Olfactory receptor neuron profiling using sandalwood odorants.

Abstract:

:The mammalian olfactory system can discriminate between volatile molecules with subtle differences in their molecular structures. Efforts in synthetic chemistry have delivered a myriad of smelling compounds of different qualities as well as many molecules with very similar olfactive properties. One important class of molecules in the fragrance industry are sandalwood odorants. Sandalwood oil and four synthetic sandalwood molecules were selected to study the activation profile of endogenous olfactory receptors when exposed to compounds from the same odorant family. Dissociated rat olfactory receptor neurons were exposed to the sandalwood molecules and the receptor activation studied by monitoring fluxes in the internal calcium concentration. Olfactory receptor neurons were identified that were specifically stimulated by sandalwood compounds. These neurons expressed olfactory receptors that can discriminate between sandalwood odorants with slight differences in their molecular structures. This is the first study in which an important class of perfume compounds was analyzed for its ability to activate endogenous olfactory receptors in olfactory receptor neurons.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Bieri S,Monastyrskaia K,Schilling B

doi

10.1093/chemse/bjh050

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

483-7

issue

6

eissn

0379-864X

issn

1464-3553

pii

29/6/483

journal_volume

29

pub_type

杂志文章
  • Clinical bitterness masking test for phantogeusia.

    abstract::It is difficult to determine the reason why a patient complains of a bitter taste when their mouth is empty. We examined a new diagnostic test using a bitterness masking substance. The bitterness masking substance, 'Benecoat BMI-60' (hereafter BMI-60), is a masking substance specific to the taste cells' bitterness rec...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/26.1.91

    authors: Ishimaru T,Hatanaka S,Miwa T,Furukawa M

    更新日期:2001-01-01 00:00:00

  • Switch and bait: probing the discriminative basis of odor identification via recognition memory.

    abstract::When people misidentify everyday odors, as they often do, their errors may conceivably lie in faulty perceptions or in faulty access to the names. Discussions of the matter usually focus on the latter, as if people had no problems with perceptual accuracy. (The problem of faulty access may get attention because its hi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/21.1.35

    authors: Cain WS,Potts BC

    更新日期:1996-02-01 00:00:00

  • Adding cocoa to sucrose: the effect on cold pain tolerance.

    abstract::The sweet taste of sucrose acts as an analgesic, whereas the taste of a bitter substance decreases pain tolerance. The present experiment explores the analgesic effect of a complex taste and asks how adding cocoa, a substance often associated with sweet foods but that has a bitter taste, to a sucrose solution affects ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq016

    authors: Eggleston K,White TL,Sheehe PR

    更新日期:2010-05-01 00:00:00

  • A method for the rapid automated assessment of olfactory function.

    abstract::We have developed a strategy for the rapid high-throughput screening of odor responsivity in genetically altered mice (in fact, any experimentally altered animal). Specifically, the report presents the development and validation of a fully automated procedure based on the evaluation of an animal's stimulus-induced ref...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bji017

    authors: Youngentob SL

    更新日期:2005-03-01 00:00:00

  • Analysis of slow hyperpolarizing potentials in frog taste cells induced by glossopharyngeal nerve stimulation.

    abstract::Electrical stimulation of the frog glossopharyngeal (GP) nerve evoked slow hyperpolarizing potentials (HPs) in taste cells. This study aimed to clarify whether slow HPs were postsynaptically induced in taste cells. The slow HPs were recorded intracellularly with a microelectrode. When Ca2+ concentration in the blood p...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjh072

    authors: Sato T,Okada Y,Toda K

    更新日期:2004-10-01 00:00:00

  • Visual-Olfactory Interactions: Bimodal Facilitation and Impact on the Subjective Experience.

    abstract::Odors are inherently ambiguous and therefore susceptible to redundant sensory as well as context information. The identification of an odor object relies largely on visual input. Thus far, it is unclear whether visual and olfactory stimuli are indeed integrated at an early perceptual stage and which role the congruenc...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjy018

    authors: Amsellem S,Höchenberger R,Ohla K

    更新日期:2018-05-23 00:00:00

  • Asymmetrical Processing of Olfactory Input in the Piriform Cortex Mediates "Activation" of the Avian Navigation Circuitry.

    abstract::The role of odors in the long-distance navigation of birds has elicited intense debate for more than half a century. Failure to resolve many of the issues fueling this debate is due at least in part to the absence of controls for a variety of non-specific effects that odors have on the navigational process. The presen...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw084

    authors: Jorge PE,Marques PAM,Pinto BV,Phillips JB

    更新日期:2016-11-01 00:00:00

  • Taste sensitivity and aging: high incidence of decline revealed by repeated threshold measures.

    abstract::Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/20.4.451

    authors: Stevens JC,Cruz LA,Hoffman JM,Patterson MQ

    更新日期:1995-08-01 00:00:00

  • Structural role of the terminal disulfide bond in the sweetness of brazzein.

    abstract::Brazzein, a 54 residue sweet-tasting protein, is thought to participate in a multipoint binding interaction with the sweet taste receptor. Proposed sites for interaction with the receptor include 2 surface loops and the disulfide bond that connects the N- and C-termini. However, the importance of each site is not well...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr057

    authors: Dittli SM,Rao H,Tonelli M,Quijada J,Markley JL,Max M,Assadi-Porter F,Maillet E

