Calcium homeostasis and dichlorvos induced neurotoxicity in rat brain.


:The present study was designed to investigate the possible effects of chronic dichlorvos exposure on the various aspects of calcium homeostasis in rat brain. Chronic dichlorvos administration caused significant rise in the intrasynaptosomal calcium levels. The activity of major calcium expelling enzyme i.e. Ca2+ATPase was found to be declined. Also, the depolarization induced calcium uptake via voltage operated calcium channels increased significantly. Concomitant to the increase in intrasynaptosomal calcium, calpain activity was found to be increased. The results presented herein, indicate that the toxic effects of dichlorvos could be mediated through modifications in the intracellular calcium homeostasis which may lead to impaired neuronal function.


Mol Cell Biochem


Raheja G,Gill KD





Has Abstract


2002-03-01 00:00:00












  • Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.

    abstract::We have investigated how diabetes affects the expression of adropin (ADR) in rat brain, cerebellum, kidneys, heart, liver, and pancreas tissues. The rats in the diabetic group were administered an intraperitoneal (i.p.) injection of a single dose of 60 mg/kg streptozotocin (STZ) dissolved in a 0.1 M phosphate-citrate ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Aydin S,Kuloglu T,Aydin S,Eren MN,Yilmaz M,Kalayci M,Sahin I,Kocaman N,Citil C,Kendir Y

    更新日期:2013-08-01 00:00:00

  • Down-regulation of lncRNA BLACAT1 inhibits ovarian cancer progression by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p.

    abstract::Ovarian cancer has the highest mortality in gynecologic malignancies. LncRNA BLACAT1 serves crucial functions in various cancers, but its role in ovarian cancer has not been investigated. In this article, our team explored the role and the potential regulatory mechanism of BLACAT1 in ovarian cancer. Quantitative RT-PC...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Yang H,Qi Y,Wang XL,Gu JJ,Shi TM

    更新日期:2020-04-01 00:00:00

  • Myristoylation of endothelial cell nitric oxide synthase is important for extracellular release of nitric oxide.

    abstract::Endothelial cell nitric oxide synthase (NOS) is known to have a N-myristoylation consensus sequence. Such a consensus sequence is not evident in the macrophage, smooth muscle and neuronal NOS. A functional role for this N-terminal myristoylation is not clear yet. In the present study, we examined the effect of N-termi...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Sakoda T,Hirata K,Kuroda R,Miki N,Suematsu M,Kawashima S,Yokoyama M

    更新日期:1995-11-22 00:00:00

  • Differential expression of signaling pathways in odontogenic differentiation of ectomesenchymal cells isolated from the first branchial arch.

    abstract::The aim of this study was to screen for differential expression of signaling pathways in odontogenic differentiation of ectomesenchymal cells isolated from the first branchial arch of embryonic day 10 (E10) mice by real time RT-PCR microarray. Observations of cellular morphology, immunocytochemistry, and RT-PCR were u...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Yu Y,Li M,Sun J,Yang M,Long J,Tian W,Tang W,Li T,Liu L

    更新日期:2011-05-01 00:00:00

  • The interrelationship of somatostatin and guanylate cyclase activity.

    abstract::Somatostatin has been shown to inhibit the release of various polypeptide hormones including insulin, glucagon, gastrin, thyroid stimulating hormone, and growth hormone. The mechanism by which somatostatin inhibits the release of these various polypeptide hormones has not been fully elucidated. It has been reported th...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Vesely DL

    更新日期:1980-11-20 00:00:00

  • Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line.

    abstract::Cytochrome P450 is known to cause carcinogen activation and correspondingly increased cancer risk in animal models. In order to determine whether P450 in the colon may be involved in cancer development in the human, the human colon cell line LS174T was examined for the presence of various cytochromes P450. Two isozyme...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: White TB,Hammond DK,Vásquez H,Strobel HW

    更新日期:1991-03-27 00:00:00

  • A simple mechanism decreasing free metabolite pool size in static spatial channelling.

    abstract::We propose a simple mechanism which enables decrease of the free pool of channelled metabolite in static spatial channelling, when the concentration of the enzyme consuming the channelled metabolite is greater than the concentration of the enzyme producing this metabolite. Spatial channelling occurs between two enzyme...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Korzeniewski B,Quant PA

    更新日期:1997-04-01 00:00:00

  • Effect of p58GTA on beta-1,4-galactosyltransferase 1 activity and cell-cycle in human hepatocarcinoma cells.

    abstract::Beta-1,4-galactosyltransferase 1 (beta1,4-GT 1) is the key enzyme transferring galactose to the terminal N-acetylglucosamine (GlcNAc) forming Galbeta3-->4GlcNAc structure in the Golgi apparatus. In addition, it also serves as a cell adhesion molecule by recognizing and binding to terminal GlcNAc of glycoconjugates on ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang SW,Xu SL,Cai MM,Yan J,Zhu XY,Hu Y,Gu JX

    更新日期:2001-05-01 00:00:00

  • HIF-1alpha involvement in low temperature and anoxia survival by a freeze tolerant insect.

