Silencing of Y-box binding protein-1 by RNA interference inhibits proliferation, invasion, and metastasis, and enhances sensitivity to cisplatin through NF-κB signaling pathway in human neuroblastoma SH-SY5Y cells.

abstract：:Cofilin is an actin-binding protein of low molecular weight which is widely distributed in eukaryotes and is deeply involved in the dynamics of actin assembly in the cytoplasm. The actin-binding ability of cofilin is inhibited by inositol phosphates (PIP2), and the PIP2- and actin-binding site(s) has been localized in...

journal_title：Molecular and cellular biochemistry

authors： Kusano K,Abe H,Obinata T

更新日期：1999-01-01 00:00:00

abstract：:Cyclophosphamide (CP), an alkylating agent widely used in cancer chemotherapy causes cardiac membrane damage. Lupeol, a pentacyclic triterpene, isolated from Crataeva nurvala stem bark and its ester, lupeol linoleate possess a wide range of medicinal properties. The effect of lupeol and its ester was evaluated in CP i...

journal_title：Molecular and cellular biochemistry

authors： Sudharsan PT,Mythili Y,Selvakumar E,Varalakshmi P

更新日期：2006-11-01 00:00:00

abstract：:The present study was addressed to understand the interrelationship between Receptor-Ck activation, mevalonate pathway and primary response genes such as c-fos, c-myc and cyclin 'D' involved in the cell cycle. The results reported here unambiguously revealed that the phosphatidic acid (generated through the activation...

journal_title：Molecular and cellular biochemistry

authors： Kaur M,Kaul D,Sobti RC

更新日期：1998-04-01 00:00:00

abstract：:The phosphorylation of rat cardiac microsomal proteins was investigated with special attention to the effects of okadaic acid (an inhibitor of protein phosphatases), inhibitor 2 of protein phosphatase 1 and inhibitor of cyclic AMP-dependent protein kinase (protein kinase A). The results showed that okadaic acid (5 mic...

journal_title：Molecular and cellular biochemistry

authors： Sulakhe PV,Vo XT,Morris TE,Pato MD,Khandelwal RL

更新日期：1997-10-01 00:00:00

abstract：:To understand the hypocholesterolemic activity of green tea, our in vitro studies screened the relative efficacy of two structurally distinct green tea catechins, epicatechin (EC) and epigallocatechin gallate (EGCG), on apolipoprotein B-100 (apoB) and lipid production using a well established human hepatoma cell-line,...

journal_title：Molecular and cellular biochemistry

authors： Yee WL,Wang Q,Agdinaoay T,Dang K,Chang H,Grandinetti A,Franke AA,Theriault A

更新日期：2002-01-01 00:00:00

abstract：:Transportin3 (TNPO3) shuttles the SR proteins from the cytoplasm to the nucleus. The SR family includes essential splicing factors, such as SRSF1, that influence alternative splicing, controlling protein diversity in muscle and satellite cell differentiation. Given the importance of alternative splicing in the myogeni...

journal_title：Molecular and cellular biochemistry

authors： Costa R,Rodia MT,Zini N,Pegoraro V,Marozzo R,Capanni C,Angelini C,Lattanzi G,Santi S,Cenacchi G

更新日期：2021-01-15 00:00:00

abstract：:A comparative study has been carried out on the micro-localization of catalase in mouse tissues subsequent to treatment with a representative range of hypolipidemic drugs. A commonality of effect was shown by clofibrate (ethyl-alpha-p-chlorophenoxyisobutyrate), Wy-14,643 (4-chloro-6-[2,3 xylidino)-2-pyrimidinylthio] a...

journal_title：Molecular and cellular biochemistry

authors： Klucis E,Crane D,Masters C

更新日期：1984-11-01 00:00:00

abstract：:Under synchronized conditions daily rhythms run in precise phase relationships. Long lasting shift-work disturbs circadian rhythms and causes metabolism dysfunction. As a result of frequent shifts of the light (L):dark (D) cycle the circadian system has to adjust to a new regimen repeatedly, and organism can never ach...

journal_title：Molecular and cellular biochemistry

authors： Szántóová K,Zeman M,Veselá A,Herichová I

更新日期：2011-02-01 00:00:00

abstract：:The incorporation of radiolabeled arachidonic acid (3[H]-AA) in normoxic cardiomyocytes (MC), cardiac endothelial cells (EC) and fibroblast-like cells (FL) isolated from adult rat heart was studied. Deposition of 3[H]-AA in the cellular lipid pool was assessed with biochemical and autoradiographic techniques. Extracti...

journal_title：Molecular and cellular biochemistry

authors： Linssen MC,Willemsen PH,Heijnen VV,van der Vusse GJ

更新日期：1992-10-21 00:00:00

abstract：:Understanding transmembrane signalling process is one of the major challenge of the decade. In most tissues, since Fisher and Krebs's discovery in the 1950's, protein phosphorylation has been widely recognized as a key event of this cellular function. Indeed, binding of hormones or neurotransmitters to specific membra...

