Krüppel-like factor 4 regulates the expression of inducible nitric oxide synthase induced by TNF-α in human fibroblast-like synoviocyte MH7A cells.

abstract：:To understand the mechanism underlying the transcriptional regulation of the immediate early gene TIS11, we characterized the 5'-flanking region of the rat TIS11 gene. When fused to the luciferase reporter gene, the 5.3-kb 5'-flanking region of the rat TIS11 gene exhibited functional promoter activity in pheochromocyt...

journal_title：Molecular and cellular biochemistry

authors： Murata T,Niimi Y,Kaneda N

更新日期：2000-11-01 00:00:00

abstract：:The inhibitory effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in vitro is found (Mol Cell Biochem 228: 39-47, 2001). This study, furthermore, was undertaken to determine the effect of MK-7 on the bone-resorbing factor-induced bone resorption using the femo...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Uchiyama S,Tsukamoto Y

更新日期：2003-03-01 00:00:00

abstract：:Recent studies suggest JAK2 signaling may be a therapeutic target for treatment of gastric cancer (GC). However, the exact roles of JAK2 in gastric carcinogenesis are not very clear. Here, we have targeted JAK2 to be silenced by shRNA and investigated the biological functions and related mechanisms of JAK2 in GC cell ...

journal_title：Molecular and cellular biochemistry

authors： Qian C,Yao J,Wang J,Wang L,Xue M,Zhou T,Liu W,Si J

更新日期：2014-02-01 00:00:00

abstract：:Recombinant COMP-Ang1, a chimera of angiopoietin-1 (Ang1), and a short coiled-coil domain of cartilage oligomeric matrix protein (COMP) can stimulate multiple cellular processes. Proliferative capacity of periodontal ligament (PDL) fibroblasts (PLFs) is important for maintaining PDL integrity and homeostasis. In this ...

journal_title：Molecular and cellular biochemistry

authors： Lim SS,Kook SH,Lee JC

更新日期：2016-05-01 00:00:00

abstract：:In this study we assessed activities of antioxidant enzymes, lipid peroxidation end-products, and nitric oxide (NO) levels in women with postmenopausal osteoporosis (PMO). Relationship between oxidative stress parameters and NO levels with bone mineral density (BMD) and clinical variables influencing bone mass and hea...

journal_title：Molecular and cellular biochemistry

authors： Ozgocmen S,Kaya H,Fadillioglu E,Aydogan R,Yilmaz Z

更新日期：2007-01-01 00:00:00

abstract：:To define metabolic influences on cardiac myosin expression and sarcoplasmic reticulum (SR) Ca(2+)-stimulated ATPase streptozotocin-diabetic rats were treated for 9-10 wk with etomoxir, an inhibitor of carnitine palmitoyl transferase I (CPT-1) and fatty acid synthesis, or an antilipolytic drug, acipimox. Etomoxir redu...

journal_title：Molecular and cellular biochemistry

authors： Rupp H,Elimban V,Dhalla NS

更新日期：1994-03-16 00:00:00

abstract：:Previous studies in isolated perfused heart and in atrial preparations have demonstrated significant reductions in beating rate in STZ-induced diabetic rats, which suggests that sinus arrhythmias in diabetes mellitus may be partly caused by intrinsic alteration of sino-atrial node (SAN) function. The effects of diabet...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Nowotny N,Zilahi E,El Haj MA,Lei M

更新日期：2007-11-01 00:00:00

abstract：:This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy) and modulation in...

journal_title：Molecular and cellular biochemistry

authors： Mishra S,Reddy DS,Jamwal VS,Bansal DD,Patel DD,Malhotra P,Gupta AK,Singh PK,Jawed S,Kumar R

更新日期：2013-07-01 00:00:00

abstract：:SAP155 is an essential component of the spliceosome and its phosphorylation is required for splicing catalysis, but little is known concerning its function and regulation during spermatogenesis in postnatal murine testes. We report that inhibition of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) IA...

journal_title：Molecular and cellular biochemistry

authors： Eto K,Sonoda Y,Abe S

更新日期：2011-09-01 00:00:00

abstract：:Control of mitochondrial respiration depends on ADP availability to the F1-ATPase. An electrochemical gradient of ADP and ATP across the mitochondrial inner membrane is maintained by the adenine nucleotide translocase which provides ADP to the matrix for ATP synthesis and ATP for energy-dependent processes in the cyto...

journal_title：Molecular and cellular biochemistry

authors： McMillin JB,Pauly DF

更新日期：1988-06-01 00:00:00

abstract：:Magnesium ions variably influenced activity of highly purified thymidylate synthetase preparations from different mouse tumors, activating the enzyme from Ehrlich ascites carcinoma (EAC) cells and inhibiting the enzyme from L1210 and L5178Y cells and from 5-fluorodeoxyuridine (FdUrd)-resistant EAC cells. In the presen...

