Olfactory functions in Parkinson's disease and Alzheimer's disease.

abstract：:A list of 147 tetralin- and indan-like compounds was compiled from the literature for investigating the relationship between molecular structure and musk odor. Each compound in the data set was represented by 374 CODESSA and 970 TAE descriptors. A genetic algorithm (GA) for pattern recognition analysis was used to id...

journal_title：Chemical senses

authors： Lavine BK,White C,Mirjankar N,Sundling CM,Breneman CM

更新日期：2012-10-01 00:00:00

abstract：:The experiments had 2 main goals: 1) to add to the sparse literature on how retronasal aromas interact with bitter tastes, and 2) to determine whether modulation of taste intensity by aroma depends on temporal contiguity, as one might expect if flavor interactions depend on cross-modal binding (similar to object perce...

journal_title：Chemical senses

authors： Isogai T,Wise PM

更新日期：2016-09-01 00:00:00

abstract：:The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...

journal_title：Chemical senses

authors： Nahon DF,Roozen JP,de Graaf C

更新日期：1998-02-01 00:00:00

abstract：:Taste sensitivity plays a major role in controlling feeding behavior, and alterations in feeding habit induced by changes in taste sensitivity can drive speciation. We investigated variability in taste preferences in wild-derived inbred lines from the Drosophila melanogaster Genetic Reference Panel. Preferences for di...

journal_title：Chemical senses

authors： Uchizono S,Tanimura T

更新日期：2017-05-01 00:00:00

abstract：:Olfactory perception is highly variable from one person to another, as a function of individual and contextual factors. Here, we investigated the influence of 2 important factors of variation: culture and semantic information. More specifically, we tested whether cultural-specific knowledge and presence versus absence...

journal_title：Chemical senses

authors： Ferdenzi C,Joussain P,Digard B,Luneau L,Djordjevic J,Bensafi M

更新日期：2017-01-01 00:00:00

abstract：:Current ambiguity concerning the related issues of optimal means for measurement of odor sensitivity and the functional properties of the olfactory system hinders progress in basic and applied research on the human sense of smell. To address these needs, we selected n-amyl acetate (nAA) as a test odorant and developed...

journal_title：Chemical senses

authors： Walker JC,Hall SB,Walker DB,Kendal-Reed MS,Hood AF,Niu XF

更新日期：2003-11-01 00:00:00

abstract：:Different odorant-binding proteins (OBPs) were isolated from total antennal homogenates of male and female Bombyx mori. Proteins were separated according to their isoelectric point by using preparative fast-flow isoelectrofocusing. Odorant-binding proteins were identified in immunoblots by antisera raised against the ...

journal_title：Chemical senses

authors： Maida R,Proebstl T,Laue M

更新日期：1997-10-01 00:00:00

abstract：:Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences fo...

journal_title：Chemical senses

authors： Tordoff MG,Aleman TR,McCaughey SA

更新日期：2015-01-01 00:00:00

abstract：:Hyperosmia is suspected in pregnancy; however, no empirical study using validated measures of olfactory function has clearly confirmed the anecdotal reports of this phenomenon. The goal of the current study is to compare the olfactory sensitivity of pregnant women to that of nonpregnant women and men. All participants...

journal_title：Chemical senses

authors： Cameron EL

更新日期：2014-02-01 00:00:00

abstract：:We have measured concentration detection (i.e., psychometric) functions to determine the odor detectability of homologous aliphatic aldehydes (propanal, butanal, hexanal, octanal, and nonanal) and helional. Subjects (16 < or = n < or = 18) used a 3-alternative forced-choice procedure against carbon-filtered air (blank...

journal_title：Chemical senses

authors： Cometto-Muñiz JE,Abraham MH

更新日期：2010-05-01 00:00:00

abstract：:In this review we report data from freely breathing animals in an attempt to show how respiratory dynamics can influence bulbar and cortical activity. Relying on in vivo data as well as in vitro observations, we try to emphasize the multiple mechanisms that underlie this modulation, its multiple origins, and its possi...

