Hexose metabolism in pancreatic islets: the glucose-6-phosphatase riddle.

abstract：:We report the isolation of a full length cDNA from cardiac muscle that encodes a approximately 73 kDa calcium/calmodulin (CaM) dependent kinase IIbeta isoform (CaMKIIbeta(C)) that was generated by alternative splicing of the CaMKIIbeta gene. Antipeptide antibodies raised to specific regions of the kinase identified a ...

journal_title：Molecular and cellular biochemistry

authors： Singh P,Leddy JJ,Chatzis GJ,Salih M,Tuana BS

更新日期：2005-02-01 00:00:00

abstract：:Heart failure is a leading cause of hospitalization worldwide. No major significant improvements in prognosis have been achieved for heart failure over the last several decades despite advances in disease management. Heart failure itself represents a final common endpoint for several disease entities, including hypert...

journal_title：Molecular and cellular biochemistry

authors： Koch WJ

更新日期：2004-08-01 00:00:00

abstract：:The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascor...

journal_title：Molecular and cellular biochemistry

authors： Rajakumar DV,Rao MN

更新日期：1994-11-09 00:00:00

abstract：:In this review we analyze the concepts and the experimental data on the mechanisms of the regulation of energy metabolism in muscle cells. Muscular energetics is based on the force-length relationship, which in the whole heart is expressed as a Frank-Starling law, by which the alterations of left ventricle diastolic v...

journal_title：Molecular and cellular biochemistry

authors： Saks VA,Kuznetsov AV,Vendelin M,Guerrero K,Kay L,Seppet EK

更新日期：2004-01-01 00:00:00

abstract：:This paper describes a purification procedure and some properties of a nonspecific nucleoside phosphotransferase of chick embryo, an activity which catalyzes the transfer of chick embryo, an activity which catalyzes the transfer of the phosphate ester from a deoxyribonucleotide or a pyrimidine ribonucleotide to a deox...

journal_title：Molecular and cellular biochemistry

authors： Tesoriere G,Vento R,Calvaruso G,Taibi G

更新日期：1979-06-15 00:00:00

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:The actions of cyclic AMP are subject to several levels of post-receptor modulation in cardiac tissue. Isoproterenol and prostaglandin E1 both stimulate cAMP accumulation, but only isoproterenol causes activation of particulate cAMP-dependent protein kinase, leading to activation of phosphorylase kinase and glycogen p...

journal_title：Molecular and cellular biochemistry

authors： Bode DC,Brunton LL

更新日期：1988-07-01 00:00:00

abstract：:Mature uteroferrin (Uf; Mr = 35,500) is a progesterone-induced acid phosphatase secreted by the pig uterus. It contains a single, unphosphorylated, high mannose-type oligosaccharide. Endometrial explants cultured in vitro secrete Uf with a Mr of 37,000 (37k Uf) having phosphorylated high mannose oligosaccharides. In t...

journal_title：Molecular and cellular biochemistry

authors： Baumbach GA,Saunders PT,Ketcham CM,Bazer FW,Roberts RM

更新日期：1991-07-10 00:00:00

abstract：:Interleukin 8 (IL-8) is a chemoattractant associated with ovulation in the mammalian ovary. This chemokine is also involved in the recruitment and activation of neutrophils. Using bovine tissue, we examined the possible role of IL-8 in steroid production by theca cells of the large ovarian follicles. IL-8 promoted pro...

journal_title：Molecular and cellular biochemistry

authors： Shimizu T,Imamura E,Magata F,Murayama C,Miyamoto A

更新日期：2013-02-01 00:00:00

abstract：:Cyclic AMP (300 micron) activates phosphofructokinase from dialyzed haemolysates of mature rat erythrocytes. The main conclusions are: a) Cyclic AMP, at pH 7.1 and low concentrations of fructose-6-phosphate, is able to reverse the inhibition produced by different amounts of ATP (up to 1.5 mM). b) The cyclic nucleotide...

journal_title：Molecular and cellular biochemistry

authors： Pinilla M,Luque J

更新日期：1977-05-03 00:00:00

abstract：:Exposure to ambient particulate matter has been reported to be associated with increased rates of lung cancer. Previously we showed that total suspended particulate matter (PM) induces oxidative DNA damage in epithelial lung cells. The aim of the present study was to further investigate the mechanism of PM-induced DNA...

