Abstract:
:The interaction of deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one) L1, the first clinically available oral iron chelator, with the tetrameric allosteric protein hemoglobin from human red blood cells has been investigated spectrofluorometrically and by circular dichroism spectroscopy. The interaction is hydrogenbond like electrostatic in nature, the binding constant being 4.54 x 10(3) M(-1) in 0.15 M NaCl. Circular dichroism studies indicate a conformational change of hemoglobin in presence of deferiprone, helicity of hemoglobin being reduced in presence of increasing concentration of the drug L1.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Chakraborty D,Bhattacharyya Mdoi
10.1023/a:1007049701572keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
17-20issue
1-2eissn
0300-8177issn
1573-4919journal_volume
204pub_type
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journal_title:Molecular and cellular biochemistry
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