journal_title：Chemical senses

authors： Buonviso N,Amat C,Litaudon P

更新日期：2006-02-01 00:00:00

abstract：:Atypical glomeruli (AtG) are clearly distinguishable from typical ones because of their strong cholinergic innervation. AtG are located in defined positions in the caudal half of the main olfactory bulb of rodents. The AtG partially overlap with other specialized olfactory subsystems, such as the modified glomerular c...

journal_title：Chemical senses

authors： Weruaga E,Briñón JG,Porteros A,Arévalo R,Aijón J,Alonso JR

更新日期：2001-01-01 00:00:00

abstract：:Associative plasticity is a basic essential attribute of nervous systems. As shown by numerous reports, Drosophila is able to establish simple forms of appetitive and aversive olfactory associations at both larval and adult stages. Whereas most adult studies on aversive learning employed electric shock as a negative r...

journal_title：Chemical senses

authors： Pauls D,Pfitzenmaier JE,Krebs-Wheaton R,Selcho M,Stocker RF,Thum AS

更新日期：2010-05-01 00:00:00

abstract：:A metacognitive perspective is utilized to elucidate why it is so difficult to name common odors and what characterizes the subjective knowledge people have about their actual odor knowledge. Odor-naming failures are often accompanied by strong feelings of knowing (FOK) or feelings of imminent retrieval of what it is ...

journal_title：Chemical senses

authors： Jönsson FU,Tchekhova A,Lönner P,Olsson MJ

更新日期：2005-05-01 00:00:00

abstract：:Chemical signals are common in most crustacean social interactions and are often perceived via chemosensory (olfactory) organs on the first antenna. Intermolt courtship behaviors and mating were investigated in size-matched pairs of intermolt European lobsters (Homarus gammarus) where the olfactory receptors of either...

journal_title：Chemical senses

authors： Skog M

更新日期：2009-02-01 00:00:00

abstract：:Analysis of single fibers isolated from a branch of the facial/trigeminal complex innervating the maxillary barbel of the channel catfish, Ictalurus punctatus, indicated the existence of bimodal (taste/tactile) fibers. Of the 60 single fibers recorded, 14 (23%) responded to both taste (amino acid) and tactile stimulat...

journal_title：Chemical senses

authors： Ogawa K,Marui T,Caprio J

更新日期：1997-08-01 00:00:00

abstract：:In this issue of Chemical Senses, Münch et al. present a thorough analysis of how mixtures of odorants interact with olfactory receptors (ORs) borne by olfactory receptor neurons (ORNs). Using fruit fly ORNs expressing the receptor OR22a, they provide a clear example of mixture interaction and confirm that the respons...

journal_title：Chemical senses

authors： Rospars JP

更新日期：2013-05-01 00:00:00

abstract：:In order to study potential mixture interactions among bitter compounds, selected sodium salts were added to five compounds presented either alone or as binary bitter-compound mixtures. Each compound was tested at a concentration that elicited 'weak' perceived bitterness. The bitter compounds were mixed at these conce...

journal_title：Chemical senses

authors： Keast RS,Canty TM,Breslin PA

更新日期：2004-06-01 00:00:00

abstract：:Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in ...

journal_title：Chemical senses

authors： Stevens JC,Cruz LA,Hoffman JM,Patterson MQ

更新日期：1995-08-01 00:00:00

abstract：:In 20 normal and four anosmic participants, instantaneous inhalation and exhalation flow rates were recorded in response to 15 s stimulations with clean air or propionic acid concentrations (0.16, 1.14, 8.22 and 59.15 p.p.m., v/v) that ranged from peri-threshold for normals to clearly supra-threshold for anosmics. Eac...

journal_title：Chemical senses

authors： Walker JC,Kendal-Reed M,Hall SB,Morgan WT,Polyakov VV,Lutz RW

更新日期：2001-05-01 00:00:00

abstract：:We have previously modeled the interaction of the sweet protein brazzein with the extracellular domains of the sweet taste receptor. Here, we describe the application of that model to the design of 12 new highly potent analogs of brazzein. Eight of the 12 analogs have higher sweetness potency than wild-type brazzein. ...

