Evolution of the family of intracellular lipid binding proteins in vertebrates.

abstract：:CK2 is a highly conserved protein kinase involved in different cellular processes, which shows a higher activity in actively proliferating mammalian cells and in various types of cancer and cancer cell lines. We recently demonstrated that CK2 activity is strongly influenced by growth rate in yeast cells as well. Here,...

journal_title：Molecular and cellular biochemistry

authors： Tripodi F,Cirulli C,Reghellin V,Brambilla L,Marin O,Coccetti P

更新日期：2011-10-01 00:00:00

abstract：:Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules. In this study, we report that FAM98A, whose biologic...

journal_title：Molecular and cellular biochemistry

authors： Ozeki K,Sugiyama M,Akter KA,Nishiwaki K,Asano-Inami E,Senga T

更新日期：2019-01-01 00:00:00

abstract：:Idiopathic pes equinovarus is a congenital deformity of the foot and lower leg defined as a fixation of the foot in adduction, supination, and varus. Although the pathogenesis of clubfoot remains unclear, it has been suggested that fibroblasts and growth factors are involved. To directly analyze the protein compositio...

journal_title：Molecular and cellular biochemistry

authors： Ošt'ádal M,Eckhardt A,Herget J,Mikšík I,Dungl P,Chomiak J,Frydrychová M,Burian M

更新日期：2015-03-01 00:00:00

abstract：:Treatment of bovine pulmonary artery smooth muscle cells with endothelin-1 (ET-1) caused an increase in the expression and activation of proMMP-2 in the cells. The present study was undertaken to determine the underlying mechanisms involved in this scenario. We demonstrated that (i) pretreatment with NADPH oxidase inh...

journal_title：Molecular and cellular biochemistry

authors： Sarkar J,Chowdhury A,Chakraborti T,Chakraborti S

更新日期：2016-04-01 00:00:00

abstract：:In this study, we have characterized the negative regulation of the IL-12 p40 expression by TGF-beta in macrophages. Although murine IL-12 p40 promoter contains a putative TGF-beta inhibitory element (TIE), neither mutation nor deletion of the TIE had any effect on the inhibitory activity of TGF-beta. The NF-kappaB p6...

journal_title：Molecular and cellular biochemistry

authors： Ogawa K,Funaba M,Tsujimoto M

更新日期：2008-01-01 00:00:00

abstract：:Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of myeloid precursor cells. One of the signaling mechanisms for the G-CSF receptor (G-CSF-R) involves the activation of Ras/MAP kinase (MEK) pathway. Since Raf is an important, common link between Ras and MEK in the Ra...

journal_title：Molecular and cellular biochemistry

authors： Deshpande RV,Moore MA

更新日期：1998-01-01 00:00:00

abstract：:Bladder smooth muscle contraction is mediated by both direct calcium entry through the cell membrane, and by calcium induced calcium release (CICR) from the sarcoplasmic reticulum (SR) storage sites. Ryanodine is a neutral plant alkaloid which binds to an ion channel located on the SR membrane. Its effects in cardiac ...

journal_title：Molecular and cellular biochemistry

authors： Gong C,Zderic SA,Levin RM

更新日期：1994-08-31 00:00:00

abstract：:Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was ex...

journal_title：Molecular and cellular biochemistry

authors： Wang Z,Ren W,Zhao F,Han Y,Liu C,Jia K

更新日期：2020-02-01 00:00:00

abstract：:Young female Zucker fa/fa rats of 370-430 g were implanted with osmotic minipumps releasing 3.5 micromol/day-kg of estrone oleate in liposomes (Merlin-2) into the bloodstream for up to 14 days. Merlin-2 induced a sustained loss of appetite, and a decrease in body weight of 3.5%, which contrasts with the 8.2% increase ...

journal_title：Molecular and cellular biochemistry

authors： Adán C,Grasa MM,Cabot C,Esteve M,Vilà R,Masanés R,Estruch J,Fernández-López JA,Remesar X,Alemany M

更新日期：1999-07-01 00:00:00

abstract：:The tRNA modifying enzyme, S-adenosylmethionine:tRNA(guanine-7-)-methyltransferase, has been extensively purified from Salmonella typhimurium. A rapid and efficient purification method using phosphocellulose chromatography followed by ammonium sulfate precipitation and Sephadex G-100 gel filtration is described. The e...

