Properties of Na,K-ATPase in cerebellum of male and female rats: effects of acute and prolonged diabetes.

abstract：:Cigarette smoking is associated with a number of fatal diseases, including cancer of different organs. A number of oxoaldehydes are found in cigarette smoke, among which methylglyoxal (MG) is known to cause toxicity to cells upon accumulation. In biological systems, MG is converted to s-d-lactoylglutathione by glyoxal...

journal_title：Molecular and cellular biochemistry

authors： Biswas S,Gairola CG,Das SK

更新日期：2002-01-01 00:00:00

abstract：:To identify and characterize endothelial cell surface components that bind plasminogen, we used ligand-blotting to study binding of plasminogen to sodium dodecyl sulphate solubilized extracts of human umbilical vein endothelial cells. It was observed that glu-plasminogen bound predominantly to a 45 kDa endothelial cel...

journal_title：Molecular and cellular biochemistry

authors： Dudani AK,Hashemi S,Aye MT,Ganz PR

更新日期：1991-12-11 00:00:00

abstract：OBJECTIVES:To assess the oxidative effects of raloxifene use in postmenopausal women by investigating protein carbonyl levels in the plasma. METHODS:Nineteen osteoporotic postmenopausal women treated with raloxifene for 12 months were included in the study. Another seventeen postmenopausal women matched for age and po...

journal_title：Molecular and cellular biochemistry

authors： Korucuoğlu U,Ciftçi B,Gülbahar O,Biri A,Nas T,Gürsoy R,Aricioğlu A

更新日期：2006-10-01 00:00:00

abstract：:The T-box transcription factor TBX2 is known for its role as a critical regulator of melanoma cell proliferation, but its role in regulating melanogenesis has not been widely studied. Here we use a series of experiments to show in primary and immortalized mouse melanocytes that TBX2 acts as regulator of melanogenesis ...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Pan L,Su Z,Wang J,Li H,Ma X,Liu Y,Lu F,Qu J,Hou L

更新日期：2016-04-01 00:00:00

abstract：:Our interest in the role of sulfhydryl groups (SH) in regulating or altering transport across biological membranes has focused on the significance of a critical SH group associated with the Ca2+-release protein from skeletal muscle sarcoplasmic reticulum (SR). We have shown that binding of heavy metals to this group o...

journal_title：Molecular and cellular biochemistry

authors： Abramson JJ,Salama G

更新日期：1988-07-01 00:00:00

abstract：:In order to understand the molecular basis of cold adaptation, we have used directed evolution to transform a thermophilic lipase LipR1 into its psychrophilic counterpart. A single round of random mutagenesis followed by screening for improved variants yielded a mutant with single-point mutation LipR1M1 (S130T), with ...

journal_title：Molecular and cellular biochemistry

authors： Sharma M,Kumar R,Singh R,Kaur J

更新日期：2017-06-01 00:00:00

abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

journal_title：Molecular and cellular biochemistry

authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

更新日期：2009-06-01 00:00:00

abstract：:This paper reviews characteristics of microsomal membrane structure; long chain fatty acids, acyl CoA derivatives, retinoids and the microsomal formation of acyl CoA derivatives and retinyl esters. It is analyzed how the movement of these molecules at the intracellular level is affected by their respective binding pro...

journal_title：Molecular and cellular biochemistry

authors： Catalá A

更新日期：1993-03-24 00:00:00

abstract：:Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxidation for ATP generation or the lipogenic routes that generate bioactive lipids such as the inositol phosphol...

journal_title：Molecular and cellular biochemistry

authors： Radif Y,Ndiaye H,Kalantzi V,Jacobs R,Hall A,Minogue S,Waugh MG

更新日期：2018-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-...

journal_title：Molecular and cellular biochemistry

authors： Xie L,Qian X,Liu B

更新日期：2010-08-01 00:00:00

abstract：:Prolonged ischemia-reperfusion results in various damages in skeletal muscle. Following reperfusion, although the damaged muscles undergo regeneration, the precise process and mechanism of regeneration have not yet been fully understood. Here, we show the altered levels of plasma biochemical markers of muscle damage, ...

