The kinetics of pancreatic ribonuclease reaction with alkaline and acidic forms of poly A.

abstract：:MAP/Microtubule affinity-regulating kinase 4 (MARK4), a Ser/Thr protein kinases, is related to the Par-1 (partitioning-defective) gene products, and is the human ortholog of Par-1. MARK4 shows its role in the cell polarity at the time of embryonic development. It is mostly located at the basal region of cells, providi...

journal_title：Molecular and cellular biochemistry

authors： Naz F,Islam A,Ahmad F,Hassan MI

更新日期：2015-12-01 00:00:00

abstract：:In recent years, there has been growing interest in estimating the degree of heating caused by the diagnostic ultrasound in clinical practice. Both theoretical and experimental methods have been suggested for estimating the heating potential, or thermal hazard, of diagnostic ultrasound. Aim of this study was to evalua...

journal_title：Molecular and cellular biochemistry

authors： Karagöz I,Biri A,Babacan F,Kavutçu M

更新日期：2007-01-01 00:00:00

abstract：:Endothelial cells are known to produce reactive oxygen species by several mechanisms. Functional consequences of increased production of reactive oxygen species were investigated in vitro after stimulation with several proinflammatory cytokines. Time dependent increases in DCF-fluorescence as a measure of reactive oxy...

journal_title：Molecular and cellular biochemistry

authors： Volk T,Hensel M,Schuster H,Kox WJ

更新日期：2000-03-01 00:00:00

abstract：:Cancer stem cells (CSCs) are believed to be responsible for tumor metastasis, recurrence, and high mortality of cancer patients due to their high tumorigenicity resistance to chemo-radiotherapy. Morusin possesses anti-cancer activity through attenuation of NF-κB activity, which is up-regulated in cancer stem cells. Th...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Guo H,Yang L,Dong L,Lin C,Zhang J,Lin P,Wang X

更新日期：2013-07-01 00:00:00

abstract：:Idiopathic pes equinovarus is a congenital deformity of the foot and lower leg defined as a fixation of the foot in adduction, supination, and varus. Although the pathogenesis of clubfoot remains unclear, it has been suggested that fibroblasts and growth factors are involved. To directly analyze the protein compositio...

journal_title：Molecular and cellular biochemistry

authors： Ošt'ádal M,Eckhardt A,Herget J,Mikšík I,Dungl P,Chomiak J,Frydrychová M,Burian M

更新日期：2015-03-01 00:00:00

abstract：:The function of the uterine smooth muscle in gestation and parturition is affected by a variety of hormones and biomolecules, some of which alter the intracellular levels of cAMP and Ca2+. Since the activity of smooth muscle MLCK has been shown to be modulated by phosphorylation, the effect of this modification of pre...

journal_title：Molecular and cellular biochemistry

authors： Pato MD,Kerc E,Lye SJ

更新日期：1995-08-01 00:00:00

abstract：:Glucose-6-phosphatase activity was measured in rat liver or pancreatic islet crude homogenates and microsomes. The data recorded in the liver were comparable to those reported in prior studies. However, in the islets, the hydrolysis of D-glucose 6-phosphate by disrupted microsomes represented, when expressed relative ...

journal_title：Molecular and cellular biochemistry

authors： Perales MA,Sener A,Malaisse WJ

更新日期：1991-02-27 00:00:00

abstract：:The flux through the de novo pyrimidine biosynthetic pathway is controlled by the multifunctional protein CAD, which catalyzes the first three steps. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr456 and Ser1406 by the MAP kinase and PKA cascade...

journal_title：Molecular and cellular biochemistry

authors： Kotsis DH,Masko EM,Sigoillot FD,Di Gregorio R,Guy-Evans HI,Evans DR

更新日期：2007-07-01 00:00:00

abstract：:Osteosarcoma (OS) is a type of malignant tumor arising from soft-tissues of bone and displays poor prognosis in most cases. However, the molecular mechanism by which OS initiates and progresses is still not completely elucidated. miR-155 has been shown to be overexpressed in OS specimen and cell lines. Our study is in...

journal_title：Molecular and cellular biochemistry

authors： Sun X,Geng X,Zhang J,Zhao H,Liu Y

更新日期：2015-05-01 00:00:00

abstract：:Using rat liver mitochondria, as model systems, we have examined the ability of the natural compound and the food-flavoring agent, vanillin to protect membranes against oxidative damage induced by photosensitization at concentrations normally used in food preparations. Vanillin, at a concentration of 2.5 mmol/L, has a...

