Abstract:
:The PKC family of serine/threonine kinases have been implicated in a diverse array of cellular responses. Adult cardiac myocytes express multiple PKC isozymes, which participate in the response of muscle cells to extracellular stimuli, modulate contractile properties, and promote cell growth and survival. Recently, the classification of this ubiquitous family of signaling molecules has been expanded from three to four subfamilies. This review will focus on the application of pharmacologic and molecular approaches to explore the biology of cardiac PKC isozymes. The availability of transgenic mice and peptide PKC modulators have been instrumental in identifying target substrates for activated cardiac PKC isozymes, as well as the identification of specific isozymes linked to distinct growth characteristics and cell phenotype. The rapid growth of knowledge in the area of PKC signaling and PKC substrate interactions, may result in the development of therapeutic modalities with the potential to arrest or reverse the progression of cardiovascular diseases.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Malhotra A,Kang BP,Opawumi D,Belizaire W,Meggs LGdoi
10.1023/a:1012261903611keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
97-107issue
1-eissn
0300-8177issn
1573-4919journal_volume
225pub_type
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