The kinase DYRKIA regulates pre-mRNA splicing in spermatogonia and proliferation of spermatogonia and Sertoli cells by phosphorylating a spliceosomal component, SAP155, in postnatal murine testes.

abstract：:Magnesium ions variably influenced activity of highly purified thymidylate synthetase preparations from different mouse tumors, activating the enzyme from Ehrlich ascites carcinoma (EAC) cells and inhibiting the enzyme from L1210 and L5178Y cells and from 5-fluorodeoxyuridine (FdUrd)-resistant EAC cells. In the presen...

journal_title：Molecular and cellular biochemistry

authors： Rode W,Jastreboff MM

更新日期：1984-01-01 00:00:00

abstract：:N-Methyl-N-nitrosourea (MNU)-induced rat mammary adenocarcinomas contain high levels of a novel leupeptin-sensitive serine endopeptidase. Its properties apparently differ from those of other similar endopeptidases reported to be present in various normal and malignant mammalian tissues. The same leupeptinsensitive ser...

journal_title：Molecular and cellular biochemistry

authors： Eto I,Bandy MD

更新日期：1990-04-18 00:00:00

abstract：:The molecular mechanism of fatty acid uptake and utilization is of high medical relevance for the treatment of obesity, diabetes, and cardiovascular disease. Neuronal processes, hormones, and transcription factors are master regulators of these essential processes while their fine-tuning is achieved by modulating the ...

journal_title：Molecular and cellular biochemistry

authors： Digel M,Ehehalt R,Stremmel W,Füllekrug J

更新日期：2009-06-01 00:00:00

abstract：:To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intim...

journal_title：Molecular and cellular biochemistry

authors： Tertov VV,Kaplun VV,Mikhailova IA,Suprun IV,Orekhov AN

更新日期：2001-09-01 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in the world. Circular RNA hsa_circHN1_005 (circ_HN1), also termed as hsa_circ_0045602, is reported as an oncogene in GC. However, the molecular mechanism of circ_HN1 in GC development has not been fully explored. Here, we surveyed the regulato...

journal_title：Molecular and cellular biochemistry

authors： Wang D,Jiang X,Liu Y,Cao G,Zhang X,Kuang Y

更新日期：2020-09-19 00:00:00

abstract：:Glycosphingolipid biosynthesis was examined using [3H]-galactose as a precursor as rat L6 myoblasts fused to form multinucleated myotubes. Incorporation of label into neutral glycolipids decreased steadily as the population of myotubes increased, so that final biosynthesis was one-half that observed with myoblasts (p ...

journal_title：Molecular and cellular biochemistry

authors： Leskawa KC,Erwin RE,Buse PE,Hogan EL

更新日期：1988-09-01 00:00:00

abstract：:Stratifin is a member of 14-3-3 protein family, a highly conserved group of proteins constituted by seven isoforms. They are involved in numerous crucial intracellular functions such as cell cycle and apoptosis, regulation of signal transduction pathways, cellular trafficking, cell proliferation and differentiation, c...

journal_title：Molecular and cellular biochemistry

authors： Medina A,Ghaffari A,Kilani RT,Ghahary A

更新日期：2007-11-01 00:00:00

abstract：:The presence of a prostatic-like acid phosphatase is reported in human lactating milk. Its activity is associated with skim milk and it could be separated from the other acid phosphatases only after Triton X-100 treatment. By all the criteria applied, it appears to be very similar to prostatic acid phosphatase. An app...

journal_title：Molecular and cellular biochemistry

authors： Podhajcer OL,Filmus JE,Mordoh J

更新日期：1985-02-01 00:00:00

abstract：:The development of hypercholesterolemia is a multifactorial process in which elevated plasma cholesterol levels play a central role. This study analyzed the variability of the expression and activity of myosin light chain kinase (MLCK) and endothelial permeability in the artery wall of rabbits after feeding the animal...

journal_title：Molecular and cellular biochemistry

authors： Zhu HQ,Zhou Q,Jiang ZK,Gui SY,Wang Y

更新日期：2011-01-01 00:00:00

abstract：:Angiotensin receptor blockers provide cardiovascular protection in heart failure patients. We have studied the effect of 8 weeks treatment with telmisartan (5 mg kg(-1) day(-1)) on cardiovascular complications associated with streptozotocin (STZ) diabetic rats. Wistar rats were made diabetic with STZ (45 mg kg(-1), iv...

