当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Effect of beta-alanyl-L-histidinato zinc on protein components in osteoblastic MC3T3-El cells: increase in osteocalcin, insulin-like growth factor-I and transforming growth factor-beta.

Effect of beta-alanyl-L-histidinato zinc on protein components in osteoblastic MC3T3-El cells: increase in osteocalcin, insulin-like growth factor-I and transforming growth factor-beta.

Abstract：

:The effect of beta-alanyl-L-histidinato zinc (AHZ) on protein components in osteoblastic MC3T3-E1 cells was investigated. Cells were cultured for 3 days at 37 degrees C in CO2 incubator in plastic dishes containing alpha-modified minimum essential medium supplemented with 10% fetal bovine serum. After the cultures, the medium was exchanged for that containing 0.1% bovine serum albumin plus various concentrations of AHZ or other reagents, and the cells were cultured further 3 or 6 days. The homgenate of cells was analyzed with SDS-polyacrylamide gel electrophoresis (SDS-PAGE). The presence of AHZ (10(-7) to 10(-5) M) caused an appreciable increase of many protein components in cells. Especially, the 67 killo-dalton (kDa) and 44 kDa proteins which are the major components from control cells were clearly increased by the presence of AHZ. Furthermore, the concentrations of osteocalcin, insulin-like growth factor-I and transforming growth factor-beta in the culture medium secreted from osteoblastic cells were markedly increased by the presence of AHZ (10(-6) and 10(-5) M). The effect of AHZ was a greater than that of zinc sulfate (10(-6) and 10(-5) M). The present findings suggest that AHZ can increase many proteins which are involved in the stimulation of bone formation and cell proliferation in osteoblastic cells.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Yamaguchi M,Hashizume M

doi

10.1007/BF00926077

subject

Has Abstract

pub_date

1994-07-27 00:00:00

pages

163-9

issue

2

eissn

0300-8177

issn

1573-4919

journal_volume

136

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • An inverse relation between mitochondrial hexokinase content and phosphoglucomutase activity of rat tissues.

    abstract：:The hexokinase: fumarase ratios of mitochondria isolated from ten tissues of the rat were determined, and compared with the tissue content of phosphoglucomutase and phosphorylase, taken as representatives of enzymes concerned with glycogen metabolism. A generally inverse relationship was found between the mitochondria...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00215278

    authors： Wilson JE,Felgner PL

    更新日期：1977-11-25 00:00:00

  • The molecular mechanism and potential role of heat shock-induced p53 protein accumulation.

    abstract：:Workers who are exposed to extreme heat or work in hot environments may be at risk of heat stress. Exposure to extreme heat can result in occupational illnesses and injuries. On the other hand, local and regional heat therapy has been used for the treatment of some cancers, such as liver cancer, lung cancer, and kidne...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-013-1607-9

    authors： Han J,Xu X,Qin H,Liu A,Fan Z,Kang L,Fu J,Liu J,Ye Q

    更新日期：2013-06-01 00:00:00

  • Alteration of antioxidant status following sympathectomy: differential effects of modified plasma levels of adrenaline and noradrenaline.

    abstract：:The influence of altered levels of endogenous catecholamines following adrenalectomy or 6-hydroxydopamine (6-OH) treatment (alone or in combination) on enzymatic (glutathione reductase, catalase, glutathione peroxidase and Cu, Zn superoxide dismutase) and non-enzymatic (glutathione) antioxidant components of heart, li...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Toleikis PM,Godin DV

    更新日期：1995-11-08 00:00:00

  • Role of high-energy phosphate metabolism in hydrogen peroxide-induced cardiac dysfunction.

    abstract：:This study was undertaken to clarify the role of high-energy phosphate metabolism in hydrogen peroxide-induced cardiac dysfunction using phosphorus and fluorine nuclear magnetic resonance spectroscopy. The exposure of a Langendorff-perfused heart to hydrogen peroxide (200-400 micromol/L, 8 min) provoked biphasic contr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007042611127

    authors： Matsumoto Y,Kaneko M,Iimuro M,Fujise Y,Hayashi H

    更新日期：2000-01-01 00:00:00

  • Poly(ADP-ribose) polymerase activity in intact or permeabilized leukocytes from mammalian species of different longevity.

    abstract：:Poly(ADP-ribosyl)ation is a eukaryotic posttranslational protein modification catalyzed by poly(ADP-ribose) polymerase (PARP), a highly conserved nuclear enzyme which uses NAD as substrate. We have previously tested PARP activity in permeabilized mononuclear blood cells (MNC) from 13 mammalian species as a function of...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Bürkle A,Müller M,Wolf I,Küpper JH