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    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Morin P Jr,McMullen DC,Storey KB

    更新日期:2005-12-01 00:00:00

  • Properties of chloroplasts isolated by phase partition.

    abstract::Chloroplasts from spinach can be separated into at least three different populations by countercurrent distribution using polymer two-phase systems. The chloroplast particles of the three populations differ in protein/chlorophyll ratio, ultrastructure and metabolism. One population, peak I, consists of intact chloropl...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


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    更新日期:1976-06-15 00:00:00

  • Methylated oxypurines and induction of differentiation of murine erythroleukemia cells.

    abstract::Murine erythroleukemia cell lines derived from Friend virus infected mice can be induced to differentiate in vitro by numerous agents. Among these compounds are certain naturally occurring purines such as hypoxanthine or 1-methylhypoxanthine. We have extended these studies to other modified oxypurines and have identif...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Kerr SJ

    更新日期:1990-01-18 00:00:00

  • Vitamin A metabolism in cultured somatic cells from rat testis.

    abstract::Sertoli and peritubular myoid cells, the somatic cells of the seminiferous tubule, support growth and differentiation of developing germ cells. This action strictly depends on the availability of in situ synthesized retinoic acid and we have previously documented the ability of Sertoli, but not peritubular cell extrac...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Cavazzini D,Catizone A,Galdieri M,Ottonello S

    更新日期:2003-10-01 00:00:00

  • Purification and characterization of tripeptide aminopeptidase from bovine dental follicles.

    abstract::Tripeptide aminopeptidase (EC was purified from bovine dental follicles by a series of chromatographies. Purified enzyme had a specific activity of 59.5 units per mg protein with L-prolyl-glycylglycine as substrate. The pH optimum was 8.0. The purified native enzyme had a Mr of 230,000 and was shown to be a ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Hiraoka BY,Harada M

    更新日期:1993-12-08 00:00:00

  • MiR-506 inhibits PRRSV replication in MARC-145 cells via CD151.

    abstract::Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine, which is caused by PRRS virus (PRRSV). CD151, one of PRRSV entry mediators, determines the cell susceptibility for PRRSV. Emerging evidence indicates that the host microRNAs (miRNAs) play key roles in modu...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Wu J,Peng X,Zhou A,Qiao M,Wu H,Xiao H,Liu G,Zheng X,Zhang S,Mei S

    更新日期:2014-09-01 00:00:00

  • Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7.

    abstract::MicroRNA-125b (miR-125b) reduces myocardial infarct area and restrains myocardial ischemia reperfusion injury (I/R). In this study, we aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosomes carrying miR-125b on I/R rats. The myocardial I/R model in rats was constructed by ligation...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Chen Q,Liu Y,Ding X,Li Q,Qiu F,Wang M,Shen Z,Zheng H,Fu G

    更新日期:2020-02-01 00:00:00

  • Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer.

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    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Guo D,Huang J,Gong J

    更新日期:2012-04-01 00:00:00

  • BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells.

    abstract::Ischemia/reperfusion injury causes cardiomyocyte apoptosis, ventricular remodeling, leading to a dilated heart. Hypoxia is one of the causes involved in ischemia damage, and BNIP3 is a hypoxia-inducible marker and also a sensor to induce mitochondria-dependent apoptosis. Recent reports discussed ablating BNIP3 can res...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Weng YJ,Kuo WW,Kuo CH,Tung KC,Tsai CH,Lin JA,Tsai FJ,Hsieh DJ,Huang CY,Hwang JM

    更新日期:2010-12-01 00:00:00

  • In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox.

    abstract::Though, it is quite well-known how retinoic acid (RA) is able to induce neuritogenesis in different in vitro models, the putative role exerted by reactive oxygen species (ROS) during this process still need to be further studied. For such purpose, we used a neuronal-like cell line (SH-SY5Y cells) in order to investiga...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: da Frota Junior ML,Pires AS,Zeidán-Chuliá F,Bristot IJ,Lopes FM,de Bittencourt Pasquali MA,Zanotto-Filho A,Behr GA,Klamt F,Gelain DP,Moreira JC

    更新日期:2011-12-01 00:00:00

  • The effects of ischemia and experimental conditions on the respiration rate of cardiac fibers.

    abstract::The mitochondrial respiratory parameters were measured in situ, i.e. in saponin-skinned rabbit cardiac fibers and in fibers treated with saponin + collagenase. It was found that the decrease of maximal ADP-stimulated respiration rate of saponin-skinned fibers with pyruvate + malate under the conditions of total ischem...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Toleikis A,Majiene D,Trumbeckaite S,Dagys A

    更新日期:1997-09-01 00:00:00

  • Association of estrogen receptor β and estrogen-related receptor α gene polymorphisms with bone mineral density in postmenopausal women.

