Myofibrillar creatine kinase and cardiac contraction.

abstract：:3H-1,2-Dithiole-3-thione (D3T), a potent member of dithiolethiones, induces phase 2 enzymes by activating an Nrf2/Keap1-dependent signaling pathway. It was proposed that interaction between D3T and two adjacent sulfhydryl groups of Keap1 might cause dissociation of Keap1 from Nrf2, leading to Nrf2 activation. This stu...

journal_title：Molecular and cellular biochemistry

authors： Jia Z,Zhu H,Trush MA,Misra HP,Li Y

更新日期：2008-01-01 00:00:00

abstract：:Five isoforms of CK2 may exist simultaneously in yeast cells: free catalytic subunits CK2α', CK2α and three holoenzymatic structures composed of αα'ββ', α(2)ββ' and α'(2)ββ'. Each isolated and purified form exhibits properties typical for CK2, but they differ in substrate specificity as well as in sensitivity to speci...

journal_title：Molecular and cellular biochemistry

authors： Janeczko M,Masłyk M,Szyszka R,Baier A

更新日期：2011-10-01 00:00:00

abstract：:Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...

journal_title：Molecular and cellular biochemistry

authors： Kraniak JM,Sun D,Mattingly RR,Reiners JJ Jr,Tainsky MA

更新日期：2010-11-01 00:00:00

abstract：:Ileal bile acid-binding protein (I-BABP) is a soluble bile acids (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. In the gut, its expression is strictly restricted to the ileum, where it is thought to be involved in the active BA reabsorption. Therefore, I-BABP gene expression levels...

journal_title：Molecular and cellular biochemistry

authors： Landrier JF,Grober J,Zaghini I,Besnard P

更新日期：2002-10-01 00:00:00

abstract：:Calycopterin is a flavonoid compound isolated from Dracocephalum kotschyi that has multiple medical uses, as an antispasmodic, analgesic, anti-hyperlipidemic, and immunomodulatory agents. However, its biological activity and the mechanism of action are poorly investigated. Herein, we investigated the apoptotic effect ...

journal_title：Molecular and cellular biochemistry

authors： Esmaeili MA,Farimani MM,Kiaei M

更新日期：2014-12-01 00:00:00

abstract：:Adenosine (ADO) is an intermediary metabolite of adenosine trisphosphate degradation and a vasoactive mediator. We showed previously that ADO induces contraction and proliferation in rat mesangial cells by a mechanism involving A1 and A2 receptors. The studies concerning the effect of ADO on extracellular matrix (ECM)...

journal_title：Molecular and cellular biochemistry

authors： Martínez-Salgado C,García-Cenador B,Fuentes-Calvo I,Macías Núñez JF,López-Novoa JM

更新日期：2007-11-01 00:00:00

abstract：:We studied the effects of SEB on [14C]-choline transport and metabolism of choline containing phospholipids in cultured human kidney proximal tubular (PT) cells. SEB increased the uptake of [14C]-choline in PT cells as a function of toxin concentration, incubation time, and pH. The maximum increase in uptake (3.5-5-fo...

journal_title：Molecular and cellular biochemistry

authors： Khullar M,Chatterjee S

更新日期：1995-05-24 00:00:00

abstract：:S-glutathionylation, the formation of mixed disulfides of glutathione with cysteine residues of proteins, is a broadly observed physiological modification that occurs in response to oxidative stress. Since cysteine residues are particularly susceptible to oxidative modification by reactive oxygen species, S-glutathion...

journal_title：Molecular and cellular biochemistry

authors： Leonberg AK,Chai YC

更新日期：2007-10-01 00:00:00

abstract：:In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity...

journal_title：Molecular and cellular biochemistry

authors： Yu YS,Zheng H

更新日期：2012-06-01 00:00:00

abstract：:Recent studies suggest JAK2 signaling may be a therapeutic target for treatment of gastric cancer (GC). However, the exact roles of JAK2 in gastric carcinogenesis are not very clear. Here, we have targeted JAK2 to be silenced by shRNA and investigated the biological functions and related mechanisms of JAK2 in GC cell ...

journal_title：Molecular and cellular biochemistry

authors： Qian C,Yao J,Wang J,Wang L,Xue M,Zhou T,Liu W,Si J

更新日期：2014-02-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbid events in hypertension. TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. Six hundred and eighty essential hype...