journal_title：Molecular and cellular biochemistry

authors： Goyal BR,Mesariya P,Goyal RK,Mehta AA

更新日期：2008-07-01 00:00:00

abstract：:Recently there has been a moderate resurgence in the use of flax-seed in a variety of ways including bread. The scientific basis of its use is very limited. There is some claim for beneficial effects in cancer and lupus nephritis. These claims could be due to its ability to scavenge oxygen radicals. However, its antio...

journal_title：Molecular and cellular biochemistry

authors： Prasad K

更新日期：1997-03-01 00:00:00

abstract：:The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes i...

journal_title：Molecular and cellular biochemistry

authors： Wilkie D

更新日期：1977-02-04 00:00:00

abstract：OBJECTIVE:Chronic adenosine A2b receptor stimulation has been shown to prevent ventricular remodelling after myocardial infarction (MI). We hypothesized that this effect is due to the inhibition of cardiac myocyte apoptosis in the myocardium remote from the infarction. METHODS:Rats were subjected to MI by LAD ligation...

journal_title：Molecular and cellular biochemistry

authors： Simonis G,Wiedemann S,Joachim D,Weinbrenner C,Marquetant R,Strasser RH

更新日期：2009-08-01 00:00:00

abstract：:This comparative study investigates the relationship between sarcoplasmic reticulum (SR) calcium(Ca2+)-ATPase transport activity and phospholamban (PLB) phosphorylation in whole cardiac homogenates of spontaneously hypertensive rats (SHR) and their parent, normotensive Wistar Kyoto (WKY) strain during early postnatal ...

journal_title：Molecular and cellular biochemistry

authors： Freestone N,Singh J,Krause EG,Vetter R

更新日期：1996-10-01 00:00:00

abstract：:Persistent activation of nuclear factor B (NF-κB) is very important in the modulation of macrophages cellular response to microbial infections. The deubiquitinase USP14, which is critical for ubiquitin-mediated proteasomal degradation of proteins, is known to be involved in cancer, neurological diseases, and aging. Ho...

journal_title：Molecular and cellular biochemistry

authors： Liu N,Kong T,Chen X,Hu H,Gu H,Liu S,Chen X,Yang Q,Li A,Xiong X,Zhang Z

更新日期：2017-07-01 00:00:00

abstract：:The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosome...

journal_title：Molecular and cellular biochemistry

authors： Mangos S,Krawetz R,Kelly GM

更新日期：2000-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have the potential for self-renewal and multipotential differentiation to regenerate damaged tissues or recover functional absence in diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents in magnetic resonance imaging (MRI) for labeling cells in vitro a...

journal_title：Molecular and cellular biochemistry

authors： Zeng G,Wang G,Guan F,Chang K,Jiao H,Gao W,Xi S,Yang B

更新日期：2011-11-01 00:00:00

abstract：:A systematic comparison of the impact of some potential endocrine disruptors (EDs) on modulation of androgen receptor (AR) and pregnane and xenobiotic receptor (PXR) function was conducted in a multi-step analysis. Promoter-reporter-based transcription assays were performed in conjunction with receptor dynamic studies...

journal_title：Molecular and cellular biochemistry

authors： Chaturvedi NK,Kumar S,Negi S,Tyagi RK

更新日期：2010-12-01 00:00:00

abstract：:Membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC), a key enzyme for the recovery of photoreceptors to the dark state, has a topology identical to and cytoplasmic domains homologous to those of peptide-regulated GCs. However, under the prevailing concept, its activation mechanism is signific...

journal_title：Molecular and cellular biochemistry

authors： Bondarenko VA,Hayashi F,Usukura J,Yamazaki A

更新日期：2010-01-01 00:00:00

abstract：:Formation of lanthionine, a dehydroalanine crosslink, is associated with aging of the human lens and cataractogenesis. In this study we investigated whether modification of lens proteins by glutathione could proceed through an alternative pathway: that is, by the formation of a nonreducible thioether bond between prot...

journal_title：Molecular and cellular biochemistry

authors： Linetsky M,LeGrand RD

更新日期：2005-04-01 00:00:00

abstract：:We studied the effects of SEB on [14C]-choline transport and metabolism of choline containing phospholipids in cultured human kidney proximal tubular (PT) cells. SEB increased the uptake of [14C]-choline in PT cells as a function of toxin concentration, incubation time, and pH. The maximum increase in uptake (3.5-5-fo...