journal_title：Molecular and cellular biochemistry

authors： Colonna A,Ciliberto G,Santamaria R,Cimino F,Salvatore F

更新日期：1983-01-01 00:00:00

abstract：:Rat Langendorff hearts perfused with media that do not contain erythrocytes or fluorocarbon as oxygen carriers are borderline aerobic during 5 Hz pacing. This follows from the release of catabolic products measured: lactate, urate and Iysophosphatidyl-choline (IysoPC). Addition of L-carnitine to the perfusion medium r...

journal_title：Molecular and cellular biochemistry

authors： Hulsmann WC,Peschechera A,Serafini F,Ferrari LE

更新日期：1996-03-09 00:00:00

abstract：:Rat pancreatic acinar cells AR 4-2J respond to dexamethasone by differentiation and a decreased proliferation rate. Protein labelling by [3H]-mevalonolactone, used as a precursor of farnesyl and geranylgeranyl isoprenoid groups, was increased in the presence of dexamethasone. In these same conditions, dexamethasone de...

journal_title：Molecular and cellular biochemistry

authors： Lambert M,Bui ND

更新日期：1999-12-01 00:00:00

abstract：:One of the atrial natriuretic factor (ANF) receptors is a 180 kDa protein (180 kDa mGC) which possesses the extraordinary characteristic of being bifunctional: it is both a receptor and a guanylate cyclase. In addition to the 180 kDa mGC, there exists another 120-130 kDa protein which is also bifunctional and a 120 kD...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1992-01-15 00:00:00

abstract：:The effects of different dietary fats on peritoneal macrophage plasma membrane fluidity, intracellular cyclic AMP (cAMP) production, GTP hydrolysis and TNF binding and TNF-induced IL1 and IL6 production was investigated. After a four week period, fluidity, as determined by both fluorescence recovery after photobleachi...

journal_title：Molecular and cellular biochemistry

authors： Tappia PS,Ladha S,Clark DC,Grimble RF

更新日期：1997-01-01 00:00:00

abstract：:The regulation of the guinea-pig pancreatic acinar plasma membrane Ca2+ pump by protein kinase A, protein kinase C and calmodulin was investigated. The results were compared with the effects of these regulators on the high affinity Ca(2+)-ATPase found in this membrane preparation. The catalytic subunit of cyclic AMP-d...

journal_title：Molecular and cellular biochemistry

authors： Mahey R,Allen BG,Bridges MA,Katz S

更新日期：1992-06-26 00:00:00

abstract：:Cell proliferation and migration are crucial in many physiological processes including development, cancer, tissue repair, and wound healing. Cell migration is regulated by several signaling molecules. Identification of genes related to cell migration is required to understand molecular mechanism of non-healing chroni...

journal_title：Molecular and cellular biochemistry

authors： Demirci S,Doğan A,Apdik H,Tuysuz EC,Gulluoglu S,Bayrak OF,Şahin F

更新日期：2018-01-01 00:00:00

abstract：:A noncholinergic nicotine receptor on human phagocytic leukocytes has been characterized using the binding of 3H-(d,1)-nicotine. The average affinity +/- standard deviation of (d,1)-nicotine for the receptor on neutrophils is 36 +/- 18 nM (n = 6). The binding is saturable with an average of 8.7 x 10(4) sites per neutr...

journal_title：Molecular and cellular biochemistry

authors： Davies BD,Hoss W,Lin JP,Lionetti F

更新日期：1982-04-16 00:00:00

abstract：:Enzymes have proven to be sensitive and versatile labels for immunochemical assays. The sensitivity of an enzyme label stems from its extraordinary catalytic power which in turn provides a great amplification of signals. Its versatility, however, stems from the fact that enzyme activity can be modulated by a number of...

journal_title：Molecular and cellular biochemistry

authors： Ngo TT,Lenhoff HM

更新日期：1982-04-16 00:00:00

abstract：:We studied the effects of SEB on [14C]-choline transport and metabolism of choline containing phospholipids in cultured human kidney proximal tubular (PT) cells. SEB increased the uptake of [14C]-choline in PT cells as a function of toxin concentration, incubation time, and pH. The maximum increase in uptake (3.5-5-fo...

journal_title：Molecular and cellular biochemistry

authors： Khullar M,Chatterjee S

更新日期：1995-05-24 00:00:00

abstract：:Angiotensin II (Ang II) has been shown to induce receptor activator of nuclear factor-κB ligand (RANKL) expression in osteoblasts associated with its effect on reactive oxygen species (ROS) production. The objective of the present study was to investigate the potential pathways by which Ang II induces RANKL expression...

