Oxidation of cardiolipin is involved in functional impairment and disintegration of liver mitochondria by hypoxia/reoxygenation in the presence of increased Ca²⁺ concentrations.

abstract：:Rat pancreatic acinar cells AR 4-2J respond to dexamethasone by differentiation and a decreased proliferation rate. Protein labelling by [3H]-mevalonolactone, used as a precursor of farnesyl and geranylgeranyl isoprenoid groups, was increased in the presence of dexamethasone. In these same conditions, dexamethasone de...

journal_title：Molecular and cellular biochemistry

authors： Lambert M,Bui ND

更新日期：1999-12-01 00:00:00

abstract：:Histone acetylation and deacetylaion play important roles in chromatin remodeling and gene expression. An imbalance of these reactions leads to aberrant behavior of the cells in the cell cycle, which in turn contributes to carcinogenesis. Histone deacetylase (HDAC) inhibitors have been shown to have anti-tumor effects...

journal_title：Molecular and cellular biochemistry

authors： Lee KH,Choi EY,Kim MK,Kim KO,Jang BI,Kim SW,Kim SW,Song SK,Kim JR

更新日期：2010-10-01 00:00:00

abstract：:Interactions of cytochrome P450 2B1 were probed using 8-anilino-1-naphthalenesulfonic acid (ANS), a well known and frequently used reporter group for hydrophobic interactions. Titration of cytochrome P450 2B1 with ANS revealed 6.6 +/- 0.2 ANS binding sites per molecule of P450 2B1 with a Kd value of 42 +/- 2 microM. I...

journal_title：Molecular and cellular biochemistry

authors： Yu XC,Strobel HW

更新日期：1996-09-20 00:00:00

abstract：:Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightl...

journal_title：Molecular and cellular biochemistry

authors： Mahajan PB,Thompson EA

更新日期：1991-05-29 00:00:00

abstract：:Catalase plays a major role in the protection of tissues from toxic effects of H2O2 and partially reduced oxygen species. In the present study catalase was extracted and purified 330-fold from goat lung by acetone fractionation and successive chromatographies on DEAE-cellulose, Sephadex G-200, Blue Sepharose CL-6B and...

journal_title：Molecular and cellular biochemistry

authors： Chatterjee U,Sanwal GG

更新日期：1993-09-22 00:00:00

abstract：:Albumin complementary DNA (cDNA) was transcribed from purified albumin mRNA from the liver of Xenopus laevis. The resultant cDNA was an almost full length copy as defined by denaturing gel electrophoresis; was hybridized specifically to albumin mRNA with pseudo-first-order reaction kinetics and the mRNA . cDNA hybrid ...

journal_title：Molecular and cellular biochemistry

authors： Dimitriadis GJ,Zongza-Dimitriadis V

更新日期：1983-01-01 00:00:00

abstract：:Fibrates and WY-14643 are widely used as lipid-lowering drugs via modulation of peroxisome proliferator-activated receptor alpha (PPAR α) for the treatment of a wide range of metabolic disorders. Here, to address the question whether PPAR α agonists can affect the enzymatic activity of 11beta-hydroxysteroid dehydrogen...

journal_title：Molecular and cellular biochemistry

authors： Kim CH,Ramu R,Ahn JH,Bae MA,Cho YS

更新日期：2010-11-01 00:00:00

abstract：:Physiological, pharmacological, histochemical and biochemical studies indicate that dopamine receptors are heterogenous in the central nervous system with each individual functions. This review describes pharmacological and biochemical characteristics of dopamine receptors, particularly in canine caudate nucleus, whic...

journal_title：Molecular and cellular biochemistry

authors： Maeno H

更新日期：1982-03-19 00:00:00

abstract：:The roles of TGF-beta and the interaction between TGF-beta and EGFR signaling are critical in Sertoli cell, though the knowledge about them is limited. RT-PCR was used to characterize the status of TGF-beta signaling in clinical testicular specimens with complete Sertoli cell-only syndrome (SCOS). The mouse Sertoli ce...

journal_title：Molecular and cellular biochemistry

authors： Sun T,Xin Z,Jin Z,Wu Y,Gong Y

更新日期：2008-12-01 00:00:00

abstract：:Hypermethylation of promoter CpG islands represents an alternative mechanism to inactivate tumor suppressor genes. This study was to detect promoter methylation status and mRNA expression levels of ARRDC3, ELP3, GATA5, and PAX6, and to explore the association between methylation and expression in invasive ductal carci...

