IGF2BP1: a novel binding protein of p38 MAPK.

abstract：:To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intim...

journal_title：Molecular and cellular biochemistry

authors： Tertov VV,Kaplun VV,Mikhailova IA,Suprun IV,Orekhov AN

更新日期：2001-09-01 00:00:00

abstract：:Hepatocyte cell adhesion molecule (HepaCAM) plays a crucial role in tumor progression and has been recognized as a novel tumor suppressor gene. The high protein expression level of protein kinase Cε (PKCε) has been discovered in many tumor types. In the present study, we determined HepaCAM and PKCε protein levels in h...

journal_title：Molecular and cellular biochemistry

authors： Tan B,Tan J,Du H,Quan Z,Xu X,Jiang X,Luo C,Wu X

更新日期：2014-06-01 00:00:00

abstract：:Monitoring the kinetic behavior of adenylate kinase (AK) and creatine kinase (CK) in intact cells by 18O-phosphoryl oxygen exchange analysis has provided new perspectives from which to more fully define the involvement of these phosphotransferases in cellular bioenergetics. A primary function attributable to both AK a...

journal_title：Molecular and cellular biochemistry

authors： Dzeja PP,Zeleznikar RJ,Goldberg ND

更新日期：1998-07-01 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:Cellular FLICE-like inhibitory protein (Flip) is a negative regulator of nuclear factor κB signaling which has been shown previously to complicate with cardiac hypertrophy. In the present study, we tested the hypothesis that the knockout of Flip would increase cardiac hypertrophy in vivo and in vitro. The effects of F...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Wu L,Wu J,Li Y,Hou L

更新日期：2014-12-01 00:00:00

abstract：:Ovarian cancer is one of the greatest causes of cancer death in women. The association of TMEM49 and ovarian cancer is poorly defined. Here, we reported that TMEM49 was significantly increased in ovarian tumor tissues compared to ovarian normal tissues. Furthermore, down-regulation of TMEM49 through RNA interference i...

journal_title：Molecular and cellular biochemistry

authors： Zheng L,Chen L,Zhang X,Zhan J,Chen J

更新日期：2016-05-01 00:00:00

abstract：:Nickel compounds are carcinogenic and induce malignant transformation of cultured cells. Since nickel has low mutagenic potential, it may act predominantly through epigenetic mechanisms, including down-regulation of tumor suppressor genes. FHIT is a tumor suppressor gene whose expression is frequently reduced or lost ...

journal_title：Molecular and cellular biochemistry

authors： Kowara R,Salnikow K,Diwan BA,Bare RM,Waalkes MP,Kasprzak KS

更新日期：2004-01-01 00:00:00

abstract：:Eukaryotic protein synthesis initiation factor eIF-2 is usually isolated as a heterotrimer (alphabeta gamma). By use of Sephacryl S-300 fractionation an alpha subunit-deficient form of eIF-2 was identified in impure preparations from rabbit reticulocyte lysate and it appeared in these preparations to be still active i...

journal_title：Molecular and cellular biochemistry

authors： Mouat MF,Manchester K

更新日期：1998-06-01 00:00:00

abstract：:The aim of the study was to find out whether administration of selenium (Se) will protect the immature heart against ischemia/reperfusion.The control pregnant rats were fed laboratory diet (0.237 mg Se/kg diet); experimental rats received 2 ppm Na(2)SeO(3) in the drinking water from the first day of pregnancy until da...

journal_title：Molecular and cellular biochemistry

authors： Ostadalova I,Vobecky M,Chvojkova Z,Mikova D,Hampl V,Wilhelm J,Ostadal B

更新日期：2007-06-01 00:00:00

abstract：:A method is described for analysing molecular species of glycerophospholipids. Diglycerides obtained by phospholipase C-catalysed hydrolysis of the phospholipid are separated into the diacyl- alkylacyl- and alkenylacyl- subclasses by HPLC on silicic acid. The molecular species of diacylglycerol are separated by HPLC o...

journal_title：Molecular and cellular biochemistry

authors： Vecchini A,Panagia V,Binaglia L

更新日期：1997-07-01 00:00:00

abstract：:A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which al...

