Comparative studies on human and bovine nasal cartilage proteoglycan complex components.

abstract：:In this study, the effect of (Boc-Lys (Boc)-Arg-Asp-Ser (tBu)-OtBu), a tetrapeptide derivative (PEP1261) was examined for antiproliferative potency and apoptotic induction. Synovial fibroblasts were isolated from collagen-induced arthritic (CIA) rats and exposed to peptides viz., PEP1261, and parental peptides (KRDS a...

journal_title：Molecular and cellular biochemistry

authors： Kumar DA,Settu K,Raju KV,Kumanan K,Manohar BM,Puvanakrishnan R

更新日期：2006-01-01 00:00:00

abstract：:Partially purified D-aspartate oxidase from beef kidney has been tested in the presence of butanedione or phenylglyoxal, which specifically modify the arginine molecule. The results obtained clearly indicate that arginine residues are involved in the binding of the substrate to the active site of the enzyme. ...

journal_title：Molecular and cellular biochemistry

authors： Crifò C,Santoro L,Rinaldi A,De Marco C

更新日期：1977-08-19 00:00:00

abstract：:The role of glycogen content in the heart for the development of isoprenaline-induced myocardial lesions (IML) was studied in Wistar rats and in two inbred rat strains: In IR rats (resistant to the development of IML) and in IS rats (sensitive to IML development). Glycogen content in the heart can be dramatically lowe...

journal_title：Molecular and cellular biochemistry

authors： Mráz M,Hynie S

更新日期：1996-10-01 00:00:00

abstract：:Cultured human and rat endothelial cells were used to study cellular toxicity and Ca2+ signalling upon exposure to reactive oxygen species. Superoxide and hydrogen peroxide (O2.-/H2O2) were produced by the hypoxanthine/xanthine oxidase system (HX/XO) and caused intracellular Ca2+ concentration ([Ca2+]i) to rise steadi...

journal_title：Molecular and cellular biochemistry

authors： Volk T,Hensel M,Kox WJ

更新日期：1997-06-01 00:00:00

abstract：:Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models. Their receptor is the Na+,K+ ATPase, but other plasma membrane proteins might bind CGs as well. Herein, we evaluated the short- and long-lasting cytotoxic effects o...

journal_title：Molecular and cellular biochemistry

authors： Schneider NFZ,Menegaz D,Dagostin ALA,Persich L,Rocha SC,Ramos ACP,Cortes VF,Fontes CFL,de Pádua RM,Munkert J,Kreis W,Braga FC,Barbosa LA,Silva FRMB,Simões CMO

更新日期：2021-01-18 00:00:00

abstract：:ANRIL is a long noncoding RNA transcribed from the INK4 locus that encodes three tumor suppressor genes, p15, p16, and ARF. Previous studies demonstrated that ANRIL represses p15 and p16, which positively regulate the pRB pathway, leading to repression of cellular senescence of human normal fibroblasts. However, the r...

journal_title：Molecular and cellular biochemistry

authors： Naemura M,Tsunoda T,Inoue Y,Okamoto H,Shirasawa S,Kotake Y

更新日期：2016-01-01 00:00:00

abstract：:Pig intestinal brush borders (BB) were radiolabeled by iodination using the lactoperoxidase-hydrogen peroxide procedure. The BB were then detergent solubilized, centrifuged to remove particulate material, and chromatographed on Sepharose CL-4B. The fractions were incubated with K88+ E. coli using an in vitro binding a...

journal_title：Molecular and cellular biochemistry

authors： Staley TE,Wilson IB

更新日期：1983-01-01 00:00:00

abstract：:A noncholinergic nicotine receptor on human phagocytic leukocytes has been characterized using the binding of 3H-(d,1)-nicotine. The average affinity +/- standard deviation of (d,1)-nicotine for the receptor on neutrophils is 36 +/- 18 nM (n = 6). The binding is saturable with an average of 8.7 x 10(4) sites per neutr...

journal_title：Molecular and cellular biochemistry

authors： Davies BD,Hoss W,Lin JP,Lionetti F

更新日期：1982-04-16 00:00:00

abstract：:The effect of peritoneal dialysis (PD) with high-glucose dialysis fluid on the VEGF family, tristetraprolin (TTP), angiogenesis and lymphangiogenesis was investigated. Forty male SD rats were randomised into five groups: normal group, sham operation group, uraemia group, PD 2-week group and PD4-week group. After 4 wee...

journal_title：Molecular and cellular biochemistry

authors： Xiao J,Gao H,Jin Y,Zhao Z,Guo J,Liu Z,Zhao Z

更新日期：2014-07-01 00:00:00

abstract：:Endothelial cell nitric oxide synthase (NOS) is known to have a N-myristoylation consensus sequence. Such a consensus sequence is not evident in the macrophage, smooth muscle and neuronal NOS. A functional role for this N-terminal myristoylation is not clear yet. In the present study, we examined the effect of N-termi...