journal_title：Molecular and cellular biochemistry

authors： Wang D,Yang PN,Chen J,Zhou XY,Liu QJ,Li HJ,Li CL

更新日期：2014-11-01 00:00:00

abstract：:Caveolin-1 (Cav-1) expression frequently found in lung cancer was linked with disease prognosis and progression. This study reveals for the first time that Cav-1 sensitizes cisplatin-induced lung carcinoma cell death by the mechanism involving oxidative stress modulation. We established stable Cav-1 overexpressed (H46...

journal_title：Molecular and cellular biochemistry

authors： Pongjit K,Chanvorachote P

更新日期：2011-12-01 00:00:00

abstract：:The purpose of this study was to determine if selected biochemical parameters representing the contractile and calcium regulating systems of cardiac muscle scaled among mammals having inherently different resting heart rates (RHR). Eight mammalian species with RHR ranging from 51 to 475 beats per minute (bpm) were stu...

journal_title：Molecular and cellular biochemistry

authors： Hamilton N,Ianuzzo CD

更新日期：1991-08-14 00:00:00

abstract：:Vaccinia virus (VV) and other pathogenic poxviruses encode for a complement control protein. The VV complement control protein or VCP, was one of the first soluble microbial proteins postulated to have an active role in the immunomodulation of the host defense. Since then, 2 other poxviruses, including variola virus a...

journal_title：Molecular and cellular biochemistry

authors： Kotwal GJ,Miller CG,Justus DE

更新日期：1998-08-01 00:00:00

abstract：:In order to establish the distribution with time of proteins microinjected into mammalian cells, horseradish peroxidase (HRP) was microinjected into baby hamster kidney (BHK) cells using chicken erythrocyte ghosts. At time intervals following initiation of fusion between ghosts and target cells, samples were fixed wit...

journal_title：Molecular and cellular biochemistry

authors： McClung JK,Ulrich RG,Kletzien RF

更新日期：1987-01-01 00:00:00

abstract：:Endochondral ossification, an important stage of fracture healing, is regulated by a variety of signaling pathways. Transforming growth factor β (TGFβ) superfamily plays important roles and comprises TGFβs, bone morphogenetic proteins (BMPs), and growth differentiation factors. TGFβs primarily regulate cartilage forma...

journal_title：Molecular and cellular biochemistry

authors： Sheu TJ,Zhou W,Fan J,Zhou H,Zuscik MJ,Xie C,Yin G,Berk BC

更新日期：2014-12-01 00:00:00

abstract：:Total cellular creatine content is an important bioenergetic parameter in skeletal muscle. To understand its regulation we investigated creatine transport and accumulation in the G8 cultured skeletal myoblast line. Like other cell types, these contain a creatine transporter, whose activity, measured using a radiolabel...

journal_title：Molecular and cellular biochemistry

authors： Odoom JE,Kemp GJ,Radda GK

更新日期：1996-05-24 00:00:00

abstract：:In the eluted fractions of histone-treated crude extracts separated by Sephadex G-200 filtration, multiple protein kinase (PK) activities, including three from brain and two from skeletal muscle, were augmented by both S-100 protein and parvalbumin on the phosphorylation of endogenous substrates. One additional PK act...

journal_title：Molecular and cellular biochemistry

authors： Kuo WN,Blake T,Cheema IR,Dominguez J,Nicholson J,Puente K,Shells P,Lowery J

更新日期：1986-06-01 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates the expression of integrins alpha 5 beta 1 and v beta 3 as well as focal adhesion kinase (FAK) and phosphorylated FAK (pY3...

journal_title：Molecular and cellular biochemistry

authors： Cai WJ,Li MB,Wu X,Wu S,Zhu W,Chen D,Luo M,Eitenmüller I,Kampmann A,Schaper J,Schaper W

更新日期：2009-02-01 00:00:00

abstract：:The role of C-X-C chemokine receptor type 4 (CXCR4) in umbilical mesenchymal stem cells (UMSCs) as therapy for liver disease is ill understood. The aim of the study was to evaluate rat UMSCs (rUMSCs) on CXCR4 expression and homing to injured liver tissue. rUMSCs were isolated from umbilical cords of pregnant rats. Acu...

