Alterations in human gingival glycosaminoglycan pattern in inflammation and in phenytoin induced overgrowth.

abstract：:The metabolism of D-glucose was characterized in both normal dispersed rat islet cells and the 2-mercaptoethanol-dependent insulin-secreting cells of the INS-1 line. The normal and tumoral islet cells differed from one another by the relative magnitude, concentration dependency and hierarchy of the increase in the pro...

journal_title：Molecular and cellular biochemistry

authors： Nadi AB,Olivares E,Malaisse WJ

更新日期：2000-07-01 00:00:00

abstract：:The involvement of a hypocalcemic hormone calcitonin (CT) in the expression of hepatic Ca(2+)-binding protein regucalcin mRNA was investigated. The change of regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb). A single oral administration of calcium chloride (100...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Kanayama Y,Shimokawa N

更新日期：1994-07-13 00:00:00

abstract：:Ischemia of the heart is accompanied by the tissue accumulation of long-chain fatty acids and their metabolic derivatives such as beta-hydroxy fatty acids and fatty acyl-CoA and acyl-L-carnitine esters. These substances might be detrimental for proper myocardial function. Previously, it has been suggested that intrace...

journal_title：Molecular and cellular biochemistry

authors： Glatz JF,Vork MM,van der Vusse GJ

更新日期：1993-06-09 00:00:00

abstract：:The phosphorylation of rat cardiac microsomal proteins was investigated with special attention to the effects of okadaic acid (an inhibitor of protein phosphatases), inhibitor 2 of protein phosphatase 1 and inhibitor of cyclic AMP-dependent protein kinase (protein kinase A). The results showed that okadaic acid (5 mic...

journal_title：Molecular and cellular biochemistry

authors： Sulakhe PV,Vo XT,Morris TE,Pato MD,Khandelwal RL

更新日期：1997-10-01 00:00:00

abstract：:Cryptotanshinone (CPT) is a natural compound extracted from herbal medicine that has been previously shown to possess antitumor properties in various types of human cancer cells. In the present study, we examined the potential role of CPT in the treatment of colorectal cancer. Using SW480, HCT116, and LOVO colorectal ...

journal_title：Molecular and cellular biochemistry

authors： Li W,Saud SM,Young MR,Colburn NH,Hua B

更新日期：2015-08-01 00:00:00

abstract：:Prolonged ischemia-reperfusion results in various damages in skeletal muscle. Following reperfusion, although the damaged muscles undergo regeneration, the precise process and mechanism of regeneration have not yet been fully understood. Here, we show the altered levels of plasma biochemical markers of muscle damage, ...

journal_title：Molecular and cellular biochemistry

authors： Itoh M,Shimokawa N,Tajika Y,Murakami T,Aotsuka N,Lesmana R,Farenia R,Iwasaki T,Okda J,Yorifuji H,Koibuchi N

更新日期：2013-01-01 00:00:00

abstract：:NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. Although methods for expression and purification of...

journal_title：Molecular and cellular biochemistry

authors： Ohashi K,Kawai S,Koshimizu M,Murata K

更新日期：2011-09-01 00:00:00

abstract：:The aim of the present study was to investigate whether lipid metabolism in the nuclei is affected by changes in the metabolism of free fatty acids in the liver. The experiments were carried out on 3 groups of rats: 1 - control-male, 2 - female, and 3 - male, treated with bezafibrate (a peroxisome proliferator). The r...

journal_title：Molecular and cellular biochemistry

authors： Górski J,Zendzian-Piotrowska M,Wolfrum C,Nawrocki A,Spener F

更新日期：2000-11-01 00:00:00

abstract：:Previous results from our laboratory have shown that a novel carotenoid derivative (disodium disuccinate astaxanthin; Cardax) produced dose-related reductions in myocardial infarct size (IS) in Sprague-Dawley rats when it was administered at any of three doses (25, 50 and 75 mg/kg, iv) on four consecutive days, follow...

journal_title：Molecular and cellular biochemistry

authors： Gross GJ,Lockwood SF

更新日期：2005-04-01 00:00:00

abstract：:Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...

