Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia.

abstract：:Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have recently been shown to be involved in a multiplicity of physiological responses through modulation of signaling pathways. Some of the specific signaling components altered by reactive oxygen and nitrogen species (RONS) have begun to be identified. ...

journal_title：Molecular and cellular biochemistry

authors： Forman HJ,Torres M,Fukuto J

更新日期：2002-05-01 00:00:00

abstract：:Phospholipase Cε (PLCε), a downstream effector of small GTPase superfamily, has been identified to play a crucial role in tumorigenesis. Previously, our studies have showed that PLCε promotes proliferation of renal cell carcinoma (RCC) cells. However, the molecular mechanisms by which PLCε enhances the survival phenot...

journal_title：Molecular and cellular biochemistry

authors： Du HF,Ou LP,Song XD,Fan YR,Yang X,Tan B,Quan Z,Luo CL,Wu XH

更新日期：2014-04-01 00:00:00

abstract：:Understanding the driving forces for the hepatic uptake of endogenous and exogenous substrates in isolated cells and organs is fundamental to describing the underlying hepatic physiology/pharmacology. In this study we investigated whether uptake of plasma protein-bound [3H]-palmitate across the hepatocyte wall is gove...

journal_title：Molecular and cellular biochemistry

authors： Burczynski FJ,Hung D,Wang GQ,Elmadhoun B,Lewis A,Chang P,Rajaraman G,Robert S

更新日期：2005-02-01 00:00:00

abstract：:Tryptophan as a circulating precursor of serotonin (5-HT) may suppress food intake and body weight. Tryptophan administration can enhance the generation of reactive oxygen species (ROS) by inducing oxidative pathway in vivo and in vitro. We have examined the effect of repeated tryptophan administration on food consump...

journal_title：Molecular and cellular biochemistry

authors： Coşkun S,Ozer C,Gönül B,Take G,Erdoğan D

更新日期：2006-06-01 00:00:00

abstract：:Pluripotent stem cells within the adipose stromal compartment, termed adipose-derived stromal cells (ASCs), have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. Imaging with expression of exogenous or endogenous green fluorescent protein (GFP) reporters facilitates the detaile...

journal_title：Molecular and cellular biochemistry

authors： Lin Y,Tian W,Chen X,Yan Z,Li Z,Qiao J,Liu L,Tang W,Zheng X

更新日期：2005-09-01 00:00:00

abstract：:The purpose of this investigation was to determine whether fibronectin preparations from both chicken plasma and cell surface of fibroblasts can promote phagocytosis of gelatin-coated latex particles. Chicken plasma fibronectin was isolated (a) by ammonium sulfate fractionation, chromatography on Sepharose-4B followed...

journal_title：Molecular and cellular biochemistry

authors： Marquette D,Molnar J,Yamada K,Schlesinger D,Darby S,Van Alten P

更新日期：1981-05-26 00:00:00

abstract：:Heart failure is a leading cause of hospitalization worldwide. No major significant improvements in prognosis have been achieved for heart failure over the last several decades despite advances in disease management. Heart failure itself represents a final common endpoint for several disease entities, including hypert...

journal_title：Molecular and cellular biochemistry

authors： Koch WJ

更新日期：2004-08-01 00:00:00

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:Membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC), a key enzyme for the recovery of photoreceptors to the dark state, has a topology identical to and cytoplasmic domains homologous to those of peptide-regulated GCs. However, under the prevailing concept, its activation mechanism is signific...

journal_title：Molecular and cellular biochemistry

authors： Bondarenko VA,Hayashi F,Usukura J,Yamazaki A

更新日期：2010-01-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are widely used to treat hyperacid secretion and stomach ulcers. The study investigated the anti-secretory and anti-ulcer effects of esomeprazole, the S-isomer of omeprazole on dimaprit, histamine and dibutyryl adenosine 3, 5 cyclic monophosphate (dbcAMP)-evoked gastric acid secretion, ac...

