Mitochondrial abnormalities and peripheral neuropathy in inflammatory myopathy, especially inclusion body myositis.

abstract：:Recently, it has been appreciated that cultured mast cells are significant sources of cytokines. However, the role of interkeukin-1 (IL-1) on mast cells and/or basophil degranulation is still unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1...

journal_title：Molecular and cellular biochemistry

authors： Conti P,Bouchet W,Feliciani C,Mammarella S,Kudchadker L,Barbacane RC,Reale M,Haggag I,Bruneau G,Thibault J,Theoharides TC

更新日期：1996-02-09 00:00:00

abstract：:Gap junctional communication during the progression of cell cycle from quiescent G0 to S phase was examined in cultured clone 9 rat liver cells. The transfer of scrape-loaded fluorescent dye was suppressed immediately after the stimulation of cell cycle progression in a synchronized cell population. Northern blot anal...

journal_title：Molecular and cellular biochemistry

authors： Koo SK,Kim DY,Park SD,Kang KW,Joe CO

更新日期：1997-02-01 00:00:00

abstract：:The IL-6-related cytokines, LIF and cardiotrophin-1, are important growth promoting and cardioprotective agents for cardiomyocytes. However, factors that regulate their actions in the heart are poorly understood. In this study, we tested the hypothesis that endothelin-1, a peptide hormone that produces a pattern of ca...

journal_title：Molecular and cellular biochemistry

authors： Booz GW,Day JN,Speth R,Baker KM

更新日期：2002-11-01 00:00:00

abstract：:NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. Although methods for expression and purification of...

journal_title：Molecular and cellular biochemistry

authors： Ohashi K,Kawai S,Koshimizu M,Murata K

更新日期：2011-09-01 00:00:00

abstract：:Mitoapocynin is a triphenylphosphonium conjugated derivative of apocynin that specifically locates to the mitochondria. It has been developed as a mitochondrially targeted therapeutic antioxidant. We attempted to attenuate the mitochondrial ROS induced in H9c2 cardiac myoblast cells treated with norepinephrine. Mitoap...

journal_title：Molecular and cellular biochemistry

authors： Mahmood A,Bisoyi P,Banerjee R,Yousuf M,Goswami SK

更新日期：2021-01-30 00:00:00

abstract：:Ischemia/reperfusion injury causes cardiomyocyte apoptosis, ventricular remodeling, leading to a dilated heart. Hypoxia is one of the causes involved in ischemia damage, and BNIP3 is a hypoxia-inducible marker and also a sensor to induce mitochondria-dependent apoptosis. Recent reports discussed ablating BNIP3 can res...

journal_title：Molecular and cellular biochemistry

authors： Weng YJ,Kuo WW,Kuo CH,Tung KC,Tsai CH,Lin JA,Tsai FJ,Hsieh DJ,Huang CY,Hwang JM

更新日期：2010-12-01 00:00:00

abstract：:In this paper we review some of the large quantities of information currently available concerning the identification, structure and function of Ca(2+)-binding proteins of endoplasmic and sarcoplasmic reticulum membranes. The review places particular emphasis on identification and discussion of Ca2+ 'storage' proteins...

journal_title：Molecular and cellular biochemistry

authors： Milner RE,Famulski KS,Michalak M

更新日期：1992-05-13 00:00:00

abstract：:A literature search has been conducted to see to what extent steady-state kinetics studies in the period 1965-1976 have revealed deviations from Michaelis-Menten kinetics. It was found that over 800 enzymes have been reported as giving complex curves for a variety of reasons and a group by group classification of all ...

journal_title：Molecular and cellular biochemistry

authors： Hill CM,Waight RD,Bardsley WG

更新日期：1977-05-03 00:00:00

abstract：:In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistanc...

journal_title：Molecular and cellular biochemistry

authors： Balakumar M,Raji L,Prabhu D,Sathishkumar C,Prabu P,Mohan V,Balasubramanyam M