journal_title：Molecular and cellular biochemistry

authors： Knaapen AM,Shi T,Borm PJ,Schins RP

更新日期：2002-05-01 00:00:00

abstract：:A monocyte chemotactic protein (MCP-1) is thought to play a major role in recruiting monocytes to the vascular endothelium where the adherence of monocytes is one of the earliest events in atherogenesis. We cloned MCP-1 cDNA from a lambda gt 11 cDNA library constructed from human aortic endothelial mRNA to test whethe...

journal_title：Molecular and cellular biochemistry

authors： Li YS,Shyy YJ,Wright JG,Valente AJ,Cornhill JF,Kolattukudy PE

更新日期：1993-09-08 00:00:00

abstract：:Inflammation-induced colonic motility dysfunction is associated with a disturbance in Ca(2+) ion transporting mechanisms. The main objective of this study was to identify the types of Na-Ca-exchanger-1 (NCX-1) variants expressed in the rat colon, and how this was affected by colitis. In addition, the effect of colitis...

journal_title：Molecular and cellular biochemistry

authors： Shubair M,Oriowo MA,Khan I

更新日期：2012-11-01 00:00:00

abstract：:Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED and the conn...

journal_title：Molecular and cellular biochemistry

authors： Liu B,Qiao J,Hu J,Fan M,Zhao Y,Su H,Wang Z,Yu Q,Ma Q,Li Y,Lv Z,Wang R

更新日期：2020-10-01 00:00:00

abstract：:Salidroside, a phenol glycoside of plant origin, has been documented to possess a broad spectrum of pharmacological properties, including protective effects against neuronal death induced by different insults. To provide further insights into the neuroprotective functions peculiar to salidroside, this study used prima...

journal_title：Molecular and cellular biochemistry

authors： Zhang S,Chen X,Yang Y,Zhou X,Liu J,Ding F

更新日期：2011-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-...

journal_title：Molecular and cellular biochemistry

authors： Xie L,Qian X,Liu B

更新日期：2010-08-01 00:00:00

abstract：:Renilla luciferase reporter is a widely used internal control in dual luciferase reporter assay system, where its transcription is driven by a constitutively active promoter. However, the authenticity of the Renilla luciferase response in some experimental settings has recently been questioned. Testicular receptor 4 (...

journal_title：Molecular and cellular biochemistry

authors： Zhang D,Atlasi SS,Patel KK,Zhuang Z,Heaney AP

更新日期：2017-06-01 00:00:00

abstract：:Hyperhomocysteinemia is associated with various pathologies including cardiovascular disease, stroke, and cognitive dysfunctions. Systemic administration of homocysteine can trigger seizures in animals, and patients with homocystinuria suffer from epileptic seizures. Available data suggest that homocysteine can be har...

journal_title：Molecular and cellular biochemistry

authors： Rasić-Marković A,Stanojlović O,Hrncić D,Krstić D,Colović M,Susić V,Radosavljević T,Djuric D

更新日期：2009-07-01 00:00:00

abstract：:The astonishing growth rate of deer antlers offers a valuable model for the discovery of novel factors and regulatory systems controlling rapid tissue growth. Numerous molecules have been identified in growing antlers using a variety of techniques. However, little is known about the spatial distribution of these molec...

journal_title：Molecular and cellular biochemistry

authors： Deb-Choudhury S,Wang W,Clerens S,McMahon C,Dyer JM,Li C

更新日期：2015-11-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is a highly conserved histone methyltransferase, which is overexpressed in different types of cancers such as breast and prostate cancer. It is reported that EZH2 can directly down-regulate RUNX3 by increasing histone H3 methylation. However, the role of EZH2 in the development and p...

journal_title：Molecular and cellular biochemistry

authors： Lian R,Ma H,Wu Z,Zhang G,Jiao L,Miao W,Jin Q,Li R,Chen P,Shi H,Yu W

更新日期：2018-02-01 00:00:00

abstract：:Recently, it has been appreciated that cultured mast cells are significant sources of cytokines. However, the role of interkeukin-1 (IL-1) on mast cells and/or basophil degranulation is still unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1...

journal_title：Molecular and cellular biochemistry

authors： Conti P,Bouchet W,Feliciani C,Mammarella S,Kudchadker L,Barbacane RC,Reale M,Haggag I,Bruneau G,Thibault J,Theoharides TC