journal_title：Molecular and cellular biochemistry

authors： Khullar M,Chatterjee S

更新日期：1995-05-24 00:00:00

abstract：:Cancer stem cells (CSCs) are believed to be responsible for tumor metastasis, recurrence, and high mortality of cancer patients due to their high tumorigenicity resistance to chemo-radiotherapy. Morusin possesses anti-cancer activity through attenuation of NF-κB activity, which is up-regulated in cancer stem cells. Th...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Guo H,Yang L,Dong L,Lin C,Zhang J,Lin P,Wang X

更新日期：2013-07-01 00:00:00

abstract：:Gonolobus condurango plant extract is used as an anticancer drug in some traditional systems of medicine including homeopathy, but it apparently lacks any scientific validation. Further, no detailed study is available to suggest whether condurango-glycoside-A (CGA), a major ingredient of condurango serves as a potent ...

journal_title：Molecular and cellular biochemistry

authors： Bishayee K,Paul A,Ghosh S,Sikdar S,Mukherjee A,Biswas R,Boujedaini N,Khuda-Bukhsh AR

更新日期：2013-10-01 00:00:00

abstract：:Glomerular mesangial cells play an important role in the development of glomerulosclerosis. Mesangial cell apoptosis has been shown to be involved in different stages of development of glomerulonephritis. The aim of the present study was to evaluate the effect of inhibition of serine/threonine phosphatases by okadaic ...

journal_title：Molecular and cellular biochemistry

authors： Parameswaran N,Spielman WS,Brooks DP,Nambi P

更新日期：2004-05-01 00:00:00

abstract：:In recent years, there has been growing interest in estimating the degree of heating caused by the diagnostic ultrasound in clinical practice. Both theoretical and experimental methods have been suggested for estimating the heating potential, or thermal hazard, of diagnostic ultrasound. Aim of this study was to evalua...

journal_title：Molecular and cellular biochemistry

authors： Karagöz I,Biri A,Babacan F,Kavutçu M

更新日期：2007-01-01 00:00:00

abstract：:Angiotensin II has previously been reported to have in vivo and in vitro cardiac hypertrophic effects. We used the salt-sensitive Dahl rat genetic strain to separate mechanical (pressure overload) vs. hormonal (renin-angiotensin system) input in cardiac hypertrophy. Blood pressure was significantly increased and left ...

journal_title：Molecular and cellular biochemistry

authors： Peeler TC,Baker KM,Esmurdoc CF,Chernin MI

更新日期：1991-05-29 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is a highly conserved histone methyltransferase, which is overexpressed in different types of cancers such as breast and prostate cancer. It is reported that EZH2 can directly down-regulate RUNX3 by increasing histone H3 methylation. However, the role of EZH2 in the development and p...

journal_title：Molecular and cellular biochemistry

authors： Lian R,Ma H,Wu Z,Zhang G,Jiao L,Miao W,Jin Q,Li R,Chen P,Shi H,Yu W

更新日期：2018-02-01 00:00:00

abstract：:The conserved N-domain of the STAT proteins has been implicated in several activities crucial to cytokine signaling including receptor recruitment and STAT activation, cooperative DNA binding and STAT-dependent gene expression. We evaluated the role of the STAT3 N-domain in the IL-6 signal transduction pathway leading...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Badgwell DB,Bevers JJ 3rd,Schlessinger K,Murray PJ,Levy DE,Watowich SS

更新日期：2006-08-01 00:00:00

abstract：:Myofibroblasts are metabolically and morphologically distinctive fibroblasts expressing alpha-smooth muscle actin (alpha-SMA), and their activation plays a key role in development of the fibrotic response. In an activated state, myofibroblasts cease to proliferate and start to synthesize large amounts of extracellular...

journal_title：Molecular and cellular biochemistry

authors： Nakatani T,Honda E,Hayakawa S,Sato M,Satoh K,Kudo M,Munakata H

更新日期：2008-01-01 00:00:00

abstract：:The oxygenase domain of the inducible nitric oxide synthase, Delta65 iNOSox is a dimer that binds heme, L-Arginine (L-Arg), and tetrahydrobiopterin (H(4)B) and is the site for NO synthesis. The role of H(4)B in iNOS structure-function is complex and its exact structural role is presently unknown. The present paper pro...

journal_title：Molecular and cellular biochemistry

authors： Sengupta R,Sahoo R,Ray SS,Dutta T,Dasgupta A,Ghosh S

更新日期：2006-03-01 00:00:00