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The effect of L-NAME administrations after oral mucosal incision on wound NO level in rabbit.

Abstract：

:The aim of the current study was to comparatively investigate the effect of inhibition of nitric oxide (NO) production by N-nitro-L-arginine methyl ester (L-NAME), an isoform non-specific inhibitor of nitric oxide synthase (NOS), after oral mucosal incision on wound tissue NO levels. A standard incision was applied to the oral mucosa of rabbits. After oral mucosal incision, rabbits were divided into five groups as follows: (1) Untreated incisional group (control); (2) Titanium (Ti) implanted group; (3) Ti + Polyethylene glycol (PEG) 4000 implanted group; (4) Ti + PEG 4000 + L-NAME (2 x 10(-4) M) implanted group and (5) i.p. L-NAME administrated group (10 mg/kg). At 5 days after oral incision operations, wound tissue strips and plasma were obtained from rabbits. Oral wound tissue and plasma nitric oxide, plasma thiobarbituric acid reactive substances (TBARS) and total sulfhydryl group (RSH) levels were investigated. Plasma TBARS and NOx levels decreased after i.p. L-NAME administration. Total RSH group levels were not changed in all groups (p>0.05). This means that L-NAME inhibits the deteriorating effects of free radicals without affecting healing. L-NAME in PEG and titanium also has no effect on tissue and plasma NOx levels. These findings indicate that NO generation will not be affected both Ti and local nitric oxide synthase (NOS) inhibitor.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Coşkun S,Karataş F,Acartürk F,Olmuş H,Selvi M,Erbaş D

doi

10.1007/s11010-005-6628-6

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

65-9

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

278

pub_type

杂志文章

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