    更新日期:2011-11-01 00:00:00

  • The distribution of sugar chains on the vomeronasal epithelium observed with an atomic force microscope.

    abstract::The distribution of sugar chains on tissue sections of the rat vomeronasal epithelium, and the adhesive force between the sugar and its specific lectin were examined with an atomic force microscope (AFM). AFM tips were modified with a lectin, Vicia villosa agglutinin, which recognizes terminal N-acetyl-D-galactosamine...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/24.1.1

    authors: Osada T,Takezawa S,Itoh A,Arakawa H,Ichikawa M,Ikai A

    更新日期:1999-02-01 00:00:00

  • Representation of primary plant odorants in the antennal lobe of the moth Heliothis virescens using calcium imaging.

    abstract::The primary olfactory centre, the antennal lobe of Heliothis virescens moths, contains 62 glomeruli which process plant odour information and four male-specific glomeruli which form the macroglomerular complex, involved in processing information about pheromone and interspecific signals. Using calcium imaging, we reco...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjh026

    authors: Skiri HT,Galizia CG,Mustaparta H

    更新日期:2004-03-01 00:00:00

  • Using Errors by Guard Honeybees (Apis mellifera) to Gain New Insights into Nestmate Recognition Signals.

    abstract::Although the honeybee (Apis mellifera) is one of the world most studied insects, the chemical compounds used in nestmate recognition, remains an open question. By exploiting the error prone recognition system of the honeybee, coupled with genotyping, we studied the correlation between cuticular hydrocarbon (CHC) profi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv053

    authors: Pradella D,Martin SJ,Dani FR

    更新日期:2015-11-01 00:00:00

  • CRISPR/Cas 9-Mediated Mutations as a New Tool for Studying Taste in Honeybees.

    abstract::Honeybees rely on nectar as their main source of carbohydrates. Sucrose, glucose, and fructose are the main components of plant nectars. Intriguingly, honeybees express only 3 putative sugar receptors (AmGr1, AmGr2, and AmGr3), which is in stark contrast to many other insects and vertebrates. The sugar receptors are o...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjaa063

    authors: Değirmenci L,Geiger D,Rogé Ferreira FL,Keller A,Krischke B,Beye M,Steffan-Dewenter I,Scheiner R

    更新日期:2020-11-07 00:00:00

  • Olfactory memory: the long and short of it.

    abstract::It has been proposed that memory for odors does not have a short-term (or working) memory system. The distinction between short- and long-term memory in other sensory modalities has been generally supported by three main lines of evidence: capacity differences between the proposed systems, evidence of differential cod...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/23.4.433

    authors: White TL

    更新日期:1998-08-01 00:00:00

  • Working range of stimulus flux transduction determines dendrite size and relative number of pheromone component receptor neurons in moths.

    abstract::We are proposing that the "relative" abundances of the differently tuned pheromone-component-responsive olfactory receptor neurons (ORNs) on insect antennae are not a result of natural selection working to maximize absolute sensitivity to individual pheromone components. Rather, relative abundances are a result of spe...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjr122

    authors: Baker TC,Domingue MJ,Myrick AJ

    更新日期:2012-05-01 00:00:00

  • The septal organ of the rat during postnatal development.

    abstract::The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjg047

    authors: Weiler E,Farbman AI

    更新日期:2003-09-01 00:00:00

  • Do tastants have a smell?

    abstract::The stimuli used in taste research are usually considered to be odourless. This was tested in two experiments with aqueous solutions of two representative compounds for each of the five taste qualities including umami. In the first experiment elderly and young subjects rated the intensity and pleasantness of three con...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjh251

    authors: Mojet J,Köster EP,Prinz JF

    更新日期:2005-01-01 00:00:00

  • Male but not female olfaction is crucial for intermolt mating in European lobsters (Homarus gammarus L.).

    abstract::Chemical signals are common in most crustacean social interactions and are often perceived via chemosensory (olfactory) organs on the first antenna. Intermolt courtship behaviors and mating were investigated in size-matched pairs of intermolt European lobsters (Homarus gammarus) where the olfactory receptors of either...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjn073

    authors: Skog M

    更新日期:2009-02-01 00:00:00

  • A metamemory perspective on odor naming and identification.

    abstract::A metacognitive perspective is utilized to elucidate why it is so difficult to name common odors and what characterizes the subjective knowledge people have about their actual odor knowledge. Odor-naming failures are often accompanied by strong feelings of knowing (FOK) or feelings of imminent retrieval of what it is ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bji030

    authors: Jönsson FU,Tchekhova A,Lönner P,Olsson MJ

    更新日期:2005-05-01 00:00:00

  • Differential inputs from chemosensory appendages mediate feeding responses to glucose in wild-type and glucose-averse German cockroaches, Blattella germanica.