journal_title：Molecular and cellular biochemistry

authors： Kraniak JM,Sun D,Mattingly RR,Reiners JJ Jr,Tainsky MA

更新日期：2010-11-01 00:00:00

abstract：:AcMNPV is the first baculovirus to be sequenced and is considered a model of baculovirus. ac154 is a later expression gene in AcMNPV genome and its function is unknown. In this study, we explored the function of Ac154 in AcMNPV infection process in host Sf9 cells. The results showed that Ac154 was distributed in both ...

journal_title：Molecular and cellular biochemistry

authors： Bai H,Liang A,Fu Y

更新日期：2020-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of death worldwide. Novel non-invasive, high diagnostic value screening test is urgently needed to improve survival rate, treatment and prognosis. Stable, small, circulating microRNA (miRNA) offers unique opportunities for the early diagnosis of several diseases. It acts as tum...

journal_title：Molecular and cellular biochemistry

authors： Sabry D,El-Deek SEM,Maher M,El-Baz MAH,El-Bader HM,Amer E,Hassan EA,Fathy W,El-Deek HEM

更新日期：2019-04-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:A number of nutritional supplements containing antioxidants are advertised for better vision health. Do they benefit the average consumer? The literature was examined for the effectiveness of antioxidants for human eye health, and for the intricacies in collection of such evidence. The following diseases were consider...

journal_title：Molecular and cellular biochemistry

authors： Grover AK,Samson SE

更新日期：2014-03-01 00:00:00

abstract：:Chemotherapy remains the core of anticancer treatment. However, despite the tremendous strides made in the development of targeted anticancer therapies, emergence of resistance to chemotherapeutic drugs is still a major obstacle in the successful management of resistant tumors. Therefore, profound investigation into t...

journal_title：Molecular and cellular biochemistry

authors： Peng L,Zhu H,Wang J,Sui H,Zhang H,Jin C,Li L,Xu T,Miao R

更新日期：2015-07-01 00:00:00

abstract：:In addition of being an important inflammatory biomarker and a risk factor for cardiovascular disease, much evidence indicates that the C-reactive protein (CRP) contributes to the atherosclerosis development process. This plasmatic protein synthesized by hepatocytes in response to inflammation and tissue injury induce...

journal_title：Molecular and cellular biochemistry

authors： Cossette É,Cloutier I,Tardif K,DonPierre G,Tanguay JF

更新日期：2013-01-01 00:00:00

abstract：:Lysosomes are defined traditionally with the marker enzyme acid phosphatase. We showed recently that lysosomes from human fibroblasts can be separated into a light and dense fraction as well as prelysosomal population. We now provide evidence that although acid phosphatase is enriched in all three fractions, the marke...

journal_title：Molecular and cellular biochemistry

authors： Kelly BM,Waheed A,Van Etten R,Chang PL

更新日期：1989-06-01 00:00:00

abstract：:L-asparaginase EC 3.5.1.1 was purified to homogeneity from Thermus thermophilus. The apparent molecular mass of L-asparaginase by SDS-PAGE was found to be 33 kDa, whereas by its mobility on Sephacryl S-300 superfine column was around 200 kDa, indicating that the enzyme at the native stage acts as hexamer. The purified...

journal_title：Molecular and cellular biochemistry

authors： Pritsa AA,Kyriakidis DA

更新日期：2001-01-01 00:00:00

abstract：:Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein. It is both a receptor and a guanylate cyclase. This critical conclusion...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1991-01-16 00:00:00

abstract：:The purpose of this study was to investigate the effect of metal-catalyzed oxidation by H(2)O(2) on the structure, oligomerization, and chaperone function of alphaA- and alphaB-crystallins. Recombinant alphaA-and alphaB-crystallins were prepared by expressing them in E. coli and purifying by size-exclusion chromatogra...

journal_title：Molecular and cellular biochemistry

authors： Rajan S,Horn C,Abraham EC

更新日期：2006-08-01 00:00:00

abstract：:Iron ions play a central role in .OH radicals formation and induction of oxidative stress in living organisms. Iron-catalyzed .OH radical formation degrades deoxyribose to thiobarbituric acid reactive substances (TBA-RS). This paper analyzes kinetic properties of the Fe(III)-EDTA-catalyzed deoxyribose degradation in t...

journal_title：Molecular and cellular biochemistry

authors： Hermes-Lima M,Wang EM,Schulman HM,Storey KB,Ponka P

更新日期：1994-08-17 00:00:00

abstract：:Many recent studies have suggested that bergapten (BP), a class of native compound with numerous biological activities such as anti-resorptive properties, may exert protective effects against postmenopausal bone loss. However, it remains unknown whether BP regulates or improves the osteogenic function of bone marrow s...

