Calcium homeostasis and dichlorvos induced neurotoxicity in rat brain.

Abstract:

:The present study was designed to investigate the possible effects of chronic dichlorvos exposure on the various aspects of calcium homeostasis in rat brain. Chronic dichlorvos administration caused significant rise in the intrasynaptosomal calcium levels. The activity of major calcium expelling enzyme i.e. Ca2+ATPase was found to be declined. Also, the depolarization induced calcium uptake via voltage operated calcium channels increased significantly. Concomitant to the increase in intrasynaptosomal calcium, calpain activity was found to be increased. The results presented herein, indicate that the toxic effects of dichlorvos could be mediated through modifications in the intracellular calcium homeostasis which may lead to impaired neuronal function.

journal_name

Mol Cell Biochem

authors

Raheja G,Gill KD

doi

10.1023/a:1014873031013

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

13-8

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

232

pub_type

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