journal_title：Molecular and cellular biochemistry

authors： Deng C,Qin A,Zhao W,Feng T,Shi C,Liu T

更新日期：2014-11-01 00:00:00

abstract：:The effects of Mg2+ and Ca2+ deprivation on survival and growth of normal and transformed cultured cells were studied. Normal fibroblast from several origins (mouse, hamster and human) did not grow in 2 microM Mg2+ medium, whereas transformed fibroblasts (mouse and rat) and tumor cells of other types (mouse adrenocort...

journal_title：Molecular and cellular biochemistry

authors： Ribeiro SM,Armelin HA

更新日期：1984-01-01 00:00:00

abstract：:Thymol is a phytochemical component present in many plants used as food additive in order to promote animal growth due to its several biological properties. However, possible side effects of thymol remain poorly known limited to few reports. In this sense, we evaluated the enzymes of the purinergic signaling such as, ...

journal_title：Molecular and cellular biochemistry

authors： Baldissera MD,Souza CF,De Matos AFIM,Baldisserotto B,Stefani LM,da Silva AS

更新日期：2019-02-01 00:00:00

abstract：:A proliferation-inducing ligand (APRIL) is overexpressed in most tumor cells and tissues, especially in tumors of the alimentary system, such as colorectal cancer (CRC), gastric cancer, and liver cancer. RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown and holds great promise for the tr...

journal_title：Molecular and cellular biochemistry

authors： Wang J,Ding W,Sun B,Jing R,Huang H,Shi G,Wang H

更新日期：2012-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death, and its increasing incidence worldwide is a cause for concern. The recombinant analgesic-antitumor peptide (rAGAP), a protein consisting of small ubiquitin-related modifier linked with a hexa-histidine tag, exhibited the antitumor activit...

journal_title：Molecular and cellular biochemistry

authors： Cao Q,Lu W,Zhou T,Liu Y,Cai X,Zhu J,Cao P

更新日期：2019-05-01 00:00:00

abstract：:Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production. The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enh...

journal_title：Molecular and cellular biochemistry

authors： Kirtikara K,Laulederkind SJ,Raghow R,Kanekura T,Ballou LR

更新日期：1998-04-01 00:00:00

abstract：:Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions play a critical role for the formation of stress granules. In this study, we report that FAM98A, whose biologic...

journal_title：Molecular and cellular biochemistry

authors： Ozeki K,Sugiyama M,Akter KA,Nishiwaki K,Asano-Inami E,Senga T

更新日期：2019-01-01 00:00:00

abstract：:Brain membrane lipid fatty acid composition and consequently membrane fluidity change with increasing age. Intracellular fatty acid binding proteins (FABPs) such as heart H-FABP and the brain specific B-FABP, detected by immunoblotting of brain tissue, are thought to be involved in fatty acid uptake, metabolism, and d...

journal_title：Molecular and cellular biochemistry

authors： Pu L,Igbavboa U,Wood WG,Roths JB,Kier AB,Spener F,Schroeder F

更新日期：1999-08-01 00:00:00

abstract：:Glioblastoma is the most common and deadly type of brain cancer. The poor prognosis may be largely attributed to inadequate disease response to current chemotherapeutic agents. Activation of p38 is associated with deleterious outcomes in glioblastoma patients, as its signaling mediates chemoresistance mechanisms. Anti...

journal_title：Molecular and cellular biochemistry

authors： Su BC,Chen JY

更新日期：2020-01-01 00:00:00

abstract：:The dramatic segregation of the nucleolar components in winter-acclimatized carp is the most striking cellular-phenotypical feature observed during the seasonal adaptation of this fish toward the circannual changes in its habitat. Our studies also show that the carp habitat temperature and photoperiod winter condition...

journal_title：Molecular and cellular biochemistry

authors： Alvarez M,Kausel G,Figueroa J,Vera MI

更新日期：2001-11-01 00:00:00

abstract：:Studies presented here show that cellular NAD, which we hypothesize to be the relevant biomarker of niacin status, is significantly lower in humans than in the commonly studied animal models of carcinogenesis. We show that nicotinamide and the resulting cellular NAD concentration modulate expression of the tumor suppr...

journal_title：Molecular and cellular biochemistry

authors： Jacobson EL,Shieh WM,Huang AC

更新日期：1999-03-01 00:00:00

abstract：:Cellular FLICE-like inhibitory protein (Flip) is a negative regulator of nuclear factor κB signaling which has been shown previously to complicate with cardiac hypertrophy. In the present study, we tested the hypothesis that the knockout of Flip would increase cardiac hypertrophy in vivo and in vitro. The effects of F...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Wu L,Wu J,Li Y,Hou L

更新日期：2014-12-01 00:00:00