更新日期：2016-12-01 00:00:00

abstract：:The aim of our work was to study (1) the antioxidant properties of lipoic acid (LA) and its reduced metabolite dihydrolipoic acid (DHLA) formed by reduction of LA and (2) the effects of treatment with LA and DHLA on (a) K(+) efflux from human red blood cells and (b) post-ischemic recovery and oxidative stress in isola...

journal_title：Molecular and cellular biochemistry

authors： Ghibu S,Lauzier B,Delemasure S,Amoureux S,Sicard P,Vergely C,Muresan A,Mogosan C,Rochette L

更新日期：2009-01-01 00:00:00

abstract：:Autophagy of mitochondria, i.e., mitophagy, plays a crucial role in coping with stressors in the aging process, metabolic disturbances, and neurological disorders. Impairments of the process might consequently lead to enhanced accumulation of aged and aggregated proteins and reduced cellular integrity in response to s...

journal_title：Molecular and cellular biochemistry

authors： Civelek M,Mehrkens JF,Carstens NM,Fitzenberger E,Wenzel U

更新日期：2019-02-01 00:00:00

abstract：:The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic...

journal_title：Molecular and cellular biochemistry

authors： Ohnami S,Ohshima K,Nagashima T,Urakami K,Shimoda Y,Saito J,Naruoka A,Hatakeyama K,Mochizuki T,Serizawa M,Ohnami S,Kusuhara M,Yamaguchi K

更新日期：2017-07-01 00:00:00

abstract：:Piperine is a major component of black (Piper nigrum Linn) and long pepper (Piper longum Linn) used widely in various systems of traditional medicine. We have evaluated the effect of piperine on mitochondrial tricarboxylic acid cycle and phase I and glutathione-metabolizing enzymes in Benzo(a)pyrene induced experiment...

journal_title：Molecular and cellular biochemistry

authors： Selvendiran K,Thirunavukkarasu C,Singh JP,Padmavathi R,Sakthisekaran D

更新日期：2005-03-01 00:00:00

abstract：:Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain dam...

journal_title：Molecular and cellular biochemistry

authors： Streck EL,De Prá SDT,Ferro PR,Carvalho-Silva M,Gomes LM,Agostini JF,Damiani A,Andrade VM,Schuck PF,Ferreira GC,Scaini G

更新日期：2017-11-01 00:00:00

abstract：:Although studies performed in vitro and with transfected cells in culture suggest a role for liver fatty acid binding protein (L-FABP) in regulating fatty acid oxidation and fat deposition, the physiological significance of this possibility is not completely clear. To begin to address this question, the effect of L-FA...

journal_title：Molecular and cellular biochemistry

authors： Martin GG,Atshaves BP,McIntosh AL,Payne HR,Mackie JT,Kier AB,Schroeder F

更新日期：2009-04-01 00:00:00

abstract：:Members of the family of intracellular lipid binding proteins (iLBPs) have been implicated in cytoplasmic transport of lipophilic ligands, such as long-chain fatty acids and retinoids. iLBPs are low molecular mass proteins (14-16 kDa) sharing a common structural fold. The iLBP family likely arose through duplication a...

journal_title：Molecular and cellular biochemistry

authors： Schaap FG,van der Vusse GJ,Glatz JF

更新日期：2002-10-01 00:00:00

abstract：:Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative stress in periphera...

journal_title：Molecular and cellular biochemistry

authors： Quintanilha JCF,Visacri MB,Sousa VM,Bastos LB,Vaz CO,Guarnieri JPO,Amaral LS,Malaguti C,Lima CSP,Vercesi AE,Moriel P

更新日期：2018-03-01 00:00:00

abstract：:Full-length hexokinase (HK; ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1), a truncate form of the enzyme lacking the first 11 amino acids (HK-11aa) and the 50 kDa C-terminal half ('mini'-HK) containing the catalytic domain, were overexpressed and purified to homogeneity to investigate the influence of the N-terminal...

