Molecular and cellular biochemistry

authors： Mas-Oliva J,Pérez-Montfort R,Cárdenas-García M,Rivas-Duro M

更新日期：1991-01-16 00:00:00

abstract：:The RNase hydrolysis of random-coil (alkaline form) poly A follows biphasic kinetics at low salt concentrations. However, its resistance to RNase increases with the ionic strength. Helical (acidic form) poly A is alos susceptible to RNase but its hydrolysis follows first-order kinetics, and its resistance increases as...

journal_title：Molecular and cellular biochemistry

authors： Iqbal ZM

更新日期：1975-10-31 00:00:00

abstract：:In order to study the mechanism of entry and localization of bilirubin (BR) into cell membrane, binding of BR to sealed and human serum albumin (HSA)-entrapped sealed membranes was studied by CD spectroscopy. An induced bisignate CD cotton effects (CDCEs) of BR-bound sealed membranes were observed with maxima at 515 n...

journal_title：Molecular and cellular biochemistry

authors： Rashid H,Khan MM,Tayyab S

更新日期：2005-09-01 00:00:00

abstract：:Early responses of lungs to a single radiation dose of 30 Gy were marked by an inflammatory reaction and the onset of pneumonitis within 4 weeks following hemithorax radiation in the rat. Superoxide dismutase reduced the severity of radiation lesions in lungs. ...

journal_title：Molecular and cellular biochemistry

authors： Malaker K,Das RM

更新日期：1988-12-01 00:00:00

abstract：:Epidermal growth factor (EGF)-like family members mediate a wide range of biological activities including cell proliferation and migration. Increasing evidence indicated that EGF plays an important role in the process of wound healing by stimulating fibroblast motility. The aim of this study was to see whether EGF-lik...

journal_title：Molecular and cellular biochemistry

authors： Yang RH,Qi SH,Ruan SB,Lin ZP,Lin Y,Zhang FG,Chen XD,Xie JL

更新日期：2016-12-01 00:00:00

abstract：:Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules. In this study, we report that FAM98A, whose biologic...

journal_title：Molecular and cellular biochemistry

authors： Ozeki K,Sugiyama M,Akter KA,Nishiwaki K,Asano-Inami E,Senga T

更新日期：2019-01-01 00:00:00

abstract：:The effect of alloxan-induced diabetes was studied on the activity of monoamine oxidase (MAO), the oxidative deaminating enzyme of monoamine neurotransmitters. MAO was assayed from discrete brain regions like medial preoptic area and median eminence--arcuate region of hypothalamus, septum, amygdala, thalamus, hippocam...

journal_title：Molecular and cellular biochemistry

authors： Lakhman SS,Kaur G

更新日期：1997-12-01 00:00:00

abstract：:The natriuretic peptide receptor-A (NPR-A) is involved in blood pressure and body fluid regulation in order to help maintain cardiovascular homeostasis. It has been shown that these biological effects are mediated through the natriuretic peptide family of hormones, which bind NPR-A according to the rank order ANP>BNP>...

journal_title：Molecular and cellular biochemistry

authors： Marquis M,Fenrick R,Pedro L,Bouvier M,De Léan A

更新日期：1999-04-01 00:00:00

abstract：:Treatment of bovine pulmonary artery smooth muscle plasma membrane suspension with the oxidant tert-butylhydroperoxide (t-buOOH) increases Ca2+ATPase activity. The smooth muscle plasma membrane possesses a Ca2+ dependent protease activity in the gelatin containing zymogram having an apparent molecular mass of 72 kDa. ...

journal_title：Molecular and cellular biochemistry

authors： Das S,Chakraborti T,Mandal M,Mandal A,Chakraborti S

更新日期：2002-08-01 00:00:00

abstract：:Cytosolic purine nucleoside phosphorylase (PNPase) is a well known, and described enzyme which exists in a variety of organisms, both procaryotic and eucaryotic. More recently this enzyme was found in bovine liver mitochondria. The mitochondrial purine nucleoside phosphorylase was purified 63 fold and has a molecular ...

