The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells.

Abstract:

:A healthy taste system is important to the maintenance of nutrition and overall quality of life, and taste disorders are associated with many inflammatory states. We previously determined the immune cells in normal human gustatory tissue; they are predominantly dendritic cells and CD4 T cells with a few macrophages and B lymphocytes present. There are, however, few reports of the subtypes of resident lymphocytes in or near taste tissues. The present study further characterized the distribution and population of the major subtypes of T cells in situ within biopsies of healthy human fungiform papillae (FP). Immunohistochemical analyses indicated that T-helper (Th)1 cells (CCR5+) were more predominant in FP than Th2 T cells (CCR4+). CD45RO+ memory T cells were the principal T cells in gustatory tissue, whereas CD45RA+ naive T cells were uncommon. Regarding subcompartments of the tissue, most intraepithelial lymphocytes of FPs were gamma/delta T cells, whereas the major subtype of lymphocytes in the lamina propria were alpha/beta T cells. Regulatory T cells that express CTLA-4 (CD152) and interleukin-2 receptors (IL-2R, CD25) were found at low levels in FP. The T cells stand ready to respond to inflammatory and infectious insults and may play a role in the taste alterations observed during acute and chronic inflammatory states.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Feng P,Wang H,Feldman RS,Pribitkin EA,Breslin PA

doi

10.1093/chemse/bjq040

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

501-9

issue

6

eissn

0379-864X

issn

1464-3553

pii

bjq040

journal_volume

35

pub_type

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