    更新日期：1994-09-01 00:00:00

  • Three immunologically similar atrial natriuretic factor receptors.

    abstract：:One of the atrial natriuretic factor (ANF) receptors is a 180 kDa protein (180 kDa mGC) which possesses the extraordinary characteristic of being bifunctional: it is both a receptor and a guanylate cyclase. In addition to the 180 kDa mGC, there exists another 120-130 kDa protein which is also bifunctional and a 120 kD...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00230875

    authors： Marala RB,Sharma RK

    更新日期：1992-01-15 00:00:00

  • Oxidative damage to sarcoplasmic reticulum Ca(2+)-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation.

    abstract：:The major protein in the sarcoplasmic reticulum (SR) membrane is the Ca2+ transporting ATPase which carries out active Ca2+ pumping at the expense of ATP hydrolysis. The aim of this work was to elucidate the mechanisms by which oxidative stress induced by Fenton's reaction (Fe(2+)+H2O2-->HO.+OH-+Fe3+) alters the funct...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00420912

    authors： Castilho RF,Carvalho-Alves PC,Vercesi AE,Ferreira ST

    更新日期：1996-06-21 00:00:00

  • Novel classes of fatty acid and retinol binding protein from nematodes.

    abstract：:Parasitic nematodes have recently been found to produce proteins which represent two new classes of fatty acid and retinoid binding protein. The first is the nematode polyprotein allergens/antigens (NPAs) which, as their name suggests, are synthesised as large polyproteins which are subsequently cleaved at regularly s...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：

    authors： McDermott L,Cooper A,Kennedy MW

    更新日期：1999-02-01 00:00:00

  • Clearance of thrombin in vivo: significance of alternative pathways.

    abstract：:The clearance of thrombin seems to occur at more than one site and by different mechanisms. This contributes to maintaining thrombin at the right concentrations to act optimally on its various substrates, and thus, to produce the proper amount of proteolytic conversions so that coagulation is precisely controlled. The...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/BF00214768

    authors： Carlson TH

    更新日期：1986-08-01 00:00:00

  • Novel missense mutation in FHIT gene: interpreting the effect in HPV-mediated cervical cancer in Indian women.

    abstract：:Human papillomavirus (HPV) is considered to be a major etiological factor but is not sufficient for the development of cervical cancer. Other host factors including altered tumor suppressor gene activities might contribute to the carcinogenic process. Fragile Histidine Triad (FHIT) has been shown to play a pivotal rol...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-009-0240-0

    authors： Neyaz MK,Hussain S,Hassan MI,Das BC,Husain SA,Bharadwaj M

    更新日期：2010-02-01 00:00:00

  • The connexin43 gap junction protein is phosphorylated by protein kinase A and protein kinase C: in vivo and in vitro studies.

    abstract：:There is general agreement that the connexin43 gap junction protein is a substrate for phosphorylation by protein kinase C but there is no similar consensus regarding the action of protein kinase A. Our previous studies demonstrated that channels formed by connexin43 were reversibly gated in response to microinjected ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1019902920693

    authors： Shah MM,Martinez AM,Fletcher WH

    更新日期：2002-09-01 00:00:00

  • Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation.

    abstract：:Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet destruction severely affects the normal functioning of thrombosis and hemostasis. In addition, frequent exposure of platelets to chemical entities and therapeutic drugs ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-016-2667-4

    authors： Jagadish S,Rajeev N,NaveenKumar SK,Sharath Kumar KS,Paul M,Hegde M,Basappa,Sadashiva MP,Girish KS,Rangappa KS

    更新日期：2016-03-01 00:00:00

  • High altitude hypoxia: an intricate interplay of oxygen responsive macroevents and micromolecules.

    abstract：:Physiological responses to high altitude hypoxia are complex and involve a range of mechanisms some of which occur within minutes of oxygen deprivation while others reset a cascade of biosynthetic and physiological programs within the cellular milieu. The O2 sensitive events occur at various organisational levels in t...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1023/a:1026080320034

    authors： Sarkar S,Banerjee PK,Selvamurthy W

    更新日期：2003-11-01 00:00:00

  • Regulation of calcium transport in pancreatic acinar plasma membranes from guinea pig.

