Genetic polymorphism of CYP3A5 in Indian chronic myeloid leukemia patients.

abstract：:Human eosinophil-derived neurotoxin (EDN) or RNase 2, found in the non-core matrix of eosinophils is a ribonuclease belonging to the Ribonuclease A superfamily. EDN manifests a number of bioactions including neurotoxic and antiviral activities, which are dependent on its ribonuclease activity. The core of the catalyti...

journal_title：Molecular and cellular biochemistry

authors： Sikriwal D,Seth D,Dey P,Batra JK

更新日期：2007-09-01 00:00:00

abstract：:Hepatic stellate cells (HSCs), also referred to as Ito cells, perisinusiodal cells and fat-storing cells, have numerous vital functions. They are the main extracellular matrix-producing cells within the liver and are involved in the storage of retinol. HSCs are also known to secrete a number of liver mitogens. Current...

journal_title：Molecular and cellular biochemistry

authors： Riccalton-Banks L,Bhandari R,Fry J,Shakesheff KM

更新日期：2003-06-01 00:00:00

abstract：:Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightl...

journal_title：Molecular and cellular biochemistry

authors： Mahajan PB,Thompson EA

更新日期：1991-05-29 00:00:00

abstract：:The interaction of deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one) L1, the first clinically available oral iron chelator, with the tetrameric allosteric protein hemoglobin from human red blood cells has been investigated spectrofluorometrically and by circular dichroism spectroscopy. The interaction is hydrogenbond l...

journal_title：Molecular and cellular biochemistry

authors： Chakraborty D,Bhattacharyya M

更新日期：2000-01-01 00:00:00

abstract：:Regulation of L-type Ca2+ channels is complex, because many factors, such as phosphorylation, divalent cations, and proteins, specified or unspecified, have been shown to affect the channel activities. An additional complication is that these factors interact with one another to achieve final outcomes. Recent molecula...

journal_title：Molecular and cellular biochemistry

authors： Yamaoka K,Kameyama M

更新日期：2003-11-01 00:00:00

abstract：:Transport characteristics of essential trace elements as zinc, copper, selenium and iron have been studied in maternal-fetal direction in normal pregnancies, using in vitro perfusion of human placental lobules. Solutions of trace elements corresponding to twice the physiological concentrations were injected (100 micro...

journal_title：Molecular and cellular biochemistry

authors： Nandakumaran M,Dashti HM,Al-Saleh E,Al-Zaid NS

更新日期：2003-10-01 00:00:00

abstract：:Cisplatin is a widely used antineoplastic agent in the treatment of head and neck cancer. However, it is highly nephrotoxic. Oxidative stress is the main mechanism responsible for cisplatin-induced nephrotoxicity. The aim of this study was to characterize cisplatin-induced nephrotoxicity, oxidative stress in periphera...

journal_title：Molecular and cellular biochemistry

authors： Quintanilha JCF,Visacri MB,Sousa VM,Bastos LB,Vaz CO,Guarnieri JPO,Amaral LS,Malaguti C,Lima CSP,Vercesi AE,Moriel P

更新日期：2018-03-01 00:00:00

abstract：:Proteoglycans carrying chondroitin sulfate side chains have been shown to fulfill important biological functions in development, disease, and signaling. One area of considerable interest is the functional importance of chondroitin sulfates as inhibitors of the regeneration of axonal projections in the mammalian centra...

journal_title：Molecular and cellular biochemistry

authors： Klüppel M

更新日期：2011-05-01 00:00:00

abstract：:Tryptophan as a circulating precursor of serotonin (5-HT) may suppress food intake and body weight. Tryptophan administration can enhance the generation of reactive oxygen species (ROS) by inducing oxidative pathway in vivo and in vitro. We have examined the effect of repeated tryptophan administration on food consump...

journal_title：Molecular and cellular biochemistry

authors： Coşkun S,Ozer C,Gönül B,Take G,Erdoğan D

更新日期：2006-06-01 00:00:00

abstract：:Cultured endothelial cells have been used in the past as a source of endothelium-derived relaxing factor (EDRF) and of prostacyclin (PGI2). Although cell cultures are essential for observation of prolonged exposure to media or when there is delayed response, they are time consuming and sterile conditions are essential...

