CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.

abstract：:To examine the essential mechanisms of steroid production in ovarian theca cells, we analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid produ...

journal_title：Molecular and cellular biochemistry

authors： Murayama C,Miyazaki H,Miyamoto A,Shimizu T

更新日期：2008-07-01 00:00:00

abstract：:Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent. MTX-associated neurotoxicity is an important clinical problem. The aim of this study was to investigate the role of caffeic acid phenethyl ester (CAPE) on cerebellar oxidative stress induced by MTX in rats. A total of 19...

journal_title：Molecular and cellular biochemistry

authors： Uzar E,Koyuncuoglu HR,Uz E,Yilmaz HR,Kutluhan S,Kilbas S,Gultekin F

更新日期：2006-10-01 00:00:00

abstract：:Calcineurin inhibitors are used in immunosuppressive therapy applied after transplantation, but they are associated with major metabolic side effects including the development of new onset diabetes. Previously, we have shown that the calcineurin inhibiting drugs tacrolimus and cyclosporin A reduce adipocyte and myocyt...

journal_title：Molecular and cellular biochemistry

authors： Fonseca ACRG,Carvalho E,Eriksson JW,Pereira MJ

更新日期：2018-08-01 00:00:00

abstract：:Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acetylcholine, and calcium. NO availability is reduced in end-stage renal...

journal_title：Molecular and cellular biochemistry

authors： Di Pietro N,Giardinelli A,Sirolli V,Riganti C,Di Tomo P,Gazzano E,Di Silvestre S,Panknin C,Cortese-Krott MM,Csonka C,Kelm M,Ferdinandy P,Bonomini M,Pandolfi A

更新日期：2016-06-01 00:00:00

abstract：:Development and repair of the skeletal system and other organs are highly dependent on precise regulation of the bone morphogenetic protein (BMP) pathway. The use of BMPs clinically to induce bone formation has been limited in part by the requirement of much higher doses of recombinant proteins in primates than were n...

journal_title：Molecular and cellular biochemistry

authors： Sangadala S,Yoshioka K,Enyo Y,Liu Y,Titus L,Boden SD

更新日期：2014-01-01 00:00:00

abstract：:Effectiveness of selenium in different forms like sodium selenite, selenocysteine and selenomethionine has been compared in four different doses, namely 4, 6, 8 and 10 ppm of each, in terms of their bioavailability and prolongation of survival of Dalton's lymphoma (DL) bearing mice. Selenomethionine, at a dose of 8 pp...

journal_title：Molecular and cellular biochemistry

authors： Mukhopadhyay-Sardar S,Rana MP,Chatterjee M

更新日期：2000-03-01 00:00:00

abstract：:Satb2 is a special AT-rich binding transcription factor essential for osteoblast differentiation and bone formation. Specific microRNAs (miRNAs) have been identified to regulate the complex process of osteogenic differentiation. It remains unclear how miRNA expressions is changed in the Satb2-induced osteogenic differ...

journal_title：Molecular and cellular biochemistry

authors： Gong Y,Lu J,Yu X,Yu Y

更新日期：2016-06-01 00:00:00

abstract：:Saccharomyces cerevisiae contains vacuoles corresponding to lysosomes in higher eukaryotes. Lysosomes are dynamic (not silent) organelles in which enzymes can be easily integrated or released when exposed to stressful conditions. Changes in lysosomal enzymes have been observed due to oxidative stress, resulting in an ...

journal_title：Molecular and cellular biochemistry

authors： Yoon J,Sekhon SS,Kim YH,Min J

更新日期：2016-06-01 00:00:00

abstract：:Natural compounds with free-radical scavenging activity have potential role in maintaining human health and preventing diseases. In this study, we report the antioxidant and cytoprotective properties of 14-aminotetradecanoic acid (ATDA) isolated from the Decalepis hamiltonii roots. ATDA is a potent scavenger of supero...

journal_title：Molecular and cellular biochemistry

authors： Srivastava A,Rao LJ,Shivanandappa T

更新日期：2012-05-01 00:00:00

abstract：:Nitric oxide (NO) is a messenger molecule which regulates many physiological functions like immunity, vascular tone and serves as a neurotransmitter. Although it is known to participate in healing process, its role in collagen synthesis is not clear. Therefore, the present investigation was done to study the role of N...