journal_title：Molecular and cellular biochemistry

authors： Itoh M,Shimokawa N,Tajika Y,Murakami T,Aotsuka N,Lesmana R,Farenia R,Iwasaki T,Okda J,Yorifuji H,Koibuchi N

更新日期：2013-01-01 00:00:00

abstract：:Vascular endothelial and -smooth muscle cells have been shown to use fatty acids as substrates for oxidative phosphorylation. Endothelial cells are more vulnerable to oxidative stress than muscle cells and are prone to loose carnitine early during hypoperfusion. This has been suggested by two observations. The first i...

journal_title：Molecular and cellular biochemistry

authors： Hülsmann WC,Dubelaar ML

更新日期：1992-10-21 00:00:00

abstract：:Activation of either the A(1) adenosine receptor (A(1)R) or the A(3) adenosine receptor (A(3)R), by their specific agonists CCPA and Cl-IB-MECA, respectively, protects cardiac cells in culture against ischemic injury. Yet the full protective mechanism remains unclear. In this study, we therefore examined the involveme...

journal_title：Molecular and cellular biochemistry

authors： Leshem-Lev D,Hochhauser E,Chanyshev B,Isak A,Shainberg A

更新日期：2010-12-01 00:00:00

abstract：:The underlying molecular mechanism of carcinogenesis in oral squamous cell carcinoma (OSCC) is poorly understood and appears to be controlled on many genetic, environmental, and hormonal factors. Obestatin and ghrelin, two recently discovered hormones, are co-expressed in endocrine cells. The purpose of this investiga...

journal_title：Molecular and cellular biochemistry

authors： Alnema MM,Aydin S,Ozkan Y,Dagli AF,Ozercan HI,Yildirim N,Sahin I,Karaoglu A,Kilic N,Yilmaz M,Ozercan MR,Donder E

更新日期：2010-06-01 00:00:00

abstract：:Diabetes mellitus is a serious global health problem, and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The chronic effects of neonatal alloxan- (ALX) induced diabetes mellitus on ventricular myocyte contraction and intracellular Ca(2+) transport have been investigat...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Hassan Z,Qureshi MA

更新日期：2011-01-01 00:00:00

abstract：:Epidemiological studies suggest that n-3 polyunsaturated fatty acids (PUFA) are involved in the prevention of cardiovascular disease. Stress is known to increase the incidence of CVD and the present study was realised to evaluate some physiological and biochemical effects of dietary docosahexaenoic acid (DHA) in male ...

journal_title：Molecular and cellular biochemistry

authors： Rousseau D,Moreau D,Raederstorff D,Sergiel JP,Rupp H,Muggli R,Grynberg A

更新日期：1998-01-01 00:00:00

abstract：:MicroRNA (miRNAs) is demonstrated to be present in the blood of humans and has been increasingly suggested as a novel biomarker for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. In this study, we aim to evaluate the diagnostic and ...

journal_title：Molecular and cellular biochemistry

authors： He F,Lv P,Zhao X,Wang X,Ma X,Meng W,Meng X,Dong S

更新日期：2014-09-01 00:00:00

abstract：:In recent years, there has been growing interest in estimating the degree of heating caused by the diagnostic ultrasound in clinical practice. Both theoretical and experimental methods have been suggested for estimating the heating potential, or thermal hazard, of diagnostic ultrasound. Aim of this study was to evalua...

journal_title：Molecular and cellular biochemistry

authors： Karagöz I,Biri A,Babacan F,Kavutçu M

更新日期：2007-01-01 00:00:00

abstract：:Endothelial dysfunction is one of the most important pathological events during the development of several diabetic complications including stroke. The aim of this work was to investigate the role of actin depolymerizing factor (ADF) in advanced glycation endproducts (AGEs)-induced impairment in mouse brain microvascu...

journal_title：Molecular and cellular biochemistry

authors： Liu X,Zhang R,Di H,Zhao D,Wang J

更新日期：2017-09-01 00:00:00

abstract：:Magnesium ions variably influenced activity of highly purified thymidylate synthetase preparations from different mouse tumors, activating the enzyme from Ehrlich ascites carcinoma (EAC) cells and inhibiting the enzyme from L1210 and L5178Y cells and from 5-fluorodeoxyuridine (FdUrd)-resistant EAC cells. In the presen...