journal_title：Molecular and cellular biochemistry

authors： Sakoda T,Hirata K,Kuroda R,Miki N,Suematsu M,Kawashima S,Yokoyama M

更新日期：1995-11-22 00:00:00

abstract：:Kawasaki disease is an immune-mediated acute, systemic vasculitis and is the leading cause of acquired heart disease in children in the developed world. Bifidobacterium (BIF) is one of the dominant bacteria in the intestines of humans and many mammals and is able to adjust the intestinal flora disorder. The Caco-2 cel...

journal_title：Molecular and cellular biochemistry

authors： Nie N,Bai C,Song S,Zhang Y,Wang B,Li Z

更新日期：2020-01-01 00:00:00

abstract：:The heptahelical lutropin receptor (LHR) signals primarily via the Gs-adenylyl cyclase pathway and undergoes ligand-mediated receptor desensitization and internalization. A loss-of-function rat LHR mutant was recently described in which a single amino acid residue replacement in exoloop 3, K583E, had no effect on huma...

journal_title：Molecular and cellular biochemistry

authors： Bhowmick N,Narayan P,Puett D

更新日期：1998-10-01 00:00:00

abstract：:The aim of this study was to screen for differential expression of signaling pathways in odontogenic differentiation of ectomesenchymal cells isolated from the first branchial arch of embryonic day 10 (E10) mice by real time RT-PCR microarray. Observations of cellular morphology, immunocytochemistry, and RT-PCR were u...

journal_title：Molecular and cellular biochemistry

authors： Yu Y,Li M,Sun J,Yang M,Long J,Tian W,Tang W,Li T,Liu L

更新日期：2011-05-01 00:00:00

abstract：:Guanidino compounds of guanidinoethanesulfonic acid, guanidinoacetic acid, guanidinosuccinic acid, N-acetylarginine, beta-guanidinopropionic acid, creatinine, gamma-guanidinobutyric acid, arginine, guanidine, methylguanidine, homoarginine and alpha-guanidinoglutaric acid are present in the mammalian brain. These guani...

journal_title：Molecular and cellular biochemistry

authors： Hiramatsu M

更新日期：2003-02-01 00:00:00

abstract：:The sarcoplasmic reticulum (SR) plays a critical role in mediating cardiac contractility and its function is abnormal in the diabetic heart. However, the mechanisms underlying SR dysfunction in the diabetic heart are not clear. Because protein phosphorylation regulates SR function, this study examined the phosphorylat...

journal_title：Molecular and cellular biochemistry

authors： Vasanji Z,Dhalla NS,Netticadan T

更新日期：2004-06-01 00:00:00

abstract：:The human breast cancer cell line MCF7 does not express heart-type fatty acid binding protein (H-FABP), a marker protein for differentiated mammary gland. MCF7 cells transfected with the bovine H-FABP cDNA expressed the corresponding protein and were characterized by growth inhibition and lower tumorgenicity in nude m...

journal_title：Molecular and cellular biochemistry

authors： Buhlmann C,Börchers T,Pollak M,Spener F

更新日期：1999-09-01 00:00:00

abstract：:Transportin3 (TNPO3) shuttles the SR proteins from the cytoplasm to the nucleus. The SR family includes essential splicing factors, such as SRSF1, that influence alternative splicing, controlling protein diversity in muscle and satellite cell differentiation. Given the importance of alternative splicing in the myogeni...

journal_title：Molecular and cellular biochemistry

authors： Costa R,Rodia MT,Zini N,Pegoraro V,Marozzo R,Capanni C,Angelini C,Lattanzi G,Santi S,Cenacchi G

更新日期：2021-01-15 00:00:00

abstract：:Myostatin belongs to the Transforming Growth Factor-beta (TGF-beta) superfamily and is expressed in developing and mature skeletal muscle. Biologically, the role of myostatin seems to be extremely well conserved during evolution since inactivating mutations in myostatin gene cause similar phenotype of heavy muscling i...

journal_title：Molecular and cellular biochemistry

authors： Jeanplong F,Sharma M,Somers WG,Bass JJ,Kambadur R

更新日期：2001-04-01 00:00:00

abstract：:Various factors appear to control muscle energetics, often in conjunction. This calls for a quantitative approach of the type provided by Metabolic Control Analysis for intermediary metabolism and mitochondrial oxidative phosphorylation. To the extent that direct transfer of high energy phosphates and spatial organiza...