journal_title：Molecular and cellular biochemistry

authors： Leonard SS,Bower JJ,Shi X

更新日期：2004-01-01 00:00:00

abstract：:The cardiac subtype of Na+/H+ exchanger (NHE-1) plays an important role in the regulation of intracellular pH (pHi) and also can be a major route for Na+ influx. Although intracellular ATP is required for the optimal function of NHE-1, the regulation of the exchanger by ATP is less well characterized. This study was d...

journal_title：Molecular and cellular biochemistry

authors： Sugiyama S,Satoh H,Nomura N,Terada H,Watanabe H,Hayashi H

更新日期：2001-01-01 00:00:00

abstract：:Ileal bile acid-binding protein (I-BABP) is a soluble bile acids (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. In the gut, its expression is strictly restricted to the ileum, where it is thought to be involved in the active BA reabsorption. Therefore, I-BABP gene expression levels...

journal_title：Molecular and cellular biochemistry

authors： Landrier JF,Grober J,Zaghini I,Besnard P

更新日期：2002-10-01 00:00:00

abstract：:The deiodinases regulate the activation and inactivation of Thyroid hormones (TH), in both physiological and pathological conditions. The three deiodinases, DIO1, DIO2 and DIO3, have different catalytic role and cellular and tissue distribution. Aim of this study is to evaluate a rat model of regional ischemia/reperfu...

journal_title：Molecular and cellular biochemistry

authors： Sabatino L,Kusmic C,Iervasi G

更新日期：2020-12-01 00:00:00

abstract：:Bladder smooth muscle contraction is mediated by both direct calcium entry through the cell membrane, and by calcium induced calcium release (CICR) from the sarcoplasmic reticulum (SR) storage sites. Ryanodine is a neutral plant alkaloid which binds to an ion channel located on the SR membrane. Its effects in cardiac ...

journal_title：Molecular and cellular biochemistry

authors： Gong C,Zderic SA,Levin RM

更新日期：1994-08-31 00:00:00

abstract：:Physiological, pharmacological, histochemical and biochemical studies indicate that dopamine receptors are heterogenous in the central nervous system with each individual functions. This review describes pharmacological and biochemical characteristics of dopamine receptors, particularly in canine caudate nucleus, whic...

journal_title：Molecular and cellular biochemistry

authors： Maeno H

更新日期：1982-03-19 00:00:00

abstract：:Stress genes can be ascribed to have been generated by the organism for their intrinsic urge to survive against the changing environmental odds, during the evolutionary process. This concept has been supported by a large number of reports describing individual types of phenomena. These have been reconciled and globali...

journal_title：Molecular and cellular biochemistry

authors： Ray PK

更新日期：1999-06-01 00:00:00

abstract：:Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED and the conn...

journal_title：Molecular and cellular biochemistry

authors： Liu B,Qiao J,Hu J,Fan M,Zhao Y,Su H,Wang Z,Yu Q,Ma Q,Li Y,Lv Z,Wang R

更新日期：2020-10-01 00:00:00

abstract：:β-Adrenergic receptor (β-AR) stimulation induces cardiac myocyte apoptosis and plays an important role in myocardial remodeling. Here we investigated expression of various apoptosis-related genes affected by β-AR stimulation, and examined first time the role of ataxia telangiectasia mutated kinase (ATM) in cardiac myo...

journal_title：Molecular and cellular biochemistry

authors： Foster CR,Singh M,Subramanian V,Singh K

更新日期：2011-07-01 00:00:00

abstract：:Preadipocyte migration is a fundamental and important process for the development of tissue organization, especially in the development of primitive adipose tissue and adipocyte tissue wound healing. However, excessive migration may result in abnormal development and fibrosis-related diseases such as hypertrophic scar...

journal_title：Molecular and cellular biochemistry

authors： Liu X,Xu Q,Long X,Liu W,Zhao Y,Hayashi T,Hattori S,Fujisaki H,Ogura T,Tashiro SI,Onodera S,Yamato M,Ikejima T

