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Vaspin protects mouse mesenchymal stem cells from oxidative stress-induced apoptosis through the MAPK/p38 pathway.

Abstract：

:The aim of the work was to study the influence of vaspin on oxidative stress-induced apoptosis of mouse mesenchymal stem cells (MSCs). MSCs originated from bone marrow of C57BL/6 mouse were treated with vaspin and/or H2O2 in a dose-dependent manner. Cellular viability detected by CCK-8 and cell apoptosis studied by flow cytometry and TUNEL assay were observed in these cells. The protein expressions of PI3K, p-PI3K, Akt, p-Akt, T-ERK1/2, p-ERK1/2, p38, p-p38, JNK, and p-JNK were tested by Western blot. Vaspin had no significant effect on cellular viability, but significantly reduced H2O2-induced apoptosis. Western blot assay showed that pretreatment with vaspin promoted the activation of p-p38. Inhibition of p38 by SB203580 suppressed the protective effect of vaspin on oxidative stress-induced apoptosis. Vaspin inhibits oxidative stress-induced apoptosis of MSCs via the activation of MAPK/p38 signaling pathway. These findings indicate that vaspin is prone to osteoporosis protection.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Zhu X,Zhang L,Chen Y,Chen B,Huang H,Lv J,Hu S,Shen J

doi

10.1007/s11010-019-03614-8

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

107-114

issue

1-2

eissn

0300-8177

issn

1573-4919

pii

10.1007/s11010-019-03614-8

journal_volume

462

pub_type

杂志文章

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