journal_title：Molecular and cellular biochemistry

authors： Zhang Y,Zhang Y,Kou J,Wang C,Wang K

更新日期：2014-11-01 00:00:00

abstract：:Transmission of extra cellular signals across biological membranes results in the generation of lipid metabolites which in turn influence specific cellular events such as cell growth or differentiation. Many of these lipid messengers can activate protein kinase C (PKC) isozymes of which one function is to perpetuate t...

journal_title：Molecular and cellular biochemistry

authors： Sista P,Edmiston S,Darges JW,Robinson S,Burns DJ

更新日期：1994-12-21 00:00:00

abstract：:We have previously demonstrated that Cationic Arginine-Rich Peptides (CARPs) and in particular poly-arginine-18 (R18; 18-mer of arginine) exhibit potent neuroprotective properties in both in vitro and in vivo neuronal injury models. Based on the current literature, there is a consensus that arginine residues by virtue...

journal_title：Molecular and cellular biochemistry

authors： MacDougall G,Anderton RS,Ouliel E,Gao J,Redmond SL,Knuckey NW,Meloni BP

更新日期：2020-01-01 00:00:00

abstract：:Lysosomes are defined traditionally with the marker enzyme acid phosphatase. We showed recently that lysosomes from human fibroblasts can be separated into a light and dense fraction as well as prelysosomal population. We now provide evidence that although acid phosphatase is enriched in all three fractions, the marke...

journal_title：Molecular and cellular biochemistry

authors： Kelly BM,Waheed A,Van Etten R,Chang PL

更新日期：1989-06-01 00:00:00

abstract：:Glycodelin A (GdA) is a dimeric glycoprotein synthesized by the human endometrium under progesterone regulation. Based on the high sequence similarity with β-lactoglobulin, it is placed under the lipocalin superfamily. The protein is one of the local immunomodulators present at the feto-maternal interface which affect...

journal_title：Molecular and cellular biochemistry

authors： Ponnalagu D,Karande AA

更新日期：2013-05-01 00:00:00

abstract：:Using a synthetic peptide that encompasses the zinc finger domain of the eukaryotic transcription factor Sp1, we produced a number of monoclonal antibodies that specifically reacted with the target antigen. Analysis by competitive inhibition assay of five of the monoclonal antibodies revealed that they all recognized ...

journal_title：Molecular and cellular biochemistry

authors： Katai H,Terato K,Raghow R

更新日期：1991-02-27 00:00:00

abstract：:There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels i...

journal_title：Molecular and cellular biochemistry

authors： Soundararajan A,Prabu P,Mohan V,Gibert Y,Balasubramanyam M

更新日期：2019-08-01 00:00:00

abstract：:SAP155 is an essential component of the spliceosome and its phosphorylation is required for splicing catalysis, but little is known concerning its function and regulation during spermatogenesis in postnatal murine testes. We report that inhibition of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) IA...

journal_title：Molecular and cellular biochemistry

authors： Eto K,Sonoda Y,Abe S

更新日期：2011-09-01 00:00:00

abstract：:Treatment of P-type ATPases (from mammalian sources) by fluorescein isothiocyanate (ITC) revealed the ITC label on a lysine residue that was than considered as essential for binding of ATP in the ATP-binding site of these enzymes. On the other hand, experiments with site directed mutagenesis excluded the presence of a...

journal_title：Molecular and cellular biochemistry

authors： Breier A,Ziegelhöffer A,Famulsky K,Michalak M,Slezák J

更新日期：1996-07-01 00:00:00

abstract：:NAD kinase (NADK, EC 2.7.1.23) is the sole NADP(+)-biosynthetic enzyme that catalyzes phosphorylation of NAD(+) to yield NADP(+) using ATP as a phosphoryl donor, and thus, plays a vital role in the cell and represents a potentially powerful antimicrobial drug target. Although methods for expression and purification of...

journal_title：Molecular and cellular biochemistry

authors： Ohashi K,Kawai S,Koshimizu M,Murata K

更新日期：2011-09-01 00:00:00

abstract：:Lipids form an essential part of the biomembrane and it is of paramount importance to study their conformational aspects. It is found that the present methods of nomenclature for lipids are totally inadequate for describing these diverse amphipathic molecules. Further the existing methods are incompatible in terms of ...

journal_title：Molecular and cellular biochemistry

authors： Chandrasekhur I,Sasisekharan V

更新日期：1989-11-23 00:00:00