journal_title：Molecular and cellular biochemistry

authors： Rode W,Jastreboff MM

更新日期：1984-01-01 00:00:00

abstract：:Immunoassays such as rocket immunoelectrophoresis, western dot blot hybridization, and competitive ELISA analysis were used to estimate and compare homology among fishes (several species), crab, toad, chicken and rodent metallothioneins. The relative abundance of tissue-specific metallothionein in catfish was highest ...

journal_title：Molecular and cellular biochemistry

authors： Chatterjee A,Maiti IB

更新日期：1990-05-10 00:00:00

abstract：:In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistanc...

journal_title：Molecular and cellular biochemistry

authors： Balakumar M,Raji L,Prabhu D,Sathishkumar C,Prabu P,Mohan V,Balasubramanyam M

更新日期：2016-12-01 00:00:00

abstract：:In the infarcted rat heart, the increase of NO occurs in the hypertrophied myocardium of non-infarcted areas and its antihypertrophic efficacy has been well established. As another endogenous regulator and the reliable index of heart pathology, B-type natriuretic peptide also exhibits the antihypertrophic properties i...

journal_title：Molecular and cellular biochemistry

authors： Wang T,Yan M,Li J,Zheng X

更新日期：2007-08-01 00:00:00

abstract：:Naringenin, a flavanone mainly derived from grapes and citrus fruits, has been reported to exhibit cardioprotective effects. Accumulating evidence has confirmed that endoplasmic reticulum (ER) stress-mediated apoptosis participates in the process of myocardial ischemia/reperfusion injury and inhibiting ER stress is a ...

journal_title：Molecular and cellular biochemistry

authors： Tang JY,Jin P,He Q,Lu LH,Ma JP,Gao WL,Bai HP,Yang J

更新日期：2017-01-01 00:00:00

abstract：:In rat cardiac sarcolemmal membranes a phosphoinositide-specific phospholipase C (PLC) was found to be present. The enzyme hydrolysed exogenous [3H-]phosphatidylinositol 4,5-biphosphate ([3H-]PtdIns(4,5)P2) in an optimized assay mixture containing 15 micrograms SL protein, 100 mM NaCl, 1 mM free Ca2+, 14 mM Na-cholate...

journal_title：Molecular and cellular biochemistry

authors： Meij JT,Panagia V

更新日期：1992-10-21 00:00:00

abstract：:The insoluble inclusion bodies of soluble leukemia inhibitory factor receptor fusion protein (gp 190 sol DAF) was solubilized in 8 M urea on the unfolding transitions, and several factors on the aggregate formation were indirectly analyzed for the refolding of gp 190 sol DAF. Results indicate that the refolding yield ...

journal_title：Molecular and cellular biochemistry

authors： Liu H,Moreau JF,Gualde N,Fu J

更新日期：1997-04-01 00:00:00

abstract：:Streptococcus pneumoniae is an important pathogen of pneumonia in human. Human alveolar epithelium acts as an effective barrier and is an active participant in host defense against invasion of bacterial by production of various mediators. Sirtuin 1 (SIRT1), the prototypic class III histone deacetylase, is involved in ...

journal_title：Molecular and cellular biochemistry

authors： Lin L,Wen SH,Guo SZ,Su XY,Wu HJ,Chong L,Zhang HL,Zhang WX,Li CC

更新日期：2014-09-01 00:00:00

abstract：:Using rat liver mitochondria, as model systems, we have examined the ability of the natural compound and the food-flavoring agent, vanillin to protect membranes against oxidative damage induced by photosensitization at concentrations normally used in food preparations. Vanillin, at a concentration of 2.5 mmol/L, has a...

journal_title：Molecular and cellular biochemistry

authors： Kamat JP,Ghosh A,Devasagayam TP

更新日期：2000-06-01 00:00:00

abstract：:The binding of nuclear factor on the promoter region of the regucalcin gene and the expression of regucalcin in the kidney cortex of rats was investigated. Nuclear extracts from kidney cortex were used for oligonucleotide competition gel mobility shift assay. An oligonucleotide between position -523 and -506 in the 5'...

journal_title：Molecular and cellular biochemistry

authors： Misawa H,Yamaguchi M

更新日期：2001-03-01 00:00:00

abstract：:It has been reported that HER2 level is strongly correlated with the expression of MMP-7 in some carcinomas. HER2 is a preferred heterodimerization partner of EGFR, HER3, and HER4. HER2 overexpression is believed to enhance the signaling from these receptors in response to binding of their specific ligands. In this st...

