Taste sensitivity and aging: high incidence of decline revealed by repeated threshold measures.


:Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in each of 15 older (over 64 years) and 15 younger (under 27 years) adult subjects. Threshold was determined by a procedure similar to past studies and with the same results: much scatter and considerable overlap between the thresholds of younger and older subjects. A quite contrasting picture emerges, however, when each subject's six threshold determinations are averaged. Averaging shrinks the individual differences among subjects, as well as the over-lap between younger and older subjects. Although virtually all elderly subjects now revealed taste weakness, reliable individual differences in degree of weakness abound among them, suggesting various individual rates of physiological aging. In contrast, young persons exhibit greater uniformity of sensitivity. These findings were brought out by inter-test correlations, which were much higher for the older subjects; i.e. an older subject who tended to score high (low) on one test tended to score high (low) on the other tests. The study confirms the tenuous nature of brief threshold tests as indices of personal sensitivity as found earlier also in olfactory thresholds and in concurrent measurement of two-point touch thresholds in the present study. This revealed correlated losses between repeated taste and touch thresholds from the same 15 older subjects, unrelated to their exact chronological age.


Chem Senses


Chemical senses


Stevens JC,Cruz LA,Hoffman JM,Patterson MQ




Has Abstract


1995-08-01 00:00:00












  • Pregnancy does not affect human olfactory detection thresholds.

    abstract::Hyperosmia is suspected in pregnancy; however, no empirical study using validated measures of olfactory function has clearly confirmed the anecdotal reports of this phenomenon. The goal of the current study is to compare the olfactory sensitivity of pregnant women to that of nonpregnant women and men. All participants...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Cameron EL

    更新日期:2014-02-01 00:00:00

  • Cross-adaptation and bitterness inhibition of L-tryptophan, L-phenylalanine and urea: further support for shared peripheral physiology.

    abstract::A previous study investigating individuals' bitterness sensitivities found a close association among three compounds: L-tryptophan (L-trp), L-phenylalanine (L-phe) and urea (Delwiche et al., 2001, Percept. Psychophys. 63, 761-776). In the present experiment, psychophysical cross-adaptation and bitterness inhibition ex...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Keast RS,Breslin PA

    更新日期:2002-02-01 00:00:00

  • Distortion of olfactory perception: diagnosis and treatment.

    abstract::Clinically, olfaction can fail in any of three ways: (i) decreased sensitivity (hyposmia, anosmia) and two types of distortion (dysosmia); (ii) distorted quality of an odorant stimulation (troposmia); (iii) perceived odor when no odorant is present (phantosmia, hallucination). The distortions are usually much more ups...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Leopold D

    更新日期:2002-09-01 00:00:00

  • Potential semiochemical molecules from birds: a practical and comprehensive compilation of the last 20 years studies.

    abstract::During the past 2 decades, considerable progress has been made in the study of bird semiochemistry, and our goal was to review and evaluate this literature with particular emphasis on the volatile organic constituents. Indeed, since the importance of social chemosignaling in birds is becoming more and more apparent, t...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Campagna S,Mardon J,Celerier A,Bonadonna F

    更新日期:2012-01-01 00:00:00

  • Derivation and evaluation of a labeled hedonic scale.

    abstract::The objective of this study was to develop a semantically labeled hedonic scale (LHS) that would yield ratio-level data on the magnitude of liking/disliking of sensation equivalent to that produced by magnitude estimation (ME). The LHS was constructed by having 49 subjects who were trained in ME rate the semantic magn...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Lim J,Wood A,Green BG

    更新日期:2009-11-01 00:00:00

  • Evaluation of copper speciation and water quality factors that affect aqueous copper tasting response.

    abstract::This study determined taste thresholds for copper as its speciation was varied among free cupric ion, complexed cupric ion, and precipitated cupric particles. The impact of copper chemistry on taste is important as copper is added to many beverages and can be present in drinking water as a natural mineral or due to co...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Cuppett JD,Duncan SE,Dietrich AM

    更新日期:2006-09-01 00:00:00

  • Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.

    abstract::Presynaptic inhibition is the suppression of neurotransmitter release from a neuron by inhibitory input onto its presynaptic terminal. In the olfactory system, the primary sensory afferents from the olfactory neuroepithelium to the brain's olfactory bulb are strongly modulated by a presynaptic inhibition that has been...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: McGann JP

    更新日期:2013-07-01 00:00:00

  • A sexually dimorphic group of atypical glomeruli in the mouse olfactory bulb.

    abstract::Atypical glomeruli (AtG) are clearly distinguishable from typical ones because of their strong cholinergic innervation. AtG are located in defined positions in the caudal half of the main olfactory bulb of rodents. The AtG partially overlap with other specialized olfactory subsystems, such as the modified glomerular c...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Weruaga E,Briñón JG,Porteros A,Arévalo R,Aijón J,Alonso JR

    更新日期:2001-01-01 00:00:00

  • Food perception with age and its relationship to pleasantness.