journal_title：Molecular and cellular biochemistry

authors： Kibira S,Dudek R,Narayan KS,Bing RJ

更新日期：1991-11-13 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are two hormones produced and secreted by the heart to control blood pressure, body fluid homeostasis and electrolyte balance. Each peptide binds to a common family of 3 receptors (GC-A, GC-B and C-receptor) with varying degrees of affinity. The pro...

journal_title：Molecular and cellular biochemistry

authors： Tse MY,Watson JD,Sarda IR,Flynn TG,Pang SC

更新日期：2001-03-01 00:00:00

abstract：:Previous studies in isolated perfused heart and in atrial preparations have demonstrated significant reductions in beating rate in STZ-induced diabetic rats, which suggests that sinus arrhythmias in diabetes mellitus may be partly caused by intrinsic alteration of sino-atrial node (SAN) function. The effects of diabet...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Nowotny N,Zilahi E,El Haj MA,Lei M

更新日期：2007-11-01 00:00:00

abstract：:Glycodelin A (GdA) is a dimeric glycoprotein synthesized by the human endometrium under progesterone regulation. Based on the high sequence similarity with β-lactoglobulin, it is placed under the lipocalin superfamily. The protein is one of the local immunomodulators present at the feto-maternal interface which affect...

journal_title：Molecular and cellular biochemistry

authors： Ponnalagu D,Karande AA

更新日期：2013-05-01 00:00:00

abstract：:AcMNPV is the first baculovirus to be sequenced and is considered a model of baculovirus. ac154 is a later expression gene in AcMNPV genome and its function is unknown. In this study, we explored the function of Ac154 in AcMNPV infection process in host Sf9 cells. The results showed that Ac154 was distributed in both ...

journal_title：Molecular and cellular biochemistry

authors： Bai H,Liang A,Fu Y

更新日期：2020-01-01 00:00:00

abstract：:Deficient wound healing is a common multifactorial complication in diabetic patients, but the cellular and molecular mechanisms involved are poorly defined. In the present study, we analyzed the effects of hyperglycemia on integrins expression in rat dermal fibroblasts and addressed its role in cell adhesion and migra...

journal_title：Molecular and cellular biochemistry

authors： Almeida ME,Monteiro KS,Kato EE,Sampaio SC,Braga TT,Câmara NO,Lamers ML,Santos MF

更新日期：2016-10-01 00:00:00

abstract：:In the present study we investigated if administration of vitamin A could protect rat liver microsomes and mitochondria from in vitro peroxidation. Appreciable decrease of chemiluminescence and lipid peroxidation was measured in microsomal membranes from rats receiving vitamin A, with respect to control animals. In me...

journal_title：Molecular and cellular biochemistry

authors： Palacios A,Piergiacomi VA,Catalá A

更新日期：1996-01-12 00:00:00

abstract：:Cellular senescence is a restricting factor for regenerative therapies with somatic stem cells. We showed previously that the onset of cellular senescence inhibits the osteogenic differentiation in stem cells of the dental follicle (DFCs), although the mechanism remains elusive. Two different pathways are involved in ...

journal_title：Molecular and cellular biochemistry

authors： Morsczeck C,Hullmann M,Reck A,Reichert TE

更新日期：2018-02-01 00:00:00

abstract：:Cultured human and rat endothelial cells were used to study cellular toxicity and Ca2+ signalling upon exposure to reactive oxygen species. Superoxide and hydrogen peroxide (O2.-/H2O2) were produced by the hypoxanthine/xanthine oxidase system (HX/XO) and caused intracellular Ca2+ concentration ([Ca2+]i) to rise steadi...

journal_title：Molecular and cellular biochemistry

authors： Volk T,Hensel M,Kox WJ

更新日期：1997-06-01 00:00:00

abstract：:Cutaneous changes like rash and hair loss, as well as other neurogenic inflammation side effects, occur frequently during anticancer treatment with the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), erlotinib. These adverse events may be so severe that they impair the patient's compliance with ...

journal_title：Molecular and cellular biochemistry

authors： Chmielinska JJ,Kramer JH,Mak IT,Spurney CF,Weglicki WB

更新日期：2020-02-01 00:00:00

abstract：:The function of the uterine smooth muscle in gestation and parturition is affected by a variety of hormones and biomolecules, some of which alter the intracellular levels of cAMP and Ca2+. Since the activity of smooth muscle MLCK has been shown to be modulated by phosphorylation, the effect of this modification of pre...