journal_title：Molecular and cellular biochemistry

authors： Kamat JP,Ghosh A,Devasagayam TP

更新日期：2000-06-01 00:00:00

abstract：:Circulating lipid peroxide, antioxidant components and the activities of defense enzymes were estimated in uterine cervical carcinoma patients (before and after radiotherapy and radiotherapy combined chemotherapy) and compared with controls. Some of the antioxidant components such as glutathione, vitamin E and seleniu...

journal_title：Molecular and cellular biochemistry

authors： Bhuvarahamurthy V,Balasubramanian N,Govindasamy S

更新日期：1996-05-10 00:00:00

abstract：:Gonolobus condurango plant extract is used as an anticancer drug in some traditional systems of medicine including homeopathy, but it apparently lacks any scientific validation. Further, no detailed study is available to suggest whether condurango-glycoside-A (CGA), a major ingredient of condurango serves as a potent ...

journal_title：Molecular and cellular biochemistry

authors： Bishayee K,Paul A,Ghosh S,Sikdar S,Mukherjee A,Biswas R,Boujedaini N,Khuda-Bukhsh AR

更新日期：2013-10-01 00:00:00

abstract：:A membrane-bound L-asparaginase (EC 3.5.1.1) of Tetrahymena pyriformis was purified to homogeneity. The purified enzyme is a lipoprotein, since it is inactivated by phospholipase C and its activity is restored by the addition of naturally occurring lipids, such as phosphatidylcholine, triolein and oleyl acetate. The r...

journal_title：Molecular and cellular biochemistry

authors： Tsirka SA,Kyriakidis DA

更新日期：1988-10-01 00:00:00

abstract：:The aim of this study was to investigate the effects of oxidative stress on PLD activity, [Ca2+]i and pHi levels and the possible relationship among them. Moreover, since atrial natriuretic peptide (ANP) protects against oxidant-induced injury, we investigated the potential protective role of the hormone in rat aortic...

journal_title：Molecular and cellular biochemistry

authors： De Vito P,Di Nardo P,Palmery M,Peluso I,Luly P,Baldini PM

更新日期：2003-10-01 00:00:00

abstract：:The antioxidant activity of anthocyanins has been well characterized in vitro; many cases has been postulated to provide an important exogenous mediator of oxidative stress in the gastrointestinal tract. The objective of this study was to evaluate the efficacy of anthocyanin protection against peroxyl radical (AAPH)-i...

journal_title：Molecular and cellular biochemistry

authors： Elisia I,Kitts DD

更新日期：2008-05-01 00:00:00

abstract：:Thymoquinone (TQ) is a highly perspective chemotherapeutic agent against gliomas and glioblastomas because of its ability to cross the blood-brain barrier and its selective cytotoxicity for glioblastoma cells compared to primary astrocytes. Here, we tested the hypothesis that TQ-induced mild oxidative stress provokes ...

journal_title：Molecular and cellular biochemistry

authors： Krylova NG,Drobysh MS,Semenkova GN,Kulahava TA,Pinchuk SV,Shadyro OI

更新日期：2019-12-01 00:00:00

abstract：:In this work we investigated the effects of retinoic acid (RA) in Sertoli cells. Sertoli cells isolated from 15-day-old Wistar rats were previously cultured for 48 h and then treated with RA for 24 h. RA at high doses (1-10 microM) increased TBARS levels and induced a decrease in cell viability. At low doses (0.1-100 ...

journal_title：Molecular and cellular biochemistry

authors： Conte da Frota ML Jr,Gomes da Silva E,Behr GA,Roberto de Oliveira M,Dal-Pizzol F,Klamt F,Moreira JC

更新日期：2006-04-01 00:00:00

abstract：:The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review tra...

journal_title：Molecular and cellular biochemistry

authors： Haus-Seuffert P,Meisterernst M

更新日期：2000-09-01 00:00:00

abstract：:Gastrointestinal symptoms are fairly common in diabetes mellitus. Glimepride, is a latest second generation sulfonylurea used for the treatment of type II diabetes mellitus, is a insulin secrectagogue; indirectly, it also increases insulin secretion and its specific effect on pancreatic ATP-dependent K(+) channel inhi...

journal_title：Molecular and cellular biochemistry

authors： Phadatare PD,Chandrashekhar VM

更新日期：2011-08-01 00:00:00

abstract：:Zonation of ethanol oxidation and metabolic effects along the hepatic acini were investigated in the bivascularly perfused liver of fed rats. Ethanol was infused into the hepatic artery in antegrade and retrograde perfusion. Inhibition of glycolysis by ethanol, expressed as micromol min(-1) (ml accessible cell space)(...

