Fuel smoke condensate induced DNA damage in human lymphocytes and protection by turmeric (Curcuma longa).

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00

abstract：:Cancer stem cells (CSCs) are believed to be responsible for tumor metastasis, recurrence, and high mortality of cancer patients due to their high tumorigenicity resistance to chemo-radiotherapy. Morusin possesses anti-cancer activity through attenuation of NF-κB activity, which is up-regulated in cancer stem cells. Th...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Guo H,Yang L,Dong L,Lin C,Zhang J,Lin P,Wang X

更新日期：2013-07-01 00:00:00

abstract：:The hexokinase: fumarase ratios of mitochondria isolated from ten tissues of the rat were determined, and compared with the tissue content of phosphoglucomutase and phosphorylase, taken as representatives of enzymes concerned with glycogen metabolism. A generally inverse relationship was found between the mitochondria...

journal_title：Molecular and cellular biochemistry

authors： Wilson JE,Felgner PL

更新日期：1977-11-25 00:00:00

abstract：:The effects of Mg2+ and Ca2+ deprivation on survival and growth of normal and transformed cultured cells were studied. Normal fibroblast from several origins (mouse, hamster and human) did not grow in 2 microM Mg2+ medium, whereas transformed fibroblasts (mouse and rat) and tumor cells of other types (mouse adrenocort...

journal_title：Molecular and cellular biochemistry

authors： Ribeiro SM,Armelin HA

更新日期：1984-01-01 00:00:00

abstract：:This work investigates the effect of alloxan-induced short-term diabetes (24 h) on D-3-hydroxybutyrate metabolism at physiological and non-physiological concentrations of the ketone body in the isolated non-working perfused rat heart. Also the effect of insulin (2 mU.ml-1) on D-3-hydroxybutyrate metabolism was investi...

journal_title：Molecular and cellular biochemistry

authors： Sultan AM

更新日期：1992-03-04 00:00:00

abstract：:The angiotensin converting enzyme (ACE) is a key factor in the production of angiotensin II and in the degradation of bradykinin. Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis. Factor VII (FACTOR VII) is the first enzyme in the extrinsic pathwa...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Maithil N,Thakur H,Sharma Y,Talwar KK

更新日期：2010-08-01 00:00:00

abstract：:Apoptosis is a physiological mechanism for the control of DNA integrity in mammalian cells. Vanadium induces both DNA damage and apoptosis. It is suggested that vanadium-induced apoptosis serves to eliminate DNA-damaged cells. This study is designed to clarify a role of reactive oxygen species in the mechanism of apop...

journal_title：Molecular and cellular biochemistry

authors： Ye J,Ding M,Leonard SS,Robinson VA,Millecchia L,Zhang X,Castranova V,Vallyathan V,Shi X

更新日期：1999-12-01 00:00:00

abstract：:Guanylyl cyclases in eukaryotic unicells were biochemically investigated in the ciliates Paramecium and Tetrahymena, in the malaria parasite Plasmodium and in the ameboid Dictyostelium. In ciliates guanylyl cyclase activity is calcium-regulated suggesting a structural kinship to similarly regulated membrane-bound guan...

journal_title：Molecular and cellular biochemistry

authors： Linder JU,Schultz JE

更新日期：2002-01-01 00:00:00

abstract：:Sustained cardiac hypertrophy (CH) is related to a variety of physiological as well as pathological stimuli and eventually increases the risk of heart failure. HOTAIR has been identified as a competing endogenous RNA in multiple human biological processes. Whether lncRNA-HOTAIR is involved in the progress of CH and ho...

journal_title：Molecular and cellular biochemistry

authors： Lai Y,He S,Ma L,Lin H,Ren B,Ma J,Zhu X,Zhuang S

更新日期：2017-08-01 00:00:00

abstract：:ING proteins are tumor suppressors involved in the regulation of gene transcription, cell cycle arrest, apoptosis, and senescence. Here, we show that ING1b expression is upregulated by several DNA-damaging agents, in a p53-independent manner. ING1b stimulates DNA repair of a variety of DNA lesions requiring activation...