journal_title：Molecular and cellular biochemistry

authors： Shukla A,Rasik AM,Shankar R

更新日期：1999-10-01 00:00:00

abstract：:The effects of different dietary fats on peritoneal macrophage plasma membrane fluidity, intracellular cyclic AMP (cAMP) production, GTP hydrolysis and TNF binding and TNF-induced IL1 and IL6 production was investigated. After a four week period, fluidity, as determined by both fluorescence recovery after photobleachi...

journal_title：Molecular and cellular biochemistry

authors： Tappia PS,Ladha S,Clark DC,Grimble RF

更新日期：1997-01-01 00:00:00

abstract：:This study investigated the anticancer effects of embelin in human gastric cancer cells and the underlying molecular mechanisms. Gastric cancer cells were treated with embelin and 5-FU for methyl-thiazolyl-tetrazolium bromide cell viability assay and flow cytometric detection of cell viability and apoptosis. Protein p...

journal_title：Molecular and cellular biochemistry

authors： Wang DG,Sun YB,Ye F,Li W,Kharbuja P,Gao L,Zhang DY,Suo J

更新日期：2014-01-01 00:00:00

abstract：:Ileal bile acid-binding protein (I-BABP) is a soluble bile acids (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. In the gut, its expression is strictly restricted to the ileum, where it is thought to be involved in the active BA reabsorption. Therefore, I-BABP gene expression levels...

journal_title：Molecular and cellular biochemistry

authors： Landrier JF,Grober J,Zaghini I,Besnard P

更新日期：2002-10-01 00:00:00

abstract：:delta-Crystallin is a major structural protein of avian and reptilian lenses that is absent from the lenses of fish, amphibia and mammals. It appears to be a tetrameric protein with a native molecular weight near 200 000 (200K) and polypeptide molecular weight near 50K and 48K) (see Note added in proof). The alpha-cry...

journal_title：Molecular and cellular biochemistry

authors： Piatigorsky J

更新日期：1984-01-01 00:00:00

abstract：:We have investigated how diabetes affects the expression of adropin (ADR) in rat brain, cerebellum, kidneys, heart, liver, and pancreas tissues. The rats in the diabetic group were administered an intraperitoneal (i.p.) injection of a single dose of 60 mg/kg streptozotocin (STZ) dissolved in a 0.1 M phosphate-citrate ...

journal_title：Molecular and cellular biochemistry

authors： Aydin S,Kuloglu T,Aydin S,Eren MN,Yilmaz M,Kalayci M,Sahin I,Kocaman N,Citil C,Kendir Y

更新日期：2013-08-01 00:00:00

abstract：:Murine erythroleukemia cell lines derived from Friend virus infected mice can be induced to differentiate in vitro by numerous agents. Among these compounds are certain naturally occurring purines such as hypoxanthine or 1-methylhypoxanthine. We have extended these studies to other modified oxypurines and have identif...

journal_title：Molecular and cellular biochemistry

authors： Kerr SJ

更新日期：1990-01-18 00:00:00

abstract：:The heptahelical lutropin receptor (LHR) signals primarily via the Gs-adenylyl cyclase pathway and undergoes ligand-mediated receptor desensitization and internalization. A loss-of-function rat LHR mutant was recently described in which a single amino acid residue replacement in exoloop 3, K583E, had no effect on huma...

journal_title：Molecular and cellular biochemistry

authors： Bhowmick N,Narayan P,Puett D

更新日期：1998-10-01 00:00:00

abstract：:Nickel compounds are carcinogenic and induce malignant transformation of cultured cells. Since nickel has low mutagenic potential, it may act predominantly through epigenetic mechanisms, including down-regulation of tumor suppressor genes. FHIT is a tumor suppressor gene whose expression is frequently reduced or lost ...

journal_title：Molecular and cellular biochemistry

authors： Kowara R,Salnikow K,Diwan BA,Bare RM,Waalkes MP,Kasprzak KS

更新日期：2004-01-01 00:00:00

abstract：:Failure in obtaining expression of functional adrenocorticotropic hormone receptor (ACTHR, or melanocortin 2 receptor, MC2R) in non-adrenal cells has hindered molecular analysis of ACTH signaling pathways. Here, we ectopically expressed the mouse ACTHR in Balb/c mouse 3T3 fibroblasts to analyze ACTH signaling pathways...

journal_title：Molecular and cellular biochemistry

authors： Forti FL,Dias MH,Armelin HA

更新日期：2006-12-01 00:00:00

abstract：:p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. We investigated the role of p90RSK in lung adenocarcinomas and whether the inhibition of p90RSK...