journal_title：Molecular and cellular biochemistry

authors： Lopez CH,Constantin J,Gimenes D,Suzuki-Kemmelmeier F,Bracht A

更新日期：2004-03-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:The effect of oral administration of sodium orthovanadate (SOV) and Trigonella foenum graecum seed powder (TSP), a medicinal plant used extensively in Asia, on the mitochondrial metabolism in the alloxan diabetic rats has been investigated. Rats were injected with alloxan monohydrate (20 mg/100 g body wt) or vehicle (...

journal_title：Molecular and cellular biochemistry

authors： Thakran S,Salimuddin,Baquer NZ

更新日期：2003-05-01 00:00:00

abstract：:The IL-6-related cytokines, LIF and cardiotrophin-1, are important growth promoting and cardioprotective agents for cardiomyocytes. However, factors that regulate their actions in the heart are poorly understood. In this study, we tested the hypothesis that endothelin-1, a peptide hormone that produces a pattern of ca...

journal_title：Molecular and cellular biochemistry

authors： Booz GW,Day JN,Speth R,Baker KM

更新日期：2002-11-01 00:00:00

abstract：:The present investigation was carried out to evaluate the antioxidant nature of ethanolic extract of Terminalia arjuna bark (EETA) on N-nitrosodiethylamine (DEN) induced liver cancer in male Wistar albino rats. Liver cancer was induced by single intraperitonial injection of DEN (200 mg/kg). After 2 weeks of DEN admini...

journal_title：Molecular and cellular biochemistry

authors： Sivalokanathan S,Ilayaraja M,Balasubramanian MP

更新日期：2006-01-01 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates the expression of integrins alpha 5 beta 1 and v beta 3 as well as focal adhesion kinase (FAK) and phosphorylated FAK (pY3...

journal_title：Molecular and cellular biochemistry

authors： Cai WJ,Li MB,Wu X,Wu S,Zhu W,Chen D,Luo M,Eitenmüller I,Kampmann A,Schaper J,Schaper W

更新日期：2009-02-01 00:00:00

abstract：:Casein kinase II is a protein serine/threonine kinase that is ubiquitously distributed in eukaryotes. Molecular cloning studies and protein sequence analysis of purified proteins have demonstrated the existence of two related, but distinct, isoenzymic forms of its catalytic subunit in mammals and birds. At present, th...

journal_title：Molecular and cellular biochemistry

authors： Litchfield DW,Lüscher B

更新日期：1993-11-01 00:00:00

abstract：:Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decreased antioxidant defense is implicated in the cytotoxicity of xenobiotics including drugs and environmental chemicals. Endosulfan, a highly toxic organochlorine insecticide, causes cytotoxic cell death by inducing oxidat...

journal_title：Molecular and cellular biochemistry

authors： Murali M,Carvalho MS,Shivanandappa T

更新日期：2020-05-01 00:00:00

abstract：:The neuropathogenesis of influenza-associated encephalopathy in children and Reye's syndrome remains unclear. A surveillance effort conducted during 2000-2003 in South-West Japan reveals that almost all fatal and handicapped influenza-associated encephalopathy patients exhibit a disorder of mitochondrial beta-oxidatio...

journal_title：Molecular and cellular biochemistry

authors： Yao D,Kuwajima M,Chen Y,Shiota M,Okumura Y,Yamada H,Kido H

更新日期：2007-05-01 00:00:00

abstract：:In order to understand the molecular basis of cold adaptation, we have used directed evolution to transform a thermophilic lipase LipR1 into its psychrophilic counterpart. A single round of random mutagenesis followed by screening for improved variants yielded a mutant with single-point mutation LipR1M1 (S130T), with ...

journal_title：Molecular and cellular biochemistry

authors： Sharma M,Kumar R,Singh R,Kaur J

更新日期：2017-06-01 00:00:00

abstract：:Glycosaminoglycans were extracted from normal, inflamed and phenytoin induced overgrowth of human gingival tissue by proteolysis and alcohol precipitation. Extracts were run in a Dowex-1 column and the fractions were treated with mucopolysaccharidases. Cellulose acetate electrophoresis was carried out with or without ...

journal_title：Molecular and cellular biochemistry

authors： Suresh R,Puvanakrishnan R,Dhar SC

更新日期：1992-10-07 00:00:00