journal_title：Molecular and cellular biochemistry

authors： Haag R,Lewis RA

更新日期：1994-06-29 00:00:00

abstract：:Reviews on the pathogenic mechanisms of Shigella species show a lacunae in the understanding of the bacterial antioxidant defense system and its regulations. This study was done to investigate the regulation of expression of antioxidant enzymes in clinical isolates of Shigella species, under various growth conditions....

journal_title：Molecular and cellular biochemistry

authors： Prakash R,Devaraj H,Devaraj SN

更新日期：2004-12-01 00:00:00

abstract：:Although studies performed in vitro and with transfected cells in culture suggest a role for liver fatty acid binding protein (L-FABP) in regulating fatty acid oxidation and fat deposition, the physiological significance of this possibility is not completely clear. To begin to address this question, the effect of L-FA...

journal_title：Molecular and cellular biochemistry

authors： Martin GG,Atshaves BP,McIntosh AL,Payne HR,Mackie JT,Kier AB,Schroeder F

更新日期：2009-04-01 00:00:00

abstract：:The effect of beta-alanyl-L-histidinato zinc (AHZ) on protein components in osteoblastic MC3T3-E1 cells was investigated. Cells were cultured for 3 days at 37 degrees C in CO2 incubator in plastic dishes containing alpha-modified minimum essential medium supplemented with 10% fetal bovine serum. After the cultures, th...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Hashizume M

更新日期：1994-07-27 00:00:00

abstract：:The presence of a prostatic-like acid phosphatase is reported in human lactating milk. Its activity is associated with skim milk and it could be separated from the other acid phosphatases only after Triton X-100 treatment. By all the criteria applied, it appears to be very similar to prostatic acid phosphatase. An app...

journal_title：Molecular and cellular biochemistry

authors： Podhajcer OL,Filmus JE,Mordoh J

更新日期：1985-02-01 00:00:00

abstract：:Experiments were conducted to study the functional implication of a mannose-binding glycoprotein found in the day 4 post coital (p.c.) rat uterus, using a mono-specific polyclonal antibody raised against the glycoprotein. Western Blot and immunohistochemical techniques were employed to study the distribution of the gl...

journal_title：Molecular and cellular biochemistry

authors： Mehta M,Chowdhury M

更新日期：1999-05-01 00:00:00

abstract：:Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats. To further explore the mechanism of action of arjunolic acid, antiplatelet activity, anticoagulant assays, electroca...

journal_title：Molecular and cellular biochemistry

authors： Sumitra M,Manikandan P,Kumar DA,Arutselvan N,Balakrishna K,Manohar BM,Puvanakrishnan R

更新日期：2001-08-01 00:00:00

abstract：:In this study we tested the hypothesis that reduced myofibrillar ATPase activities in end-stage heart failure are associated with a redistribution of myosin isozymes. Cardiac myofibrils were isolated from left ventricular free wall from normal human hearts and hearts at end-stage heart failure caused by coronary arter...

journal_title：Molecular and cellular biochemistry

authors： Alousi AA,Grant AM,Etzler JR,Cofer BR,Van der Bel-Kahn J,Melvin D

更新日期：1990-07-17 00:00:00

abstract：:Cytochrome c oxidase (COX), like other multi-subunit components of the respiratory chain, is controlled by both the nuclear and the mitochondrial genome. In order to find wether there is a close relationship between mRNAs encoded by the nucleus and by the mitochondrion, and between these mRNAs and enzyme activity, we ...

journal_title：Molecular and cellular biochemistry

authors： Gagnon J,Kurowski TT,Wiesner RJ,Zak R

更新日期：1991-09-18 00:00:00

abstract：:Computer retrieval in a database, comprising 7,225 muscle cases, revealed that mitochondrial myopathies do not occur more frequently in inflammatory myopathies (3.74%) than in the whole series (3.69%). A more detailed study of inclusion body myositis (IBM), however, showed that severe mitochondrial alterations were ap...

journal_title：Molecular and cellular biochemistry

authors： Schröder JM,Molnar M

更新日期：1997-09-01 00:00:00

abstract：:Sirtuin 3 (SIRT3) modulates mitochondria-localized processes and is implicated in the metabolic reprogramming of cancer cells, especially fatty acid (FA) synthesis. However, the relationship between SIRT3 and aberrant lipid synthesis in cervical cancer remains unclear. Here, we investigated the clinical relevance of S...