journal_title：Molecular and cellular biochemistry

authors： Bianchi M,Serafini G,Bartolucci E,Giammarini C,Magnani M

更新日期：1998-12-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:ING proteins are tumor suppressors involved in the regulation of gene transcription, cell cycle arrest, apoptosis, and senescence. Here, we show that ING1b expression is upregulated by several DNA-damaging agents, in a p53-independent manner. ING1b stimulates DNA repair of a variety of DNA lesions requiring activation...

journal_title：Molecular and cellular biochemistry

authors： Ceruti JM,Ogara MF,Menéndez C,Palmero I,Cánepa ET

更新日期：2013-06-01 00:00:00

abstract：:Hyperlipidemia is a well-known risk factor for atherosclerosis and statins are widely used to treat patients with elevated levels of lipids in their plasma. Notwithstanding the proven benefits of statin drugs on both primary and secondary prevention of heart disease, the high cost of statin treatment, in addition to p...

journal_title：Molecular and cellular biochemistry

authors： Man RY,Lynn EG,Cheung F,Tsang PS,O K

更新日期：2002-04-01 00:00:00

abstract：:Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT. These studies indicated that the abnormalities of BM-MSCs may be involved in the...

journal_title：Molecular and cellular biochemistry

authors： Gu Z,Tan W,Feng G,Meng Y,Shen B,Liu H,Cheng C

更新日期：2014-02-01 00:00:00

abstract：:Nitric oxide (NO) is a messenger molecule which regulates many physiological functions like immunity, vascular tone and serves as a neurotransmitter. Although it is known to participate in healing process, its role in collagen synthesis is not clear. Therefore, the present investigation was done to study the role of N...

journal_title：Molecular and cellular biochemistry

authors： Shukla A,Rasik AM,Shankar R

更新日期：1999-10-01 00:00:00

abstract：:Cellular senescence is a restricting factor for regenerative therapies with somatic stem cells. We showed previously that the onset of cellular senescence inhibits the osteogenic differentiation in stem cells of the dental follicle (DFCs), although the mechanism remains elusive. Two different pathways are involved in ...

journal_title：Molecular and cellular biochemistry

authors： Morsczeck C,Hullmann M,Reck A,Reichert TE

更新日期：2018-02-01 00:00:00

abstract：:The inhibitory effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in vitro is found (Mol Cell Biochem 228: 39-47, 2001). This study, furthermore, was undertaken to determine the effect of MK-7 on the bone-resorbing factor-induced bone resorption using the femo...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Uchiyama S,Tsukamoto Y

更新日期：2003-03-01 00:00:00

abstract：:The mechanism of the effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein degradation induced by lipopolysaccharide (LPS) has been evaluated in murine myotubes. HMB (50 muM) completely attenuated total protein degradation induced by LPS (1-100 ng/ml), formation of reactive oxygen species (ROS) and activation of...

journal_title：Molecular and cellular biochemistry

authors： Russell ST,Tisdale MJ

更新日期：2009-10-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:The contractile hyporesponsiveness of the streptozotocin diabetic rat heart in vitro to beta-adrenergic agonists is eliminated when the heart is perfused with N(G)-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor of nitric oxide synthase (NOS). The following study evaluated the hypothesis that an incr...

journal_title：Molecular and cellular biochemistry

authors： Smith JM,Sondgeroth KB,Wahler GM

更新日期：2007-06-01 00:00:00

abstract：:Pig intestinal brush borders (BB) were radiolabeled by iodination using the lactoperoxidase-hydrogen peroxide procedure. The BB were then detergent solubilized, centrifuged to remove particulate material, and chromatographed on Sepharose CL-4B. The fractions were incubated with K88+ E. coli using an in vitro binding a...

journal_title：Molecular and cellular biochemistry

authors： Staley TE,Wilson IB

更新日期：1983-01-01 00:00:00

abstract：:BTF3, initially discovered as a factor required for transcription inititation of RNA polymerase II, is expressed in two isoforms, termed a and b. BTF3b, the transcriptionally inactive isoform, was identified as an interaction partner of protein kinase CK2 subunit beta employing the interaction trap system for screenin...

journal_title：Molecular and cellular biochemistry

authors： Grein S,Pyerin W

更新日期：1999-01-01 00:00:00