journal_title：Molecular and cellular biochemistry

authors： Yuan G,Qian L,Song L,Shi M,Li D,Yu M,Hu M,Shen B,Guo N

更新日期：2008-11-01 00:00:00

abstract：:Hepatocyte cell adhesion molecule (HepaCAM) plays a crucial role in tumor progression and has been recognized as a novel tumor suppressor gene. The high protein expression level of protein kinase Cε (PKCε) has been discovered in many tumor types. In the present study, we determined HepaCAM and PKCε protein levels in h...

journal_title：Molecular and cellular biochemistry

authors： Tan B,Tan J,Du H,Quan Z,Xu X,Jiang X,Luo C,Wu X

更新日期：2014-06-01 00:00:00

abstract：:Salidroside, a phenol glycoside of plant origin, has been documented to possess a broad spectrum of pharmacological properties, including protective effects against neuronal death induced by different insults. To provide further insights into the neuroprotective functions peculiar to salidroside, this study used prima...

journal_title：Molecular and cellular biochemistry

authors： Zhang S,Chen X,Yang Y,Zhou X,Liu J,Ding F

更新日期：2011-08-01 00:00:00

abstract：:Lipoprotein-X (Lp-X) is found in the plasma of patients with familial lecithin: cholesterol acyltransferase (LCAT) deficiency syndromes. The majority of the patients with this disorder develop progressive glomerulosclerosis. In this study, the effect of Lp-X on lipid metabolism in perfused rat kidney was investigated....

journal_title：Molecular and cellular biochemistry

authors： O K,Ly M,Fang DZ,Frohlich J,Choy PC

更新日期：1997-08-01 00:00:00

abstract：:Sinomenine, a pure alkaloid extract from Sinomenium acutum, has anti-inflammatory and immunoregulatory functions. This study investigated the efficiency and the signalling pathways involved in the effect of sinomenine on vascular smooth muscle cell (VSMC) dedifferentiation in response to platelet-derived growth factor...

journal_title：Molecular and cellular biochemistry

authors： Zhu L,Hao Y,Guan H,Cui C,Tian S,Yang D,Wang X,Zhang S,Wang L,Jiang H

更新日期：2013-01-01 00:00:00

abstract：:Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent. MTX-associated neurotoxicity is an important clinical problem. The aim of this study was to investigate the role of caffeic acid phenethyl ester (CAPE) on cerebellar oxidative stress induced by MTX in rats. A total of 19...

journal_title：Molecular and cellular biochemistry

authors： Uzar E,Koyuncuoglu HR,Uz E,Yilmaz HR,Kutluhan S,Kilbas S,Gultekin F

更新日期：2006-10-01 00:00:00

abstract：:We have investigated heme oxygenase (HO) and antioxidant status in the novel isolation and characterization of aortic endothelial cells (AECs) from a random bred wild-type strain (WILD) and selectively bred atherosclerosis-susceptible (SUS) and -resistant (RES) strains of Japanese quail. Cultured AECs expressed acetyl...

journal_title：Molecular and cellular biochemistry

authors： Hoekstra KA,Godin DV,Kurtu J,Cheng KM

更新日期：2003-10-01 00:00:00

abstract：:Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models. Their receptor is the Na+,K+ ATPase, but other plasma membrane proteins might bind CGs as well. Herein, we evaluated the short- and long-lasting cytotoxic effects o...

journal_title：Molecular and cellular biochemistry

authors： Schneider NFZ,Menegaz D,Dagostin ALA,Persich L,Rocha SC,Ramos ACP,Cortes VF,Fontes CFL,de Pádua RM,Munkert J,Kreis W,Braga FC,Barbosa LA,Silva FRMB,Simões CMO

更新日期：2021-01-18 00:00:00

abstract：:This paper reviews the model of the control of mitochondrial substrate oxidation by Ca2+ ions. The mechanism is the activation by Ca2+ of four mitochondrial dehydrogenases, viz. glycerol 3-phosphate dehydrogenase, the pyruvate dehydrogenase multienzyme complex (PDH), NAD-linked isocitrate dehydrogenase (NAD-IDH) and 2...

journal_title：Molecular and cellular biochemistry

authors： Hansford RG,Zorov D

更新日期：1998-07-01 00:00:00

abstract：:The application of nucleic acid hybridization techniques to the study of liver regeneration has led to a revision of some well-established ideas about the patterns of gene expression during regenerative growth. This paper focuses on two broad problems: a) the extent to which mRNA populations in regenerating liver diff...

journal_title：Molecular and cellular biochemistry

authors： Fausto N

更新日期：1984-01-01 00:00:00