MicroRNAs: novel biomarkers for gastrointestinal carcinomas.

Abstract:

:MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-throughput method developed, the miRNA profiles of cancer tissues have been comprehensively studied and specific miRNAs signatures have been identified as potential biomarkers for cancer diagnosis, therapy effect prediction, and prognosis. Additionally, the exploration in cell-free miRNAs has achieved inspiring results, indicating a more applicable cancer biomarker. We made a review and tried to figure out their potential application as biomarkers in the gastrointestinal carcinomas.

journal_name

Mol Cell Biochem

authors

Xie L,Qian X,Liu B

doi

10.1007/s11010-010-0463-0

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

291-9

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

341

pub_type

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