Effect of melatonin on phagocytic activity and intracellular free calcium concentration in testicular macrophages from normal and streptozotocin-induced diabetic rats.

abstract：:Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, has been implicated in the inflammation mediated by macrophages and endothelial cells by regulating the expression of inflammatory mediators. Here, we investigated whether KLF4 affects the expression of inducible nitric oxide synthase (iNOS), an importa...

journal_title：Molecular and cellular biochemistry

authors： Mo X,Chen J,Wang X,Pan Z,Ke Y,Zhou Z,Xie J,Lv G,Luo X

更新日期：2018-01-01 00:00:00

abstract：:Both early diagnostic and prognostic assessment of the acute abdomen in preterm infants are hampered by the lack of a sensitive and specific parameter for intestinal injury. In this prospective clinical study we wanted to estimate the value of intestinal (I-) and liver (L-) fatty acid binding protein (FABP) in diagnos...

journal_title：Molecular and cellular biochemistry

authors： Guthmann F,Börchers T,Wolfrum C,Wustrack T,Bartholomäus S,Spener F

更新日期：2002-10-01 00:00:00

abstract：:Concentrations of 1-4 mumol l-1 isoproterenol cause both in right ventricular papillary muscles and in enzymatically isolated myocytes of the guinea-pig a Ca2+ overload-induced state which is functionally characterized by biphasic (multiphasic) twitches and biphasic (multiphasic) intracellular calcium transients, resp...

journal_title：Molecular and cellular biochemistry

authors： Löhn M,Szymanski G,Markwardt F

更新日期：1996-07-01 00:00:00

abstract：:Myostatin (MSTN) is primarily expressed in muscle and plays an important role in muscle and fat development in pigs. However, there is little information about the regulation of pig MSTN. In order to elucidate whether pig MSTN could be regulated by muscle- and fat-related factors, the porcine MSTN promoter was amplifi...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Wen J,Ding Y,Gao Q,Huang H,Ran Z,Qian Y,Peng J,Jiang S

更新日期：2012-04-01 00:00:00

abstract：:Fenugreek and Balanites are two plants commonly used in Egyptian folk medicine as hypoglycemic agents. In the present study, the effects of 21 days oral administration of Fenugreek seed and Balanites fruit extracts (1.5 g/kg bw) on the liver and kidney glycogen content and on some key liver enzymes of carbohydrate met...

journal_title：Molecular and cellular biochemistry

authors： Gad MZ,El-Sawalhi MM,Ismail MF,El-Tanbouly ND

更新日期：2006-01-01 00:00:00

abstract：:The role of antioxidant enzymes, particularly superoxide dismutase (SOD), in immortalization and malignant transformation is discussed. SOD (generally MnSOD) has been found to be lowered in a wide variety of tumor types when compared to an appropriate normal cell control. Levels of immunoreactive MnSOD protein and mRN...

journal_title：Molecular and cellular biochemistry

authors： Oberley LW,Oberley TD

更新日期：1988-12-01 00:00:00

abstract：:Oxidants and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) activate nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factors, and enhance the expression of both pro-inflammatory and protective antioxidant genes. Remodelling of chromatin within the nucleus, contr...

journal_title：Molecular and cellular biochemistry

authors： Rahman I,Gilmour PS,Jimenez LA,MacNee W

更新日期：2002-05-01 00:00:00

abstract：:The purpose of this study was to determine if selected biochemical parameters representing the contractile and calcium regulating systems of cardiac muscle scaled among mammals having inherently different resting heart rates (RHR). Eight mammalian species with RHR ranging from 51 to 475 beats per minute (bpm) were stu...

journal_title：Molecular and cellular biochemistry

authors： Hamilton N,Ianuzzo CD

更新日期：1991-08-14 00:00:00

abstract：:Fenofibrate, a selective (1)PPAR-alpha activator, is prescribed to treat human dyslipidemia. The aim of this study was to delineate the mechanism of fenofibrate-mediated reductions in adiposity, improvements in insulin sensitivity, and lowering of triglycerides (TG) and free fatty acids (FFA) and to investigate if the...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RA,Jahagirdar R,Azhar S,Sharma S,Bisgaier CL

更新日期：2006-04-01 00:00:00

abstract：:In addition of being an important inflammatory biomarker and a risk factor for cardiovascular disease, much evidence indicates that the C-reactive protein (CRP) contributes to the atherosclerosis development process. This plasmatic protein synthesized by hepatocytes in response to inflammation and tissue injury induce...

journal_title：Molecular and cellular biochemistry

authors： Cossette É,Cloutier I,Tardif K,DonPierre G,Tanguay JF

更新日期：2013-01-01 00:00:00

abstract：:In order to study the mechanism of entry and localization of bilirubin (BR) into cell membrane, binding of BR to sealed and human serum albumin (HSA)-entrapped sealed membranes was studied by CD spectroscopy. An induced bisignate CD cotton effects (CDCEs) of BR-bound sealed membranes were observed with maxima at 515 n...