journal_title：Molecular and cellular biochemistry

authors： Xu LX,Hao LJ,Ma JQ,Liu JK,Hasim A

更新日期：2020-01-01 00:00:00

abstract：:The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascor...

journal_title：Molecular and cellular biochemistry

authors： Rajakumar DV,Rao MN

更新日期：1994-11-09 00:00:00

abstract：:This study was designed to investigate the alterations in the levels of various proteases such as angiotensin converting enzyme (ACE), kallikrein, aminopeptidases, urokinase and plasmin in serum-heart and kidney and to find out whether the changes in the levels of these enzymes could explain the pathogeneses of hypert...

journal_title：Molecular and cellular biochemistry

authors： Rajashree S,Puvanakrishnan R

更新日期：1999-07-01 00:00:00

abstract：:Various factors appear to control muscle energetics, often in conjunction. This calls for a quantitative approach of the type provided by Metabolic Control Analysis for intermediary metabolism and mitochondrial oxidative phosphorylation. To the extent that direct transfer of high energy phosphates and spatial organiza...

journal_title：Molecular and cellular biochemistry

authors： Kholodenko BN,Cascante M,Westerhoff HV

更新日期：1995-02-23 00:00:00

abstract：:The present study was addressed to understand the interrelationship between Receptor-Ck activation, mevalonate pathway and primary response genes such as c-fos, c-myc and cyclin 'D' involved in the cell cycle. The results reported here unambiguously revealed that the phosphatidic acid (generated through the activation...

journal_title：Molecular and cellular biochemistry

authors： Kaur M,Kaul D,Sobti RC

更新日期：1998-04-01 00:00:00

abstract：:The interaction of deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one) L1, the first clinically available oral iron chelator, with the tetrameric allosteric protein hemoglobin from human red blood cells has been investigated spectrofluorometrically and by circular dichroism spectroscopy. The interaction is hydrogenbond l...

journal_title：Molecular and cellular biochemistry

authors： Chakraborty D,Bhattacharyya M

更新日期：2000-01-01 00:00:00

abstract：:The OCT4 transcription factor is a crucial stem cells marker and it has been related to the cancer stem cells concept. Moreover, it has also been associated to the multiple drug resistance (MDR) phenotype. Our first results pointed out a straight relation between OCT4 and ABC transporters in K562-derivative MDR (Lucen...

journal_title：Molecular and cellular biochemistry

authors： Oliveira BR,Figueiredo MA,Trindade GS,Marins LF

更新日期：2015-02-01 00:00:00

abstract：:Obesity-induced low-grade inflammation (metaflammation) impairs insulin receptor signaling. This has been implicated in the development of insulin resistance. Insulin signaling in the target tissues is mediated by stress kinases such as p38 mitogen-activated protein kinase, c-Jun NH2-terminal kinase, inhibitor of NF-k...

journal_title：Molecular and cellular biochemistry

authors： Nandipati KC,Subramanian S,Agrawal DK

更新日期：2017-02-01 00:00:00

abstract：:Previous results with p9-RNA, obtained from lymph nodes of animals immunized with the peptide p9 of HIV-1, suggested that its effects on lymphocytes could be mediated by RNA-dependent protein kinase (PKR). Here we report that p9-RNA activates PKR leading to the degradation of the inhibitor I-kappaB alpha and the conco...

journal_title：Molecular and cellular biochemistry

authors： De Lucca FL,Sales VS,Souza LR,Murad JM,Watanabe MA

更新日期：2003-05-01 00:00:00

abstract：:Tyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Increased or decreased neuronal activity, stress, lesions, drug effects, endocrinological manipulations and experimental models of hypertension are associated with alt...

journal_title：Molecular and cellular biochemistry

authors： Masserano JM,Weiner N

更新日期：1983-01-01 00:00:00

abstract：:Hypertriglyceridemia is a common complex metabolic trait that is associated with increased atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation, increased risk of pancreatitis. Hierarchical cluster analysis using clinical and biochemical features of the Frederickson hyperlipoproteinemia...

journal_title：Molecular and cellular biochemistry

authors： Hegele RA,Pollex RL

更新日期：2009-06-01 00:00:00