journal_title：Molecular and cellular biochemistry

authors： Ceruti JM,Ogara MF,Menéndez C,Palmero I,Cánepa ET

更新日期：2013-06-01 00:00:00

abstract：:The ability of the gap junction phosphoprotein connexin-43 (Cx43) to inhibit DNA synthesis in primary cardiomyocytes is regulated by serine (S) 262, a protein kinase C phosphorylation site that also affects metabolic coupling. We have now examined if the S262-regulated growth suppression is operating in transformed ce...

journal_title：Molecular and cellular biochemistry

authors： Dang X,Jeyaraman M,Kardami E

更新日期：2006-09-01 00:00:00

abstract：:Adenosine (ADO) is an intermediary metabolite of adenosine trisphosphate degradation and a vasoactive mediator. We showed previously that ADO induces contraction and proliferation in rat mesangial cells by a mechanism involving A1 and A2 receptors. The studies concerning the effect of ADO on extracellular matrix (ECM)...

journal_title：Molecular and cellular biochemistry

authors： Martínez-Salgado C,García-Cenador B,Fuentes-Calvo I,Macías Núñez JF,López-Novoa JM

更新日期：2007-11-01 00:00:00

abstract：:The role of the subunits of phosphoinositide (PI) 3-kinase in NF-kappaB activation in silica-stimulated RAW 264.7 cells was investigated. Results indicate that PI3-kinase activity was increased in response to silica. The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-s...

journal_title：Molecular and cellular biochemistry

authors： Kang JL,Lee HS,Pack IS,Hur KC,Castranova V

更新日期：2003-06-01 00:00:00

abstract：:Adenovirus-mediated gene transfer is a promising method for studies of vascular biology and potentially for gene therapy. Intravascular approaches for gene transfer to blood vessels in vivo generally require interruption of blood flow and have several limitations. We have used two alternative approaches for gene trans...

journal_title：Molecular and cellular biochemistry

authors： Ooboshi H,Ríos CD,Heistad DD

更新日期：1997-07-01 00:00:00

abstract：:Shin et al. (Biochim Biophys Acta 444: 794-801, 1976) described the subcellular location of [3H]folic acid after injection into rats. The microsomal fraction of the liver contained relatively large amounts of tracer initially but lower amounts at later times. Because of the heterogeneous nature of the microsomal fract...

journal_title：Molecular and cellular biochemistry

authors： Brody T,Stokstad EL

更新日期：1990-09-03 00:00:00

abstract：:Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. These processes are mediated by the binding of ADP to an externally oriented protein of the platelet plasma membrane. An affinity analog of ATP, a competitive inhibitor of the action of ADP,...

journal_title：Molecular and cellular biochemistry

authors： Colman RW,Figures WR

更新日期：1984-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) for long was known as immunomodulator and tumor marker having multifaceted actions on the activity of normal and transformed cells. In present study, we have investigated the involvement of AFP in regulation of THP-1 cell line invasion and underlying mechanisms. Treatment with human recombinant...

journal_title：Molecular and cellular biochemistry

authors： Zubkova E,Semenkova L,Dudich E,Dudich I,Parfyonova Y,Menshikov M

更新日期：2013-07-01 00:00:00

abstract：:Studies were carried out on glucose-6-phosphate dehydrogenase (G6P-DH) during the differentiation of rabbit bone marrow erythroid cells. It was found that G6P-DH, although displaying a 7-fold activity decrease, did not change the relative amounts of its three dimeric forms. Using homogeneous enzyme preparations, we ob...

journal_title：Molecular and cellular biochemistry

authors： Ninfali P,Palma F,Fornaini G

更新日期：1987-06-01 00:00:00

abstract：:CYP3A5 is an important genetic contributor to inter-individual differences in CYP3A-dependent clinically important drugs of metabolism and also of various endogenous compounds and environmental contaminants. The CYP3A5*3 allele results in a truncated protein with loss of CYP3A5 expression and CYP3A5*6 is associated wi...

journal_title：Molecular and cellular biochemistry

authors： Bajpai P,Tripathi AK,Agrawal D

更新日期：2010-03-01 00:00:00

abstract：:Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production. The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enh...