journal_title：Molecular and cellular biochemistry

authors： Rashid H,Khan MM,Tayyab S

更新日期：2005-09-01 00:00:00

abstract：:Myofibroblasts are metabolically and morphologically distinctive fibroblasts expressing alpha-smooth muscle actin (alpha-SMA), and their activation plays a key role in development of the fibrotic response. In an activated state, myofibroblasts cease to proliferate and start to synthesize large amounts of extracellular...

journal_title：Molecular and cellular biochemistry

authors： Nakatani T,Honda E,Hayakawa S,Sato M,Satoh K,Kudo M,Munakata H

更新日期：2008-01-01 00:00:00

abstract：:This study examined the role of the protein kinase C (PKC) signalling pathway in the regulation of expression of human complement factor I (CFI) gene. The production of CFI by Hep G2 cells was enhanced in a dose- and time-dependent fashion by 12-O-tetradecanoyl-1,2-phorbol 13-acetate (TPA), a potent PKC activator. 4Al...

journal_title：Molecular and cellular biochemistry

authors： Minta J,Fung M

更新日期：1999-11-01 00:00:00

abstract：:Caffeic acid (3,4-dihydroxy cinnamic acid) (CA) is naturally found in fruits, vegetables, olive oil, and coffee. This study was undertaken to evaluate the anticancer effect of caffeic acid on HT-1080 human fibrosarcoma cell line. The antiproliferative effect of caffeic acid was determined by MTT assay, and the oxidati...

journal_title：Molecular and cellular biochemistry

authors： Rajendra Prasad N,Karthikeyan A,Karthikeyan S,Reddy BV

更新日期：2011-03-01 00:00:00

abstract：:We investigated whether chronic in vivo treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates cardiac contractile function by impairing mitochondrial respiration. Wy-14,643 (25 mg kg(-1) day(-1)) was administered to Wistar rats by oral gavage for 14 consecutive days, after wh...

journal_title：Molecular and cellular biochemistry

authors： Zungu M,Young ME,Stanley WC,Essop MF

更新日期：2009-10-01 00:00:00

abstract：:A highly purified preparation of filamentous hemagglutinin (FHA) from Bordetella pertussis was analyzed for its protein composition by gel electrophoretic methods. In this preparation of FHA the following native species could be detected by polyacrylamide gel electrophoresis (PAGE) at pH 3.2: S1 and S2 (inactive subun...

journal_title：Molecular and cellular biochemistry

authors： An der Lan B,Cowell JL,Burstyn DG,Manclark CR,Chrambach A

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:It has been reported that long intergenic non-protein-coding RNA 324 (LINC00324) promotes liver cancer by upregulating Fas ligand (FasL), which is a major player in intervertebral disk degeneration (IDD), indicating the involvement of LINC00324 in IDD. This study was carried out to investigate the interactio...

journal_title：Molecular and cellular biochemistry

authors： Chen Y,Wu Y,Chen R,Xu C,Chen Q

更新日期：2021-01-28 00:00:00

abstract：:The present paper shows that human chronic myeloid (K562) cells exposed 3 h to 20 microM 3'-azido-3'-deoxythymidine (AZT) exhibit marked variations of the oligosaccharide moiety of glycoconjugates. These changes were analyzed by confocal fluorescence microscopy, upon incubation of control and AZT-treated cells with bi...

journal_title：Molecular and cellular biochemistry

authors： Lizzi AR,D'Alessandro AM,Bozzi A,Cinque B,Oratore A,D'Andrea G

更新日期：2007-06-01 00:00:00

abstract：:Changes in the ecto-5'-nucleotidase activity-an extracellular nucleotide catabolic enzyme may lead to the inflammation and endothelial dysfunction. We investigated the effect of CD73 deletion on the endothelial function and L-arginine metabolism in various age groups of mice. 1-,3-,6-, and 12-month-old, male C57BL/6 J...

journal_title：Molecular and cellular biochemistry

authors： Mierzejewska P,Zabielska MA,Kutryb-Zajac B,Tomczyk M,Koszalka P,Smolenski RT,Slominska EM

更新日期：2019-08-01 00:00:00

abstract：:It is well known that mitochondria are only partly an autonomous system since they are subjected to nuclear control. For this reason, in studying mitochondrial genes one has to consider constantly the integration of mitochondrial and nuclear genetic systems. This fact makes experimental approaches still more sophistic...