更新日期：1996-02-09 00:00:00

abstract：:Inhibition of synthesis of estradiol 17beta by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17beta, or addition of tamoxifen - an estrogen receptor antagonist, to human placental minces resulted in an increase in the level of LDL-receptor mRNA. This increase could be blocked b...

journal_title：Molecular and cellular biochemistry

authors： Shanker YG,Shetty UP,Rao AJ

更新日期：1998-10-01 00:00:00

abstract：:Ionizing radiation induces apoptosis in human Molt-4 leukemia cells in a p53-dependent manner. The tumor suppressor p53 stimulates various downstream targets that presumably trigger, individually or in concert, de novo ceramide synthesis and intrinsic apoptosis via mitochondrial outer membrane permeabilization (MOMP)....

journal_title：Molecular and cellular biochemistry

authors： Kobeissy H,Hage-Sleiman R,Dakdouk Z,Kozhaya L,Dbaibo G

更新日期：2020-12-01 00:00:00

abstract：:A comparative study has been carried out on the micro-localization of catalase in mouse tissues subsequent to treatment with a representative range of hypolipidemic drugs. A commonality of effect was shown by clofibrate (ethyl-alpha-p-chlorophenoxyisobutyrate), Wy-14,643 (4-chloro-6-[2,3 xylidino)-2-pyrimidinylthio] a...

journal_title：Molecular and cellular biochemistry

authors： Klucis E,Crane D,Masters C

更新日期：1984-11-01 00:00:00

abstract：:Accumulating data have shown that microRNAs are involved in the pathogenesis of cancer. miR-202 has been confirmed to be downregulated in several types of human cancer. However, the expression and biological role of miR-202 in osteosarcoma (OS) carcinogenesis and progression remain unclear. In this study, we demonstra...

journal_title：Molecular and cellular biochemistry

authors： Sun Z,Zhang T,Hong H,Liu Q,Zhang H

更新日期：2014-12-01 00:00:00

abstract：:Full-length hexokinase (HK; ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1), a truncate form of the enzyme lacking the first 11 amino acids (HK-11aa) and the 50 kDa C-terminal half ('mini'-HK) containing the catalytic domain, were overexpressed and purified to homogeneity to investigate the influence of the N-terminal...

journal_title：Molecular and cellular biochemistry

authors： Bianchi M,Serafini G,Bartolucci E,Giammarini C,Magnani M

更新日期：1998-12-01 00:00:00

abstract：:This study was designed to investigate the alterations in the levels of various proteases such as angiotensin converting enzyme (ACE), kallikrein, aminopeptidases, urokinase and plasmin in serum-heart and kidney and to find out whether the changes in the levels of these enzymes could explain the pathogeneses of hypert...

journal_title：Molecular and cellular biochemistry

authors： Rajashree S,Puvanakrishnan R

更新日期：1999-07-01 00:00:00

abstract：:We studied the effects of SEB on [14C]-choline transport and metabolism of choline containing phospholipids in cultured human kidney proximal tubular (PT) cells. SEB increased the uptake of [14C]-choline in PT cells as a function of toxin concentration, incubation time, and pH. The maximum increase in uptake (3.5-5-fo...

journal_title：Molecular and cellular biochemistry

authors： Khullar M,Chatterjee S

更新日期：1995-05-24 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in the world. Circular RNA hsa_circHN1_005 (circ_HN1), also termed as hsa_circ_0045602, is reported as an oncogene in GC. However, the molecular mechanism of circ_HN1 in GC development has not been fully explored. Here, we surveyed the regulato...

journal_title：Molecular and cellular biochemistry

authors： Wang D,Jiang X,Liu Y,Cao G,Zhang X,Kuang Y

更新日期：2020-09-19 00:00:00

abstract：:This review describes a comprehensive analysis of a surface plasmon resonance (SPR)-based biosensor study of molecular interactions in the insulin-like growth factor (IGF) molecular axis. In this study, we focus on the interaction between the polypeptide growth factors IGF-I and IGF-II with six soluble IGF binding pro...

journal_title：Molecular and cellular biochemistry

authors： Beattie J,Phillips K,Shand JH,Szymanowska M,Flint DJ,Allan GJ

更新日期：2008-01-01 00:00:00