journal_title：Molecular and cellular biochemistry

authors： Abdulrahman N,Jaballah M,Poomakkoth N,Riaz S,Abdelaziz S,Issa A,Mraiche F

更新日期：2016-07-01 00:00:00

abstract：:Using rat liver mitochondria, as model systems, we have examined the ability of the natural compound and the food-flavoring agent, vanillin to protect membranes against oxidative damage induced by photosensitization at concentrations normally used in food preparations. Vanillin, at a concentration of 2.5 mmol/L, has a...

journal_title：Molecular and cellular biochemistry

authors： Kamat JP,Ghosh A,Devasagayam TP

更新日期：2000-06-01 00:00:00

abstract：:Clinically significant occlusive vascular lesions contain more extracellular matrix (ECM) proteins and lipid deposition than healthy vascular tissue. The events leading to this condition remain unresolved. One possibility is that ECM deposition may exceed ECM degradation which would contribute to the expansion of the ...

journal_title：Molecular and cellular biochemistry

authors： Wilson D,Massaeli H,Russell JC,Pierce GN,Zahradka P

更新日期：2003-07-01 00:00:00

abstract：:Prion protein (PrP) interacts with some kringle domain-containing proteins. Kringle domains serve as binding domains in the interaction with PrP. The structural conservation among kringle domains leads to the hypothesis that any protein containing these domains can interact with PrP and be involved in prion pathogenes...

journal_title：Molecular and cellular biochemistry

authors： Kim Y,Song J,Mays CE,Titlow W,Yoon D,Ryou C

更新日期：2009-08-01 00:00:00

abstract：:Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesising and releasing the vasoactive autacoids nitric oxide (NO) and prostacyclin (PGI2). The fluid shear stress ex...

journal_title：Molecular and cellular biochemistry

authors： Fleming I,Bauersachs J,Busse R

更新日期：1996-04-12 00:00:00

abstract：:The aim of the present investigation was to study the regulation of apolipoprotein E by two dietary nutrients, saturated fat and cholesterol, known to raise plasma cholesterol levels. ApoE is a protein component of several classes of lipoproteins including VLDL and HDL, and dietary lipids may regulate VLDL and apoE-co...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RA

更新日期：1996-02-23 00:00:00

abstract：:The tRNA modifying enzyme, S-adenosylmethionine:tRNA(guanine-7-)-methyltransferase, has been extensively purified from Salmonella typhimurium. A rapid and efficient purification method using phosphocellulose chromatography followed by ammonium sulfate precipitation and Sephadex G-100 gel filtration is described. The e...

journal_title：Molecular and cellular biochemistry

authors： Colonna A,Ciliberto G,Santamaria R,Cimino F,Salvatore F

更新日期：1983-01-01 00:00:00

abstract：:Stress genes can be ascribed to have been generated by the organism for their intrinsic urge to survive against the changing environmental odds, during the evolutionary process. This concept has been supported by a large number of reports describing individual types of phenomena. These have been reconciled and globali...

journal_title：Molecular and cellular biochemistry

authors： Ray PK

更新日期：1999-06-01 00:00:00

abstract：:The development and growth of the prostate gland depends on androgen stimulation. Dihydrotestosterone (DHT) is the primary androgen responsible for prostate development and also for the pathogenesis of benign prostatic hyperplasia (BPH). The incidence of prostate cancer (PCa) and benign prostatic hypertrophy (BPH) con...

journal_title：Molecular and cellular biochemistry

authors： Torres JM,Gómez-Capilla JA,Ruiz E,Ortega E

更新日期：2003-08-01 00:00:00

abstract：:N-Methyl-N-nitrosourea (MNU)-induced rat mammary adenocarcinomas contain high levels of a novel leupeptin-sensitive serine endopeptidase. Its properties apparently differ from those of other similar endopeptidases reported to be present in various normal and malignant mammalian tissues. The same leupeptinsensitive ser...

journal_title：Molecular and cellular biochemistry

authors： Eto I,Bandy MD

更新日期：1990-04-18 00:00:00

abstract：:Cervical cancer remains the second leading cause of gynecologic cancer-related mortality among women worldwide. STING (stimulator of interferon genes) was reported to be involved in the immune surveillance of tumors. However, the specific role of STING in cervical cancer remains unclear. In this study, we found that t...

journal_title：Molecular and cellular biochemistry

authors： Shi F,Su J,Wang J,Liu Z,Wang T

更新日期：2020-11-03 00:00:00