journal_title：Molecular and cellular biochemistry

authors： Xiao JJ,Zhao WJ,Zhang XT,Zhao WL,Wang XX,Yin SH,Jiang F,Zhao YX,Chen FN,Li SL

更新日期：2015-11-01 00:00:00

abstract：:To investigate the involvement of transforming growth factor-β1 (TGF-β1) and tissue inhibitor of metalloproteinase 4 (TIMP-4) in influencing the severity of atrial fibrosis in rheumatic heart disease (RHD) patients with atrial fibrillation (AF). The degree of myocardial fibrosis was evaluated using Masson staining. Th...

journal_title：Molecular and cellular biochemistry

authors： Sun Y,Huang ZY,Wang ZH,Li CP,Meng XL,Zhang YJ,Su F,Ma N

更新日期：2015-08-01 00:00:00

abstract：:Lens epithelial cells are the metabolic unit of the lens and antioxidant enzymes are mainly concentrated here. The purpose of this study was to maintain human lens epithelial cells (HLEC) in culture and examine the status of antioxidant enzymes (glutathione peroxidase (GSHPx), catalase (CAT), glutathione-S-transferase...

journal_title：Molecular and cellular biochemistry

authors： Mohanty I,Joshi S,Trivedi D,Srivastava S,Tandon R,Gupta SK

更新日期：2002-09-01 00:00:00

abstract：:Peroxisomes and peroxisomal enzyme expression were investigated biochemically and morphometrically in guinea pig intestinal epithelial cells at different stages of their migration along the crypt-villus axis. Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzy...

journal_title：Molecular and cellular biochemistry

authors： Phipps AN,Connock MJ,Johnson P,Burdett K

更新日期：2000-01-01 00:00:00

abstract：:Knowledge of transcription and translation has advanced our understanding of cardiac diseases. Here, we present the hypothesis that the stability of mRNA mediated by the 3'-untranslated region (3'-UTR) plays a role in changing gene expression in cardiovascular pathophysiology. Several proteins that bind to sequences i...

journal_title：Molecular and cellular biochemistry

authors： Misquitta CM,Iyer VR,Werstiuk ES,Grover AK

更新日期：2001-08-01 00:00:00

abstract：:Biochemical and structural changes occurring in the myocardium with aging are mainly resulting from the association of a general tissue atrophy with the hypertrophy of the remaining myocytes. Whilst hypertrophy seems to be a compensatory process to the loss of cardiomyocytes and to a mild systolic hypertensive conditi...

journal_title：Molecular and cellular biochemistry

authors： Muscari C,Giaccari A,Giordano E,Clô C,Guarnieri C,Caldarera CM

更新日期：1996-07-01 00:00:00

abstract：:Recent studies have shown that adult osteoporosis could be induced by ageing and estrogen deficiency and homocysteine (Hcy) is an independent risk factor of fracture in osteoporosis patients. In this study, we found hypermethylation of the promoter A region in the estrogen receptor alpha (ERα) gene, and methylation in...

journal_title：Molecular and cellular biochemistry

authors： Lv H,Ma X,Che T,Chen Y

更新日期：2011-09-01 00:00:00

abstract：:Adenylate kinases (AK, EC 2.7.4.3) have been considered important enzymes for energy homeostasis and metabolic signaling. To gain a better understanding of their cell-specific significance we studied the structural and functional aspects of products of one adenylate kinase gene, AK1, in mouse tissues. By combined comp...

journal_title：Molecular and cellular biochemistry

authors： Janssen E,Kuiper J,Hodgson D,Zingman LV,Alekseev AE,Terzic A,Wieringa B

更新日期：2004-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from dental tissues show promise for use in tooth-related tissue regeneration, but the molecular mechanisms underlying their directed differentiation remain unclear, limiting their usefulness. Sonic Hedgehog (Shh) signaling is a major signaling pathway that regulates cell differen...

journal_title：Molecular and cellular biochemistry

authors： Jiang Q,Du J,Yin X,Shan Z,Ma Y,Ma P,Du J,Fan Z

更新日期：2013-11-01 00:00:00