Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells.

abstract：:The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gli...

journal_title：Molecular and cellular biochemistry

authors： Shervington A,Cruickshanks N,Wright H,Atkinson-Dell R,Lea R,Roberts G,Shervington L

更新日期：2006-02-01 00:00:00

abstract：:Interferon-stimulated gene15 (ISG15) is the first characterized ubiquitin-like protein, which is strongly induced by type I interferons (IFN-α/β), bacterial endotoxin, and cellular stress. Up-regulation of ISG15 is observed in several cancer cell types and is associated with cancer progression. As many cytokines can i...

journal_title：Molecular and cellular biochemistry

authors： Chairatvit K,Wongnoppavich A,Choonate S

更新日期：2012-09-01 00:00:00

abstract：:Cultured human and rat endothelial cells were used to study cellular toxicity and Ca2+ signalling upon exposure to reactive oxygen species. Superoxide and hydrogen peroxide (O2.-/H2O2) were produced by the hypoxanthine/xanthine oxidase system (HX/XO) and caused intracellular Ca2+ concentration ([Ca2+]i) to rise steadi...

journal_title：Molecular and cellular biochemistry

authors： Volk T,Hensel M,Kox WJ

更新日期：1997-06-01 00:00:00

abstract：:Endothelin-1 (ET-1), a peptide isolated from the culture medium of endothelial cells, mediates a variety of physiological and pathological responses including mitogenesis. We have compared the expression of ET receptors in untransformed versus ras-transformed NIH-3T3 murine fibroblasts and in untransformed versus SV40...

journal_title：Molecular and cellular biochemistry

authors： Nambi P,Mattern MR,Wu HL,Pullen M,Nuthulaganti P,Hofmann GA,Kumar C

更新日期：1997-10-01 00:00:00

abstract：:Genetic adaptation is one of the key features of Escherichia coli (E. coli) that ensure its survival in different hostile environments. E. coli seems to initiate biofilm development in response to specific environmental cues. A number of properties inherent within bacterial biofilms indicate that their gene expression...

journal_title：Molecular and cellular biochemistry

authors： Adnan M,Morton G,Hadi S

更新日期：2011-11-01 00:00:00

abstract：:Apocytochrome c has a potent ability to insert spontaneously into membrane. To identify which sequences were critical for this insertion activity, a series of peptides N19, C8, C15 and C21, corresponding to sequences 1-19, 81-88, 74-88 and 68-88 of apocytochrome c, respectively, were synthesized and purified. Insertio...

journal_title：Molecular and cellular biochemistry

authors： Wang X,Han X,Yang F

更新日期：2004-07-01 00:00:00

abstract：:The results of our experiments demonstrated that one hour of ischemia followed by one hour of reflow in the kidney caused a reduction in (Na+K+)ATPase activity and microsomal sulfhydryl content as well as an increase in microsomal lipid peroxidation. Renal venous malondialdehyde concentration was increased soon after ...

journal_title：Molecular and cellular biochemistry

authors： Kato M,Kako KJ

更新日期：1987-12-01 00:00:00

abstract：:The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns of lncRNAs and genes were examined by RNA-seq. GO and KEGG pathway analysi...

journal_title：Molecular and cellular biochemistry

authors： Han W,Yu G,Meng X,Hong H,Zheng L,Wu X,Zhang D,Yan B,Ma Y,Li X,Wang Q

更新日期：2019-10-01 00:00:00

abstract：:The metabolism of D-glucose was characterized in both normal dispersed rat islet cells and the 2-mercaptoethanol-dependent insulin-secreting cells of the INS-1 line. The normal and tumoral islet cells differed from one another by the relative magnitude, concentration dependency and hierarchy of the increase in the pro...

journal_title：Molecular and cellular biochemistry

authors： Nadi AB,Olivares E,Malaisse WJ

更新日期：2000-07-01 00:00:00

abstract：:This work investigates the effect of alloxan-induced short-term diabetes (24 h) on D-3-hydroxybutyrate metabolism at physiological and non-physiological concentrations of the ketone body in the isolated non-working perfused rat heart. Also the effect of insulin (2 mU.ml-1) on D-3-hydroxybutyrate metabolism was investi...