journal_title：Molecular and cellular biochemistry

authors： Kirtikara K,Laulederkind SJ,Raghow R,Kanekura T,Ballou LR

更新日期：1998-04-01 00:00:00

abstract：:Cytosolic purine nucleoside phosphorylase (PNPase) is a well known, and described enzyme which exists in a variety of organisms, both procaryotic and eucaryotic. More recently this enzyme was found in bovine liver mitochondria. The mitochondrial purine nucleoside phosphorylase was purified 63 fold and has a molecular ...

journal_title：Molecular and cellular biochemistry

authors： Haag R,Lewis RA

更新日期：1994-06-29 00:00:00

abstract：:In the past decades, a greater understanding of acute pancreatitis has led to improvement in mortality rates. Nevertheless, this disease continues to be a health care system problem due to its economical costs. Future strategies such as antioxidant supplementation could be very promising, regarding to beginning and pr...

journal_title：Molecular and cellular biochemistry

authors： Carrasco C,Holguín-Arévalo MS,Martín-Partido G,Rodríguez AB,Pariente JA

更新日期：2014-02-01 00:00:00

abstract：:To examine the essential mechanisms of steroid production in ovarian theca cells, we analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid produ...

journal_title：Molecular and cellular biochemistry

authors： Murayama C,Miyazaki H,Miyamoto A,Shimizu T

更新日期：2008-07-01 00:00:00

abstract：:The effect of CK2beta on the activity of CK2alpha and other protein kinases that can bind this regulatory subunit is not fully understood. In an attempt to improve our understanding of this effect, chimeras of CK2alpha and CK1alpha have been constructed. These chimeras contain different portions of the CK2alpha amino ...

journal_title：Molecular and cellular biochemistry

authors： Jedlicki A,Allende CC,Allende JE

更新日期：2008-09-01 00:00:00

abstract：:The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascor...

journal_title：Molecular and cellular biochemistry

authors： Rajakumar DV,Rao MN

更新日期：1994-11-09 00:00:00

abstract：:Parasitic nematodes have recently been found to produce proteins which represent two new classes of fatty acid and retinoid binding protein. The first is the nematode polyprotein allergens/antigens (NPAs) which, as their name suggests, are synthesised as large polyproteins which are subsequently cleaved at regularly s...

journal_title：Molecular and cellular biochemistry

authors： McDermott L,Cooper A,Kennedy MW

更新日期：1999-02-01 00:00:00

abstract：:A systematic comparison of the impact of some potential endocrine disruptors (EDs) on modulation of androgen receptor (AR) and pregnane and xenobiotic receptor (PXR) function was conducted in a multi-step analysis. Promoter-reporter-based transcription assays were performed in conjunction with receptor dynamic studies...

journal_title：Molecular and cellular biochemistry

authors： Chaturvedi NK,Kumar S,Negi S,Tyagi RK

更新日期：2010-12-01 00:00:00

abstract：:Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules. In this study, we report that FAM98A, whose biologic...

journal_title：Molecular and cellular biochemistry

authors： Ozeki K,Sugiyama M,Akter KA,Nishiwaki K,Asano-Inami E,Senga T

更新日期：2019-01-01 00:00:00

abstract：:N-Methyl-N-nitrosourea (MNU)-induced rat mammary adenocarcinomas contain high levels of a novel leupeptin-sensitive serine endopeptidase. Its properties apparently differ from those of other similar endopeptidases reported to be present in various normal and malignant mammalian tissues. The same leupeptinsensitive ser...

journal_title：Molecular and cellular biochemistry

authors： Eto I,Bandy MD

更新日期：1990-04-18 00:00:00

abstract：:Src-suppressed C kinase substrate (SSeCKS) plays a role in membrane-cytoskeletal remodeling to regulate mitogenesis, cell differentiation, and motility. Previous study showed that lipopolysaccharide (LPS) induced a selective and strong expression of SSeCKS in the vascular endothelial cells of lung. Here we show that L...

journal_title：Molecular and cellular biochemistry

authors： Cheng C,Liu H,Ge H,Qian J,Qin J,Sun L,Chen M,Yan M,Shen A

更新日期：2007-11-01 00:00:00