Rabbit bone marrow glucose-6-phosphate dehydrogenase during erythroid cell development.

abstract：:In liver fibrosis, the quiescent hepatic stellate cells (HSC) are activated to proliferate and express the activated myofibroblast phenotype, losing fat droplets and the stored vitamin A, and depositing more extracellular matrix. Therapeutic strategies for liver fibrosis are focused on HSC. Pentoxifylline (PTF), an an...

journal_title：Molecular and cellular biochemistry

authors： Cardoso CC,Paviani ER,Cruz LA,Guma FC,Borojevic R,Guaragna RM

更新日期：2003-12-01 00:00:00

abstract：:Whether the response of the fetal heart to ischemia-reperfusion is associated with activation of the c-Jun N-terminal kinase (JNK) pathway is not known. In contrast, involvement of the sarcolemmal L-type Ca2+ channel (LCC) and the mitochondrial KATP (mitoKATP) channel has been established. This work aimed at investiga...

journal_title：Molecular and cellular biochemistry

authors： Sarre A,Gardier S,Maurer F,Bonny C,Raddatz E

更新日期：2008-06-01 00:00:00

abstract：:Liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities were significantly decreased in both diabetic and fasted rats. Treatment of diabetic rats with insulin resulted in liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities that were significantly greater ...

journal_title：Molecular and cellular biochemistry

authors： Martins RN,Stokes GB,Masters CL

更新日期：1986-05-01 00:00:00

abstract：:The present study was addressed to understand the interrelationship between Receptor-Ck activation, mevalonate pathway and primary response genes such as c-fos, c-myc and cyclin 'D' involved in the cell cycle. The results reported here unambiguously revealed that the phosphatidic acid (generated through the activation...

journal_title：Molecular and cellular biochemistry

authors： Kaur M,Kaul D,Sobti RC

更新日期：1998-04-01 00:00:00

abstract：:The molecular signaling events leading to protection from oxidative stress-induced apoptosis upon contact inhibition have not been fully investigated. Previous research has indicated a role for mitogen-activated protein kinases (MAPKs) in the regulation of contact inhibition, and these proteins have also been associat...

journal_title：Molecular and cellular biochemistry

authors： Gaballah M,Slisz M,Hutter-Lobo D

更新日期：2012-01-01 00:00:00

abstract：:Identifying low-abundance mutations is important for the therapy and diagnose of cancer. Since the potential for tumor heterogeneity, the efficient detection of cancer-relevant mutations largely depends on the sensitivity of the methods employed. To confirm whether the mutation detection platforms affect the perceived...

journal_title：Molecular and cellular biochemistry

authors： Jiang W,Wang W,Fu F,Teng X,Wang H,Wang H,Teng L

更新日期：2012-07-01 00:00:00

abstract：:Phospholipase C-beta (PLCbeta) isozymes (PLCbeta(1) and PLCbeta(3)) have been extensively characterized in cardiac tissue, but no data are available for the PLCbeta(4) isozyme. In this study, PLCbeta((1-4)) isozymes mRNA relative expression was studied by real-time PCR (RT-PCR) in human, rat, and murine left ventricle...

journal_title：Molecular and cellular biochemistry

authors： Otaegui D,Querejeta R,Arrieta A,Lazkano A,Bidaurrazaga A,Arriandiaga JR,Aldazabal P,Garro MA

更新日期：2010-04-01 00:00:00

abstract：:Tedisamil is antiarrhythmic class III drug with antifibrillating/defibrillating potency linked to enhancement of intermyocyte gap junctional electrical coupling most likely via its sympathomimetic cAMP-related mechanisms. This study was designed to examine the effect of tedisamil on cAMP level in guinea pig hearts in ...

journal_title：Molecular and cellular biochemistry

authors： Tribulova N,Ravingerova T,Okruhlicova L,Gabauer I,Fickova M,Pancza D,Slezak J,Manoach M

更新日期：2000-07-01 00:00:00

abstract：:Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death...

journal_title：Molecular and cellular biochemistry

authors： Chen F,Vallyathan V,Castranova V,Shi X

更新日期：2001-06-01 00:00:00

abstract：:The present study is to investigate the effect and mechanism of action of interleukin (IL)-17A and its receptor IL-17RA on non-small cell lung cancer (NSCLC). A total of 139 NSCLC patients were included in the study. NSCLC tissues and tumor-adjacent tissues were collected from the patients. Human NSCLC cell lines H157...