journal_title：Molecular and cellular biochemistry

authors： Pucéat M,Vassort G

更新日期：1996-04-12 00:00:00

abstract：:Knowledge of transcription and translation has advanced our understanding of cardiac diseases. Here, we present the hypothesis that the stability of mRNA mediated by the 3'-untranslated region (3'-UTR) plays a role in changing gene expression in cardiovascular pathophysiology. Several proteins that bind to sequences i...

journal_title：Molecular and cellular biochemistry

authors： Misquitta CM,Iyer VR,Werstiuk ES,Grover AK

更新日期：2001-08-01 00:00:00

abstract：:Glutathione acts as a protein disulphide reductant, which detoxifies herbicides by conjugation, either spontaneously or by the activity of one of a number of glutathione-S-transferases (GSTs), and regulates gene expression in response to environmental stress and pathogen attack. GSTs play roles in both normal cellular...

journal_title：Molecular and cellular biochemistry

authors： Banerjee S,Goswami R

更新日期：2010-03-01 00:00:00

abstract：:Cysteine-rich secretory protein 3 (CRISP-3) is upregulated in prostate cancer as compared to the normal prostate tissue. Higher expression of CRISP-3 has been linked to poor prognosis and hence it has been thought to act as a prognostic marker for prostate cancer. It is proposed to have a role in innate immunity but i...

journal_title：Molecular and cellular biochemistry

authors： Pathak BR,Breed AA,Apte S,Acharya K,Mahale SD

更新日期：2016-01-01 00:00:00

abstract：:Cardiac muscle-related microRNAs play important roles in cardiac development and disease by translational silencing of mRNAs, the dominant mechanism of microRNA action. To test whether they could be involved in daunorubicin-associated cardiomyopathy (DACM), we determined expression patterns of myomiRs in two distinct ...

journal_title：Molecular and cellular biochemistry

authors： Doka G,Malikova E,Galkova K,La Rocca G,Kruzliak P,Adamek M,Rodrigo L,Krenek P,Klimas J

更新日期：2017-08-01 00:00:00

abstract：:The pathophysiologic importance of insulin resistance in diseases such as obesity and diabetes mellitus has led to great interest in defining the mechanism of insulin action as well as the means to overcome the biochemical defects responsible for the resistance. Vanadium compounds have been discovered to mimic many of...

journal_title：Molecular and cellular biochemistry

authors： Fantus IG,Tsiani E

更新日期：1998-05-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) responds to a variety of oxidative stresses. We examined whether HO-1 expression influences pro-thrombotic processes, in which the involvement of oxidative stress has been reported. Since HO-1 knockout mice with a C57/BL6J background were not viable, embryonic cells from HO-1 deficient mice (E1...

journal_title：Molecular and cellular biochemistry

authors： Matsumoto H,Ishikawa K,Itabe H,Maruyama Y

更新日期：2006-10-01 00:00:00

abstract：:Plants in the form of food or other remedial forms have been used for the treatment of various human ailments. Diabetes is one such disorder in which various form of plants and herbal remedies have been tried. Brassicajuncea (BJ) seeds (Rai) are consumed in India as a spice in various food items. Previous studies have...

journal_title：Molecular and cellular biochemistry

authors： Grover JK,Yadav S,Vats V

更新日期：2002-12-01 00:00:00

abstract：:Histone H1 of rat alveolar macrophages, neutrophilic granulocytes and monocytes extracted with 5% (v/v) perchloric acid was studied in order to see whether a protein similar to histone H1 degrees of rat liver exists in these specialized cells. The biochemical methods used involved SDS and acid-urea polyacrylamide gel ...

journal_title：Molecular and cellular biochemistry

authors： Ghadam P,Rabbani A

更新日期：2002-07-01 00:00:00

abstract：:The aim of this study was to investigate the effects of oxidative stress on PLD activity, [Ca2+]i and pHi levels and the possible relationship among them. Moreover, since atrial natriuretic peptide (ANP) protects against oxidant-induced injury, we investigated the potential protective role of the hormone in rat aortic...

journal_title：Molecular and cellular biochemistry

authors： De Vito P,Di Nardo P,Palmery M,Peluso I,Luly P,Baldini PM

更新日期：2003-10-01 00:00:00

abstract：:Thymoquinone (TQ) is a highly perspective chemotherapeutic agent against gliomas and glioblastomas because of its ability to cross the blood-brain barrier and its selective cytotoxicity for glioblastoma cells compared to primary astrocytes. Here, we tested the hypothesis that TQ-induced mild oxidative stress provokes ...