journal_title：Molecular and cellular biochemistry

authors： Kholodenko BN,Cascante M,Westerhoff HV

更新日期：1995-02-23 00:00:00

abstract：:The aim of our work was to study (1) the antioxidant properties of lipoic acid (LA) and its reduced metabolite dihydrolipoic acid (DHLA) formed by reduction of LA and (2) the effects of treatment with LA and DHLA on (a) K(+) efflux from human red blood cells and (b) post-ischemic recovery and oxidative stress in isola...

journal_title：Molecular and cellular biochemistry

authors： Ghibu S,Lauzier B,Delemasure S,Amoureux S,Sicard P,Vergely C,Muresan A,Mogosan C,Rochette L

更新日期：2009-01-01 00:00:00

abstract：:Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet destruction severely affects the normal functioning of thrombosis and hemostasis. In addition, frequent exposure of platelets to chemical entities and therapeutic drugs ...

journal_title：Molecular and cellular biochemistry

authors： Jagadish S,Rajeev N,NaveenKumar SK,Sharath Kumar KS,Paul M,Hegde M,Basappa,Sadashiva MP,Girish KS,Rangappa KS

更新日期：2016-03-01 00:00:00

abstract：:The angiotensin converting enzyme (ACE) is a key factor in the production of angiotensin II and in the degradation of bradykinin. Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis. Factor VII (FACTOR VII) is the first enzyme in the extrinsic pathwa...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Maithil N,Thakur H,Sharma Y,Talwar KK

更新日期：2010-08-01 00:00:00

abstract：:As a m6A methylation modifier, METTL3 is functionally involved in various biological processes. Nevertheless, the role of METTL3 in osteogenesis is not determined up to date. In the current study, METTL3 is identified as a crucial regulator in the progression of osteogenic differentiation. Loss of METTL3 significantly...

journal_title：Molecular and cellular biochemistry

authors： Yu J,Shen L,Liu Y,Ming H,Zhu X,Chu M,Lin J

更新日期：2020-01-01 00:00:00

abstract：:In this study, indirect immunofluorescence labeling was used to examine the cellular dynamic distribution of Thr11 phosphorylated H3 at mitosis in MCF-7 cells. The Thr11 phosphorylation was observed beginning at prophase at centromeres. Upon progression of mitosis, fluorescence signal was enhanced in the central regio...

journal_title：Molecular and cellular biochemistry

authors： Zhou H,Li D,Song L,Liu R,Chen J,Huang X

更新日期：2008-04-01 00:00:00

abstract：:delta-Crystallin is a major structural protein of avian and reptilian lenses that is absent from the lenses of fish, amphibia and mammals. It appears to be a tetrameric protein with a native molecular weight near 200 000 (200K) and polypeptide molecular weight near 50K and 48K) (see Note added in proof). The alpha-cry...

journal_title：Molecular and cellular biochemistry

authors： Piatigorsky J

更新日期：1984-01-01 00:00:00

abstract：:In mammals, protein kinase CK2 has two isozymic forms of its catalytic subunit, designated CK2alpha and CK2alpha'. CK2alpha and CK2alpha' exhibit extensive similarity within their catalytic domains but have completely unrelated C-terminal sequences. To systematically examine the cellular functions of each CK2 isoform ...

journal_title：Molecular and cellular biochemistry

authors： Litchfield DW,Bosc DG,Canton DA,Saulnier RB,Vilk G,Zhang C

更新日期：2001-11-01 00:00:00

abstract：:With structural similarity but functional diversity, Smad2 and Smad3 interact with each other to mediate transforming growth factor-β (TGF-β)-triggered signaling transduction. However, in the hepatic fibrosis, the detailed roles of R-Smads, and interaction between Smad2 and Smad3 are still undefined. In this setting, ...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Liu C,Meng XM,Huang C,Xu F,Li J

更新日期：2015-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-...

journal_title：Molecular and cellular biochemistry

authors： Xie L,Qian X,Liu B

更新日期：2010-08-01 00:00:00

abstract：:There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels i...

journal_title：Molecular and cellular biochemistry

authors： Soundararajan A,Prabu P,Mohan V,Gibert Y,Balasubramanyam M

更新日期：2019-08-01 00:00:00

abstract：:The underlying molecular mechanism of carcinogenesis in oral squamous cell carcinoma (OSCC) is poorly understood and appears to be controlled on many genetic, environmental, and hormonal factors. Obestatin and ghrelin, two recently discovered hormones, are co-expressed in endocrine cells. The purpose of this investiga...

journal_title：Molecular and cellular biochemistry

authors： Alnema MM,Aydin S,Ozkan Y,Dagli AF,Ozercan HI,Yildirim N,Sahin I,Karaoglu A,Kilic N,Yilmaz M,Ozercan MR,Donder E

更新日期：2010-06-01 00:00:00