journal_title：Molecular and cellular biochemistry

authors： Wu Z,He D,Zhao S,Wang H

更新日期：2019-05-01 00:00:00

abstract：:Cellular senescence is a restricting factor for regenerative therapies with somatic stem cells. We showed previously that the onset of cellular senescence inhibits the osteogenic differentiation in stem cells of the dental follicle (DFCs), although the mechanism remains elusive. Two different pathways are involved in ...

journal_title：Molecular and cellular biochemistry

authors： Morsczeck C,Hullmann M,Reck A,Reichert TE

更新日期：2018-02-01 00:00:00

abstract：:Accumulating data have shown that microRNAs are involved in the pathogenesis of cancer. miR-202 has been confirmed to be downregulated in several types of human cancer. However, the expression and biological role of miR-202 in osteosarcoma (OS) carcinogenesis and progression remain unclear. In this study, we demonstra...

journal_title：Molecular and cellular biochemistry

authors： Sun Z,Zhang T,Hong H,Liu Q,Zhang H

更新日期：2014-12-01 00:00:00

abstract：:Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyopathy, peripartum cardiomyopathy, and myocarditis, and have been increasingly seen as a treatment target. We recently i...

journal_title：Molecular and cellular biochemistry

authors： Haberland A,Wallukat G,Berg S,Schulz AM,Freyse EJ,Vetter R,Salzsieder E,Müller J,Kreutz R,Schimke I

更新日期：2014-08-01 00:00:00

abstract：:There is a wealth of information regarding the import and export of nuclear proteins in general. Nevertheless, the available data that deals with the nucleocytoplasmic movement of steroid hormone receptors remains highly limited. Some research findings reported during the past five years have succeeded in identifying ...

journal_title：Molecular and cellular biochemistry

authors： Sebastian T,Sreeja S,Thampan RV

更新日期：2004-05-01 00:00:00

abstract：:Iron ions play a central role in .OH radicals formation and induction of oxidative stress in living organisms. Iron-catalyzed .OH radical formation degrades deoxyribose to thiobarbituric acid reactive substances (TBA-RS). This paper analyzes kinetic properties of the Fe(III)-EDTA-catalyzed deoxyribose degradation in t...

journal_title：Molecular and cellular biochemistry

authors： Hermes-Lima M,Wang EM,Schulman HM,Storey KB,Ponka P

更新日期：1994-08-17 00:00:00

abstract：:The pyridine nucleotides have important non-redox activities as cellular effectors and metabolic regulators [1-3]. The enzyme-catalyzed cleavage of the nicotinamide-ribosyl bond of NAD+ and the attendant delivery of the ADPRibosyl moiety to acceptors is central to these many diverse biological activities. Included are...

journal_title：Molecular and cellular biochemistry

authors： Oppenheimer NJ

更新日期：1994-09-01 00:00:00

abstract：:The oxygenase domain of the inducible nitric oxide synthase, Delta65 iNOSox is a dimer that binds heme, L-Arginine (L-Arg), and tetrahydrobiopterin (H(4)B) and is the site for NO synthesis. The role of H(4)B in iNOS structure-function is complex and its exact structural role is presently unknown. The present paper pro...

journal_title：Molecular and cellular biochemistry

authors： Sengupta R,Sahoo R,Ray SS,Dutta T,Dasgupta A,Ghosh S

更新日期：2006-03-01 00:00:00

abstract：:For evaluation whether the membrane fatty acid-binding protein is related to mGOT, studies on the structure and function of both purified proteins were performed. Physicochemical characterization revealed that both proteins are different: the membrane fatty acid-binding protein has a molecular weight of 40 kD and a pI...

journal_title：Molecular and cellular biochemistry

authors： Stremmel W,Diede HE,Rodilla-Sala E,Vyska K,Schrader M,Fitscher B,Passarella S

更新日期：1990-10-15 00:00:00

abstract：:The antioxidant activity of epigallocatechin gallate (EGCG) was studied in different in vitro model systems, which enabled evaluation of both chemical and physical factors involved in assessing the role of EGCG in oxidative reactions. EGCG suppressed the initiation rate and prolonged the lag phase duration of peroxyl ...

journal_title：Molecular and cellular biochemistry

authors： Hu C,Kitts DD

更新日期：2001-02-01 00:00:00

abstract：:Both early diagnostic and prognostic assessment of the acute abdomen in preterm infants are hampered by the lack of a sensitive and specific parameter for intestinal injury. In this prospective clinical study we wanted to estimate the value of intestinal (I-) and liver (L-) fatty acid binding protein (FABP) in diagnos...