    abstract：:The regulation of the guinea-pig pancreatic acinar plasma membrane Ca2+ pump by protein kinase A, protein kinase C and calmodulin was investigated. The results were compared with the effects of these regulators on the high affinity Ca(2+)-ATPase found in this membrane preparation. The catalytic subunit of cyclic AMP-d...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00227572

    authors： Mahey R,Allen BG,Bridges MA,Katz S

    更新日期：1992-06-26 00:00:00

  • Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells.

    abstract：:Human monoblastoid cells (U937) grown in the presence of therapeutically relevant dideoxycytidine concentrations (0.1 microM) become resistant to the drug thanks to an altered deoxycytidine kinase. In this paper we show that deoxycytidine kinase mRNA is significantly reduced in drug-resistant U937 cells (U937-R) altho...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1014441209108

    authors： Innoceta A,Galluzzi L,Ruzzo A,Andreoni F,Chiarantini L,Magnani M

    更新日期：2002-02-01 00:00:00

  • Altered expression of gap junction connexin proteins may partly underlie heart rhythm disturbances in the streptozotocin-induced diabetic rat heart.

    abstract：:Previous studies in isolated perfused heart and in atrial preparations have demonstrated significant reductions in beating rate in STZ-induced diabetic rats, which suggests that sinus arrhythmias in diabetes mellitus may be partly caused by intrinsic alteration of sino-atrial node (SAN) function. The effects of diabet...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9537-z

    authors： Howarth FC,Nowotny N,Zilahi E,El Haj MA,Lei M

    更新日期：2007-11-01 00:00:00

  • Correction to: JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.

    abstract：:The article "JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells", written by "Patrick T. Caswell, Martin Dickens", was originally published electronically on the publisher's internet portal https://link.springer.com/article/10.1007/s11010-017-3222-7 on 20 November ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 已发布勘误

    doi：10.1007/s11010-018-3354-4

    authors： Caswell PT,Dickens M

    更新日期：2018-07-01 00:00:00

  • Transient Ca2+ changes in endothelial cells induced by low doses of reactive oxygen species: role of hydrogen peroxide.

    abstract：:Cultured human and rat endothelial cells were used to study cellular toxicity and Ca2+ signalling upon exposure to reactive oxygen species. Superoxide and hydrogen peroxide (O2.-/H2O2) were produced by the hypoxanthine/xanthine oxidase system (HX/XO) and caused intracellular Ca2+ concentration ([Ca2+]i) to rise steadi...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1006886215193

    authors： Volk T,Hensel M,Kox WJ

    更新日期：1997-06-01 00:00:00

  • Right ventricular collagen and fibronectin levels in patients with pulmonary atresia and ventricular septal defect.

    abstract：:Pulmonary atresia (PA) with ventricular septal defect (VSD) is an extreme form of tetralogy of Fallot with characteristic right ventricular hypertrophy. To reduce the right ventricular overload, these children have to undergo staged corrective surgery to restore physiological pulmonary perfusion. We studied the degree...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Peters TH,de Jong PL,Klompe L,Berger RM,Saxena PR,Sharma HS,Bogers AJ

    更新日期：2003-09-01 00:00:00

  • Properties of Na,K-ATPase in cerebellum of male and female rats: effects of acute and prolonged diabetes.

    abstract：:The present study was oriented to gender specificity of Na,K-ATPase in cerebellum, the crucial enzyme maintaining the intracellular homeostasis of Na ions in healthy and diabetic Wistar rats. The effects of diabetes on properties of the Na,K-ATPase in cerebellum derived from normal and streptozotocin (STZ)-diabetic ra...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-016-2859-y

    authors： Kaločayová B,Mézešová L,Barteková M,Vlkovičová J,Jendruchová V,Vrbjar N

    更新日期：2017-01-01 00:00:00

  • Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.

    abstract：:To examine the essential mechanisms of steroid production in ovarian theca cells, we analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid produ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9764-y

    authors： Murayama C,Miyazaki H,Miyamoto A,Shimizu T

    更新日期：2008-07-01 00:00:00

  • Synergistic effect of TRM2/RNC1 and EXO1 in DNA double-strand break repair in Saccharomyces cerevisiae.

    abstract：:In our recently published study, we provided in vitro as well as in vivo data demonstrating the involvement of TRM2/RNC1 in homologous recombination based repair (HRR) of DNA double strand breaks (DSBs), in support of such claims reported earlier. To further validate its role in DNA DSB processing, our present study r...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9493-7

    authors： Choudhury SA,Asefa B,Kauler P,Chow TY

    更新日期：2007-10-01 00:00:00

  • SAMD9 is a (epi-) genetically regulated anti-inflammatory factor activated in RA patients.