    abstract::Glucose is a universal phagostimulant in many animal species, including the cockroach Blattella germanica. However, some natural populations of B. germanica have been found that are behaviorally deterred from eating glucose. In dose-response studies, glucose was a powerful phagostimulant for wild-type cockroaches, but...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr023

    authors: Wada-Katsumata A,Silverman J,Schal C

    更新日期:2011-09-01 00:00:00

  • The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells.

    abstract::A healthy taste system is important to the maintenance of nutrition and overall quality of life, and taste disorders are associated with many inflammatory states. We previously determined the immune cells in normal human gustatory tissue; they are predominantly dendritic cells and CD4 T cells with a few macrophages an...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq040

    authors: Feng P,Wang H,Feldman RS,Pribitkin EA,Breslin PA

    更新日期:2010-07-01 00:00:00

  • Porcine VEG proteins and tear prealbumins.

    abstract::Small soluble proteins, belonging to the lipocalin family are secreted in large amounts by tongue von Ebner's glands and lachrymal glands. In humans, the lingual protein, called VEG, and the lachrymal protein, called tear prealbumin, have shown identical cDNA sequences. In the pig, we have purified homodimeric protein...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/20.1.69

    authors: Garibotti M,Christiansen H,Schmale H,Pelosi P

    更新日期:1995-02-01 00:00:00

  • Enhancement of Saltiness Perception by Monosodium Glutamate Taste and Soy Sauce Odor: A Near-Infrared Spectroscopy Study.

    abstract::Previous studies have reported that the umami taste of monosodium l-glutamate (MSG) and salty-smelling odors (e.g., soy sauce, bacon, sardines) enhance the perception of saltiness. This study aimed to investigate the neural basis of the enhancement of saltiness in human participants using functional near-infrared spec...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjx084

    authors: Onuma T,Maruyama H,Sakai N

    更新日期:2018-02-26 00:00:00

  • Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants.

    abstract::Rats can be classified as either sucralose avoiders (SA) or sucralose preferrers (SP) based on their behavioral responses in 2-bottle preference, 1-bottle intake, and brief-access licking tests. The present study demonstrates that this robust phenotypic variation in the preference for sucralose predicts acceptance of ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr126

    authors: Loney GC,Torregrossa AM,Carballo C,Eckel LA

    更新日期:2012-06-01 00:00:00

  • Sensory evaluation of mixtures of maltitol or aspartame, sucrose and an orange aroma.

    abstract::The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/23.1.59

    authors: Nahon DF,Roozen JP,de Graaf C

    更新日期:1998-02-01 00:00:00

  • A candidate pheromone receptor and two odorant receptors of the hawkmoth Manduca sexta.

    abstract::In this study, we cloned and characterized three Manduca sexta odorant receptors (ORs). One receptor is a putative pheromone receptor expressed exclusively in a cell associated with male-specific type-I trichoid sensilla. We describe the results of real-time PCR (RT-PCR) and quantitative real-time PCR (qRT-PCR) experi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp002

    authors: Patch HM,Velarde RA,Walden KK,Robertson HM

    更新日期:2009-05-01 00:00:00

  • Effects of aromatic compounds on antennal responses and on the pheromone-binding proteins of the gypsy moth (Lymantria dispar).

    abstract::Female gypsy moths emit a pheromone, (+)-disparlure, which the males follow until they locate the emitter. The male moths' antennae are covered with innervated sensory hairs, specialized in detection of the pheromone. The neurons in these sensory hairs are bathed by a solution rich in pheromone-binding protein (PBP). ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq130

    authors: Gong Y,Plettner E

    更新日期:2011-03-01 00:00:00

  • Odor and irritation thresholds for ammonia: a comparison between static and dynamic olfactometry.

    abstract::Odor and lateralization (irritation) thresholds (LTs) for ammonia vapor were measured using static and dynamic olfactometry. The purpose of the study was to explore the test-retest reliability and comparability of dynamic olfactometry methodology, generally used to determine odor thresholds following European Committe...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl031

    authors: Smeets MA,Bulsing PJ,van Rooden S,Steinmann R,de Ru JA,Ogink NW,van Thriel C,Dalton PH

    更新日期:2007-01-01 00:00:00

  • Metabolic and Sensory Influences on Odor Sensitivity in Humans.

    abstract::Our olfactory sense plays an important role in eating behavior by modulating our food preferences and intake. However, hunger or satiety may also influence how we perceive odors. Albeit speculative, contradictory results found in the past may have resulted from confounding by type of meal that participants ate to indu...

    journal_title:Chemical senses

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/chemse/bjv068

    authors: Ramaekers MG,Verhoef A,Gort G,Luning PA,Boesveldt S

    更新日期:2016-02-01 00:00:00

  • Quality of Life in Patients With Olfactory Loss Is Better Predicted by Flavor Identification Than by Orthonasal Olfactory Function.

    abstract::To date, most studies on the relationship between chemosensory performance and quality of life have focused on orthonasal measures of olfactory function. In the current investigation, we examined the predictive value of orthonasal and flavor identification indices of olfactory function on a wide spectrum of health and...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjz027

    authors: Oleszkiewicz A,Park D,Resler K,Draf J,Schulze A,Zang Y,Hähner A,Hummel T

    更新日期:2019-07-17 00:00:00