Abstract:
:MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-throughput method developed, the miRNA profiles of cancer tissues have been comprehensively studied and specific miRNAs signatures have been identified as potential biomarkers for cancer diagnosis, therapy effect prediction, and prognosis. Additionally, the exploration in cell-free miRNAs has achieved inspiring results, indicating a more applicable cancer biomarker. We made a review and tried to figure out their potential application as biomarkers in the gastrointestinal carcinomas.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Xie L,Qian X,Liu Bdoi
10.1007/s11010-010-0463-0subject
Has Abstractpub_date
2010-08-01 00:00:00pages
291-9issue
1-2eissn
0300-8177issn
1573-4919journal_volume
341pub_type
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journal_title:Molecular and cellular biochemistry
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pub_type: 杂志文章,评审
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-010-0537-z
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/BF00936444
更新日期:1993-08-25 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-011-1002-3
更新日期:2012-01-01 00:00:00
abstract::Limited proteolysis of rabbit muscle phosphorylase kinase catalyzed by chymotrypsin generates a 33 kD product whose kinase activity is independent of both calcium and pH over the range of 6.8 to 8.3 (Malencik, D.A. & Fischer, E.H. Calcium and Cell Function III: 161-188, 1982). This active preparation consists of three...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/BF01076755
更新日期:1993-11-01 00:00:00
abstract::Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-010-0551-1
更新日期:2010-11-01 00:00:00
abstract::Histone H1 of rat alveolar macrophages, neutrophilic granulocytes and monocytes extracted with 5% (v/v) perchloric acid was studied in order to see whether a protein similar to histone H1 degrees of rat liver exists in these specialized cells. The biochemical methods used involved SDS and acid-urea polyacrylamide gel ...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/a:1016193909193
更新日期:2002-07-01 00:00:00
abstract::Dendritic cells (DC) and myeloid-derived suppressor cells (MDSC) are important cells involved in immune response. DC can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Recent studies have revealed that combined treatment of bone marrow MD...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-011-0982-3
更新日期:2011-12-01 00:00:00
abstract::The contribution of anti-inflammatory property of celecoxib in the improvement of metabolic disorders in cancer is unknown. The purpose of this study was to compare the effects of celecoxib and ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDs), on several metabolic changes observed in Walker-256 tumor-bearing ...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-014-2250-9
更新日期:2015-01-01 00:00:00
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1023/a:1017941625858
更新日期:2001-07-01 00:00:00
abstract::Hypermethylation of promoter CpG islands represents an alternative mechanism to inactivate tumor suppressor genes. This study was to detect promoter methylation status and mRNA expression levels of ARRDC3, ELP3, GATA5, and PAX6, and to explore the association between methylation and expression in invasive ductal carci...
journal_title:Molecular and cellular biochemistry
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更新日期:2014-11-01 00:00:00
abstract::Ciprofloxacin induced an increment of reactive oxygen species in sensitive strains of Staphylococcus aureus leading to oxidative stress detected by chemiluminescence while resistant strains did not suffer such stress. Oxidation of lipids was performed by employing thiobarbituric acid reaction to detect the formation o...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/s11010-005-9051-0
更新日期:2006-04-01 00:00:00
abstract::The possibility of amino acids biosynthesis from sucrose, metabolites of Krebs cycle or glyoxylate and ammonium by intact bacteroids has been studied. The suspension of intact Rhizobium lupini bacteroids in phosphate buffer solution pH 7.8 was shown to catalyse the biosynthesis from sucrose and ammonium of some amino ...
journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
doi:10.1007/BF00215586
更新日期:1983-01-01 00:00:00
abstract::Cyclophosphamide (CP), an alkylating agent widely used in cancer chemotherapy causes cardiac membrane damage. Lupeol, a pentacyclic triterpene, isolated from Crataeva nurvala stem bark and its ester, lupeol linoleate possess a wide range of medicinal properties. The effect of lupeol and its ester was evaluated in CP i...
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journal_title:Molecular and cellular biochemistry
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更新日期:2006-10-01 00:00:00
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更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular and cellular biochemistry
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract::The effects of Mg2+ and Ca2+ deprivation on survival and growth of normal and transformed cultured cells were studied. Normal fibroblast from several origins (mouse, hamster and human) did not grow in 2 microM Mg2+ medium, whereas transformed fibroblasts (mouse and rat) and tumor cells of other types (mouse adrenocort...
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pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00