更新日期：2019-01-01 00:00:00

abstract：:Thialysine cannot completely substitute lysine as growth factor for a lysine-requiring E. coli mutant. However it can be utilized for growth in the presence of limiting amounts of lysine, in substitution of, and in competition with this latter. The effects of thialysine on growth rate, protein synthesis rate and cell ...

journal_title：Molecular and cellular biochemistry

authors： Cinia C,Busiello V,Coccia R,Di Girolamo M,de Marco C

更新日期：1984-01-01 00:00:00

abstract：:Protein kinase C isoforms comprise a family of structurally related serine/threonine kinases that are activated by second messenger molecules formed via receptor-dependent activation of phospholipase C. Cardiomyocytes co-express multiple protein kinase C isoforms which play key roles in a spectrum of adaptive and mala...

journal_title：Molecular and cellular biochemistry

authors： Sabri A,Steinberg SF

更新日期：2003-09-01 00:00:00

abstract：:Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated ...

journal_title：Molecular and cellular biochemistry

authors： Chaudhary P,Malhotra SS,Babu GS,Sobti RC,Gupta SK

更新日期：2019-03-01 00:00:00

abstract：:Genistein is often used as an inhibitor of tyrosine kinases. A less studied side effect of genistein is an inhibition of cyclic AMP-phosphodiesterase (cAMP-PDE) activity resulting in increased cAMP accumulation. The effect of genistein on intracellular cAMP-levels, basal and forskolin-induced, was studied in A549 huma...

journal_title：Molecular and cellular biochemistry

authors： Burvall KM,Palmberg L,Larsson K

更新日期：2002-11-01 00:00:00

abstract：:The action of micrococcal nuclease, DNase I and DNase II on mouse TLT hepatoma chromatin revealing the periodicity of its structure as visualized by denaturing and non-denaturing gel electrophoresis, was consistent with the action of these enzymes on other chromatins. Micrococcal nuclease showed a complex subnucleosom...

journal_title：Molecular and cellular biochemistry

authors： Duerksen JD,Connor KW

更新日期：1978-04-11 00:00:00

abstract：:Based on sequence relationships the cytoplasmic fatty acid-binding proteins (FABPs) of mammalian origin are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. Highly conserved sequences of FABPs within the same type correlate with immunological crossreactivities. Isoforms of...

journal_title：Molecular and cellular biochemistry

authors： Spener F,Unterberg C,Börchers T,Grosse R

更新日期：1990-10-15 00:00:00

abstract：:The present study was addressed to understand the interrelationship between Receptor-Ck activation, mevalonate pathway and primary response genes such as c-fos, c-myc and cyclin 'D' involved in the cell cycle. The results reported here unambiguously revealed that the phosphatidic acid (generated through the activation...

journal_title：Molecular and cellular biochemistry

authors： Kaur M,Kaul D,Sobti RC

更新日期：1998-04-01 00:00:00

abstract：:Oxygen is a diradical and because of its unique electronic configuration, it has the potential to form strong oxidants (e.g. superoxide radical, hydrogen peroxide and hydroxyl radical) called oxygen free radicals or partially reduced forms of oxygen (PRFO). These highly reactive oxygen species can cause cellular injur...

journal_title：Molecular and cellular biochemistry

authors： Singal PK,Dhalla AK,Hill M,Thomas TP

更新日期：1993-12-22 00:00:00

abstract：:Subsequent to the first alpha 2-adrenergic receptor (alpha 2-AR) gene cloning of alpha 2-C10 from human platelet, cloning of the first rodent alpha 2-AR cDNA, cA2-47, was reported. Based on the structural and limited pharmacological comparison, it was concluded that the rodent receptor is a molecular and pharmacologic...

journal_title：Molecular and cellular biochemistry

authors： Wypijewski K,Duda T,Sharma RK

更新日期：1995-03-23 00:00:00

abstract：:Cofilin is an actin-binding protein of low molecular weight which is widely distributed in eukaryotes and is deeply involved in the dynamics of actin assembly in the cytoplasm. The actin-binding ability of cofilin is inhibited by inositol phosphates (PIP2), and the PIP2- and actin-binding site(s) has been localized in...

journal_title：Molecular and cellular biochemistry

authors： Kusano K,Abe H,Obinata T

更新日期：1999-01-01 00:00:00