journal_title：Molecular and cellular biochemistry

authors： Neifakh SA

更新日期：1977-02-04 00:00:00

abstract：:Glomerular mesangial cells play an important role in the development of glomerulosclerosis. Mesangial cell apoptosis has been shown to be involved in different stages of development of glomerulonephritis. The aim of the present study was to evaluate the effect of inhibition of serine/threonine phosphatases by okadaic ...

journal_title：Molecular and cellular biochemistry

authors： Parameswaran N,Spielman WS,Brooks DP,Nambi P

更新日期：2004-05-01 00:00:00

abstract：:The (Ca2+ + Mg2+) ATPase which serves as a Ca2+ pump in the kidney basolateral membranes is essential to the maintenance of an intracellular Ca2+ concentration optimal for kidney function. Since atrial natriuretic peptide (ANP) is known to participate in the Ca2+ homeostasis mechanism, altered levels of ANP in diabete...

journal_title：Molecular and cellular biochemistry

authors： Sahai A,Ganguly PK

更新日期：1991-06-26 00:00:00

abstract：:Utrophin is a widely expressed cytoskeleton protein and is associated with lipid droplets (LDs) in adipocytes. The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. Here we show that SNTB2 forms a complex with utrophin...

journal_title：Molecular and cellular biochemistry

authors： Krautbauer S,Neumeier M,Haberl EM,Pohl R,Feder S,Eisinger K,Rein-Fischboeck L,Buechler C

更新日期：2019-02-01 00:00:00

abstract：:The amylase-protein amylase inhibitor system offers a unique model of specific and reversilbe protein-protein interaction. The monomeric and dimeric inhibitors, exhibiting closely related properties and interacting with the same amylase, also provide a convenient test to compare effects of monomer-monomer and monomer-...

journal_title：Molecular and cellular biochemistry

authors： Silano V,Poerio E,Buonocore V

更新日期：1977-12-29 00:00:00

abstract：:Previous results from our laboratory have shown that a novel carotenoid derivative (disodium disuccinate astaxanthin; Cardax) produced dose-related reductions in myocardial infarct size (IS) in Sprague-Dawley rats when it was administered at any of three doses (25, 50 and 75 mg/kg, iv) on four consecutive days, follow...

journal_title：Molecular and cellular biochemistry

authors： Gross GJ,Lockwood SF

更新日期：2005-04-01 00:00:00

abstract：:To understand the hypocholesterolemic activity of green tea, our in vitro studies screened the relative efficacy of two structurally distinct green tea catechins, epicatechin (EC) and epigallocatechin gallate (EGCG), on apolipoprotein B-100 (apoB) and lipid production using a well established human hepatoma cell-line,...

journal_title：Molecular and cellular biochemistry

authors： Yee WL,Wang Q,Agdinaoay T,Dang K,Chang H,Grandinetti A,Franke AA,Theriault A

更新日期：2002-01-01 00:00:00

abstract：:Human papillomavirus (HPV) is considered to be a major etiological factor but is not sufficient for the development of cervical cancer. Other host factors including altered tumor suppressor gene activities might contribute to the carcinogenic process. Fragile Histidine Triad (FHIT) has been shown to play a pivotal rol...

journal_title：Molecular and cellular biochemistry

authors： Neyaz MK,Hussain S,Hassan MI,Das BC,Husain SA,Bharadwaj M

更新日期：2010-02-01 00:00:00

abstract：:Ciprofloxacin induced an increment of reactive oxygen species in sensitive strains of Staphylococcus aureus leading to oxidative stress detected by chemiluminescence while resistant strains did not suffer such stress. Oxidation of lipids was performed by employing thiobarbituric acid reaction to detect the formation o...

journal_title：Molecular and cellular biochemistry

authors： Becerra MC,Páez PL,Laróvere LE,Albesa I

更新日期：2006-04-01 00:00:00

abstract：:Reviews on the pathogenic mechanisms of Shigella species show a lacunae in the understanding of the bacterial antioxidant defense system and its regulations. This study was done to investigate the regulation of expression of antioxidant enzymes in clinical isolates of Shigella species, under various growth conditions....

journal_title：Molecular and cellular biochemistry

authors： Prakash R,Devaraj H,Devaraj SN

更新日期：2004-12-01 00:00:00

abstract：:A number of quite specific and fairly potent inhibitors of protein kinase CK2, belonging to the classes of condensed polyphenolic compounds, tetrabromobenzimidazole/triazole derivatives and indoloquinazolines are available to date. The structural basis for their selectivity is provided by a hydrophobic pocket adjacent...

journal_title：Molecular and cellular biochemistry

authors： Sarno S,Ruzzene M,Frascella P,Pagano MA,Meggio F,Zambon A,Mazzorana M,Di Maira G,Lucchini V,Pinna LA

更新日期：2005-06-01 00:00:00