Abstract：
:Human papillomavirus (HPV) is considered to be a major etiological factor but is not sufficient for the development of cervical cancer. Other host factors including altered tumor suppressor gene activities might contribute to the carcinogenic process. Fragile Histidine Triad (FHIT) has been shown to play a pivotal role in carcinogenesis. Therefore, we made an attempt to find out point mutation of FHIT gene in HPV mediated cervical cancer in Indian women. 112 cases of cervical carcinoma tissue biopsies and 38 cervical scrapes samples of normal cytology were employed for this study. Herein, we report a novel mutation identified at nucleotide position 655, at codon 98 from CAT --> CGT with ultimate replacement of amino acid Histidine by Arginine in cervical cancer cases. Molecular modeling was performed to predict the effect of this mutation in disease pathology. We predict that this change, His to Arg substitution in substrate-binding domain may generate catalytically inactive protein with loss of tumor suppressor activity.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Neyaz MK,Hussain S,Hassan MI,Das BC,Husain SA,Bharadwaj Mdoi
10.1007/s11010-009-0240-0subject
Has Abstractpub_date
2010-02-01 00:00:00pages
53-8issue
1-2eissn
0300-8177issn
1573-4919journal_volume
335pub_type
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更新日期：2019-09-01 00:00:00
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doi：10.1007/s11010-010-0655-7
更新日期：2011-03-01 00:00:00
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journal_title：Molecular and cellular biochemistry
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doi：
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：1997-09-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/s11010-010-0396-7
更新日期：2010-07-01 00:00:00