journal_title：Molecular and cellular biochemistry

authors： Krylova NG,Drobysh MS,Semenkova GN,Kulahava TA,Pinchuk SV,Shadyro OI

更新日期：2019-12-01 00:00:00

abstract：:Five isoforms of CK2 may exist simultaneously in yeast cells: free catalytic subunits CK2α', CK2α and three holoenzymatic structures composed of αα'ββ', α(2)ββ' and α'(2)ββ'. Each isolated and purified form exhibits properties typical for CK2, but they differ in substrate specificity as well as in sensitivity to speci...

journal_title：Molecular and cellular biochemistry

authors： Janeczko M,Masłyk M,Szyszka R,Baier A

更新日期：2011-10-01 00:00:00

abstract：:Migration and invasion are important characteristics of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), which are involved in joint damage and contribute to rheumatoid arthritis (RA) pathology. However, the underlying mechanisms remain unclear. Because epithelial-mesenchymal transition (EMT) is a key mech...

journal_title：Molecular and cellular biochemistry

authors： Zhu D,Zhao J,Lou A,Huang Q,OuYang Q,Zhu J,Fan M,He Y,Ren H,Yang M

更新日期：2019-09-01 00:00:00

abstract：:Previous studies in isolated perfused heart and in atrial preparations have demonstrated significant reductions in beating rate in STZ-induced diabetic rats, which suggests that sinus arrhythmias in diabetes mellitus may be partly caused by intrinsic alteration of sino-atrial node (SAN) function. The effects of diabet...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Nowotny N,Zilahi E,El Haj MA,Lei M

更新日期：2007-11-01 00:00:00

abstract：:MicroRNAs (miRNAs, miRs) play important roles in pathogenesis and development of human diseases, including malignancy. Some may affect tumor progression through targeting tumor suppressor genes. MiR-135b has been shown to be upregulated in CRC. In this study, we evaluated the role of miR-135b in colorectal cancer (CRC...

journal_title：Molecular and cellular biochemistry

authors： Wu W,Wang Z,Yang P,Yang J,Liang J,Chen Y,Wang H,Wei G,Ye S,Zhou Y

更新日期：2014-03-01 00:00:00

abstract：:Long-chain fatty acids (e.g. arachidonic acid) have been implicated in physiological control of insulin secretion. We previously reported histidine phosphorylation of at least two islet proteins (e.g., NDP kinase and the beta subunit of trimeric G-proteins), and suggested that such a signalling step may have regulator...

journal_title：Molecular and cellular biochemistry

authors： Kowluru A

更新日期：2004-11-01 00:00:00

abstract：:The present study was aimed to investigate the protective effects of 17β-estradiol (E2) and estrogen receptor α (ERα) on isoproterenol (ISO)-treated H9c2 cardiomyoblast cells. In the present study, we treated H9c2 cells with ISO, a β-adrenergic receptor agonist, to induce myocardiac hypertrophy. Pre-administration of ...

journal_title：Molecular and cellular biochemistry

authors： Pai P,Velmurugan BK,Kuo CH,Yen CY,Ho TJ,Lin YM,Chen YF,Lai CH,Day CH,Huang CY

更新日期：2017-10-01 00:00:00

abstract：:Studies presented here show that cellular NAD, which we hypothesize to be the relevant biomarker of niacin status, is significantly lower in humans than in the commonly studied animal models of carcinogenesis. We show that nicotinamide and the resulting cellular NAD concentration modulate expression of the tumor suppr...

journal_title：Molecular and cellular biochemistry

authors： Jacobson EL,Shieh WM,Huang AC

更新日期：1999-03-01 00:00:00

abstract：:Full-length hexokinase (HK; ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1), a truncate form of the enzyme lacking the first 11 amino acids (HK-11aa) and the 50 kDa C-terminal half ('mini'-HK) containing the catalytic domain, were overexpressed and purified to homogeneity to investigate the influence of the N-terminal...

journal_title：Molecular and cellular biochemistry

authors： Bianchi M,Serafini G,Bartolucci E,Giammarini C,Magnani M

更新日期：1998-12-01 00:00:00

abstract：:To explore the effect of LYRM1 over-expression on basal and insulin-stimulated glucose uptake in rat skeletal muscle cells, and to understand the underlying mechanisms, Rat myoblasts (L6) transfected with either an empty expression vector (pcDNA3.1Myc/His B) or a LYRM1 expression vector were differentiated into myotub...

journal_title：Molecular and cellular biochemistry

authors： Kou C,Cao X,Qin D,Ji C,Zhu J,Zhang C,Zhu C,Gao C,Chen R,Guo X,Zhang M

更新日期：2011-02-01 00:00:00

abstract：:It has been established that diabetes results in a cardiomyopathy, and increasing evidence suggests that an altered substrate supply and utilization by cardiac myocytes could be the primary injury in the pathogenesis of this specific heart muscle disease. For example, in diabetes, glucose utilization is insignificant,...

journal_title：Molecular and cellular biochemistry

authors： Rodrigues B,Cam MC,McNeill JH

更新日期：1998-03-01 00:00:00