journal_title：Molecular and cellular biochemistry

authors： Pato MD,Kerc E,Lye SJ

更新日期：1995-08-01 00:00:00

abstract：:Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fif...

journal_title：Molecular and cellular biochemistry

authors： Paula RS,Souza VC,Benedet AL,Souza ER,Toledo JO,Moraes CF,Gomes L,Alho CS,Córdova C,Nóbrega OT

更新日期：2010-04-01 00:00:00

abstract：:We previously reported that curcumin induces browning of primary white adipocytes via enhanced expression of brown adipocyte-specific genes. In this study, we attempted to identify target proteins responsible for this fat-browning effect by analyzing proteomic changes in cultured white adipocytes in response to curcum...

journal_title：Molecular and cellular biochemistry

authors： Kim SW,Choi JH,Mukherjee R,Hwang KC,Yun JW

更新日期：2016-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by binding to DNA lesions. Excessive PARP 1 activation following genotoxin t...

journal_title：Molecular and cellular biochemistry

authors： Yeh TY,Sbodio JI,Nguyen MT,Meyer TN,Lee RM,Chi NW

更新日期：2005-08-01 00:00:00

abstract：:Caveolin-1 (Cav-1) expression frequently found in lung cancer was linked with disease prognosis and progression. This study reveals for the first time that Cav-1 sensitizes cisplatin-induced lung carcinoma cell death by the mechanism involving oxidative stress modulation. We established stable Cav-1 overexpressed (H46...

journal_title：Molecular and cellular biochemistry

authors： Pongjit K,Chanvorachote P

更新日期：2011-12-01 00:00:00

abstract：:Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in th...

journal_title：Molecular and cellular biochemistry

authors： Cohen BD

更新日期：2007-04-01 00:00:00

abstract：:Thialysine cannot completely substitute lysine as growth factor for a lysine-requiring E. coli mutant. However it can be utilized for growth in the presence of limiting amounts of lysine, in substitution of, and in competition with this latter. The effects of thialysine on growth rate, protein synthesis rate and cell ...

journal_title：Molecular and cellular biochemistry

authors： Cinia C,Busiello V,Coccia R,Di Girolamo M,de Marco C

更新日期：1984-01-01 00:00:00

abstract：:Sirtuin 3 (SIRT3) modulates mitochondria-localized processes and is implicated in the metabolic reprogramming of cancer cells, especially fatty acid (FA) synthesis. However, the relationship between SIRT3 and aberrant lipid synthesis in cervical cancer remains unclear. Here, we investigated the clinical relevance of S...

journal_title：Molecular and cellular biochemistry

authors： Xu LX,Hao LJ,Ma JQ,Liu JK,Hasim A

更新日期：2020-01-01 00:00:00

abstract：:Mature uteroferrin (Uf; Mr = 35,500) is a progesterone-induced acid phosphatase secreted by the pig uterus. It contains a single, unphosphorylated, high mannose-type oligosaccharide. Endometrial explants cultured in vitro secrete Uf with a Mr of 37,000 (37k Uf) having phosphorylated high mannose oligosaccharides. In t...

journal_title：Molecular and cellular biochemistry

authors： Baumbach GA,Saunders PT,Ketcham CM,Bazer FW,Roberts RM

更新日期：1991-07-10 00:00:00

abstract：:Utrophin is a widely expressed cytoskeleton protein and is associated with lipid droplets (LDs) in adipocytes. The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. Here we show that SNTB2 forms a complex with utrophin...

journal_title：Molecular and cellular biochemistry

authors： Krautbauer S,Neumeier M,Haberl EM,Pohl R,Feder S,Eisinger K,Rein-Fischboeck L,Buechler C

更新日期：2019-02-01 00:00:00

abstract：:Heat shock factor 1 (HSF1) is the major heat shock transcription factor and plays an essential role in mediating the cellular response to physiological and environmental stress. We found that LPS-induced expression of the granulocyte-colony stimulating factor (G-CSF) gene was upregulated in HSF1 knock-out (HSF1(-/-)) ...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Yang M,Wang Q,Liu M,Liang Q,Zhang H,Xiao X

更新日期：2011-06-01 00:00:00