    abstract：:To identify PBMC-expressed genes significant for RA, and to ascertain their upstream regulatory factors, as well as downstream functional effects relevant to RA pathogenesis. We performed peripheral blood mononuclear cells (PBMCs) transcriptome-wide mRNA expression profiling in a case-control discovery sample. Differe...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-019-03499-7

    authors： He P,Wu LF,Bing PF,Xia W,Wang L,Xie FF,Lu X,Lei SF,Deng FY

    更新日期：2019-06-01 00:00:00

  • Deferiprone (L1) induced conformation change of hemoglobin: A fluorescence and CD spectroscopic study.

    abstract：:The interaction of deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one) L1, the first clinically available oral iron chelator, with the tetrameric allosteric protein hemoglobin from human red blood cells has been investigated spectrofluorometrically and by circular dichroism spectroscopy. The interaction is hydrogenbond l...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1007049701572

    authors： Chakraborty D,Bhattacharyya M

    更新日期：2000-01-01 00:00:00

  • Vascular endothelial growth factor-D mediates fibrogenic response in myofibroblasts.

    abstract：:Vascular endothelial growth factor (VEGF)-D is a crucial mediator of angiogenesis. Following myocardial infarction (MI), cardiac VEGF-D and VEGF receptor (VEGFR)-3 are significantly upregulated. In addition to endothelial cells, myofibroblasts at the site of MI highly express VEGFR-3, implicating the involvement of VE...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2646-1

    authors： Zhao T,Zhao W,Meng W,Liu C,Chen Y,Bhattacharya SK,Sun Y

    更新日期：2016-02-01 00:00:00

  • Krüppel-like factor 4 regulates the expression of inducible nitric oxide synthase induced by TNF-α in human fibroblast-like synoviocyte MH7A cells.

    abstract：:Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, has been implicated in the inflammation mediated by macrophages and endothelial cells by regulating the expression of inflammatory mediators. Here, we investigated whether KLF4 affects the expression of inducible nitric oxide synthase (iNOS), an importa...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-017-3115-9

    authors： Mo X,Chen J,Wang X,Pan Z,Ke Y,Zhou Z,Xie J,Lv G,Luo X

    更新日期：2018-01-01 00:00:00

  • Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart.

    abstract：:Ventricular electrical conduction has been investigated in the streptozotocin (STZ)-induced diabetic rat. Diabetes was induced with a single injection of STZ (60 mg/kg bodyweight, ip). The ECG was measured continuously, in vivo, using a biotelemetry system. Left ventricular action potentials were recorded with an extr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-009-0074-9

    authors： Howarth FC,Jacobson M,Qureshi MA,Shafiullah M,Hameed RS,Zilahi E,Al Haj A,Nowotny N,Adeghate E

    更新日期：2009-08-01 00:00:00

  • A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2.

    abstract：:Drosophila melanogaster protein kinase CK2 (DmCK2) is a Ser/Thr protein kinase composed of catalytic alpha and regulatory beta subunits associated as an alpha2beta2 heterotetramer. Using the two hybrid system, we have screened a Drosophila embryo cDNA library in order to identify proteins that interact with DmCK2alpha...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Kalive M,Trott RL,Bidwai AP

    更新日期：2001-11-01 00:00:00

  • Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia.

    abstract：:The aim of our work was to study (1) the antioxidant properties of lipoic acid (LA) and its reduced metabolite dihydrolipoic acid (DHLA) formed by reduction of LA and (2) the effects of treatment with LA and DHLA on (a) K(+) efflux from human red blood cells and (b) post-ischemic recovery and oxidative stress in isola...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-008-9916-0

    authors： Ghibu S,Lauzier B,Delemasure S,Amoureux S,Sicard P,Vergely C,Muresan A,Mogosan C,Rochette L

    更新日期：2009-01-01 00:00:00

  • An extended developmental study of gamma-glutamyltranspeptidase in rat liver plasma membranes: identification of specific patterns of changes in activity in the adult as well as the neonatal state.

    abstract：:Homogenates and plasma membranes were isolated from the livers of male Fischer 344 rats ranging in age from 19 hr to 92 days postnatal. These plasma membranes exhibited comparable levels of purity: protein yields were 2-2.5%; relative specific activities of 5'-nucleotidase and ouabain-sensitive Na+/K(+)-ATPase were fr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00229098

    authors： Sulakhe-Hemmings SJ,Pulga VB,Tran ST

    更新日期：1992-09-22 00:00:00