    abstract::Differences between elderly subjects (n = 46, 61-86 years) and young subjects (n = 36, 18-25 years) in food perception and food liking were investigated. Intensity and liking ratings were assessed for custard dessert, in which flavor enrichment, textural change, and irritant addition were incorporated as strategies to...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Kremer S,Bult JH,Mojet J,Kroeze JH

    更新日期:2007-07-01 00:00:00

  • Chemoreceptive control of feeding processes in hydra.

    abstract::Cnidarians are the simplest metazoans to exhibit satiety after feeding. When hydra are fed to repletion, they close their mouths and cease to capture prey. As feeding stops, contractions of the tentacles and body column increase. Our earlier experiments showed that a gel chromatographic fraction of prey substances inh...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Grosvenor W,Rhoads DE,Kass-Simon G

    更新日期:1996-06-01 00:00:00

  • Guanosine 3',5'-cyclic monophosphate reduces the response of the Moth's olfactory receptor neuron to pheromone.

    abstract::The effects of the membrane-permeable dibutyryl guanosine 3', 5'-cyclic monophosphate (db-cGMP) on the bombykol-elicited receptor current and nerve impulse activity were studied using the open sensillum recording technique. db-cGMP was applied to the outer dendritic membrane of the olfactory receptor neuron of the mot...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Redkozubov A

    更新日期:2000-08-01 00:00:00

  • Chemical stimulation of the thalamic reticular nucleus inhibits the neuronal activity of the posterior insular cortex in rats.

    abstract::Extracellular neuronal responses were recorded from the posterior insular cortex following electrical and chemical stimulation of the thalamic reticular nucleus (Rt) regions. In the present study, most neurons (29/32) were first characterized for their responses to electrical stimulation of the superior laryngeal (SL)...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Hanamori T

    更新日期:2003-10-01 00:00:00

  • Olfactory discrimination of amino acids in brown bullhead catfish.

    abstract::Olfactory discrimination of amino acids was investigated in brown bullhead catfish (Ameiurus nebulosus). Based on the magnitude of the observed food search activity of catfish conditioned to single amino acids, the tested compounds were classified as being detected by the catfish as equal to, similar to, or different ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Valentincic T,Metelko J,Ota D,Pirc V,Blejec A

    更新日期:2000-02-01 00:00:00

  • The septal organ of the rat during postnatal development.

    abstract::The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Weiler E,Farbman AI

    更新日期:2003-09-01 00:00:00

  • A flux capacitor for moth pheromones.

    abstract::In this issue of Chemical Senses, Baker et al. propose a provocative and intriguing explanation for a commonly observed phenomenon in moth chemocommunication. Sex pheromones in moths typically consist of mixtures of long-chain unsaturated compounds in specific ratios. These ratios are correspondingly detected by male ...

    journal_title:Chemical senses

    pub_type: 评论,杂志文章


    authors: Olsson SB,Hansson BS

    更新日期:2012-05-01 00:00:00

  • Measurement of sensitivity to olfactory flavor: application in a study of aging and dentures.

    abstract::Olfaction involves a dual sensory process for perceiving odors orthonasally (through the nostrils) and retronasally (through the mouth). This investigation entailed developing a measure of sensitivity to an odor delivered in an orally sampled food (orange flavoring in a sucrose-sweetened gelatin) and examining sensiti...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Duffy VB,Cain WS,Ferris AM

    更新日期:1999-12-01 00:00:00

  • Expression and purification of functional ligand-binding domains of T1R3 taste receptors.

    abstract::Chemosensory receptors, including odor, taste, and vomeronasal receptors, comprise the largest group of G protein-coupled receptors (GPCRs) in the mammalian genome. However, little is known about the molecular determinants that are critical for the detection and discrimination of ligands by most of these receptors. Th...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Nie Y,Hobbs JR,Vigues S,Olson WJ,Conn GL,Munger SD

    更新日期:2006-07-01 00:00:00

  • Olfactory memory: the long and short of it.

    abstract::It has been proposed that memory for odors does not have a short-term (or working) memory system. The distinction between short- and long-term memory in other sensory modalities has been generally supported by three main lines of evidence: capacity differences between the proposed systems, evidence of differential cod...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: White TL

    更新日期:1998-08-01 00:00:00

  • Design and evaluation of new analogs of the sweet protein brazzein.

    abstract::We have previously modeled the interaction of the sweet protein brazzein with the extracellular domains of the sweet taste receptor. Here, we describe the application of that model to the design of 12 new highly potent analogs of brazzein. Eight of the 12 analogs have higher sweetness potency than wild-type brazzein. ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Walters DE,Cragin T,Jin Z,Rumbley JN,Hellekant G

    更新日期:2009-10-01 00:00:00

  • Perception of everyday odors--correlation between intensity, familiarity and strength of hedonic judgement.