journal_title：Molecular and cellular biochemistry

authors： Guthmann F,Börchers T,Wolfrum C,Wustrack T,Bartholomäus S,Spener F

更新日期：2002-10-01 00:00:00

abstract：:Regulation of matrix metalloproteinase-13 (MMP-13) by collagen matrix in the synovial fibroblasts of rheumatoid arthritis (RA) is critical event in the progressive joint destruction. Our previous study indicated that a collagen receptor, discoidin receptor 2 (DDR2), was highly expressed in the synovial fibroblasts of ...

journal_title：Molecular and cellular biochemistry

authors： Su J,Yu J,Ren T,Zhang W,Zhang Y,Liu X,Sun T,Lu H,Miyazawa K,Yao L

更新日期：2009-10-01 00:00:00

abstract：:Beta-arrestin-2 is an adaptor protein that terminates G protein activation and seems to be involved in the modulation of the inflammatory response. Small hyaluronan (HA) fragments, such as 4-mer HA oligosaccharides, are known to interact with the toll-like receptor-4 (TLR-4) with consequent activation of the nuclear f...

journal_title：Molecular and cellular biochemistry

authors： Campo GM,Avenoso A,D'Ascola A,Scuruchi M,Calatroni A,Campo S

更新日期：2015-01-01 00:00:00

abstract：:In this review we analyze the concepts and the experimental data on the mechanisms of the regulation of energy metabolism in muscle cells. Muscular energetics is based on the force-length relationship, which in the whole heart is expressed as a Frank-Starling law, by which the alterations of left ventricle diastolic v...

journal_title：Molecular and cellular biochemistry

authors： Saks VA,Kuznetsov AV,Vendelin M,Guerrero K,Kay L,Seppet EK

更新日期：2004-01-01 00:00:00

abstract：:The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF...

journal_title：Molecular and cellular biochemistry

authors： Lin J,Sun Z,Zhang W,Liu H,Shao D,Ren Y,Wen Y,Cao L,Wolfram J,Yang Z,Nie S

更新日期：2015-06-01 00:00:00

abstract：:Four situations in which membrane transport is altered by disease are discussed: (a) non-specific leaks induced by poreforming agents; (b) glucose transport and cellular stress; (c) Ca2+-ATPase and hypertension; (d) Na+ channels and HSV infection. ...

journal_title：Molecular and cellular biochemistry

authors： Pasternak CA

更新日期：1989-11-23 00:00:00

abstract：:Secretory phospholipase A2 (sPLA2) is a key enzyme participating in the inflammatory cascade followed by the action of cyclooxygenase-2 and lipoxygenases. Therefore, inhibitors of sPLA2 could be used as potent anti-inflammatory agents to treat the early phase of inflammation. In this study, we have prepared the fenopr...

journal_title：Molecular and cellular biochemistry

authors： Kameshwar VH,R KJ,Priya BS,Swamy SN

更新日期：2017-02-01 00:00:00

abstract：:A comparative study has been carried out on the micro-localization of catalase in mouse tissues subsequent to treatment with a representative range of hypolipidemic drugs. A commonality of effect was shown by clofibrate (ethyl-alpha-p-chlorophenoxyisobutyrate), Wy-14,643 (4-chloro-6-[2,3 xylidino)-2-pyrimidinylthio] a...

journal_title：Molecular and cellular biochemistry

authors： Klucis E,Crane D,Masters C

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:We reported that urinary L-FABP reflected the progression of chronic kidney disease (CKD). This study is aimed to evaluate the clinical significance of urinary liver type fatty acid binding protein (L-FABP) as a biomarker for monitoring CKD. METHODS:Urinary L-FABP was measured using human L-FABP ELISA kit (...

journal_title：Molecular and cellular biochemistry

authors： Kamijo A,Sugaya T,Hikawa A,Yamanouchi M,Hirata Y,Ishimitsu T,Numabe A,Takagi M,Hayakawa H,Tabei F,Sugimoto T,Mise N,Omata M,Kimura K

更新日期：2006-03-01 00:00:00

abstract：:Muscle injury is a common result of muscle exertion caused by overload and over-activity. In this presentation, an attempt was made to discuss models of muscle injury which involve exertion but not excessive strain, although most functional activities of the extremities require some eccentric muscle actions. Muscle in...

journal_title：Molecular and cellular biochemistry

authors： Stauber WT,Smith CA

更新日期：1998-02-01 00:00:00

abstract：:Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed t...

journal_title：Molecular and cellular biochemistry

authors： Parray HA,Yun JW

更新日期：2016-05-01 00:00:00