journal_title：Molecular and cellular biochemistry

authors： Sultan AM

更新日期：1992-03-04 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:1. Two different molecular forms of dopamine-beta-hydroxylase were isolated from human serum; a major component (Peak I enzyme) with a molecular weight of 368000 and with a higher specific activity and a minor component (Peak II enzyme) with a molecular weight of 188000 and with a lower specific activity. 2. Both form...

journal_title：Molecular and cellular biochemistry

authors： Ikeno T,Hashimoto S,Kuzuya H,Nagatsu T

更新日期：1977-12-29 00:00:00

abstract：:The inhibitory effect of menaquinone-7 (MK-7; vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in vitro is found (Mol Cell Biochem 228: 39-47, 2001). This study, furthermore, was undertaken to determine the effect of MK-7 on the bone-resorbing factor-induced bone resorption using the femo...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Uchiyama S,Tsukamoto Y

更新日期：2003-03-01 00:00:00

abstract：:Lipoamidase is found to be able to release various membrane-anchored enzymes from the membrane compartment of pig brain. Released enzymes revealed their intact enzyme activities in the soluble fraction. Lipoamidase could release at least two types of anchored enzymes, i.e. glycosyl-phosphatidylinositol-bonded and myri...

journal_title：Molecular and cellular biochemistry

authors： Oizumi J,Hayakawa K

更新日期：1992-09-22 00:00:00

abstract：:Accumulating data support the idea that apoptosis in cardiac myocytes, in part, contributes to the development of heart failure. Since a number of neurohormonal factors are activated in this state, these factors may be involved in the positive and negative regulation of apoptosis in cardiac myocytes. Norepinephrine is...

journal_title：Molecular and cellular biochemistry

authors： Iwai-Kanai E,Hasegawa K

更新日期：2004-04-01 00:00:00

abstract：:Idiopathic pes equinovarus is a congenital deformity of the foot and lower leg defined as a fixation of the foot in adduction, supination, and varus. Although the pathogenesis of clubfoot remains unclear, it has been suggested that fibroblasts and growth factors are involved. To directly analyze the protein compositio...

journal_title：Molecular and cellular biochemistry

authors： Ošt'ádal M,Eckhardt A,Herget J,Mikšík I,Dungl P,Chomiak J,Frydrychová M,Burian M

更新日期：2015-03-01 00:00:00

abstract：:Changes in demands for Na+ transport alter expression of the Na+,K+ -ATPase subunit isoforms. In skeletal muscle, the effects of these changes on expression the alpha2 isoform, the major isoform expressed in differentiated muscle cell, is not known. Therefore, this study examines regulation of the alpha-subunit isofor...

journal_title：Molecular and cellular biochemistry

authors： Ladka R,Ng YC

更新日期：2000-08-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of various berry extracts, with and without clarithromycin on Helicobacter pylori. Resistance to clarithromycin by H. pylori has been reported, leading to interest in alternatives/adjuncts to therapy with clarithromycin. H. pylori American type culture collection...

journal_title：Molecular and cellular biochemistry

authors： Chatterjee A,Yasmin T,Bagchi D,Stohs SJ

更新日期：2004-10-01 00:00:00

abstract：:Sertoli and peritubular myoid cells, the somatic cells of the seminiferous tubule, support growth and differentiation of developing germ cells. This action strictly depends on the availability of in situ synthesized retinoic acid and we have previously documented the ability of Sertoli, but not peritubular cell extrac...

journal_title：Molecular and cellular biochemistry

authors： Cavazzini D,Catizone A,Galdieri M,Ottonello S

更新日期：2003-10-01 00:00:00

abstract：:The aim of this study was to elucidate the effects of natural vanadium-containing Jeju ground water on glucose uptake in L6 myotubes and adipogensesis in 3T3 L1 cells. The Jeju ground water samples containing vanadium components were designated as S1 (8.0 ± 0.9 μg/l), S2 (24.0 ± 2.0 μg/l), and S3 (26.0 ± 2.0 μg/l), re...

journal_title：Molecular and cellular biochemistry

authors： Hwang SL,Chang HW

更新日期：2012-01-01 00:00:00

abstract：:BTF3, initially discovered as a factor required for transcription inititation of RNA polymerase II, is expressed in two isoforms, termed a and b. BTF3b, the transcriptionally inactive isoform, was identified as an interaction partner of protein kinase CK2 subunit beta employing the interaction trap system for screenin...