journal_title：Molecular and cellular biochemistry

authors： Xu HY,Hou XW,Wang LF,Wang NF,Xu J

更新日期：2010-02-01 00:00:00

abstract：:The aim of the present study was to take osteopontin (OPN) as molecular target to study its effects on injured intima model of carotid artery in rat using perivascular transfer of OPN-small interference RNA (siRNA). OPN mRNA in cultured VSMCs was quantified by real-time RT-PCR, and OPN-siRNA-002 was determined as the ...

journal_title：Molecular and cellular biochemistry

authors： Xu J,Sun Y,Wang T,Liu G

更新日期：2013-05-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine, which is caused by PRRS virus (PRRSV). CD151, one of PRRSV entry mediators, determines the cell susceptibility for PRRSV. Emerging evidence indicates that the host microRNAs (miRNAs) play key roles in modu...

journal_title：Molecular and cellular biochemistry

authors： Wu J,Peng X,Zhou A,Qiao M,Wu H,Xiao H,Liu G,Zheng X,Zhang S,Mei S

更新日期：2014-09-01 00:00:00

abstract：:The T-box transcription factor TBX2 is known for its role as a critical regulator of melanoma cell proliferation, but its role in regulating melanogenesis has not been widely studied. Here we use a series of experiments to show in primary and immortalized mouse melanocytes that TBX2 acts as regulator of melanogenesis ...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Pan L,Su Z,Wang J,Li H,Ma X,Liu Y,Lu F,Qu J,Hou L

更新日期：2016-04-01 00:00:00

abstract：:Thymoquinone (TQ) is a highly perspective chemotherapeutic agent against gliomas and glioblastomas because of its ability to cross the blood-brain barrier and its selective cytotoxicity for glioblastoma cells compared to primary astrocytes. Here, we tested the hypothesis that TQ-induced mild oxidative stress provokes ...

journal_title：Molecular and cellular biochemistry

authors： Krylova NG,Drobysh MS,Semenkova GN,Kulahava TA,Pinchuk SV,Shadyro OI

更新日期：2019-12-01 00:00:00

abstract：:Recent evidence indicated that endocan may be a potential cell marker and a new target for cancers including acute leukemia since the serum endocan level in patients with acute leukemia was associated with the status of the disease, i.e., endocan was higly expressed in untreated acute leukemia, but decreased after che...

journal_title：Molecular and cellular biochemistry

authors： Xu Z,Zhang S,Zhou Q,Wang Y,Xia R

更新日期：2014-10-01 00:00:00

abstract：:A liver cytochrome P-450 isozyme has been purified to homogeneity from protein-energy malnourished rats induced with beta-naphthoflavone (beta-NF). The purification steps included chromatography on DEAE-Sephadex-A-25, DEAE-cellulose (DE-53), hydroxylapatite (HA) and carboxymethyl-sephadex (CM) columns. The reduced car...

journal_title：Molecular and cellular biochemistry

authors： Gil L,Vasquez H,Orellana M,Selkirk J,Wold F,Strobel H

更新日期：1988-01-01 00:00:00

abstract：:Hypertriglyceridemia is a common complex metabolic trait that is associated with increased atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation, increased risk of pancreatitis. Hierarchical cluster analysis using clinical and biochemical features of the Frederickson hyperlipoproteinemia...

journal_title：Molecular and cellular biochemistry

authors： Hegele RA,Pollex RL

更新日期：2009-06-01 00:00:00

abstract：:Recent reports considered that it was the disturbance of calcium homeostasis and the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that activated hepatic stellate cells (HSCs) apoptosis and promoted fibrosis resolution. However, the signal-transducing events that are activated by ER stress after...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Li X,Wang Y,Wang H,Huang C,Li J

更新日期：2014-09-01 00:00:00

abstract：:We have examined a possibility whether or not severity and extent of coronary atherosclerosis may associate with degree of local inflammation in relation to endothelial dysfunction as is indicated by reduced NO formation. Blood samples were obtained from aortic root (Ao) and coronary sinus (CS) of 39 patients who unde...

journal_title：Molecular and cellular biochemistry

authors： Matsubara T,Ishibashi T,Hori T,Ozaki K,Mezaki T,Tsuchida K,Nasuno A,Kubota K,Tanaka T,Miida T,Aizawa Y,Nishio M