journal_title：Chemical senses

authors： Walters DE,Cragin T,Jin Z,Rumbley JN,Hellekant G

更新日期：2009-10-01 00:00:00

abstract：:The perception of sweetness and flavour were studied in viscous solutions containing 50 g/l sucrose, 100 p.p.m. iso-amyl acetate and varying concentrations of three hydrocolloid thickeners (guar gum, lambda-carrageenan and hydroxypropylmethyl cellulose). Zero-shear viscosity of the samples ranged from 1 to 5000 mPas. ...

journal_title：Chemical senses

authors： Cook DJ,Hollowood TA,Linforth RS,Taylor AJ

更新日期：2003-01-01 00:00:00

abstract：:Feeding behavior of adult rainbow trout (Oncorhynchus mykiss) is released by visual and/or chemical stimuli. Detection of either a conditioned visual or a conditioned chemical stimulus creates an excitatory feeding state within the central nervous system which turns on feeding behavior composed of swimming, turning an...

journal_title：Chemical senses

authors： Valentincic T,Caprio J

更新日期：1997-08-01 00:00:00

abstract：:The sense of smell deteriorates in normal aging, but the underling mechanisms are still elusive. Here we investigated age-related alterations in expression patterns of odorant receptor (OR) genes and functional properties of olfactory sensory neurons (OSNs)-2 critical factors that define the odor detection threshold i...

journal_title：Chemical senses

authors： Lee AC,Tian H,Grosmaitre X,Ma M

更新日期：2009-10-01 00:00:00

abstract：:Presynaptic inhibition is the suppression of neurotransmitter release from a neuron by inhibitory input onto its presynaptic terminal. In the olfactory system, the primary sensory afferents from the olfactory neuroepithelium to the brain's olfactory bulb are strongly modulated by a presynaptic inhibition that has been...

journal_title：Chemical senses

authors： McGann JP

更新日期：2013-07-01 00:00:00

abstract：:The reported effects of temperature on sweet taste in humans have generally been small and inconsistent. Here, we describe 3 experiments that follow up a recent finding that cooling from 37 to 21 °C does not reduce the initial sweetness of sucrose but increases sweet taste adaptation. In experiment 1, subjects rated t...

journal_title：Chemical senses

authors： Green BG,Nachtigal D

更新日期：2015-07-01 00:00:00

abstract：:The central projections of olfactory receptor cells associated with two distinct types of antennal sensilla in the sphinx moth Manduca sexta were revealed by anterograde staining. In both sexes, receptor axons that arise from sexually isomorphic, type-II trichoid sensilla (and possibly some basiconic sensilla) project...

journal_title：Chemical senses

authors： Christensen TA,Harrow ID,Cuzzocrea C,Randolph PW,Hildebrand JG

更新日期：1995-06-01 00:00:00

abstract：:Electrophysiological responses of olfactory receptor neurons in both male and female silkmoths (Bombyx mori) were investigated. In both sexes, the G-protein activator sodium fluoride and 1,2-dioctanoyl-sn-glycerol, a membrane-permeable analog of the protein kinase C activator diacylglycerol, elicited nerve impulse res...

journal_title：Chemical senses

authors： Pophof B,Van der Goes van Naters W

更新日期：2002-06-01 00:00:00

abstract：:In this issue of Chemical Senses, Baker et al. propose a provocative and intriguing explanation for a commonly observed phenomenon in moth chemocommunication. Sex pheromones in moths typically consist of mixtures of long-chain unsaturated compounds in specific ratios. These ratios are correspondingly detected by male ...

journal_title：Chemical senses

authors： Olsson SB,Hansson BS

更新日期：2012-05-01 00:00:00

abstract：:Odors are inherently ambiguous and therefore susceptible to redundant sensory as well as context information. The identification of an odor object relies largely on visual input. Thus far, it is unclear whether visual and olfactory stimuli are indeed integrated at an early perceptual stage and which role the congruenc...

journal_title：Chemical senses

authors： Amsellem S,Höchenberger R,Ohla K

更新日期：2018-05-23 00:00:00