    abstract::In this study, 40 Japanese, 44 German and 39 Mexican women were presented with 18 everyday odorants. They were asked to rate them for intensity on a six-point scale from not detectable to very strong, for pleasantness on an 11-point scale from -5, to neutral at 0, to +5, and for familiarity on a six-point scale from c...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Distel H,Ayabe-Kanamura S,Martínez-Gómez M,Schicker I,Kobayakawa T,Saito S,Hudson R

    更新日期:1999-04-01 00:00:00

  • The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells.

    abstract::A healthy taste system is important to the maintenance of nutrition and overall quality of life, and taste disorders are associated with many inflammatory states. We previously determined the immune cells in normal human gustatory tissue; they are predominantly dendritic cells and CD4 T cells with a few macrophages an...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Feng P,Wang H,Feldman RS,Pribitkin EA,Breslin PA

    更新日期:2010-07-01 00:00:00

  • Rapid degeneration and regeneration of the zebrafish olfactory epithelium after triton X-100 application.

    abstract::The effects of Triton X-100 on the olfactory epithelium (OE) of adult zebrafish were examined to study neuronal turnover in this model system. Fish were killed at various time points after detergent application and stained with hematoxylin and eosin to examine olfactory structures, immunocytochemistry to examine cell ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Iqbal T,Byrd-Jacobs C

    更新日期:2010-06-01 00:00:00

  • Odor and irritation thresholds for ammonia: a comparison between static and dynamic olfactometry.

    abstract::Odor and lateralization (irritation) thresholds (LTs) for ammonia vapor were measured using static and dynamic olfactometry. The purpose of the study was to explore the test-retest reliability and comparability of dynamic olfactometry methodology, generally used to determine odor thresholds following European Committe...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Smeets MA,Bulsing PJ,van Rooden S,Steinmann R,de Ru JA,Ogink NW,van Thriel C,Dalton PH

    更新日期:2007-01-01 00:00:00

  • Olfactory Coding in Antennal Neurons of the Malaria Mosquito, Anopheles gambiae.

    abstract::Olfactory receptor neurons (ORNs) in the antenna of insects serve to encode odors in action potential activity conducted to the olfactory lobe of the deuterocerebrum. We performed an analysis of the electrophysiological responses of olfactory neurons in the antennae of the female malaria mosquito Anopheles gambiae s.s...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Qiu YT,van Loon JJ,Takken W,Meijerink J,Smid HM

    更新日期:2006-11-01 00:00:00

  • Identification of gustatory-olfactory flavor mixtures: effects of linguistic labeling.

    abstract::Two experiments, using different ranges and numbers of stimuli, examined how linguistic labels affect the identification of flavor mixtures containing different proportions of sucrose (gustatory flavorant) and citral (olfactory flavorant). Both experiments asked subjects to identify each stimulus as having either "mos...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Brewer JM,Shavit AY,Shepard TG,Veldhuizen MG,Parikh R,Marks LE

    更新日期:2013-05-01 00:00:00

  • Olfactory signal modulation by molluscan cardioexcitatory tetrapeptide (FMRFamide) in axolotls (Ambystoma mexicanum).

    abstract::The terminal nerve, which innervates the nasal epithelia of most jawed vertebrates, is believed to release neuropeptides that modulate activity of sensory receptor neurons. The terminal nerve usually contains gonadotropin-releasing hormone as well as at least one other peptide that has not been characterized, but whic...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Park D,Zawacki SR,Eisthen HL

    更新日期:2003-05-01 00:00:00

  • The Perceptual Characteristics of Sodium Chloride to Sodium-Depleted Rats.

    abstract::Three experiments assessed potential changes in the rat's perception of sodium chloride (NaCl) during a state of sodium appetite. In Experiment 1, sodium-sufficient rats licking a range of NaCl concentrations (0.028-0.89M) in 15s trials showed an inverted U-shaped concentration response function peaking at 0.281M. Dep...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: St John SJ

    更新日期:2017-02-01 00:00:00

  • Individual Differences in Verbal and Non-Verbal Affective Responses to Smells: Influence of Odor Label Across Cultures.

    abstract::Olfactory perception is highly variable from one person to another, as a function of individual and contextual factors. Here, we investigated the influence of 2 important factors of variation: culture and semantic information. More specifically, we tested whether cultural-specific knowledge and presence versus absence...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章


    authors: Ferdenzi C,Joussain P,Digard B,Luneau L,Djordjevic J,Bensafi M

    更新日期:2017-01-01 00:00:00

  • A metamemory perspective on odor naming and identification.

    abstract::A metacognitive perspective is utilized to elucidate why it is so difficult to name common odors and what characterizes the subjective knowledge people have about their actual odor knowledge. Odor-naming failures are often accompanied by strong feelings of knowing (FOK) or feelings of imminent retrieval of what it is ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Jönsson FU,Tchekhova A,Lönner P,Olsson MJ

    更新日期:2005-05-01 00:00:00

  • Sensory evaluation of mixtures of maltitol or aspartame, sucrose and an orange aroma.

    abstract::The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Nahon DF,Roozen JP,de Graaf C

    更新日期:1998-02-01 00:00:00