更新日期：2003-07-01 00:00:00

abstract：:GPR12, a member of the orphan G-protein-coupled receptor family, constitutively activates the Gs protein and increases intracellular cyclic AMP concentrations. GPR12 can be activated by its known ligand-sphingosylphosphorylcholine, which regulates cellular physiological activities, including proliferation, neurite ext...

journal_title：Molecular and cellular biochemistry

authors： Lu X,Zhang N,Meng B,Dong S,Hu Y

更新日期：2012-07-01 00:00:00

abstract：:A number of acute and chronic neurodegenerative disorders are caused due to misfolding and aggregation of many intra- and extracellular proteins. Protein misfolding and aggregation processes in cells are strongly regulated by cellular molecular chaperones known as heat-shock proteins (Hsps) that include Hsp60, Hsp70, ...

journal_title：Molecular and cellular biochemistry

authors： Paul S,Mahanta S

更新日期：2014-01-01 00:00:00

abstract：:To evaluate the effects of the in vivo endotoxin treatment of the rat on (1) the contractile responses in the subsequently isolated papillary muscle to adrenergic and cholinergic agonists and (2) the biochemical parameters (cyclic GMP, nitric oxide synthesis, protein phosphorylation and ADP-ribosyslation) in the subse...

journal_title：Molecular and cellular biochemistry

authors： Sulakhe PV,Sandirasegarane L,Davis JP,Vo XT,Costain WJ,Mainra RR

更新日期：1996-10-01 00:00:00

abstract：:Syndecan-4 (S4) is a cell membrane heparan sulfate proteoglycan that plays a role in satellite cell mediated myogenesis. S4 modulates the proliferation of myogenic satellite cells, but the mechanism of how S4 functions during myogenesis is not well understood. In other cell systems, S4 has been shown to form oligomers...

journal_title：Molecular and cellular biochemistry

authors： Shin J,Song Y,McFarland DC,Velleman SG

更新日期：2012-04-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of metal-catalyzed oxidation by H(2)O(2) on the structure, oligomerization, and chaperone function of alphaA- and alphaB-crystallins. Recombinant alphaA-and alphaB-crystallins were prepared by expressing them in E. coli and purifying by size-exclusion chromatogra...

journal_title：Molecular and cellular biochemistry

authors： Rajan S,Horn C,Abraham EC

更新日期：2006-08-01 00:00:00

abstract：:Vaccinia virus (VV) and other pathogenic poxviruses encode for a complement control protein. The VV complement control protein or VCP, was one of the first soluble microbial proteins postulated to have an active role in the immunomodulation of the host defense. Since then, 2 other poxviruses, including variola virus a...

journal_title：Molecular and cellular biochemistry

authors： Kotwal GJ,Miller CG,Justus DE

更新日期：1998-08-01 00:00:00

abstract：:The article "JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells", written by "Patrick T. Caswell, Martin Dickens", was originally published electronically on the publisher's internet portal https://link.springer.com/article/10.1007/s11010-017-3222-7 on 20 November ...

journal_title：Molecular and cellular biochemistry

authors： Caswell PT,Dickens M

更新日期：2018-07-01 00:00:00

abstract：:XPO5 (Exp5, Exportin-5) is a transporter protein mainly mediating pre-microRNAs' nuclear export. Recent studies have demonstrated that XPO5 may play crucial roles in a few of cancers. However, little is known about XPO5 in hepatocellular carcinoma (HCC). In the present study, we elucidated the expression of XPO5 by qu...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Wang X,He B,Cai H,Gao Y

更新日期：2016-04-01 00:00:00

abstract：:Oxidative stress is recognized as one of the major wrongdoers in Parkinson's disease (PD) while glutathione S-transferase (GST), an endogenous antioxidant, protects from oxidative stress-induced neurodegeneration. Despite GST-pi (GST-π) encounters the toxic manifestations in PD, its role in zinc (Zn)-induced nigrostri...

journal_title：Molecular and cellular biochemistry

authors： Chauhan AK,Mittra N,Singh BK,Singh C

更新日期：2019-02-01 00:00:00

abstract：:SAP155 is an essential component of the spliceosome and its phosphorylation is required for splicing catalysis, but little is known concerning its function and regulation during spermatogenesis in postnatal murine testes. We report that inhibition of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) IA...

journal_title：Molecular and cellular biochemistry

authors： Eto K,Sonoda Y,Abe S

更新日期：2011-09-01 00:00:00