    abstract::The aim of the study was to investigate the possible association of AluI and RsaI polymorphisms of estrogen receptor β (ER-β) gene and 23-bp nucleotide repeat polymorphism of estrogen-related receptor α (ERRα) gene with bone mineral density (BMD) in postmenopausal Egyptian women. Two-hundred postmenopausal osteoporoti...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Shoukry A,Shalaby SM,Etewa RL,Ahmed HS,Abdelrahman HM

    更新日期:2015-07-01 00:00:00

  • Functional analysis of CK2beta-derived synthetic fragments.

    abstract::Synthetic peptides reproducing the amino and carboxyl terminal region of CK2beta subunit have been analyzed for their ability to mimic different properties of full length beta subunit. Peptide beta[1-77], containing both the autophosphorylation site and the down-regulatory domain 55-64, is readily phosphorylated by al...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Meggio F,Marin O,Sarno S,Pinna LA

    更新日期:1999-01-01 00:00:00

  • Knockdown of p62/sequestosome 1 attenuates autophagy and inhibits colorectal cancer cell growth.

    abstract::p62/sequestosome-1 is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis, and plays an important role at the crossroad between autophagy and cancer. But, the connection between autophagy and cancer is complex and in some cases contradictory. Human colorectal...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Ren F,Shu G,Liu G,Liu D,Zhou J,Yuan L,Zhou J

    更新日期:2014-01-01 00:00:00

  • Interactions between subunits of protein kinase CK2 and their protein substrates influences its sensitivity to specific inhibitors.

    abstract::Five isoforms of CK2 may exist simultaneously in yeast cells: free catalytic subunits CK2α', CK2α and three holoenzymatic structures composed of αα'ββ', α(2)ββ' and α'(2)ββ'. Each isolated and purified form exhibits properties typical for CK2, but they differ in substrate specificity as well as in sensitivity to speci...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Janeczko M,Masłyk M,Szyszka R,Baier A

    更新日期:2011-10-01 00:00:00

  • Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin-induced diabetic rats.

    abstract::The present study was aimed at addressing the effect of hyperglycemia on antioxidant enzymes. The expression of catalase, superoxide dismutase and glutathione peroxidase, the three primary scavenger enzymes involved in detoxifying reactive oxygen species has been evaluated in the renal cortex of rats after 6 weeks of ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Limaye PV,Raghuram N,Sivakami S

    更新日期:2003-01-01 00:00:00

  • Changes in motochondrial calcium metabolism after treating mastocytoma cells with N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate.

    abstract::Comparison of Ca2+ uptake by isolated mouse liver mitochondria, and mitochondria prepared from mastocytoma cells grown with and without N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) and theophylline showed several differences in their capacity to take up and retain calcium. In particular mitocho...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: McHardy JE,Ralph RK

    更新日期:1980-03-20 00:00:00

  • Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells.

    abstract::Cervical cancer is the most common cancer in Indian females and is associated with infection with high risk Human papillomaviruses (HPVs). Curcumin (Diferuloyl methane), a chemopreventive agent, is a natural compound extracted from Curcuma longa that allows suppression of carcinogenesis. The objective of this study wa...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Singh M,Singh N

    更新日期:2009-05-01 00:00:00

  • Effect of elevated glucose concentrations on cellular lipid peroxidation and growth of cultured human kidney proximal tubule cells.

    abstract::This study has examined whether elevated glucose can induce lipid peroxidation and contribute to the inhibition of cell growth in human kidney proximal tubule(HPT) cells. HPT cells were cultured in media containing glucose concentrations of 8 mM (control), 25 mM, and 50 mM. Lipid peroxidation was assessed by the thiob...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Jain SK,Morshed KM,Kannan K,McMartin KE,Bocchini JA Jr

    更新日期:1996-09-06 00:00:00

  • Catalytic properties of porcine pancreatic elastase: a steady-state and pre-steady-state study.

    abstract::Pre-steady-state and steady-state kinetics for the p.p. elastase-catalysed hydrolysis of ZAlaONp, one of the most favourable substrates for this serine protease, have been studied between pH 4.0 and 8.0. The results are consistent with the minimum three-step mechanism: (formula; see text) Under pre-steady-state condit...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Ascenzi P,Menegatti E,Guarneri M,Antonini E

    更新日期:1983-01-01 00:00:00

  • Dopamine receptors in canine caudate nucleus.

    abstract::Physiological, pharmacological, histochemical and biochemical studies indicate that dopamine receptors are heterogenous in the central nervous system with each individual functions. This review describes pharmacological and biochemical characteristics of dopamine receptors, particularly in canine caudate nucleus, whic...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Maeno H

    更新日期:1982-03-19 00:00:00

  • Redox signaling.

    abstract::Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have recently been shown to be involved in a multiplicity of physiological responses through modulation of signaling pathways. Some of the specific signaling components altered by reactive oxygen and nitrogen species (RONS) have begun to be identified. ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Forman HJ,Torres M,Fukuto J

    更新日期:2002-05-01 00:00:00