journal_title：Molecular and cellular biochemistry

authors： Bastaki SM,Chandranath IS,Singh J

更新日期：2008-02-01 00:00:00

abstract：:Advanced glycation end products (AGE) and its cell-bound receptor called receptor for AGE (RAGE) are implicated in the pathogenesis of numerous diseases. Soluble receptor for AGE (sRAGE) counteracts the adverse effects of AGE-RAGE interaction by competing with RAGE for binding with AGE. Low levels of serum sRAGE have ...

journal_title：Molecular and cellular biochemistry

authors： Prasad K

更新日期：2019-01-01 00:00:00

abstract：:The effect of alloxan-induced diabetes was studied on the activity of monoamine oxidase (MAO), the oxidative deaminating enzyme of monoamine neurotransmitters. MAO was assayed from discrete brain regions like medial preoptic area and median eminence--arcuate region of hypothalamus, septum, amygdala, thalamus, hippocam...

journal_title：Molecular and cellular biochemistry

authors： Lakhman SS,Kaur G

更新日期：1997-12-01 00:00:00

abstract：:It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which...

journal_title：Molecular and cellular biochemistry

authors： Cester N,Staffolani R,Rabini RA,Magnanelli R,Salvolini E,Galassi R,Mazzanti L,Romanini C

更新日期：1994-02-23 00:00:00

abstract：:Rat thymocytes, spleen lymphocytes and isolated nuclei were incubated with fatty acids and then labelled with 5-doxylstearic acid and 12-doxylstearic acid. The ESR spectra only in the case of 5-doxylstearic acid showed changes which were demonstrable only under those conditions which resulted in cytolysis. Thymocytes ...

journal_title：Molecular and cellular biochemistry

authors： Burton AF,Piette LH

更新日期：1983-01-01 00:00:00

abstract：:Though, it is quite well-known how retinoic acid (RA) is able to induce neuritogenesis in different in vitro models, the putative role exerted by reactive oxygen species (ROS) during this process still need to be further studied. For such purpose, we used a neuronal-like cell line (SH-SY5Y cells) in order to investiga...

journal_title：Molecular and cellular biochemistry

authors： da Frota Junior ML,Pires AS,Zeidán-Chuliá F,Bristot IJ,Lopes FM,de Bittencourt Pasquali MA,Zanotto-Filho A,Behr GA,Klamt F,Gelain DP,Moreira JC

更新日期：2011-12-01 00:00:00

abstract：:Inhalation of silica in a number of occupational settings can result in debilitating and costly lung disease. It is thought that the pathological replacement of functional lung tissue with fibrotic lesions in silica-induced lung disease is the result of chronic inflammation mediated by products of the silica-exposed a...

journal_title：Molecular and cellular biochemistry

authors： Chen F,Shi X

更新日期：2002-05-01 00:00:00

abstract：:The effects of Mg2+ and Ca2+ deprivation on survival and growth of normal and transformed cultured cells were studied. Normal fibroblast from several origins (mouse, hamster and human) did not grow in 2 microM Mg2+ medium, whereas transformed fibroblasts (mouse and rat) and tumor cells of other types (mouse adrenocort...

journal_title：Molecular and cellular biochemistry

authors： Ribeiro SM,Armelin HA

更新日期：1984-01-01 00:00:00

abstract：:A noncholinergic nicotine receptor on human phagocytic leukocytes has been characterized using the binding of 3H-(d,1)-nicotine. The average affinity +/- standard deviation of (d,1)-nicotine for the receptor on neutrophils is 36 +/- 18 nM (n = 6). The binding is saturable with an average of 8.7 x 10(4) sites per neutr...

journal_title：Molecular and cellular biochemistry

authors： Davies BD,Hoss W,Lin JP,Lionetti F

更新日期：1982-04-16 00:00:00

abstract：:The aim of the present study was to investigate whether lipid metabolism in the nuclei is affected by changes in the metabolism of free fatty acids in the liver. The experiments were carried out on 3 groups of rats: 1 - control-male, 2 - female, and 3 - male, treated with bezafibrate (a peroxisome proliferator). The r...

journal_title：Molecular and cellular biochemistry

authors： Górski J,Zendzian-Piotrowska M,Wolfrum C,Nawrocki A,Spener F

更新日期：2000-11-01 00:00:00

abstract：:A calcium activated photoprotein, termed mnemiopsin, which emits bioluminescence upon the addition of calcium ion, has been isolated from the Ctenophore, Memiopsis leidyi, and purified by hollow fiber techniques. The system is similar to aequorin, from the jellyfish Aequorea, except that mnemiopsin can be light-inacti...

