Abstract：
:The present study was designed to investigate the possible effects of chronic dichlorvos exposure on the various aspects of calcium homeostasis in rat brain. Chronic dichlorvos administration caused significant rise in the intrasynaptosomal calcium levels. The activity of major calcium expelling enzyme i.e. Ca2+ATPase was found to be declined. Also, the depolarization induced calcium uptake via voltage operated calcium channels increased significantly. Concomitant to the increase in intrasynaptosomal calcium, calpain activity was found to be increased. The results presented herein, indicate that the toxic effects of dichlorvos could be mediated through modifications in the intracellular calcium homeostasis which may lead to impaired neuronal function.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Raheja G,Gill KDdoi
10.1023/a:1014873031013keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
13-8issue
1-2eissn
0300-8177issn
1573-4919journal_volume
232pub_type
杂志文章abstract：:Amida was first isolated from a rat hippocampal cDNA library as an Arc-associated protein. Although previous studies have shown that Amida mRNA is predominantly expressed and developmentally regulated in rat testis and overexpression induces apoptosis, the function of Amida remains unclear. In this study, we found tha...
journal_title：Molecular and cellular biochemistry
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更新日期：2002-05-01 00:00:00
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