journal_title：Molecular and cellular biochemistry

authors： Rode W,Jastreboff MM

更新日期：1984-01-01 00:00:00

abstract：:Treatment of P-type ATPases (from mammalian sources) by fluorescein isothiocyanate (ITC) revealed the ITC label on a lysine residue that was than considered as essential for binding of ATP in the ATP-binding site of these enzymes. On the other hand, experiments with site directed mutagenesis excluded the presence of a...

journal_title：Molecular and cellular biochemistry

authors： Breier A,Ziegelhöffer A,Famulsky K,Michalak M,Slezák J

更新日期：1996-07-01 00:00:00

abstract：:Thymoquinone (TQ) is a highly perspective chemotherapeutic agent against gliomas and glioblastomas because of its ability to cross the blood-brain barrier and its selective cytotoxicity for glioblastoma cells compared to primary astrocytes. Here, we tested the hypothesis that TQ-induced mild oxidative stress provokes ...

journal_title：Molecular and cellular biochemistry

authors： Krylova NG,Drobysh MS,Semenkova GN,Kulahava TA,Pinchuk SV,Shadyro OI

更新日期：2019-12-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is an independent risk factor of cardiovascular disease, but the mechanisms of tissue injury are poorly understood. In the present study, we investigated the effect of HHcy on rat heart function, activities electron transport chain (ETC) complexes, mitochondrial protein expression, and prot...

journal_title：Molecular and cellular biochemistry

authors： Timkova V,Tatarkova Z,Lehotsky J,Racay P,Dobrota D,Kaplan P

更新日期：2016-01-01 00:00:00

abstract：:A preparation of UDP-GalNAc:sialosyl lactosylceramide N-acetylgalactosaminyl transferase (E.C. 2.4.1.92) obtained from 14-day chick embryo brain was delipidated partially by treatment with cold acetone in the presence of varying amounts of sodium dodecyl sulphate (SDS). The lipid content and the enzyme activity of the...

journal_title：Molecular and cellular biochemistry

authors： Cortassa S,Maccioni HJ

更新日期：1989-01-23 00:00:00

abstract：:Insulin stimulated phosphorylation of tyrosine residues by the insulin receptor kinase may be part of a signalling mechanism associated with insulin's action. We report that indomethacin inhibited the phosphorylation of the beta-subunit of the solubilized adipocyte insulin receptor. Indomethacin also inhibited several...

journal_title：Molecular and cellular biochemistry

authors： Malchoff CD,Messina JL,Gordon V,Tamura S,Larner J

更新日期：1985-11-01 00:00:00

abstract：:Calpain inhibitors show the potential to serve as non-surgical alternatives in treating diabetic cataract and other types of these disorders. Here, we have tested the recently developed calpain inhibitor, SJA6017, for its ability to inhibit cataractogenesis in porcine lenses. These lenses were incubated in increasing ...

journal_title：Molecular and cellular biochemistry

authors： Biswas S,Harris F,Singh J,Phoenix DA

更新日期：2004-06-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:Recent studies have shown that adult osteoporosis could be induced by ageing and estrogen deficiency and homocysteine (Hcy) is an independent risk factor of fracture in osteoporosis patients. In this study, we found hypermethylation of the promoter A region in the estrogen receptor alpha (ERα) gene, and methylation in...

journal_title：Molecular and cellular biochemistry

authors： Lv H,Ma X,Che T,Chen Y

更新日期：2011-09-01 00:00:00

abstract：:A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which al...

journal_title：Molecular and cellular biochemistry

authors： Leonard SS,Bower JJ,Shi X

更新日期：2004-01-01 00:00:00

abstract：:The simultaneous administration of the DNA topoisomerase II inhibitor etoposide (0.15 mM) and 1,25-dihydroxyvitamin D3 (VD3) (10 nM) synergistically induced the differentiation of HL-60 human promyelocytic leukemia cells. Similar results were obtained using U-937 human promonocytic cells, or the topoisomerase II inhib...

journal_title：Molecular and cellular biochemistry

authors： Torres R,Calle C,Aller P,Mata F

更新日期：2000-05-01 00:00:00