journal_title：Molecular and cellular biochemistry

authors： Grein S,Pyerin W

更新日期：1999-01-01 00:00:00

abstract：:CDK11(p58), a G2/M-specific protein kinase, has been shown to be associated with apoptosis in many cell lines, with largely unknown mechanisms. Our previous study proved that CDK11(p58)-enhanced cycloheximide (CHX)-induced apoptosis in SMMC-7721 hepatocarcinoma cells. Here we report for the first time that ectopic exp...

journal_title：Molecular and cellular biochemistry

authors： Yun X,Wu Y,Yao L,Zong H,Hong Y,Jiang J,Yang J,Zhang Z,Gu J

更新日期：2007-10-01 00:00:00

abstract：:Doxorubicin (DOX) is a DNA topoisomerase II inhibitor widely used in anticancer treatment, however, it can lead to irreversible cardiac damage with severe debilitation. TBP-binding associated factor 1 (TAF1) is increased in DOX damaged hearts in vivo and in cardiomyocytes in vitro. To identify the functional role for ...

journal_title：Molecular and cellular biochemistry

authors： Servant N,Marcantonio D,Th'ng JP,Chalifour LE

更新日期：2004-04-01 00:00:00

abstract：:The effect of Aclacinomycin B (ACM-B), an anthracycline antitumor antibiotic, on the DNA-dependent RNA synthesis using single- and double-stranded DNAs of known base content and sequence is studied. The data show that ACM-B effectively inhibits the double-stranded DNA-directed RNA synthesis with a preference of poly[d...

journal_title：Molecular and cellular biochemistry

authors： Li LH,Yu FL

更新日期：1989-10-05 00:00:00

abstract：:Transforming Growth Factor-beta (TGF-beta) plays an essential role in differentiation of dental pulp cells into odontoblasts during reparative dentine formation. However, the mechanism by which TGF-beta stimulates dental repair remains rather obscure. Human dental pulp cells were used as an in vitro model in the prese...

journal_title：Molecular and cellular biochemistry

authors： Wang FM,Hu T,Tan H,Zhou XD

更新日期：2006-10-01 00:00:00

abstract：:1. Glucokinase is one of four glucose phosphorylating enzymes present in rat liver. Its distinctive features are a high K-m for glucose (high-K-m isozyme) and a rather narrow substrate specificity. In contrast, the other three enzymes, collectively called hexokinases or low-K-m isozymes, exhibit low K-m values for glu...

journal_title：Molecular and cellular biochemistry

authors： Niemeyer H,Ureta T,Clark-Turri L

更新日期：1975-02-28 00:00:00

abstract：:Retinal pigment epithelium (RPE) exerts critical roles in the maintenance of the normal functions of the retina, whereas RPE dysfunction can induce retina neovascularization. p75 neurotrophin receptor (p75(NTR)) has been shown to play essential roles in angiogenesis. However, the function of p75(NTR) in the RPE remain...

journal_title：Molecular and cellular biochemistry

authors： Zhang J,Zhao J,Bai Y,Huang L,Yu W,Li X

更新日期：2015-01-01 00:00:00

abstract：:The endocannabinoids (eCBs) are endogenous arachidonoyl-containing lipid mediators with important roles in host defense. Macrophages are first-line defenders of the innate immune system and biosynthesize large amounts of eCBs when activated. The cellular levels of eCBs are controlled by the activities of their biosynt...

journal_title：Molecular and cellular biochemistry

authors： Lee JH,Hou X,Kummari E,Borazjani A,Edelmann MJ,Ross MK

更新日期：2018-07-01 00:00:00

abstract：:Beta-arrestin-2 is an adaptor protein that terminates G protein activation and seems to be involved in the modulation of the inflammatory response. Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear f...

journal_title：Molecular and cellular biochemistry

authors： Campo GM,Avenoso A,D'Ascola A,Scuruchi M,Calatroni A,Campo S

更新日期：2015-01-01 00:00:00

abstract：:Bipolar disorder (BD) is a psychiatric disorder characterized by alternating episodes of mania and depression. The intracerebroventricular (i.c.v) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been used as an animal model of mania, because present face, construct and predictive validities. Seve...

journal_title：Molecular and cellular biochemistry

authors： Freitas TP,Rezin GT,Gonçalves CL,Jeremias GC,Gomes LM,Scaini G,Teodorak BP,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-08-01 00:00:00