journal_title：Molecular and cellular biochemistry

authors： Girsch SJ,Hastings JW

更新日期：1978-04-11 00:00:00

abstract：:Thialysine cannot completely substitute lysine as growth factor for a lysine-requiring E. coli mutant. However it can be utilized for growth in the presence of limiting amounts of lysine, in substitution of, and in competition with this latter. The effects of thialysine on growth rate, protein synthesis rate and cell ...

journal_title：Molecular and cellular biochemistry

authors： Cinia C,Busiello V,Coccia R,Di Girolamo M,de Marco C

更新日期：1984-01-01 00:00:00

abstract：:Vasoactive peptides such as angiotensin II (AII), atrial natriuretic peptide (ANP) and vasopressin play an important role in the regulation of blood pressure. We have recently shown an augmentation of Gi alpha levels in heart and aorta from genetic and experimentally-induced hypertensive rats, which may be attributed ...

journal_title：Molecular and cellular biochemistry

authors： Anand-Srivastava MB,Palaparti A,Pion J

更新日期：1997-11-01 00:00:00

abstract：:Using a synthetic peptide that encompasses the zinc finger domain of the eukaryotic transcription factor Sp1, we produced a number of monoclonal antibodies that specifically reacted with the target antigen. Analysis by competitive inhibition assay of five of the monoclonal antibodies revealed that they all recognized ...

journal_title：Molecular and cellular biochemistry

authors： Katai H,Terato K,Raghow R

更新日期：1991-02-27 00:00:00

abstract：:Changes in demands for Na+ transport alter expression of the Na+,K+ -ATPase subunit isoforms. In skeletal muscle, the effects of these changes on expression the alpha2 isoform, the major isoform expressed in differentiated muscle cell, is not known. Therefore, this study examines regulation of the alpha-subunit isofor...

journal_title：Molecular and cellular biochemistry

authors： Ladka R,Ng YC

更新日期：2000-08-01 00:00:00

abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

journal_title：Molecular and cellular biochemistry

authors： Phipps AN,Connock MJ,Johnson P,Burdett K

更新日期：2000-01-01 00:00:00

abstract：:Sirtuin 3 (SIRT3) modulates mitochondria-localized processes and is implicated in the metabolic reprogramming of cancer cells, especially fatty acid (FA) synthesis. However, the relationship between SIRT3 and aberrant lipid synthesis in cervical cancer remains unclear. Here, we investigated the clinical relevance of S...

journal_title：Molecular and cellular biochemistry

authors： Xu LX,Hao LJ,Ma JQ,Liu JK,Hasim A

更新日期：2020-01-01 00:00:00

abstract：:Biochemical and structural changes occurring in the myocardium with aging are mainly resulting from the association of a general tissue atrophy with the hypertrophy of the remaining myocytes. Whilst hypertrophy seems to be a compensatory process to the loss of cardiomyocytes and to a mild systolic hypertensive conditi...

journal_title：Molecular and cellular biochemistry

authors： Muscari C,Giaccari A,Giordano E,Clô C,Guarnieri C,Caldarera CM

更新日期：1996-07-01 00:00:00

abstract：:Limited proteolysis of rabbit muscle phosphorylase kinase catalyzed by chymotrypsin generates a 33 kD product whose kinase activity is independent of both calcium and pH over the range of 6.8 to 8.3 (Malencik, D.A. & Fischer, E.H. Calcium and Cell Function III: 161-188, 1982). This active preparation consists of three...

journal_title：Molecular and cellular biochemistry

authors： Malencik DA,Zhao Z,Anderson SR

更新日期：1993-11-01 00:00:00

abstract：:Treatment with alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), depletes the putrescine and spermidine content, and reduces the growth rate of Ehrlich ascites tumor cells. The addition of putrescine, which is the immediate precursor of spermidine, promp...

journal_title：Molecular and cellular biochemistry

authors： Oredsson SM,Anehus S,Heby O

更新日期：1984-09-01 00:00:00

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00